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Trends of dengue infections in Malaysia,2000-2010

Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 462-466页

作者： Md.Shahin Mia Rawshan Ara Begum a.c.er Raja Datuk Zaharaton Raja Zainal Abidin Joy Jacqueline Pereira Institute for Environment and Development Universiti Kebangsaan Malaysia43600UKMBangiSelangor D.E.Malaysia Southeast Asia Disaster Prevention Research Institute Universiti Kebangsaan Malaysia43600UKMBangiSelangor D.E.Malaysia School of Development and Environmental Studies Faculty of Social Science and Humanities Universiti Kebangsaan Malaysia43600UKMBangiSelangor D.E.Malaysia

Objective:To analyze trends of dengue incidences and deaths in Malaysia from 2000 to 2010 as well as the predominant dengue virus serotypes during the last ***:We used the national data on annual reported cases,deaths,incidence rate,mortality rate,and case fatality rate of dengue fever(DF) and dengue hemorrhagic fever(DHF) as well as dengue virus serotypes prevalent in Malaysia during the last ***/ regression lines were fitted to investigate the trend of dengue incidences and deaths due to the disease for a 11-year period(2000-2010).For the distribution of national incidence rate,mortality rate,and case fatality rate of DF and DHF, descriptive statistics using mean and 95%confidence intervals(c/) for means,and range were ***:The number of dengue cases and number of deaths have increased,on average, by 14%and 8%per year *** average annual incidence rate of DF per 100 000 populations was higher as compared to that of ***,the yearly mean mortality rate of DHF per 100 000 populations was greater than that of *** simultaneous circulation of all four dengue serotypes has been found in *** a particular dengue virus serotype predominates for at least two years before it becomes replaced by another ***: The dengue situation in Malaysia has worsened with an increasing number of reported oases and deaths during the last *** increasing trend of dengue highlights the need for a more systematic surveillance and reporting of the disease.

关键词： Dengue Dengue hemorrhagic fever Trend Malaysia

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Metal-organic frameworks (MOFs) in aqueous batteries (ABs):unlocking potential through innovative materials design

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Science china chemistry 2025年

作者： Bo Han erhai Hu Bei-er Jia Ziyang Liu Shuen Tso Afriyanti Sumboja Ivandini T.Anggraningrum Anne Zulfia Syahrial Qingyu Yan ScARcE Laboratory Energy Research Institute NTU (ERIN) Nanyang Technological University School of Materials Science and Engineering Nanyang Technological University Material Science and Engineering Research Group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Department of chemistry University of Indonesia Metallurgical & Materials Engineering Department Fakultas Teknik Universitas Indonesia

Metal-organic frameworks (MOFs) represent a revolutionary class of materials in the field of energy storage,particularly for aqueous batteries (ABs).Distinguished by their large surface area,tuneable porosity,and adaptable chemical activity,MOFs offer significant advantages over conventional materials in battery *** article provides a thorough analysis of the crucial role that MOFs play in improving the efficiency of *** includes a concise review of the current research progress,emphasizing the fundamental processes by which MOFs enhance electrochemical ***,the review examines the synthesis and design strategies for the structure of MOFs to maximize ion transport,improve conductivity,and enhance *** structural advantages,chemical versatility,stability,durability and functionalization potential of MOFs are comprehensively ***,we explore the distinct advantages of MOFs in overcoming common challenges encountered in ABs,such as declining capacity,inadequate cycling stability,and limited energy *** paper also highlights the future research directions needed to fully harness their *** goal is to develop a fundamental understanding and stimulate further progress in the use of MOFs for advanced energy storage solutions.

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Modeling of sage(Salvia fruticosa Miller)phenolics diffusion in meat cubes during ultrasound assisted vacuum impregnation

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Food Bioscience 2023年第3期53卷 2302-2311页

作者： Elif Aykın-Dinçer cüneyt Dinçer Akdeniz University Engineering FacultyDepartment of Food EngineeringAntalya07058Turkey Akdeniz University Food Safety and Agricultural Research Center07058AntalyaTurkey Akdeniz University Finike Vocational SchoolDepartment of Food Processing07740AntalyaTurkey

This study aimed to investigate the modelling of the transport of sage phenolics into meat cubes under various vacuum impregnation(VI)conditions(control,VI-100,VI-250,and VI-500 mbar;ultrasound-assisted(UA)VI-100,VI-250,and VI-500 mbar).Azuara model from five different models has been proposed as a model that can be used successfully in describing kinetic *** 180 min of treatment,the phenolic contents of the samples were determined between 462.7 and 639.8 mg/*** the highest phenolic content(639.8 mg/kg)was obtained in the samples applied UAVI-100,the highest equilibrium phenolic content was calculated in the samples applied VI-100 in the calculations performed with the Azuara *** addition,the diffusion coefficients calculated for the samples varied between 8.5×10^(-6)and 11.4×10^(-6)m^(2)/s.

