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Cancer Cell：癌细胞如何在没有葡萄糖的条件下继续增殖扩张？

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现代生物医学进展 2017年第2期17卷 I0001-I0002页

作者： Stefan burén Structural Biology and Biocomputing Programme Spectroscopy and Nuclear Magnetic Resonance Unit Centro Nacional de Investigaciones Oncológicas CNIO Madrid 28029 Spain

肿瘤细胞最主要的目标就是生存，其甚至不惜破坏其所依附的有机体的健康也要达到生存的目的；为了生存肿瘤细胞会练就许多健康细胞没有的本领，包括在葡萄糖水平极低的情况下继续保持生长势头，而这或许就是常用的抗血管生成因子难以消... 详细信息

肿瘤细胞最主要的目标就是生存，其甚至不惜破坏其所依附的有机体的健康也要达到生存的目的；为了生存肿瘤细胞会练就许多健康细胞没有的本领，包括在葡萄糖水平极低的情况下继续保持生长势头，而这或许就是常用的抗血管生成因子难以消除癌症的主要原因，肿瘤细胞通常会通过妨碍提供常规的营养物质和葡萄糖的血管的发育来影响机体健康，

关键词：葡萄糖水癌细胞 Cell 血管生成因子增殖肿瘤细胞机体健康营养物质

Genetic diversity,phylogenetic position and morphometric analysis of Astacus colchicus(Decapoda,Astacidae):a new insight into Eastern European crayfish fauna

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Integrative Zoology 2021年第3期16卷 368-378页

作者： Martin BLÁHA JiríPATOKA Bella JAPOSHVILI Marek LET MilošburˇICˇ Antonín KOUBA Levan MUMLADZE Faculty of Fisheries and Protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of HydrocenosesUniversity of South Bohemia in CˇeskéBudeˇjoviceVodnˇanyCzech Republic Department of Zoology and Fisheries Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences PraguePrahaCzech Republic Institute of Zoology of Ilia State University TbilisiGeorgia

The phylogeny of European crayfish fauna,especially with respect to Eastern European species,is still far from being completely *** fill this gap,we analyzed most of the European crayfish species focusing on the phylogenetic position of the endemic crayfish Astacus colchicus,inhabiting *** mitochondrial and one nuclear marker were used to study evolutionary relationships among European crayfish species,resulting in the unique phylogenetic position of *** indicating independent species status to *** analyses revealed a deep molecular divergence of *** in comparison to ***(6.5–10.9%in mtDnA and 1.1%in nDnA)as well as to Pontastacus leptodactylus and ***(5.5–10.0%in mtDnA and 1.4–2.4%in nDnA).Absent ventral process on second male pleopod and abdominal somites II and III with pleura rounded lacking prominent spines clearly indicate taxonomic assignment to the genus Astacus;however,the species is distributed almost in the middle of Ponto-Caspian area typical by occurrence of the genus *** morphological indices linked to head length,carapace,and total body length and width were found to demonstrate apparent differences between *** and *** this study provides a novel insight into European crayfish phylogeography,we also point out the gaps in comprehensive study of the *** species complex,which could reveal details about the potential species status of particular species and subspecies within this genus.

关键词： 12S rRnA 16S rRnA cytochrome c oxidase histone H3 Ponto-Caspian crayfish

Production and characterization of ZnO nanoparticles and porous particles by ultrasonic spray pyrolysis using a zinc nitrate precursor

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 651-656页

作者： burak Ebin Elif Arτg burak zkal Sebahattin Gürmen Metallurgical & Materials Engineering Department Istanbul Technical University

ZnO nanoparticles and porous particles were produced by an ultrasonic spray pyrolysis method using a zinc nitrate precursor at various temperatures under air atmosphere. The effects of reaction temperature on the size and morphology of ZnO particles were investi- gated. The samples were characterized by energy dispersive spectroscopy, X-ray diffraction, transmission electron microscopy, and scanning electron microscopy. ZnO particles were obtained in a hexagonal crystal structure and the crystallite shapes changed from spherical to hex- agonal by elevating the reaction temperature. The crystallite size grew by increasing the temperature, in spite of reducing the residence time in the heated zone. ZnO nanoparticles were obtained at the lowest reaction temperature and ZnO porous particles, formed by aggregation of ZnO nanoparticles due to effective sintering, were prepared at higher temperatures. The results showed that the properties of ZnO particles can be controlled by changing the reaction temperature in the ultrasonic spray pyrolysis method.

