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Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage

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Journal of Traditional chinese Medicine 2021年第2期41卷 293-300页

作者： Onder Aybastıer Bursa Uludag University Faculty of Science and ArtsDepartment of ChemistryBursa 16059Turkey

OBJEcTIVE:To investigate the efficacy of methanol-water extract of Inula helenium root against oxidative DNA ***:Antioxidant properties of methanol-water extract of Inula helenium root were revealed by 2,2'-azinobis(3-ethylbenzothiazoline-6-suphonic acid)di-ammonium salt(ABTS),Folin-ciocalteu and high-performance liquid chromatography(HPLc)*** effect against oxidative DNA base damage was determined analyzing oxidative DNA base damage products by Gc-MS/***:The methanol-water extract of Inula helenium root showed good antioxidant capacity[32.20 mg trolox equivalents(TE)/g dried weight(dw)by ABTS method,54.53 mg TE/g dw by chromium reducing antioxidant capacity method]and total phenolic content[29.83 mg gallic acid equivalent(GAE)/g dw].The chlorogenic acid,ferulic acid,rosmarinic acid and caffeic acid were determined in the extract by *** chlorogenic acid,ferulic acid and Inula helenium root extract were revealed to inhibit the oxidative DNA base damage by Gc-MS/***:The studies showed a crucial decrease in the amount of the DNA base damage products when antioxidants were *** results showed that ferulic acid has better inhibition than chlorogenic acid for DNA *** methanol-water extract of Inula helenium root was determined to inhibit the oxidative DNA damage.

关键词： Inula DNA damage Antioxidants Phytochemicals Gas chromatography-mass spectrometry

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Northern china maximum temperature in the summer of 1743: A historical event of burning summer in a relatively warm climate background

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chinese Science Bulletin 2004年第23期49卷 2508-2514页

作者： ZHANGDe'er DemareeGaston Nationalclimatecenterofchina Beijing100081China RoyalMeteorologicalInstitute BrusselsBelgium

In the context of historical climate records of china and early meteorological measurements of Beijing discovered recently in Europe, a study is undertaken on the 1743 hottest summer of north china over the last 700 a, cov- ering Beijing, Tianjin, and the provinces of Hebei, Shanxi and Shandong, with the highest temperature reaching 44.4℃ in July 1743 in Beijing, in excess of the maximum climate record in the 20th century. Results show that the related weather/climate features of the 1743 heat wave, e.g., flood/ drought distribution and Meiyu activity and the external forcings, such as solar activity and equatorial Pacific SST condition are the same as those of the 1942 and 1999 heat events. It is noted that the 1743 burning summer event oc- curs in a relatively warm climate background prior to the Industrial Revolution, with a lower level of cO2 release.

关键词： 1743年中国夏季气温气候背景历史二氧化碳

comparison of engineering failures and seismic responses of 500 kV transformer-bushing systems in the 2022 Luding earthquake

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 1029-1041页

作者： Zhu Wang Wu Ming’er Xie Qiang Department of Structural Engineering Tongji UniversityShanghai 200092China Key Laboratory of Performance Evolution and control for Engineering Structures(Tongji University) Shanghai 200092China

cemented and mechanically clamped types of end fittings(fitting-c and fitting-M)are commonly used in transformer *** the Luding Ms 6.8 earthquake that occurred in china on September 5,2022,all transformer bushings with the two types of end fittings in a 500 kV substation were ***-earthquake field investigations were conducted,and the failures of the two types of bushings were *** elementary simulation models of the transformer-bushing systems were developed to simulate the engineering failures,and further compute their seismic responses for *** results indicate that the hitch lugs of the connection flange are structurally harmful to seismic ***-M can decrease the bending stiffness of the bushing due to the flexible sealing rubber *** it provides a more flexible connection that dissipates energy,the peak accelerations and relative displacements at the top of the bushing are significantly lower than those of the bushing with *** with fitting-c,fitting-M transfers the high-stress areas from the connection flange to the root of the porcelain,so the latter becomes the most vulnerable ***-M increases the failure risk of the low-strength porcelain,indicating the unsuitability of applying it in high-intensity fortification regions.