关键词： Beef meat cubes Marination Sage Phenolic extracts Enrichment Azuara model

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一种基于柱面镜聚焦系统的高灵敏度全谱光谱仪

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光谱学与光谱分析 2025年第1期45卷 222-230页

作者：陈吉文陈作儿赵迎北方工业大学电气与控制工程学院北京100144

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如c、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,... 详细信息

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如c、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,常使用光程短、系统精简的罗兰圆光学系统作为光谱仪的色散系统,并且在进行检测分析时,还需对设备腔体内部建立相对真空的环境进行实验,进而减小实验环境对真空紫外波段内各谱线强度的削弱作用。然而即使在该条件下,P和S这两种元素在真空紫外波段的谱线灵敏度仍然较弱。为此为了实现真空紫外波段范围内的高灵敏度,本研究在距离像面前30 mm处位置设计了一个柱面镜聚焦系统。其采用了材料为caF_(2)、中心厚度为5 mm以及弧矢面曲率半径为22.06 mm的柱面镜作为核心部件。并利用仿真软件Zemax对设计的光学系统进行仿真与优化,以及从非序列模式下的辐射照度仿真结果可知,柱面镜聚焦系统在几乎不影响分辨率的情况下对各波长成像灵敏度有较大的提升。最后以中低合金钢为检测样品,使用电火花激发光源对样品中各元素在紫外波段内的各谱线进行激发,进而验证光谱仪的各项性能:通过一次拟合、参比拟合以及二次拟合,建立每个元素谱峰强度和实际含量之间的数学模型,并算得各元素的拟合优度R^(2)均在0.99以上;柱面镜聚焦系统显著提高了设备在真空紫外波段的灵敏度,响应提高了1倍以上。实验结果表明,柱面镜聚焦系统的设计方法对于提升罗兰圆色散系统的灵敏度具有一定的参考价值。

关键词：紫外光谱罗兰圆光学系统柱面镜灵敏度拟合优度

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Surface charging activated mechanism change: A computational study of O, cO, and cO2 interactions on Ag electrodes

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Journal of Energy chemistry 2020年第11期29卷 307-313页

作者： Ilker Tezsevin Mauritius c.M.van de Sanden Suleyman er DIFFer-Dutch Institute for Fundamental Energy Research De Zaale 20Eindhoven 5612 AJThe Netherlands ccer-center for computational Energy Research DIFFER-Dutch Institute for Fundamental Energy ResearchDe Zaale 20Eindhoven 5612 AJThe Netherlands Department of Applied Physics Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands

Electrocatalytic and plasma-activated processes receive increasing attention in catalysis. Density functional theory(DFT) calculations are state-of-the-art tools for the fundamental study of reaction mechanisms and predicting the performance of catalytic materials. Proper application of DFT-based methods is crucial when investigating charge-doped electrode surfaces during electrocatalytic and plasma-activated reactions. Here, as a model electrode for plasma-activated cO2 splitting, we studied the interactions of O, cO, and cO2 with the neutral and progressively charged Ag(111) metal surfaces. We show that the application of correction procedures is necessary to obtain accurate adsorption energy profiles of O atoms,cO and cO2 molecules on Ag surfaces that are under the influence of additional electrons. Interestingly,the oxidation of cO is found to shift from a Langmuir–Hinshelwood mechanism on a neutral electrode to an Eley–Rideal mechanism on charged electrodes. Furthermore, we show that the surface charging of Ag(111) electrodes increase their cO2 reduction performance by enhancing the adsorption of O atoms and desorption of cO molecules. A further increase in the absolute charge-state of the electrode surface is expected to waive the thermodynamic barriers for the cO2 splitting reaction.

关键词： Density functional theory cO2 reduction Silver electrode Surface charge

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siRNA therapeutics:a clinical reality

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Science china(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)*** its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of *** years after the discovery of RNAi,siRNA therapeutics finally charts its way into *** we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease ***,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical ***,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics.

关键词： siRNA therapeutic disease treatment systemic siRNA delivery clinical application

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Phage display screening of therapeutic peptide for cancer targeting and therapy

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Protein & cell 2019年第11期10卷 787-807页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage display technology has been announced as the recipient of Nobel Prize in chemistry *** display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and *** this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening *** will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display *** will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics.

关键词： phage display tumor targeting peptide,tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor

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