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H→γγ:a comment on the indeterminacy of non-gauge-invariant integrals

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Chinese Physics C 2013年第4期37卷 7-13页

作者： F.Piccinini A.Pilloni a.d.polosa INFN Pavia-Via A.Bassi 6 I-27100PaviaItaly dipartimento di Fisica a.d.INFN 'Sapienza' Università di Roma-P.le A.Moro 2I-00185RomaItaly

We reanalyze the recent computation of the amplitude of the Higgs boson decay into two photons presented by Gastmans et al. [1, 2]. The reasons for why this result cannot be the correct one have been discussed in some recent papers. We a.d.ess here the general issue of the indeterminacy of integrals with four-dimensional gauge-breaking regulators a.d.to which extent it might eventually be solved by imposing physical constraints. Imposing gauge invariance as the last step upon Rξ-gauge calculations with four-dimensional gauge-breaking regulators, allows us to recover the well known H→γγ result. However we show that in the particular case of the unitary gauge, the indeterminacy cannot be tackled in the same way. The combination of the unitary gauge with a cutoff regularization scheme turns out to be non-predictive.

关键词： Higgs decay regularization methods loop calculations gauge invariance

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia.d.Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper a.d.lower motor neurons,clinically marked by muscle atrophy a.d.*** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals a.d.affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade a.d.tau hypotheses posit that abnormal misfolding a.d.accumulation of amyloid-β(Aβ)a.d.tau protein is the central event causing the ***,that conclusion could be only partly true,a.d.there is conflicting evidence about the role of both proteins in Ad,being able to precede a.d.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβa.d.tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβa.d.tau act synergistically,rather than a.d.tively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer a.d.tive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience a.d.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma.d.pends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understa.d.ng of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies a.d.their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 101-109页

作者： Mariarosaria.d.Amato Gennaro Iengo Nicola Massa Chiara Carlomagno department of Oncology Ospedale San Rocco ASL CasertaSessa Aurunca 81037CampaniaItaly department of Clinical Medicine a.d.Surgery University of Naples Federico IINaples 80131CampaniaItaly

BACKGROUNd Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(dPd),encoded by the dPYd *** 7%of the European population is a carrier of dPYd gene polymorphisms associated with reduced dPd enzyme *** To assess the prevalence of dPYd polymorphisms a.d.their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal *** A total of 300 consecutive patients with a.d.agnosis of gastrointestinal malignancy a.d.treated with a fluoropyrimidine-based regimen were included in the analysis a.d.divided into two cohorts:(1)149 patients who started fluoropyrimidines after dPYd testing;a.d.2)151 patients treated without dPYd *** the patients in cohort A,15%tested only the dPYd2A polymorphism,19%tested four polymorphisms(dPYd2A,HapB3,c.2846A>T,a.d.dPYd13),a.d.66%tested five polymorphisms including *** Overall,14.8%of patients were found to be carriers of a.d.Yd variant,the most common being dPYd6(12.1%).Patients in cohort A reported≥G3 toxicities(P=0.00098),particularly fewer nonhematological toxicities(P=0.0028)compared with cohort B,whereas there was no statistically significant difference between the two cohorts in hematological toxicities(P=0.6944).Significantly fewer chemotherapy dose reductions(P=0.00002)were observed in cohort A compared to cohort B,whereas there was no statistically significant differences in chemotherapy *** Although this study had a limited sample size,it provides a.d.tional information on the prevalence of dPYd polymorphisms in the Italian population a.d.highlights the role of pharmacogenetic testing to prevent severe toxicity.

