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Progress in Natural Science:Materials International 2016年第6期26卷 665-670页

作者： a.concha-balderrama G.Rojas-George J.Alvarado-Flores H.Esparza-Ponce M.H.Bocanegra-Bernal A.Reyes-Rojas Centro de Investigación en Materiales Avanzados S.C.(CIMAV) Laboratorio Nacional de NanotecnologíaMiguel de Cervantes 120 Complejo Industrial ChihuahuaCd.de Chihuahua

La0.7Sr0.3Cr0.4Mn0.6O3-δperovskite nanoparticles have been synthetized using an ethylene glycol modified solgel method and impregnated by Cu0.75Ni0.25nanoparticles. The phase transitions and nucleation kinetics were studied by time resolved x-ray diffraction, Rietveld, Raman spectroscopy and high resolution transmission electron microscopy. Findings have shown that, an atomic disorder dominates from room temperature to 400 °C. Nanoparticles with crystal size < 26 nm start through nuclei formation of La0.7Sr0.3Cr0.4Mn0.6O3-δand SrCrO4solid solutions with Pm3m cubic and P21/n monoclinic symmetry respectively in the range of 600–650 °C. Symmetry reduction from the Pm3m→R3c space group had been obtained at a lower temperature（750 °C） than those reported in the literature in oxygen atmosphere and it was confirmed by an octahedral distortion, which takes place in the crystallographic direction[221]/（122）. The Johnson-Mehl-Avrami model had described the whole process, where the existence of two phases was shown before it reached its complete D3d6point group symmetry.

关键词： Perovskite structure Sol-gel method Composite Kinetics Rietveld

Imaging-based prediction of hepatocellular carcinoma recurrence after microwave ablation as bridge therapy: A glimpse into the future

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World Journal of Transplantation 2024年第4期14卷 1-5页

作者： Cristian Lindner Rodrigo San Martín Andrés concha David Clemo Jorge Valenzuela Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of Radiology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile

Liver transplantation(LT)remains the treatment of choice for early-stage hepato-cellular carcinoma(HCC)and offers the best long-term oncological ***,the increasing waiting list for LT has led to a significant dropout rate as patients experience tumor progression beyond the Milan ***,locoregional therapies,such as microwave ablation(MWA),have emerged as promising bridge treatments for patients awaiting *** therapies have shown promising results in preventing tumor progression,thus reducing the dropout rate of LT *** the efficacy of MWA in treating HCC,tumoral recurrence after ablation remains a major challenge and significantly impacts the prognosis of HCC ***,accurately diagnosing tumoral recurrence post-ablation is *** studies have developed novel imaging features based on magnetic resonance imaging of HCC,which could provide essential information for predicting early tumoral recurrence after *** advancements could address this unresolved challenge,improving the clinical outcomes of patients on the LT waiting *** article explored the current landscape of MWA as a bridge therapy for HCC within the Milan criteria,high-lighting the emerging role of novel imaging-based features aimed at improving the prediction of tumor recurrence after MWA.

关键词： Liver transplantation Hepatocellular carcinoma Ablation techniques Multiparametric magnetic resonance imaging Interventional oncology Liver disease Microwaves

Gut microbiota in preterm infants receiving breast milk or mixed feeding

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World Journal of Clinical Pediatrics 2024年第2期13卷 135-145页

作者： Sandra Gabriela Sánchez-González Bárbara Gabriela Cárdenas-del-Castillo Elvira Garza-González Gerardo R Padilla-Rivas Isaías Rodríguez-balderrama Consuelo Treviño-Garza Fernando Félix Montes-Tapia Gerardo C Palacios-Saucedo Anthony Gutiérrez-Rodríguez Manuel Enrique de-la-O-Cavazos Department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Departamento de Bioquímica y Medicina Molecular Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Biochemistry and Molecular Medicine Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Pediatric Surgery Hospital Universitario"Dr.JoséEleuterio González"Monterrey 64460Nuevo LeónMéxico

