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老年患者术后谵妄防治中国专家共识

中华老年医学杂志 2016年第12期35卷 1257-1262页

作者： Dong br 中华医学会老年医学分会

随着全球人口期望寿命的延长和外科手术安全性的提高，老年患者对手术的需要量不断增长。谵妄是老年患者术后最常见的并发症之一。术后谵妄延长患者住院时间、增加医疗费用、延迟康复、降低认知功能和躯体功能，甚至增加患者病死率，对... 详细信息

随着全球人口期望寿命的延长和外科手术安全性的提高，老年患者对手术的需要量不断增长。谵妄是老年患者术后最常见的并发症之一。术后谵妄延长患者住院时间、增加医疗费用、延迟康复、降低认知功能和躯体功能，甚至增加患者病死率，对老年人造成了严重危害。为提高对老年患者术后谵妄的诊断、评估、预防和治疗的水平，中华医学会老年医学分会组织国内专家就老年患者术后谵妄的临床特点、风险评估及处理原则制定以下共识。本共识针对进行择期手术的65岁及以上老年人，适合老年科和外科医务人员使用。

关键词：谵妄手术后期间

Heterocyclization of thiocarbonohydrazides:Facile synthesis of 5-unsubstituted-1,3,4-thiadiazoles

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Chinese Chemical Letters 2015年第9期26卷 1183-1186页

作者： Alaa A.Hassan Fathy F.Abdel-Latif Mohamed Abdel Aziz Sara M.Mostafa Stefan brse Martin Nieger Chemistry Department Faculty of ScienceMinia University Department of Medicinal Chemistry Faculty of PharmacyEl-Minia University Institute of Organic Chemistry Karlsruhe Institute of TechnologyFritz-Haber-Weg 676131 KarlsruheGermany Laboratory of Inorganic Chemistry Department of ChemistryUniversity of Helsinki

2-（Hydrazinecarbothioyl）-N-substituted hydrazinecarbothioamides react with 2,3,5,6-tetrachloro-1,4-benzoquinone in high yields in a novel fast and facile method to give 5-unsubstituted-1,3,4-thiadiazole-2-amine *** synthesized compounds were characterized by spectroscopic methods and confirmed by using X-ray crystallography.A rationale for the formation of the products is presented.

关键词： Thiocarbonohydrazides 5-Unsubstituted 1 3 4-thiadiazol-2-amines Tetrachloro-1 4-benzoquinone X-ray crystallography

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情报科学的建模与预测

国外情报科学 1993年第1期11卷 31-36页

作者： Gain.,br 陈艳

本文描述了情报学发展的模型,用来说明历史上的重大事件,并用以观测情报科学的未来,当电子技术满足了日益复杂的社会需求时,情报学进入了繁荣时期,计算技术方面的发展,在学习曲线上是呈阶梯状的。该曲线描绘了计算工业的基本结构。本文... 详细信息

本文描述了情报学发展的模型,用来说明历史上的重大事件,并用以观测情报科学的未来,当电子技术满足了日益复杂的社会需求时,情报学进入了繁荣时期,计算技术方面的发展,在学习曲线上是呈阶梯状的。该曲线描绘了计算工业的基本结构。本文以这种逻辑发展为基础,为情报学提供了一个框架。本文为情报科学提出了一个综合研究模型,说明情报学是一个渗透各种学科、结构紧密的系统。

关键词：情报学情报研究预测

Cytokinin levels and signaling respond to wounding and the perception of herbivore elicitors in Nicotiana attenuata

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Journal of Integrative Plant Biology 2015年第2期57卷 198-212页

作者： Martin Sch?fer Ivan D. Meza-Canales Aura Navarro-Quezada Christoph brütting Radomira Vanková Ian T. Baldwin Stefan Meldau Department of Molecular Ecology Max Planck Institute for Chemical Ecology Laboratory of Hormonal Regulations in Plants Institute of Experimental Botany AS CR German Centre for integrative Biodiversity Research (i Div)

