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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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Using the polymerase chain reaction coupled with denaturing gradient gel electrophoresis to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted acute severe pancreatitis

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World Journal of Gastroenterology 2005年第45期11卷 7142-7147页

作者： Callum B Pearce Vitaly Zinkevich Iwona.beech Viera Funjika Ana Garcia Ruiz Afraa Aladawi Hamish D Duncan Queen Alexandra Hospital Microbiology Research Laboratory

AIM: To investigate the use of PCR and DGGE to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted severe ***: Patients with biochemical and clinical evidence of acute pancreatitis and an APACHE Ⅱ score ≥8 were enrolled. PCR and DGGE were employed to detect bacterial translocation in blood samples collected on d1,3, and 8 after the admission. Standard microbial blood cultures were taken when there was clinical evidence of sepsis or when felt to be clinically indicated by the supervising ***: Six patients were included. Of all the patients investigated, only one developed septic complications;the others had uneventful illness. Bacteria were detected using PCR in 4 of the 17 collected blood samples. The patient with sepsis was PCR-positive in two samples (taken on d 1 and 3), despite three negative blood cultures. Using DGGE and specific primers, the bacteria in all blood specimens which tested positive for the presence of bacterial DNA were identified as E ***: Our study confirmed thatunlike traditional microbiological techniques, PCR can detect the presence of bacteria in the blood of patients with severe AP. Therefore, this latter method in conjunction with DGGE is potentially an extremely useful tool in predicting septic morbidity and evaluating patients with the disease. Further research using increased numbers of patients, in particular those patients with necrosis and sepsis, is required to assess the reliability of PCR and DGGE in the rapid diagnosis of infection in AP.

关键词： Polymerase chain reaction Acutepancreatitis Bacterial translocation

Pseudomonas aeruginosa:Infections and novel approaches to treatment“Knowing the enemy”the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment

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Infectious Medicine

Infectious Medicine 2023年第3期2卷 178-194页

作者： Nikhil Sathe Peter beech Larry Croft Cenk Suphioglu Arnab Kapat Eugene Athan Reliance Life Sciences Pvt.Ltd. Dhirubhai Ambani Life Sciences CentreThane Belapur RoadRabaleNavi Mumbai 400701India School of Life and Environmental Sciences Deakin UniversityMelbourne Burwood Campus221 Burwood HighwayBurwood Victoria 3125Australia NeuroAllergy Research Laboratory School of Life and Environmental SciencesDeakin UniversityGeelong Campus at Waurn Ponds75 Pigdons RoadWaurn Ponds Victoria 3216Australia School of Medicine Deakin UniversityPO Box 281 Geelong 3220Australia

Pseudomonas aeruginosa is an aerobic Gram-negative rod-shaped bacterium with a comparatively large genome and an impressive genetic capability allowing it to grow in a variety of environments and tolerate a wide range of physical *** biological flexibility enables the *** to cause a broad range of infections in patients with serious underlying medical conditions,and to be a principal cause of health care associated infection *** clinical manifestations of *** include mostly health care associated infections and community-acquired *** possesses an array of virulence factors that counteract host defence *** can directly damage host tissue while utilizing high levels of intrinsic and acquired antimicrobial resistance mechanisms to counter most classes of *** co-regulates multiple resistance mechanisms by perpetually moving targets poses a significant therapeutic ***,there is an urgent need for novel approaches in the development of anti-Pseudomonas *** we review the principal infections caused by *** and we discuss novel therapeutic options to tackle antibiotic resistance and treatment of *** infections that may be further developed for clinical practice.

关键词： Pseudomonas Infections Antibiotics Resistance Novel Approaches Bacteriophages Immunotherapy Vaccines

Heminephrectomy for a large renal mass in a horseshoe kidney: A case report outlining a robotic assisted laparoscopic approach

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 78-81页

作者： Matthew Mancuso Benjamin B.beech David W.Chapman Blair St Martin Faculty of Medicine and Dentistry University of AlbertaEdmontonT6G 2R7Canada Division of Urology Department of SurgeryUniversity of AlbertaEdmontonT6G 2R7Canada

With an incidence of 1/500,a horseshoe kidney is not *** discovered in horseshoe kidney however are quite rare,and prove difficult to surgically manage due to complex vascular *** variable surgical approaches previously described,only a select few robot-assisted cases have been *** case describes one such robot-assisted laparoscopic heminephrectomy,with the use of indocyanine green and an endovascular stapler to successfully demarcate ischemia and achieve hemostasis *** complications were encountered,and pathology revealed a pT1bN0 clear cell renal cell carcinoma with negative surgical margins,demonstrating the feasibility of our approach.