BACKGROUND Preterm birth is the leading cause of mortality in newborns,with very-low-birthweight infants usually experiencing several *** milk is considered the gold standard of nutrition,especially for preterm infants with delayed gut colonization,because it contains beneficial microorganisms,such as Lactobacilli and *** To analyze the gut microbiota of breastfed preterm infants with a birth weight of 1500 g or *** An observational study was performed on preterm infants with up to 36.6 wk of gestation and a birth weight of 1500 g or less,born at the University Hospital ***éEleuterio González at Monterrey,Mexico.A total of 40 preterm neonates were classified into breast milk feeding(BM)and mixed feeding(MF)groups(21 in the BM group and 19 in the MF group),from October 2017 to June *** samples were collected before they were introduced to any feeding *** full enteral feeding was achieved,the composition of the gut microbiota was analyzed using 16S rRNA gene *** variables were compared using Student’s t-test or using the Mann–Whitney U test for nonparametric ***,evenness,equitability,Margalef’s index,Fisher’s alpha,Chao-1 index,and Shannon’s diversity index were also *** No significant differences were observed at the genus level between the *** comparison indicated higher counts of Alphaproteobacteria and Betaproteobacteria in the initial compared to the final sample of the BM group(P<0.011).In addition,higher counts of Gammaproteobacteria were detected in the final than in the initial sample(P=0.040).According to the Margalef index,Fisher’s alpha,and Chao-1 index,a decrease in species richness from the initial to the final sample,regardless of the feeding type,was observed(P<0.050).The four predominant phyla were Bacteroidetes,Actinobacteria,Firmicutes,and Proteobacteria,with Proteobacteria being the most ***,no significant differences were

关键词： Gut microbiota Human milk Preterm infant Proteobacteria Very low birth weight 16S rRNA

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer cell line

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 482-489页

作者： Jacqueline concha Caroline WEINSTEIN Maria Elvira ZUNIGA Department of Biochemistry Pharmacy School Universidad de Valparaiso Gran Bretafia 1093 Playa Ancha Valparaiso Chile School of Biochemistry Engineering Pontificia Universidad Catolica de Valparaiso General Cruz 34 Valparaiso Chile Creas Conicyt-Regional Gore Region de Valparaiso R12C1001 Blanco 1623 of 1402 Valparaiso Chile

In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps： lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions： 50℃, pH 4.0, 2% enzyme/substrate （E/S） ratio, 15 h, and a solid to liquid ratio of 1 ： 10. The pectic extract showed a degree of polymerization （DP） profile of 55.8% with DP≥7; 4.9% with DP6; 5.8% between DP2 and DP6 ; 4.7% with DP2; and 28.8% with DP1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5-25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen （4- OHT）, a classical anticancer drug, which killed 56.5% of the cells.

关键词： pectic extracts antiproliferative activity,breast cancer enzymatic treatment

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Parameter Control of Genetic Algorithms by Learning and Simulation of Bayesian Networks——A Case Study for the Optimal Ordering of Tables

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Journal of Computer Science & Technology 2013年第4期28卷 720-731页

作者： concha Bielza Juan A. Fernndez del Pozo Pedro Larranaga Computational Intelligence Group Department of Artificial IntelligenceTechnical University of Madrid

Parameter setting for evolutionary algorithms is still an important issue in evolutionary computation. There are two main approaches to parameter setting： parameter tuning and parameter control. In this paper, we introduce self-adaptive parameter control of a genetic algorithm based on Bayesian network learning and simulation. The nodes of this Bayesian network are genetic algorithm parameters to be controlled. Its structure captures probabilistie conditional （in）dependence relationships between the parameters. They are learned from the best individuals, i.e., the best configurations of the genetic algorithm. Individuals are evaluated by running the genetic algorithm for the respective parameter configuration. Since all these runs are time-consuming tasks, each genetic algorithm uses a small-sized population and is stopped before convergence. In this way promising individuals should not be lost. Experiments with an optimal search problem for simultaneous row and column orderings yield the same optima as state-of-the-art methods but with a sharp reduction in computational time. Moreover, our approach can cope with as yet unsolved high-dimensional problems.