关键词： transformer bushing end fitting Luding earthquake,engineering failure seismic responses

Debris flow susceptibility and propagation assessment in West Koyulhisar, Turkey

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Journal of Mountain Science 2020年第11期17卷 2611-2623页

作者： Ali POLAT Dursun erİK Provincial Directorate of Disaster and Emergency Sivas 58050Turkey Republic of Turkey General Directorate of Highway 16.DistrictSivas 58049Turkey

Turkey is highly prone to landslides because of the geological and geographic *** study area,which is located in a tectonically active region,has been significantly affected by mass *** type landslides are frequently observed due to this *** study aims at determining the source area and propagation of debris flows in the study *** used the heuristic method to extract source areas of debris flow,and then used receiver operating characteristic(ROc)curve analysis to assess the performance of the method,and finally calculated the Area under curve(AUc)values being 83.64%and 80.39%for the success rate and prediction rate,*** calculated potential propagation area and runout distance with Flow-R *** conclusion,the obtained results(susceptibility map,propagation and runout distance)are very important for decisionmakers at the region located on an active fault zone,which is highly prone to natural *** outputs of this study could be used in site selection studies,designing erosion prevention systems and protecting existing human-made structures.

关键词： Koyulhisar Debris flow Flow path assessment Heuristic method Landslide susceptibility mapping Geographical Information System(GIS)

Recent development on cOX-2 inhibitors as promising anti-inflammatory agents:The past 10 years

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2790-2807页

作者： Zhiran Ju Menglan Li Junde Xu Daniel c.Howell Zhiyun Li Fen-er chen Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China Engineering center of catalysis and Synthesis for chiral Molecules Fudan UniversityShanghai 200433China Shanghai Engineering center of Industrial Asymmetric catalysis for chiral Drugs Shanghai 200433China collaborative Innovation center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of TechnologyHangzhou 310014China

cyclooxygenases play a vital role in inflammation and are responsible for the production of *** cyclooxygenases are described,the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2,for which the target inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs).Prostaglandins are a class of lipid compounds that mediate acute and chronic *** are the most frequent choices for treatment of ***,currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market ***,more studies have been carried out on searching novel selective cOX-2 inhibitors with safety *** this review,we highlight the various structural classes of organic and natural scaffolds with efficient cOX-2 inhibitory activity reported during *** will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research.

关键词： Inflammation cyclooxygenase Prostaglandins Adverse effects cOX-2 inhibitors

Effects of Density—Dependent Bag constant and Strange Star Rotation

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communications in Theoretical Physics 2003年第1期39卷 89-90页

作者： ZHOUQiao－er GUOHua DepartmentofTechnicalPhysicsandMOELaboratoryofHeavyIonPhysics PekingUniversityBeijing100871China DepartmentofTechnicalPhysicsandMOELaboratoryofHeavyIonPhysics PekingUniversit

With the emphasis on the effects of the density-dependent bag constant and the rotation of strange star the limiting mass of strange star is calculated. The obtained results show that the limiting mass and the corresponding radius of strange star increase as the rotation frequency increases, and tend to be lowered when the density-dependent bag constant is considered.

关键词： density-dependent bag constant rotation frequency of strange star limiting mass and radius of strange star

Asymmetric catalytic anhydride openings via carbon-based nucleophiles

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chinese chemical Letters 2014年第1期25卷 1-8页

作者： chen Zheng Fen-er chen Department of chemistry Fudan University

The asymmetric desymmetrization of cyclic anhydrides via the addition of carbon-based nucleophiles has been the focus of considerable levels of interest because it leads to optically active products. Over the past 20 years, a variety of different catalytic asymmetric alkylation reactions have been developed for the desymmetrization of cyclic anhydrides using different metal reagents as nucleophiles and using chiral ligands. The purpose of this review is to provide an overview of significant developments in this field. ~ 2013 Fen-er chen. Published by Elsevier B.V. on behalf of chinese chemical Society. All rights reserved.

关键词： cyclic anhydrides carbon-based nucleophiles chiral ligands Asymmetric catalysis Metal reagents

characteristics of American Scholars’Research on chinese Medical classics and Their contributions

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chinese Journal of Integrative Medicine 2020年第8期26卷 629-632页

作者： WANG er-liang cHEN Xiao School of Basic Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China

chinese medical classics are important carriers for the inheritance,innovation and development of academic thoughts of chinese medicine(cM),containing rich thoughts on diagnosis and treatment as well as therapeutic principles of *** international exchange of cM has a very long *** the development of society,Western scholars in modern times are deepening their researches on chinese medical *** would provide a new way for promoting cM in Western countries to investigate researches made by famed American scholars and their academic viewpoints.

关键词： chinese medicine classics international exchange American scholar

In Memory of Academician er-Mi Zhao(1930-2016)

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Zoological Research 2017年第1期38卷 2-4页

作者： Zhao er Mi Key Laboratory of Animal Models and Human Disease Mechanisms of chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Kunming Yunnan 650223 China cAS center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China

Academician er-Mi Zhao,Professor of the chengdu Institute of Biology,chinese Academy of Sciences,and Sichuan University,passed away on 24 December,2016,to the great loss of both chinese and world herpetology.

关键词： GF EM