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Impact of pre- and peri-operative risk factors on length of stay and hospital readmission following minimally-invasive partial nephrectomy

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Asian Journal of Urology 2024年第1期11卷 72-79页

作者： Vanessa A.Lukas rahul dutta Ashok K.Hemal matvey Tsivian Timothy e.Craven Nicholas A.deebel david d.Thiel ram Anil Pathak Brigham and Women's Hospital Division of UrologyDepartment of Surgery75 Francis StreetBostonMAUSA Atrium Health Wake Forest Baptist medical Center Department of Urology1 Medical Center BlvdWinston-SalemNCUSA mayo Clinic Florida Department of Urology4500 San Pablo RoadJacksonvilleFLUSA

Objective:We conducted an analysis of the American College of Surgeons National Surgical Quality Improvement Program database for minimally-invasive partial nephrectomy cases reported with the goal to identify pre-and peri-operative variables associated with length of stay(LOS)greater than 3 days and readmission within 30 ***:records from 2008 to 2018 for“laparoscopy,surgical;partial nephrectomy”for prolonged LOS and readmission cohorts were *** analysis with Chi-square,t-tests,and multivariable logistic regression analysis with odds ratios(Ors),p-values,and 95%confidence intervals assessed statistical ***:Totally,20306 records for LOS greater than 3 days and 15854 for readmission within 30 days were *** and multivariable analysis exhibited similar *** LOS greater than 3 days,undergoing non-elective surgery(Or=5.247),transfusion of greater than four units within 72 h prior to surgery(Or=5.072),pre-operative renal failure or dialysis(Or=2.941),and poor pre-operative functional status(Or=2.540)exhibited the strongest statistically significant *** hospital readmission within 30 days,loss in body weight greater than 10%in 6 months prior to surgery(Or=2.227)and bleeding disorders(Or=2.081)exhibited strongest statistically significant ***:multiple pre-and peri-operative risk factors are independently associated with prolonged LOS and hospital readmission within 30 days of surgery using the American College of Surgeons National Surgical Quality Improvement Program *** the risks factors that can potentially be improved prior to minimally-invasive partial nephrectomy is crucial to informing patient selection,optimization strategies,and patient education.

关键词： minimally-invasive partial nephrectomy The American College of Surgeons National Surgical Quality Improvement Program Lengthof stay Hospital readmission

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Pelvic fractures in blunt trauma patients:A comparative study

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World Journal of Orthopedics 2024年第5期15卷 418-434页

作者： Alexander A Fokin Joanna Wycech Knight madison e Tharp Kyler C Brinton Phoebe K Gallagher Justin Fengyuan Xie russell d Weisz Ivan Puente Trauma and Critical Care Services Delray Medical CenterDelray BeachFL 33484United States Charles e Schmidt College of medicine Department of SurgeryFlorida Atlantic UniversityBoca RatonFL 33431United States Trauma and Critical Care Services Broward Health Medical CenterFort LauderdaleFL 33316United States Charles e Schmidt College of medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of medicine Department of SurgeryFlorida International UniversityMiamiFL 33199United States

BACKGrOUNd Pelvic fractures(PF)with concomitant injuries are on the rise due to an increase of high-energy *** of the elderly population with age related comorbidities further complicates the *** organ injuries are kindred with PF due to the proximity to pelvic *** of contrast blush(CB)on computed tomography in patients with PF is considered a sign of active bleeding,however,its clinical significance and association with outcomes is *** To analyze polytrauma patients with PF with a focus on the geriatric population,co-injuries and the value of contrast *** This retrospective cohort study included 558 patients with PF admitted to level 1 trauma center(01/2017-01/2023).Analyzed variables included:Age,sex,mechanism of injury(mOI),injury severity score(ISS),Glasgow coma scale(GCS),abbreviated injury scale(AIS),co-injuries,transfusion requirements,pelvic angiography,embolization,laparotomy,orthopedic pelvic surgery,intensive care unit and hospital lengths of stay,discharge disposition and *** study compared geriatric and non-geriatric patients,patients with and without CB and abdominal *** score matching was implemented in comparison *** PF comprised 4%of all trauma admissions.89 patients had CB.286(52%)patients had concomitant injuries including 93(17%)patients with abdominal *** patients compared to non-geriatric had more falls as mOI,lower ISS and AIS pelvis,higher GCS,less abdominal co-injuries,similar CB and angio-embolization rates,less orthopedic pelvic surgeries,shorter lengths of stay and higher *** propensity matching,orthopedic pelvic surgery rates remained lower(8%vs 19%,Pength of stay shorter,and mortality higher(13%vs 4%,Periatric *** of 89 patients with CB,45(51%)were *** propensity matching,patients with CB compared to without CB had more pelvic angiography(71%vs 12%,P<0.001),hi