关键词： genetic algorithm estimation of distribution algorithm parameter control parameter setting Bayesian network

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Abiotic and biotic drivers of struvite solubilization in contrasting soils

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Pedosphere 2023年第6期33卷 828-837页

作者： Antonio RUIZ-NAVARRO Manuel DELGADO-BAQUERIZO concha CANO-DíAZ Carlos GARCíA Felipe BASTIDA Centro de Edafologia y Biologia Aplicada del Segura Consejo Superior de Investigaciones Cientificas(CEBAS-CSIC)Department of Soil and Water ConservationEspinardoMurcia E-30100Spain ICL Specialty Fertilizers Iberia TotanaMurcia E-30850Spain Laboratorio de Biodiversidad y Funcionamiento Ecosistemico Instituto de Recursos Naturales y Agrobiologia de Sevilla(IRNAS)CSICAv.Reina Mercedes 10Sevilla E-41012Spain IRNAS-CSIC Unidad Asociada Universidad Pablo de OlavideUniversidad Pablo de Olavide(UPO)Sevilla 41013Spain Centre for Research and Development in Agrifood Systems and Sustainability(CISAS) Instituto Politecnico de Viana do Castelo(IPVC)Rua Escola Industrial e Comercial Nun'Alvares 34Viana do Castelo 4900-347Portugal

Phosphorus(P) limitation in the coming decades calls for the utilization of alternative fertilizers in agriculture. Struvite is a promising P source, but its potential role as a fertilizer is dependent on different physical, chemical, and biological properties, which are very heterogeneous in soil, complicating the prediction of the best soil conditions for its application. Here, we evaluated the solubility of struvite in soil, its redistribution into P fractions, and its potential abiotic and biotic drivers in 62 globally distributed soils with contrasting properties through an incubation assay. We found that after 40 d, about 35% of struvite P was redistributed into soil fractions more accessible to plants and microbes. Phosphorus redistribution from struvite was driven by a complex suite of soil physical, chemical, and microbial properties as well as environmental factors that varied across soils. Soil texture played a critical role in determining the redistribution of P in struvite-amended soils in soluble(H2O extraction), labile(NaHCO3 extraction), and moderately labile(NaOH extraction) *** addition, the soil solution cation concentration was one of the most important drivers of available struvite-derived P fractions. The great importance of texture and cations in determining struvite-derived P fractions in soil was contrasted with the relatively minor role of pH. At the microbial level, the number of bacterial operational taxonomic units(OTUs) from the unfertilized soils that correlated with struvite-derived P fractions was higher than that of fungi. The number of OTUs that correlated with the struvite-derived soluble P fraction was dominated by fungi, whereas the number of OTUs that correlated with the struvite-derived labile P fraction was dominated by bacteria. Overall, this study provided a predictive framework for the potential use of struvite as a P fertilizer in contrasting soils.

关键词： bacteria fungi environmental factor operational taxonomic unit phosphorus fertilizer phosphorus fraction phosphorus solubilization soil fertility soil property

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Patient with hepatocellular carcinoma related to prior acute arsenic intoxication and occult HBV:Epidemiological,clinical and therapeutic results after 14 years of follow-up

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World Journal of Gastroenterology 2006年第12期12卷 1972-1974页

作者： Teresa Casanovas-Taltavull Ana Berrozpe Sara Jordan Josepa Ribes FXavierBosch Aurora Casanova.concha Sancho Carles Valls Department of Gastroenterology Hospital Universitari de BellvitgeFeixa Llarga s/n08907 L'Hospitalet de LlobregatBarcelonaSpain Epidemiology Department of Microbiology Hospital Universitari de BellvitgeFeixa Llarga s/n08907 L'Hospitalet de LlobregatBarcelonaSpain Department of Radiology.Hospital Universitari de Bellvitge Feixa Llarga s/n08907 L'Hospitalet de LlobregatBarcelonaSpain