关键词： zinc oxide nanoparticles nanocrystallites porous materials ultrasonic applications spray pyrolysis

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Effect of early atopic sensitization in children aged 0–2 years on the development of asthma symptoms at 9–11 years of age

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World Journal of Pediatrics 2022年第11期18卷 753-760页

作者： Himmet Haluk Akar Ebru nadir burçin Beken Yakup Yeşil Division of Pediatric Immunology and Allergy University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Division of Pediatrics University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Department of Pediatric Immunology and Allergy School of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulTurkey

Background Personal genetic predisposition and early life environmental factors are important for the development of childhood *** aimed to search whether egg,milk and mite sensitizations at 0–2 years old are risk factors for asthma symptoms at 9–11 years *** A total of 210 wheezer children who had specific immunoglobulin(Ig)E in 2010–2012 were included in the study(followed by pediatric allergy).Patients were divided into non-atopic(group 1,n=157)and atopic patients[groups 2–7,n=53(5 patients were in both group 4 and group 5)]based on *** the International Study of Asthma and Allergy in Childhood questionnaire,current wheeze(CW,2nd question),exercise wheezing(EW,7th question),and dry cough(DC,8th question)were ***,parental allergies,eczema at 0–2 years,current eosinophil percentage and total IgE were *** Eczema was observed as an important risk factor[CW:odds ratio(OR)=2.83,95%confidence interval(CI)=1.54–5.23,P≤0.001;EW:OR=2.71,95%CI=1.33–5.54,P=0.006;DC:OR=3.03,95%CI=1.47–6.25,P=0.003],whereas having no atopic sensitization at 0–2-year-old(group 1)was found as a significant protective factor for asthma at 9–11 years old(CW:OR=0.32,95%CI=0.15–0.70,P=0.004;EW:OR=0.21,95%CI 0.10–0.44,P≤0.001;DC:OR=0.25,95%CI=0.10–0.59,P=0.002).Conclusion Early personal eczema is a significant risk factor for the development of asthma symptoms at 9–11 years old,whereas not having an allergic sensitization at 0–2 years old(group 1)is an important protective factor.

关键词： Asthma Children Risk factors

Production of nanocrystalline silver particles by hydrogen reduction of silver nitrate aerosol droplets

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Transactions of nonferrous Metals Society of China 2013年第3期23卷 841-848页

作者： burak EBIn Elif YAZIC I Sebahattin GüRMEn Department of Metallurgical & Materials Engineering Ist anbul Technical University34469IstanbulTurkey

nanocrystalline silver particles were produced by hydrogen reduction of silver nitrate aerosol droplets formed by high frequency ultrasonic *** dependences of the particle size,morphology and crystallite size on the precursor concentration and the reaction temperature were *** spray pyrolysis process was combined with hydrogen reduction to research the effects on the silver particle *** silver particles including slight oxide structure were prepared at temperature as low as 200 ℃ from silver nitrate under hydrogen atmosphere.X-ray diffraction（XRD） studies showed that pure silver particles were obtained above 200 ℃ reaction *** crystallite sizes of the samples ranged from 29 to 47 *** results indicate that the crystallite sizes hardly ever depended on the reaction *** slightly enlarged by increasing precursor *** observations showed that particles were obtained in spherical morphology with particle sizes between 210 and 525 *** temperature and precursor concentration strongly influenced the particle size.

关键词： silver particles nanocrystalline materials aerosol process hydrogen reduction

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脑梗塞与颅内出血的院外鉴别诊断

德国医学 2001年第4期18卷 233-234页

作者： C.Woisetschlger H.Kittler E.Oschatz a.bur W.Lang U.Waldenhofer A.n.Laggner M.M.Hirschl 周培文 Departmentof Emergency Medicine University of Vienna 华中科技大学同济医学院附属同济医院

脑梗塞和颅内出血是院外常见的病症,入院前将二者正确地区分开是十分重要的,因为涉及到不同的治疗、搬运措施,并对入院后的治疗有指导意义.现行区分两种患者的诊断计分体系需要大量的数据,而这些数据是急诊医生在院外诊断中并不容易获得... 详细信息

脑梗塞和颅内出血是院外常见的病症,入院前将二者正确地区分开是十分重要的,因为涉及到不同的治疗、搬运措施,并对入院后的治疗有指导意义.现行区分两种患者的诊断计分体系需要大量的数据,而这些数据是急诊医生在院外诊断中并不容易获得的.为此,我们进行了一项研究,用院外易获得的临床和回顾性数据建立了一个模型,以帮助区分脑梗塞和颅内出血的主要诊断结果.＃Out-of-hospital diagnosis of cerebral infarction versus intracranial

关键词：脑梗塞颅内出血诊断症状院外鉴别

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天堂雪花

琴童 2021年第9期 6-9页

作者： Florian bur

Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis

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World Journal of Gastroenterology 2005年第15期11卷 2340-2345页

作者： Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden bur(?)ak Department of Biochemistry Department of Surgery Department of Pathology

AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (nO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied nO, lipooxidative damage and glutathione in pancreas, lung and ***: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were ***: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for nO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and nO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas ***: nO increases in both pancreas and lungs in AP and nO contributes to the pathogenesis of AP under oxidative stress.

关键词： Thiobarbituric acid reactive substances Glutathione nitric oxide Acute pancreatitis

含黑云母侵入体的T—fo2轨迹及其在花岗岩中的应用

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国外花岗岩类地质与矿产 1993年第1期 1-8,36页

作者： bur.,DJM