检索结果-南通市图书馆

中华医学会第十一次全国内分泌学学术会议

作者： S.M.Poucher J.Francis S.Vickers S.Cheetham G.Birmingham K.Dickinson B.Zinker a.bellamine M.Kirby Cardiovascular Discovery Department AstraZeneca PharmaceuticalsMacclesfieldUK ASTL AstraZeneca PharmaceuticalsCharnwoodUK

背景和目的:沙格列汀(SAXA)是一个强效的选择性二肽基肽脢-4(DPP-4)抑制剂,具有为延长对DPP-4的抑制特殊设计。肠促胰素能刺激葡萄糖依赖的胰岛素分泌,而DPP-4可使肠促胰素失去活性。SAXA作用机制可能与保护肠促胰素被DPP-4的降解,进而...

背景和目的:沙格列汀(SAXA)是一个强效的选择性二肽基肽脢-4(DPP-4)抑制剂,具有为延长对DPP-4的抑制特殊设计。肠促胰素能刺激葡萄糖依赖的胰岛素分泌,而DPP-4可使肠促胰素失去活性。SAXA作用机制可能与保护肠促胰素被DPP-4的降解,进而改善β细胞应激状态下β细胞的量存。本研究评估了SAXA和西格列汀(SITA)这些DPP-4抑制剂在其相似功效的处理下其对β细胞的保护作用。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Coupling Agent Based Simulation with Dynamic Networks Analysis to Study the Emergence of Mutual Knowledge as a Percolation Phenomenon

引用

Journal of Systems Science & Complexity 2016年第5期29卷 1358-1381页

作者： DUGDALE Julie bellamine BEN SAOUD Narjes ZOUAI Fedia PAVARD Bernard Universite Grenoble Alpes LIG Grenoble France University of Agder Norway Universite de La Manouba Ecole Nationale des Sciences de l'Informatique Laboratoire RIADI Tunisia Universite P. Sabatier CNRS IRIT Toulouse France

The emergence of mutual knowledge is a major cognitive mechanism for the robustness of complex socio-technical systems. It has been extensively studied from an ethnomethodological point of view and empirically reproduced by multi-agent simulations. Whilst such simulations have been used to design real work settings the underlying theoretical grounding for the process is vague. The aim of this paper is to investigate whether the emergence of mutual knowledge(MK) in a group of colocated individuals can be explained as a percolation phenomenon. The followed methodology consists in coupling agent-based simulation with dynamic networks analysis to study information propagation phenomena: After using an agent-based simulation the authors generated and then analyzed its traces as networks where agents met and exchanged knowledge. Deep analysis of the resulting networks clearly shows that the emergence of MK is comparable to a percolation process. The authors specifically focus on how changes at the microscopic level in the proposed agent based simulator affect percolation and robustness. These results therefore provide theoretical basis for the analysis of social organizations.

关键词： Agent-based simulation complex network dynamics emergence mutual knowledge per-colation social networks.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antioxidant Machinery Related to Decreased MDA Generation by Thymus Algeriensis Essential Oil-induced Liver and Kidney Regeneration

引用

Biomedical and Environmental Sciences 2016年第9期29卷 639-649页

作者： Guesmi Fatma Amit K Tyagi bellamine Houda Landoulsi Ahmed Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of Bizerte University of Carthage 1054 Tunisia Department of Experimental Therapeutics The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Service of Anatomo-Pathology of Menzel Bourguiba Bizerte 1054 Tunisia

Objective This study was conducted to determine the histopathological and biochemical effects of Thymus algeriensis essential oil （TEO） on hydrogen peroxide （H2O2）-induced oxidative stress in liver and kidney tissues of rats. Methods Rats were treated in six groups and were exposed for 2 weeks to low （LD; 100 μmol/L） and high doses （HD; 1 mmol/L） of H2O2 in the presence or absence of TEO （180 mg/kg）. Liver and kidney atrophy was measured by using biochemical and histopathological assays. Results Our study demonstrated that H2O2 induced liver and kidney atrophy, as evidenced by the significant elevation of serum aminotransferase, urea, and creatinine levels compared with those in the control rats. Urea levels were estimated by evaluating the activity of serum urease that hydrolyzes urea into CO2 and ammonia. However, TEO treatment significantly alleviated oxidative stress in the H2O2-induced liver and kidney toxicity model by reducing the levels of malondialdehyde concomitantly with marked elevations in superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase, as well as decrease in glutathione activity. Conclusion Our data demonstrated that TEO protected against H202 toxicity by decreasing oxidant levels and DNA damage, as well as increasing antioxidant levels, indicating that TEO has a spectrum of antioxidant and DNA-protective properties.

关键词： Liver and kidney atrophy Hydrogen peroxide Thymus algeriensis Antioxidants Toxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevention of H2O2 Induced Oxidative Damages of Rat Testis by Thymus algeriensis

引用

Biomedical and Environmental Sciences 2016年第4期29卷 275-285页

作者： Fatma Guesmi Hamida Beghalem Amit K Tyagi Manel Ben Ali Ramla Ben Mouhoub Houda.bellamine Ahmed Landoulsi Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Cytokine Research Laboratory Department of Experimental Therapeutics The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Laboratory of Biomonitoring of the Environment (LRO1/ES14) Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Service of Anatomo-Pathology of Menzel Bourguiba Bizerte 7050 Tunisia

Objective We evaluate the effects of Thymus algeriensis （TEO） against hydrogen peroxide （H202） toxicity on body and testis weight, testis sperm count, testis lipid peroxidation, and antioxidant enzyme activities in rats. Methods Rats were treated with low （LD） and high dose （HD） of H202 （0.1 and 1 mmol/L） in the presence or absence of TEO （150 mg/kg）. Results The results exhibited a significant decrease in body weight and testis weight, in total sperm number decrease （P〈0.05）, sperm motility and percentage of sperm viability, leading to complete arrest, in sperm flagellar beat frequency by the gavage of 1 mmol/L H202 compared to controls. The administration of H2O2 resulted in a significant reduction in testis GSH, GPx, CAT, SOD, and GST activity and significant increase （P〈0.05） in MDA concentration compared with the untreated control animals. TEO pre-treatment protected testis from the H2O2 generated oxidative stress. These results were confirmed by histological architecture examinations. Conclusion H2O2 has the ability to alter the sperm function, characteristics and development of testis. However, TEO is an efficient natural agent, which can prevent the testis from H2O2-induced oxidative damage in rats.

关键词： Testis Hydrogen peroxide TEO Antioxidants Infertility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：