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中华物理医学与康复杂志 2016年第12期38卷 915-915页

作者： Cosman F Crittenden db Adachi JD

BACKGROUND AND OBJECTIVE Even after fracture,fewer than 25%of patients receive pharmacologic treatment for *** the discovery that sclerostin deficiency causes rare genetic conditions that are characterized by high bone mass and resistance to fracture,sclerostin has become a therapeutic target for the treatment of this *** study assessed the effect of romosozumab,a monoclonal antibody that binds and inhibits sclerostin with the dual effect of increasing bone formation and decreasing bone *** Subjects were ambulatory,postmenopausal women,55 to 90 years of age,with T scores at the total hip or femoral neck of-

关键词：骨质疏松症药物治疗单克隆抗体遗传性骨吸收骨形成骨折

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Neutrophil kinetics and function after major trauma:A systematic review

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World Journal of Critical Care Medicine 2021年第5期10卷 260-277页

作者： Liam db Finlay Andrew Conway Morris Adam M Deane Alexander JT Wood Melbourne Medical School University of MelbourneMelbourne 3052VictoriaAustralia Department of Medicine University of CambridgeCambridge 01223United Kingdom Centre for Integrated Critical Care University of MelbourneParkville 3052VictoriaAustralia Intensive Care Unit Royal Melbourne HospitalParkville 3052VictoriaAustralia

BACKGROUND Immune dysfunction following major traumatic injury is complex and strongly associated with significant morbidity and mortality through the development of multiple organ dysfunction syndrome(MODS),persistent inflammation,immunosuppression,and catabolism syndrome and *** are thought to be a pivotal mediator in the development of immune *** To provide a review with a systematic approach of the recent literature describing neutrophil kinetics and functional changes after major trauma in humans and discuss hypotheses as to the mechanisms of the observed neutrophil dysfunction in this *** Medline,Embase and PubMed were searched on January 15,*** were screened by two reviewers and those included had their reference list hand searched for additional papers of *** criteria were adults>18 years old,with an injury severity score>12 requiring admission to an intensive care *** that analysed major trauma patients as a subgroup were *** Of 107 papers screened,48 were included in the *** were heterogeneous and most studies had a moderate to significant risk of bias owing to their observational nature and small sample *** findings included a persistently elevated neutrophil count,stereotyped alterations in cell-surface markers of activation,and the elaboration of heterogeneous and immunosuppressive populations of cells in the *** of these changes correlate with clinical outcomes such as MODS and secondary *** phenotype remains a promising avenue for the development of predictive markers for immune *** Understanding of neutrophil phenotypes after traumatic injury is expanding.A greater emphasis on incorporating functional and clinically significant markers,greater uniformity in study design and assessment of extravasated neutrophils may facilitate risk stratification in patients affected by major trauma.

关键词： Neutrophils Multiple trauma Immunophenotypes Inflammation Systemic inflammatory response syndrome Intensive care units

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Neuropsychological performance after concussions and/ or posttraumatic stress disorder

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中华物理医学与康复杂志 2018年第6期40卷 413-413页

作者： Cooper db Curtiss G Armistead-Jehle P

BACKGROUND AND OBJECTIVE Between 2000 and 2016 approximately 361,000 military personnel experienced a traumatic brain injury(TBI),with the 82%of those classified as *** those events have been associated with altered cognitive performance and posttraumatic stress symptoms,this study evaluated the effects of multiple concussions on subjective and objective cognitive performance.

关键词：性能震动压力脑损害

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人类免疫缺陷病毒感染泊神经系统并发症

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世界医学杂志 1999年第5期3卷 54-63页

作者： Clif.,db

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外科病理诊断中的错误

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临床与实验病理学杂志 2005年第4期21卷 510-512页

作者： Troxel db 黄文斌（摘译）周晓军（摘译）不详南京军区南京总医院病理科南京210002

以往有文献报道,根据对所有病例进行的前瞻性研究或对部分病例随机抽样调查结果,外科病理诊断中有明显临床意义的诊断错误率为0.26％～12％.然而对5 000例连续活检标本进行"盲法"复习显示明显的临床诊断错误率仅为0.08%.因此,事实上外... 详细信息

以往有文献报道,根据对所有病例进行的前瞻性研究或对部分病例随机抽样调查结果,外科病理诊断中有明显临床意义的诊断错误率为0.26％～12％.然而对5 000例连续活检标本进行"盲法"复习显示明显的临床诊断错误率仅为0.08%.因此,事实上外科病理诊断错误率相对较低.如果考虑到病理医生采用的诊断标准比较模糊,带有较大的循证性和经验性(基于权威和主观性),在日常大量的"普通"病例中又随机混杂有少量少见的疑难复杂病例,而且有时临床提供的信息不完整,甚至令人误解,而如此之低的外科病理诊断错误率多少有些令人惊讶.……

关键词：外科病理诊断前瞻性研究错误率文献报道调查结果随机抽样临床意义临床诊断活检标本

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地震带内隧洞防水衬砌的设计

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隧道及地下工程 1999年第1期20卷 26-34页

作者： Desai,db 郭滨

１２７１０ｍ（４１７２０ｆｔ）长的ＲｉｖｅｒｓｉｄｅＢａｄｌａｎｄｓ隧道位于南加利福尼亚的圣安德烈亚斯和圣哈辛托两个最活跃断层之间，为完成不透水最终衬砌的设计和消除地震时地层震动的影响，一种新的方法得以发展并在本文... 详细信息

１２７１０ｍ（４１７２０ｆｔ）长的ＲｉｖｅｒｓｉｄｅＢａｄｌａｎｄｓ隧道位于南加利福尼亚的圣安德烈亚斯和圣哈辛托两个最活跃断层之间，为完成不透水最终衬砌的设计和消除地震时地层震动的影响，一种新的方法得以发展并在本文中加以说明。针对在地下水位以下从罗岩到硬岩且深度超过２４４ｍ（８００ｆｔ）这样的地质条件下开挖的隧洞可考虑采用的两种最终衬砌选择方案－焊接钢管和预应力混凝土圆柱管。

关键词：隧洞工程地震带衬砌防水

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