关键词： Pelvic fractures Geriatric trauma patients Abdominal co-injuries Contrast blush Contrast extravasation Angioembolization Polytrauma patients Surgical interventions Blunt trauma external and internal fixation for pelvic stabilization

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Organic stabilization in earthen plaster:eco-compatible architecture and ancient techniques in Tata Somba homes

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Frontiers of Architectural research 2024年第3期13卷 625-638页

作者： d.Ben Ghida department of Architecture University of Naples FedericoⅡNaplesItaly

The study of organic stabilization is crucial for understanding its impact on the durability and effectiveness of earthen *** natural admixtures’effects on plaster properties provides insights that aid in optimizing plaster composition and application for desired *** addition of biopolymers,known to enhance plaster performance,necessitates further investigation to understand their role in earthen plaster *** study focuses on Tata Somba homes in Benin and Togo,recognized as UNeSCO World Heritage *** unique architectural examples embody“architecture without architects”,relying solely on local traditional *** objective is to explore and revive Tata Somba’s ancient eco-technology for earth plaster *** shows that biopolymers’combined stabilization and application techniques can improve earthen plaster *** promising bio-stabilizers were identified,suggesting their potential as sustainable,effective options for CO_(2) mitigation in *** findings not only deepen our understanding of earthen architecture but also underscore the potential of merging traditional,eco-friendly building methods with modern scientific insights to create sustainable solutions for cultural heritage preservation and contemporary built environments.

关键词： Vernacular architecture Cultural heritage preservation Sustainable architecture Biopolymer earth architecture earth stabilization

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In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

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microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović Nataša V.Todorović Aleksandar J.Krmpot miroslav Živić Svetlana Savić-Šević Steva m.Lević marina Stanić dejan Pantelić Brana Jelenković mihailo d.rabasović Institute of Physiology and Biochemistry“Ivan djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia University of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for multidisciplinary research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond Ir laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser

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A new fractional order 6d chaotic model:Study of model dynamics,system structure graph,electronic circuit realization and fractional control

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Journal of Ocean engineering and Science 2024年第2期9卷 112-125页

作者： m.Higazy Norah Almalki Shabbir muhammad A.Al-Ghamdi department of mathematics and Statistics College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia department of Physics and engineering mathematics Faculty of Electronic EngineeringMenoufia UniversityMenouf 32952Egypt research Center for Advanced materials Science(rCAmS) King Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia department of Physics Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia

A new fractional 6d chaotic model is constructed in this *** new fractional 6d chaotic model has six positive parameters plus the fractional order with eight nonlinear *** complicated chaotic dy-namics of the new fractional 6d model is presented and *** basic properties of this model are studied and its chaotic attractors,dissipative feature,symmetry,equilibrium points,Lyapunov exponents are *** new dynamics of the 6d fractional model is numerically simulated using matlab *** addition,utilizing the graph theory tools certain structural characteristics are *** electrical circuit is built to implement the new 5.4 fractional order 6d ***,an active fractional order controller is proposed to control the new model at different fractional *** chaos of the new model is very useful and can be used to produce random keys for data encryption.