关键词： Horseshoe kidney Robot-assisted Laparoscopic Partial nephrectomy Tumour

Soft tissue sarcoma with metastasis to the stomach: A case report

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World Journal of Gastroenterology 2010年第40期16卷 5130-5134页

作者： Lemuel Leon Dent Cesar Yamil Cardona Michael Clause Buchholz Roosevelt Peebles Julie Denise Scott Derrick Jerome beech Billy Ray Ballard Department of Surgery Meharry Medical College Department of Gastroenterology Meharry Medical College Department of Plastic Surgery Meharry Medical College Department of Pathology Meharry Medical College

Soft tissue sarcomas are unusual malignancies comprising 1% of cancer diagnoses in the United States. Undifferentiated pleomorphic sarcoma accounts for approximately 5% of sarcomas occurring in adults. The most common site of metastasis is the lung, with other sites being bone, the brain, and the liver. Metastasis to the gastrointestinal tract has rarely been documented. We present an unusual case of high-grade pleomorphic sarcoma with metastasis to the stomach, complicated by upper gastrointestinal bleeding.

关键词： Gastrointestinal bleeding Metastatic sarcoma Undifferentiated pleomorphic sarcoma

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学校难题

上海教育 2002年第12期 15-15,17页

作者： HANNa.beech 吴进学

长年以来,亚洲一直认为他们的学校在培育最好和最聪明的学生。不断攀高的GDP,数以百万计的数学家和工程师即是明证。东亚的学生几乎总是在国际范围内的数学及科学比赛中胜过西方。因此西方的教育家们曾将目光投向东方。

关键词：数学家

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SQL展望

计算机工程与科学 1990年第2期12卷 74-80页

作者： David beech 常春喜

关系模型是数据库中常用的模型之一,使用较广,但并非尽善尽美,还有待改善。根据这个想法,我们试图将模型看成是较大图象的一部分,并希望通过以下方法扩充SQL。 1.支持用户自定义的函数、类型和对象; 2.为实现(1),在SQL中纳入关系模型,... 详细信息

关系模型是数据库中常用的模型之一,使用较广,但并非尽善尽美,还有待改善。根据这个想法,我们试图将模型看成是较大图象的一部分,并希望通过以下方法扩充SQL。 1.支持用户自定义的函数、类型和对象; 2.为实现(1),在SQL中纳入关系模型,而不是仅在其旁边增加这种模型; 3.提高查询能力,如对真量词和非规格化结果的查询; 4.允许用户自定义类型的对象通过数据库与程序或用户之间的接口进行传递。

关键词：用户自定义函数求值关系模式 SQL 谓词函数子类型信息建模超集变元变量名

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The Endoscopic Removal of a Nasally Ectopic Premolar Tooth

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Open Journal of Stomatology 2015年第5期5卷 142-146页

作者： Andrea.beech Simon Haworth David Michael Thomas Jeremy Farrier Department of Oral and Maxillofacial Surgery Gloucestershire Royal Hospital Gloucestershire Hospitals NHS Foundation Trust Gloucester UK Department of Otolaryngology Gloucestershire Royal Hospital Gloucestershire Hospitals NHS Foundation Trust Gloucester UK

Nasally ectopic teeth are rare, but can be a source of significant morbidity. Symptoms can include facial pain, nasolacrimal duct obstruction, fungal rhinitis, persistent rhinorrhea and episodic epistaxis. A nasally ectopic tooth should be considered as a differential diagnosis for a radiopaque lesion within the nasal cavity. This case illustrates the diagnosis and subsequent minimally traumatic recovery of a nasally ectopic tooth, believed to be an upper first premolar tooth, via an endoscopic approach.

关键词： Ectopic Tooth Endscopic Removal Nasal Tooth

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举国体制：良方or毒药——疯狂的金牌

财经文摘 2010年第11期 30-35页

作者： Hannan beech 张郁（编译）

伴随上海世博会入团人次如期突破7000万，广州亚运会来了。二十年间，举办过一次奥运会、一次特奥会、一次大学生运动会、两次亚运会，中国体育好不热闹。有人说，北京奥运会的荣耀与自豪犹在，广州亚运会很难再次激起国人的兴奋点，而... 详细信息

伴随上海世博会入团人次如期突破7000万，广州亚运会来了。二十年间，举办过一次奥运会、一次特奥会、一次大学生运动会、两次亚运会，中国体育好不热闹。有人说，北京奥运会的荣耀与自豪犹在，广州亚运会很难再次激起国人的兴奋点，而且金牌数肯定又是毫无悬念的遥遥领先。

关键词：举国体制金牌广州亚运会北京奥运会疯狂毒药 or 大学生运动会