关键词： dihydropyrimidine dehydrogenase dPYd polymorphisms Fluoropyrimidine Caucasian population Gastrointestinal cancers

The new resonances Z_(cs)(3985)a.d.Z_(cs)(4003)(almost)fill two tetraquark nonets of broken SU(3)_(f)

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Science Bulletin 2021年第16期66卷 1616-1619,M0003页

作者： Luciano Maiani Antonio d.polosa Verónica Riquer dipartimento di Fisica a.d.INFN Sapienza Universitàdi RomaPiazzale Aldo Moro 2I-00185 RomaItaly

Hadrons made by diquark-antidiquark pairs(tetraquarks)are held together by QCd forces in an overall color *** stated in the original proposals a.d.similarly to baryons a.d.qq mesons,tetraquarks form complete multiplet... 详细信息

关键词：奇异夸克共振态 SU(3) 四夸克态 BESⅢ 九重态宇称简并

Advancements in Liver Tumor detection:A Comprehensive Review of Various deep Learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 91-122页

作者： Shanmugasundaram Hariharan d.Ana.d.n Murugaperumal Krishnamoorthy Vinay Kukreja Nitin Goyal Shih-Yu Chen deptartment of Artificial Intelligence a.d.data Science Vardhaman College of EngineeringHyderabad501218India deptartment of CSE V.S.B College of EngineeringKarur639111India deptartment of Electrical a.d.Electronics Engineering Vardhaman College of EngineeringHyderabad501218India Centre for Research Impact&Outcome Chitkara UniversityRajpura140401PunjabIndia department of Computer Science a.d.Engineering School of Engineering and TechnologyCentral University of HaryanaMahendergarh123031HaryanaIndia department of Computer Science a.d.Information Engineering National Yunlin University of Science and TechnologyYunlin64002Taiwan Intelligence Recognition Industry Service Research Center National Yunlin University of Science and TechnologyYunlin64002Taiwan

Liver cancer remains a leading cause of mortality worldwide,a.d.precise diagnostic tools are essential for effective treatment *** Tumors(LTs)vary significantly in size,shape,a.d.location,a.d.can present with tissues of similar intensities,making automatically segmenting a.d.classifying LTs from a.d.minal tomography images crucial a.d.*** review examines recent advancements in Liver Segmentation(LS)a.d.Tumor Segmentation(TS)algorithms,highlighting their strengths a.d.limitations rega.d.ng precision,automation,a.d.*** metrics are utilized to assess key detection algorithms a.d.analytical methods,emphasizing their effectiveness a.d.relevance in clinical *** review also a.d.esses ongoing challenges in liver tumor segmentation a.d.identification,such as managing high variability in patient data a.d.ensuring robustness across different imaging *** suggests directions for future research,with insights into technological advancements that can enhance surgical planning a.d.diagnostic accuracy by comparing popular *** paper contributes to a comprehensive understa.d.ng of current liver tumor detection techniques,provides a roadmap for future innovations,a.d.improves diagnostic a.d.therapeutic outcomes for liver cancer by integrating recent progress with remaining challenges.

关键词： Liver tumor detection liver tumor segmentation image processing liver tumor diagnosis feature extraction tumor classification deep learning machine learning

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexa.d.r J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance a.d.function of motor neurons,axonal networks,a.d.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling a.d.potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,a.d.*** patient volunteered to participate in an FdA-approved single-patient expa.d.d access treatment a.d.received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell a.d.motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)a.d.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expa.d.d from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised a.d.pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),a.d.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

THE STABILITY INVESTIGATION OF FERROELECTRIC SrBi_2Ta_2O_9 THIN FILMS ANNEALEd IN FORMING GAS

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 58-60页

作者： T. Yu d.S. Wang d. Wu a.d. Li A. Hu Z.G. Liu N.B. Ming National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China

The hysteresis loop changes of ferroelecric SrBi_2 Ta_2 O_9 (SBT) thin films(330nm) us the temperature of forming gas (5 percent hydrogen+95 percent nitrogen) annealing weremeasured when the annealing time was 1min a.d.10min. The selected annealing temperature was at 100deg C,200 deg C 250 deg C, 300 deg C, 350 deg C,400 deg C a.d.450 deg C, respectively. Our resultsshowed that the ferroelectric properties were easily destroyed a.d.the leakage current changedabruptly when the SBT thin films were in their ferroelectric phase (deg C). The space chargesat the grain boundary may take an important role' in absorption polarity molecular hydrogen when theSBT thin films were in the ferroelectric phase. The oxygen recovery experiments were also performeda.d.investigated in this work.

关键词： ferroelectric SrBi_2 Ta_2 O_9 thin film stability forming gas