关键词： Chaotic systems Fractional calculus Lyapunov exponents Chaotic attractors Adjacency matrix Hermitian matrix electronic circuit realization

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Carbene chemistry for unnatural biosynthesis

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Science China(Life Sciences) 2024年第1期67卷 204-207页

作者： Jing Huang Jay d.Keasling department of Chemical and Biomolecular engineering University of CaliforniaBerkeley 94720USA Joint Bioenergy Institute Lawrence Berkeley National LaboratoryEmeryville 94608USA Biological Systems and engineering division Lawrence Berkeley National LaboratoryBerkeley 94720USA Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKongens Lyngby 2800Denmark department of Bioengineering University of CaliforniaBerkeley 94720USA Synthetic Biochemistry Center Institute for Synthetic BiologyShenzhen Institutes for Advanced TechnologiesShenzhen 518055China

Previously,chemists working in synthesis were jealous of biologists since the enzymes found in nature usually exhibited great catalytic properties(e.g.,high catalytic efficiency,excellent selectivity such as substrate selectivity,regioselectivity and stereoselectivity).However,biological systems lack many counterparts of reactions widely used in chemical synthesis.

关键词： synthesis selectivity catalytic

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role of marine natural products in the development of antiviral agents against SArS‑CoV‑2:potential and prospects

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marine Life Science & Technology 2024年第2期6卷 280-297页

作者： d.P.Nagahawatta N.m.Liyanage Thilina U.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon department of marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SArS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SArS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SArS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(mNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SArS-CoV-2 genome and ***,we highlighted anti-SArS-CoV-2 therapeutic intervention efforts utilizing mNPs and predicted SArS-CoV-2 inhibitor design.

关键词： SArS-CoV-2 marine natural products drug targets Inhibitors

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural regeneration research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-Hashem Salah O.Bashir Amal F.dawood moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz m.Al-Garni mohamed d.morsy department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia department of Basic medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia department of medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the morris Water maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mrNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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A 3d In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

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International Journal of Oral Science 2024年第2期16卷 225-237页

作者： William macalester Asme Boussahel rafael O.moreno-Tortolero mark r.Shannon Nicola West darryl Hill Adam Perriman School of Cellular and molecular medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristol Centre for Functional Nanomaterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre for Protolife research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Periodontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom max Planck-Bristol Centre for minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom

emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral ***,the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering,exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems,which will impact on cell fate and subsequent treatment ***,we design and bioprint a facile 3d in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells(hmSCs)encapsulated in a microporous hydrogel *** demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hmSCs,and that both dentine andβ-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface,which is distal to the gel-substrate *** findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3d dentine-bone interface models.

关键词： interface den surface

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extracellular vesicles-coupled mirNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1528-1549页

作者： rosane mazzarella Karina Canon‑Beltran Yulia N.Cajas meriem Hamdi encina m.Gonzalez Juliano C.da Silveira Claudia L.V.Leal d.rizos department of Animal reproduction INIA-CSICMadridSpain department of Biochemistry and molecular Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain department Agrarian Production Technical University of MadridUPMMadridSpain departamento de Ciencias Biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador department of Anatomy and embryology FV-UCMMadridSpain department of Veterinary medicine FZEA-USPPirassunungaBrazil

Background extracellular vesicles(eVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes(LmGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. Bioactive molecules within eVs in maternal reproductive fluids, such as micro rNAs(mirNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated mirNA cargo in OF-eVs from the early luteal phase and UF-eVs from the mid-luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on LmGs and sign-aling pathways crucial for early embryo development. A total of 333 mirNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed mirNAs, 19 up-regulated in UF-eVs(bta-mir-134, bta-mir-151-3p, bta-mir-155, bta-mir-188, bta-mir-181b, bta-mir-181d, bta-mir-224, bta-mir-23b-3p, bta-mir-24-3p, bta-mir-27a-3p, bta-mir-29a, bta-mir-324, bta-mir-326, bta-mir-345-3p, bta-mir-410, bta-mir-652, bta-mir-677, bta-mir-873 and bta-mir-708) and one(bta-mir-148b) in OF-eVs. These mirNAs were predicted to modulate several pathways such as Wnt, Hippo, mAPK, and lipid metabolism and degradation. differ-ences in mirNAs found in OF-eVs from the early luteal phase and UF-eVs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, mirNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： embryo-maternal interaction epigenetic exosomes mammalian Preimplantation reproductive fluids

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