Nearly half a century ago insect herbivores were found to induce the formation of green islands by manipulating cytokinin （CK） levels. However, the response of the CK pathway to attack by chewing insect herbivores remains unclear. Here, we characterize the CK pathway of Nicotiana attenuata （Torr. ex S. Wats.） and its response to wounding and perception of herbivoreassociated molecular patterns （HAMPs）. We identified 44 genes involved in CK biosynthesis, inactivation, degradation, and signaling. Leaf wounding rapidly induced transcriptional changes in multiple genes throughout the pathway, as well as in the levels of CKs, including isopentenyladenosine and cis-zeatin riboside; perception of HAMPs present in the oral secretions （OS） of the specialist herbivore Manduca sexta amplified these responses. The jasmonate pathway, which triggers many herbivore-induced processes, was not required for these HAMP-triggered changes, but rather suppressed the CK responses. Interestingly CK pathway changes were observed also in systemic leaves in response to wounding and OS application indicating a role of CKs in mediating long distance systemic processes in response to herbivory. Since wounding and grasshopper OS elicited similar accumulations of CKs in Arabidopsis thaliana L., we propose that CKs are integral components of wounding and HAMP-triggered responses in many plant species.

关键词： Arabidopsis thaliana cytokinin herbivore-associated molecular patterns herbivory insect jasmonic acid Manduca sexta Nicotiana attenuata wounding

Age,smoking and overweight contribute to the development of intestinal metaplasia of the cardia

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World Journal of Gastroenterology 2012年第17期18卷 2076-2083页

作者： Christian Felley Hanifa Bouzourene Marianne bründler G VanMelle Antoine Hadengue Pierre Michetti Gian Dorta Laurent Spahr Emiliano Giostra Jean Louis Frossard Service of Gastroenterology University Hospital1000 LausanneSwitzerland Institute of Pathology University Hospital1000 LausanneSwitzerland Institute of Social and Preventive Medicine University of Lausanne1000 LausanneSwitzerland Service of Gastroenterology Geneva University Hospital1211 GenevaSwitzerland

AIM:To assess the role of Helicobacter pylori(***),gastroesophageal reflux disease(GERD),age,smoking and body weight on the development of intestinal metaplasia of the gastric cardia(IMC).METHODS:Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this *** biopsies from the esophagus,gastroesophageal junction and stomach were evaluated for inflammation,the presence of *** and intestinal *** correlation of these factors with the presence of IMC was assessed using logistic ***:IMC was observed in 42% of the *** age,smoking habit and body mass index(BMI) were found as potential contributors to *** risk of developing IMC can be predicted in theory by combining these factors according to the following formula:Risk of IMC = a + s-2B where a = 2,…6 decade of age,s = 0 for non-smokers or ex-smokers,1 for 10 cigarettes/d and B = 0 for BMI 25 kg/m2(BMI > 27 kg/m2 in females).Among potential factors associated with IMC,*** had borderline signif icance(P = 0.07),while GERD showed no signif ***:Age,smoking and BMI are potential factors associated with IMC,while *** and GERD show no significant *** can be predicted in theory by logistic regression analysis.

关键词：吸烟者肠上皮年龄 Logistic回归分析 logistic回归幽门螺旋杆菌幽门螺杆菌超重

Ordinary Biodiversity, Local Stakeholders and Forest Management as a Driver for Regional Sustainable Development

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Open Journal of Forestry 2014年第3期4卷 249-258页

作者： Hervé brédif Laurent Simon Université Paris 1 Panthéon-Sorbonne UMR LADYSS CNRS Institut de Géographie Paris France

The protection of biodiversity which had long been bounded up with emblematic “natural” spaces is now increasingly focusing on ordinary biodiversity and rural agricultural land and forests as well as on urban and peri-urban spaces. Such ordinary biodiversity has its own specific features which make it both a relative and uncertain topic of research. Traditional nature protection instruments do not work on this dimension of the planet’s living tissue and new tools need to be deployed in conjunction with regional and local stakeholders that will provide long-term sustainable solutions for biodiversity and for local and regional development more generally. Research conducted on the Plateau de Millevaches explores the possibilities for shared caring for this biodiversity.

