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Journal of Forestry Research 2016年第2期27卷 433-442页

作者： Engin Derya Gezer Paul a.cooper Department of Forest Industry Engineering Karadeniz Technical University61080 TrabzonTurkey Faculty of Forestry University of Toronto33 Willcocks St.TorontoON M5S 3B3Canada

Chemical extraction, bioremediation, and electrodialytic processes have been extensively studied for removal of copper, chromium, and arsenic from wood treated with chromated copper arsenate （CCA）. However, one problem has not been addressed： the effects of wood species and retention levels on remediation efficiency. The objectives of this study were to investigate the effects of wood species and retention levels on removal of copper, chromium, and arsenic from CCA-treated wood samples using sodium hypochlorite. Our results showed that sodium hypochlorite （NaOC1） was very effective for removal of copper, chromium, and arsenic from CCA-C treated milled wood samples for all three species used in this study. The Cu, Cr, and As extraction efficiencies for red pine were 95 % Cu, 97 % Cr and 94 % As, for maple were 95 % Cu, 97 % Cr, and 98 % As at 4.0 kg m-3 retention levels, and for aspen were 95 % Cu, 92% Cr, and 91% As at 9.6 kg m-3 retention level, respectively. However, the results showed that wood species and initial retention levels of CCA-treated wood products played very impor- tant roles in terms of removal of Cu, Cr, and As.

关键词： Chromated copper arsenate (CCA) Remediation Remediation efficiency Wood species Retention level

Innovative approaches to genome editing in avian species

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Journal of Animal Science and Biotechnology 2018年第2期9卷 278-284页

作者： Caitlin a.cooper Timothy J.Doran Arjun Challagulla Mark L.V.Tizard Kristie A.Jenkins CSIRO Health and Biosecurity Australian Animal Health Laboratory

The tools available for genome engineering have significantly improved over the last 5 years, allowing scientist to make precise edits to the genome. Along with the development of these new genome editing tools has come advancements in technologies used to deliver them. In mammals genome engineering tools are typically delivered into in vitro fertilized single cell embryos which are subsequently cultured and then implanted into a recipient *** avian species this is not possible, so other methods have been developed for genome engineering in birds. The most common involves in vitro culturing of primordial germ cells(PGCs), which are cells that migrate through the embryonic circulatory system to the developing gonad and colonize the gonad, eventually differentiating into the gonadocytes which produce either sperm or ova. While in culture the PGCs can be modified to carry novel transgenes or gene edits, the population can be screened and enriched, and then transferred into a recipient embryo. The largest drawback of PGC culture is that culture methods do not transfer well across avian species, thus there are reliable culture methods for only a few species including the chicken. Two newer technologies that appear to be more easily adapted in a wider range of avian species are direct injection and sperm transfection assisted gene editing(STAGE).The direct injection method involves injecting genome engineering tools into the circulatory system of the developing embryo just prior to the developmental time point when the PGCs are migrating to the gonads. The genome engineering tools are complexed with transfection reagents, allowing for in vivo transfection of the PGCs. STAGE utilizes sperm transfection to deliver genome engineering tools directly to the newly fertilized embryo. Preliminary evidence indicates that both methodologies have the potential to be adapted for use in birds species other than the chicken, however further work is needed in this area.

关键词： Avian CRISPR Genome engineering PGCs Sperm TALEN

Combining targeted therapy and immune checkpoint inhibitors in the treatment of metastatic melanoma

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Cancer Biology & Medicine 2014年第4期11卷 237-246页

作者： Teresa Kim Rodabe N.Amaria Christine Spencer Alexandre Reuben Zachary a.cooper Jennifer A.Wargo Department of Surgery Massachusetts General Hospital Harvard Medical School Department of Melanoma Medical Oncology University of Texas M.D.Anderson Cancer Center Department of Genomic Medicine University of Texas M.D.Anderson Cancer Center Department of Surgical Oncology University of Texas M.D.Anderson Cancer Center

Melanoma is the deadliest form of skin cancer and has an incidence that is rising faster than any other solid tumor. Metastatic melanoma treatment has considerably progressed in the past five years with the introduction of targeted therapy(BRAF and MEK inhibitors) and immune checkpoint blockade(anti-CTLA4, anti-PD-1, and anti-PD-L1). However, each treatment modality has limitations. Treatment with targeted therapy has been associated with a high response rate, but with short-term responses. Conversely, treatment with immune checkpoint blockade has a lower response rate, but with longterm responses. Targeted therapy affects antitumor immunity, and synergy may exist when targeted therapy is combined with immunotherapy. This article presents a brief review of the rationale and evidence for the potential synergy between targeted therapy and immune checkpoint blockade. Challenges and directions for future studies are also proposed.

关键词：免疫抑制剂靶向治疗检查点转移性黑色素瘤协同作用免疫疗法 CTLA4

酪氨酸激酶受体EphA5及其配体ephrin-A5在小鼠脊髓发育过程中的表达

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Neuroscience Bulletin 2007年第5期23卷 249-255页

作者： Christopher P.WASHBURN Margaret a.cooper 周仁平罗格斯新泽西州立大学 Ernest Mario药学院生物化学系Susan Lehman Cullman癌症研究实验室

目的研究两个Eph家族分子,EphA5受体及其配体e phrin-A5,在脊髓发育过程中的表达方式。方法β-半乳糖苷酶基因敲入小鼠和配体亲和探针分析受体的表达,两种不同的亲利探针分析配体的表达,基因敲除小鼠作为对照。结果在发育过程中,EphA5... 详细信息