Little is known about the long-term survivors of acute arsenic intoxication. We present here a clinical case report of a man with chronic hepatitis B virus （HBV） infection who developed hepatocellular carcinoma four years after acute arsenic poisoning. HBsAg was detected in serum in 1990 when he voluntarily donated blood. In 1991, the patient suffered from severe psychological depression that led him to attempt suicide by massive ingestion of an arsenic-containing rodenticide. He survived with polyneuropathy and paralysis of the lower limbs, and has been wheelchair-bound since then. During participation in a follow-up study conducted among HBV carders, abdominal ultrasound detected a two-centimeter liver mass consistent with hepatocellular carcinoma. The tumor was confirmed by computed tomography （CT） and magnetic resonance image （MRI）. Because of his significant comorbidity, the patient received palliative treatment with transarterial lipiodol chemoembolization （TACE） on three occasions （1996, 1997 and 1999）. At his most recent visit in lay 2005, the patient was asymptomatic, liver enzymes were normal and the tumor was in remission on ultrasound.

关键词： HBV carriers Occult HBV HCC therapy Arsenic intoxication

1956年前后：中国与墨西哥社会主义现代主义艺术交流

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1956年前后：中国与墨西哥社会主义现代主义艺术交流

作者： Marisol Villela balderrama（雨嫣）中国美术学院

学位级别：硕士

本论文支持一种在中国形成的现代主义,即“社会主义现代主义”。20世纪50年代,该主义作为中国与其他国家美术交流的结果而出现。本文呈现有关墨西哥后革命艺术及其得以诞生并发展的社会环境,并其与建国初中华人民共和国之间的最终联系... 详细信息

本论文支持一种在中国形成的现代主义,即“社会主义现代主义”。20世纪50年代,该主义作为中国与其他国家美术交流的结果而出现。本文呈现有关墨西哥后革命艺术及其得以诞生并发展的社会环境,并其与建国初中华人民共和国之间的最终联系。本文根据社会学家皮埃尔·布迪厄(Pierre Bourdieu)的理论对20世纪上半叶的墨西哥美术界,及其与其他领域的关系(特别是国际共产主义网络)进行分析。此外,本文回顾了八次墨西哥视觉艺术家来华之旅,其中包括1952至1958年间壁画家大卫·阿尔法罗·西盖罗斯(David Alfaro Siqueiros)来华之旅和1956年在北京、上海、广州举办的墨西哥国家前沿造型艺术展。

关键词：中国墨西哥社会主义现代主义布迪厄西盖罗斯

Mid-term results of patterned laser trabeculoplasty for uncontrolled ocular hypertension and primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1199-1204页

作者： Gustavo Espinoza Yuly Andrea Castellanos-Castellanos Angelica Pedraza.concha Ignacio Rodriguez-Una Maria Fernanda Acuna Juan Camilo Parra Centro Oftalmologico Virgilio Galvis BucaramangaSantander 681004Colombia Fundacion Oftalmologica de Santander BucaramangaSantander 681004Colombia Universidad Industrial de Santander BucaramangaSantander 680002Colombia Instituto Oftalmologico Fernandez-Vega Universidad de OviedoOviedo 33012Spain