关键词： Biodiversity Conservation Forest Stakeholder Participation Decision Making

Impact and Management under Extracorporeal Circulation of a Patient with Renal Insufficiency on Dialysis with a High-Flow Arteriovenous Fistula in the Cardiac Surgery Department of the Angers Teaching Hospital about a Case and Review of the Literature

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Open Journal of Thoracic Surgery 2023年第1期13卷 1-5页

作者： Abdoulaye Kanté bréhima Coulibaly Mamadou Diakité Mamadou A. Keita Bakary Keita Drissa Traoré Nouhoum Ongoïba Patrice Binuani Christophe Baufreton Department of Thoracic and CardiovascularSurgery CHU Point G Bamako Mali Cardiac Surgery Department of the University Hospital of Angers Angers France Cardiology Department CHU Point G Bamako Mali Commune II Reference Health Center Bamako Mali

Arteriovenous fistulas have a substantial impact on systemic hemodynamics, however their effect on extracorporeal circulation is not well understood. We report our clinical observation on the management under extracorporeal circulation of a patient with renal insufficiency with a high-flow arteriovenous fistula. This is a 59-year-old man who was referred to us for surgical treatment of ischemic coronary artery disease in a context of anuric chronic renal failure. Hypothermia at 32°C is started from the start in CEC due to hyperflow at the level of the arteriovenous fistula. We performed two coronary artery bypasses of the marginal and IVA via the two internal thoracic arteries. The patient is hemofiltered in order to avoid hyperkalaemia and possibly avoid fluid overload related to filling per CEC. The clamping time was 71 minutes and the SCC lasted 141 minutes. There was no homologous transfusion in the operating room. It turns out that the input/output balance is zero at the end of the CEC. The postoperative course was simple.

关键词： Coronaryartery by Pass Grafting High Flow Arteriovenous Fistula Extracorporeal Circulation Hypothermia

Modulation of lysophosphatidic acid (LPA) receptor activity: the key to successful neural regeneration?

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Neural Regeneration Research 2020年第1期15卷 53-54页

作者： Isabel Gross Anja U.brauer Research Group Anatomy School for Medicine and Health ScienceCarl von Ossietzky University OldenburgOldenburgGermany Research Center for Neurosensory Science Carl von Ossietzky University OldenburgOldenburgGermany

The central nervous system(CNS)is characterized by a remarkably elaborate cellular architecture comprising large numbers of glial and neuronal cells with enormous functional diversity,organized into highly complex and specific *** development,the various neural cell types must first be correctly specified,then assume their appropriate positions through carefully choreographed cellular migration,and finally establish and refine their functional connections,often over long *** end result of all these processes is an extraordinarily intricate anatomical structure,able to receive,integrate,and store information and orchestrate appropriate responses.

关键词： neural specified finally

Experience after 100 patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Gastroenterology 2012年第17期18卷 2061-2066页

作者： Ingmar Knigsrainer Derek Zieker Jrg Glatzle Olivia Lauk Julia Klimek Stephan Symons Bjrn brücher Stefan Beckert Alfred Knigsrainer Department of Surgery University of TübingenHoppeSeyler-Strasse 3D-72076 TübingenGermany Center for Bioinformatics Tübingen Sand 14D-72076 TübingenGermany

AIM:To investigate perioperative patient morbidity/mortality and outcome after cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC).METHODS:Of 150 patients 100 were treated with cytoreductive surgery and HIPEC and retrospectively *** and postoperative follow-up data were *** mass index(BMI),age and peritoneal carcinomatosis index(PCI) were chosen as selection criteria with regard to tumor-free survival and perioperative morbidity for this multimodal ***:CRS with HIPEC was successfully performed in 100 out of 150 *** patients were excluded because of intraoperative *** PCI was 17(1-39).In 89% a radical resection(CC0/CC1) was *** patient died postoperatively due to multiorgan *** PCI,age nor BMI was a risk factor for postoperative complications/outcome according to the DINDO *** 9% Re-CRS with HIPEC was performed during the follow-up ***:Patient selection remains the most important *** PCI,age nor BMI alone should be an exclusion criterion for this multimodal therapy.

关键词：肿瘤细胞热化疗治疗腔内选择标准多式联运 PCI CRS