目的研究两个Eph家族分子,EphA5受体及其配体e phrin-A5,在脊髓发育过程中的表达方式。方法β-半乳糖苷酶基因敲入小鼠和配体亲和探针分析受体的表达,两种不同的亲利探针分析配体的表达,基因敲除小鼠作为对照。结果在发育过程中,EphA5表达于脊髓腹侧,而ephrin—A5表达于脊髓背侧。结论EphA5和ephrin-A5在多个脊髓发育阶段都有表达,他们可能在脊髓背腹侧组织结构的建立过程中发挥重要作用。

关键词：突触引导胚胎产生背根神经节组织化学碱性磷酸酶亲和探针 β-半乳糖苷酶

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航天飞机防热瓦的历史

导弹与航天运载技术(中英文) 1984年第4期 74-85页

作者： Paul a.cooper Paul F.Holloway 裘镜蓉

关于轨道器可重复使用的陶瓷防热系统(TPS)延误了航天飞机第一次发射的事件,在一些科普性和技术性宇航出版物上已有许多报道。本文就这些问题进行阐述并作了分析。轨道器基本上是一种惯用的蒙皮-桁条铝壳飞行器结构。铝的性能规定了该... 详细信息

关于轨道器可重复使用的陶瓷防热系统(TPS)延误了航天飞机第一次发射的事件,在一些科普性和技术性宇航出版物上已有许多报道。本文就这些问题进行阐述并作了分析。轨道器基本上是一种惯用的蒙皮-桁条铝壳飞行器结构。铝的性能规定了该结构的持续

关键词：防热瓦轨道器填充条验证试验底层结构 RSI 可靠性试验深层结构转换-生成语法致密化陶瓷材料航天飞机

Native ion Mobility mass Spectrometry for the Characterization of Biotherapeutics

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Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

第六届生物技术药物理化特性分析与质量研究技术研讨会

作者： Dale a.cooper-Shepherd Jakub Ujma Kevin Giles Nick Tomczyk Laetitia Denbigh Waters Corporation

＜正＞Overview Here we present methods to characterize biotherapeutics using native-ion mobility spectrometry-mass ***-exclusion chromatography coupled to the Vion IMS QTof is a high erformance solution for native-IMS-MS analysis of ***-native IMS-MS has the potential to compare 3D structures of antibody *** MS under reducing conditions allows determination of intact antibody and subunits in one experiment.

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

Natural parasites in conjunction with behavioral and color traits explain male agonistic behaviors in a lizard

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Current Zoology 2024年第1期70卷 59-69页

作者： Rodrigo Megia-Palma Dhanashree Paranjpe Robert D.cooper Pauline Blaimont Barry Sinervo Department of Biomedicine and Biotechnology Parasitology UnitUniversidad de Alcala(UAH)E-28805Alcala de HenaresSpain CIBio Centro de Investigagao em Biodiversidade e Recursos GeneticosInBIO Laboratorio AssociadoCampus de VairaoUniversidade do PortoP-4485-661 VairaoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairaoP-4485-661 VairaoPortugal Rupa Rahul Bajaj Center for Environment and Art Empress Botanical GardensKavade MalaPuneIndia Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCA 90095USA Department of Biology University of Houston Downtown1Main St.HoustonTX 77002USA Department of Ecology and Evolutionary Biology University of CaliforniaSanta CruzCA 95064USA

Male competition conforms to a cost-benefit model,because while aggression may increase reproductive prospects,it can also increase the risk of *** hypothesize that an additional cost in aggressive males would be an increase in parasite load associated with a high energy investment into sexual *** of these infections,in turn,may downmodulate the level of host aggression via energetic *** staged dyadic male contests in the lab to investigate the relationships of multiple parasites with the agonistic behavior of lizard hosts,Sceloporus *** also included both color and behavioral traits from opponents in the analyses because(1)color patches of lizards may serve as intraspecific signals used by conspecifics to assess the quality of opponents,and(2)contests between male lizards fit classical models of escalated aggression,where lizards increase aggression displays in response to an opponent's *** results conform to our hypothesis because male lizards displayed more pushups when they had more ***,some parasites may modulate the levels of aggression because lizards infected by hematic coccidians performed fewer ***,lizards also displayed fewer pushups when both the chroma and size of the opponent's blue patch were *** results thus also supported the role of the blue patch of *** as a sexual armament,because it contributed to the deterrence of aggression from opponent *** revealed that natural parasitic infections in lizard hosts can contribute to their agonistic *** encourage future studies to account for parasites in behavioral testswithlizards.

关键词： Ixodes pacificus Lankesterella sexual selection social interactions ticks

Alcohol associated liver disease and bariatric surgery:Current perspectives and future directions

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 650-657页

作者： Katherine M cooper Alessandro Colletta Nicholas Hebda Deepika Devuni Department of Medicine UMass Chan Medical SchoolWorcesterMA 01655United States Division of Gastroenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Bariatric surgery is a routinely performed procedure and is associated with a reduction in all-cause mortality in patients with ***,bariatric sur-gery has also been linked to increased alcohol use with up to 30%of these patients developing alcohol use disorder(AUD).The mechanism of AUD after bariatric surgery is multifactorial and includes anatomic,metabolic,and neurohumoral changes associated with post-surgical *** patients are at increased risk of alcohol associated liver disease and,in some cases,require liver *** this article,we provide a scoping review of epidemiology,patho-physiology,and clinical outcomes of alcohol-related health conditions after bariatric surgery.

关键词： Obesity medicine Alcohol use disorder Roux-en-Y gastric bypass Vertical sleeve gastrectomy Liver transplant Simultaneous liver transplant and bariatric surgery

Accelerator Neutron Dosimetry Using Composite Proportional Counting Tube

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Accelerator Neutron Dosimetry Using Composite Proportional C...