AIM:To describe the safety and efficacy of patterned laser trabeculoplasty(PLT)as an adjunctive treatment in primary open angle glaucoma(POAG)and ocular hypertension(OHT)after 18-month follow-up in Hispanic ***:A single-center,retrospective study was *** patients with OHT or POAG undergoing PLT from June 2016 to August 2016 were included in the *** parameters were intraocular pressure(IOP),the number of IOP-lowering medications,best corrected visual acuity(BCVA),laser parameters and postoperative adverse *** efficacy outcome measures were the proportion of eyes achieving an IOP reduction≥20%at 18 mo versus baseline medicated IOP or a reduction in the number of medications while maintaining IOP ***:From 40 PLT-treated eyes(mean baseline IOP 20.3±1.7 mm Hg),24 patients were analyzed(age 63.4±7.3 y).The mean IOP reductions from baseline across visits(months 1,3,6,9,12,and 18)ranged from 14.1%to 20.8%.Success rate after 18-month follow-up was 61.7%with a mean IOP of 16±3.2 mm Hg(P<0.001).The number of glaucoma IOP-lowering medications per eye(preoperative 2.1±1.1 and postoperative 2.3±1.1,P=0.86)and the mean BCVA(preoperative 0.10±0.22 and postoperative 0.11±0.22 logMAR,P=0.42)remained *** events comprised transitory IOP spikes in 4 eyes(10%)and peripheral anterior synechiae in 7 eyes(17.5%).CONCLUSION:Mid-term results of PLT show that this procedure may be an efficacious and safe technique to approach medically uncontrolled OHT or POAG patients.

关键词： glaucoma intraocular pressure ocular hypertension patterned laser trabeculoplasty

Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis

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World Journal of Gastroenterology 2005年第33期11卷 5185-5192页

作者： Laura Peran Desiree Camuesco Monica Comalada Ana Nieto Angel concha Maria Paz Diaz-Ropero Monica Olivares Jordi Xaus Antonio Zarzuelo Julio Galvez Department of Pharmacology School of Pharmacy University of Granada Spain Health and Progress Foundation Granada Spain Department of Pathology Hospital Universitario "Virgen de las Nieves" GranadaSpain Department of Immunology and Animal Sciences Puleva Biotech S.A.GranadaSpain Department of Immunology and Animal Sciences Puleva Biotech S.A. Granada Spain

AIM： To investigate the intestinal anti-inflammatory effect and mechanism of a probiotic Lactobacillus salivarius ssp. salivariusCECT5713 in the TNBS model of rat colitis. METHODS： Female Wistar rats （180-200 g） were used in this study. A group of rats were administered orally the probiotic L. salivarius ssp. salivarius （5 × 10^8 CFU suspended in 0.5 mL of skimmed milk） daily for 3 wk. Two additional groups were used for reference, a non-colitic and a control colitic without probiotic treatment, which received orally the vehicle used to administer the probiotic. Two weeks after starting the experiment, the rats were rendered colitic by intracolonic administration of 10 mg of TNBS dissolved in 0.25 mL of 500 mL/L ethanol. One week after colitis induction, all animals were killed and colonic damage was evaluated both histologically and biochemically. The biochemical studies performed in colonic homogenates include determination of myeloperoxidase （MPO） activity, glutathione （GSH） content, leukotriene B4 （LTB4） and tumor necrosis factor α （TNF-α） levels, as well as inducible nitric oxide synthase （iNOS） expression. In addition, the luminal contents obtained from colonic samples were used for microbiological studies, in order to determine Lactobacilli and Bifidobacteria counts. RESULTS： Treatment of colitic rats with L. salivarius ssp. salivarius resulted in amelioration of the inflammatory response in colitic rats, when compared with the corresponding control group without probiotic treatment. This antiinflammatory effect was evidenced macroscopically by a significant reduction in the extent of colonic necrosis and/or inflammation induced by the administration of TNBS/ethanol （2.3±0.4 cm vs3.4±0.3 cm in control group, P〈0.01） and histologically by improvement of the colonic architecture associated with a reduction in the neutrophil infiltrate in comparison with non-treated colitic rats. The latter was confirmed biochemically by a significant reduction of colonic MPO ac

关键词： Lactobacillus salivarius ssp. salivarius, TNBS rat colitis Probiotic Tumor necrosis factor α Nitric oxide