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Neural grafting for Parkinson's disease:challenges and prospects

Neural Regeneration Research 2017年第3期12卷 389-392页

作者： Thomas B.Stoker Nicholas F.Blair Roger a.barker John van Geest Center for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK Wellcome Trust-Medical Research Council Stem Cell Institute University of CambridgeCambridgeUK

Parkinson＇s disease（PD） is a neurodegenerative condition which causes a characteristic movement disorder secondary to loss of dopaminergic neurons in the substanitia *** motor disorder responds well to dopamine-replacement therapies,though these result in significant adverse effects due to non-physiological release of dopamine in the striatum,and off-target ***-based regenerative treatments offer a potential means for targeted replacement of dopamine,in a physiological *** neurons for cell-based therapies can be obtained from several *** ventral mesencephalon tissue contains dopaminergic neuron progenitors,and has been transplanted into the striatum of PD patients with good results in a number of ***,the ethical implications and logistical challenges of using fetal tissue mean that fetal ventral mesencephalon is unlikely to be used in a widespread clinical *** pluripotent stem cells can be used to generate dopaminergic neurons for transplantation,providing a source of autologous tissue for *** approach means that challenges associated with allografts,such as the potential for immune rejection,can be ***,the associated cost and difficulty in producing a standardized product from different cell lines means that,at present,this approach is not commercially viable as a cell-based *** neurons derived from embryonic stem cells offer the most promising basis for a cell-based therapy for Parkinson＇s disease,with trials due to commence in the next few *** there are ethical considerations to take into account when using embryonic tissue,the possibility of producing a standardized,optimized cell product means that this approach can be both effective,and commercially viable.

关键词： Parkinson's disease neural grafting embryonic stem cells induced pluripotent stem cells induced neurons cell-based therapies

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Physiology of medicinal and aromatic plants under drought stress

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The Crop Journal 2024年第2期12卷 330-339页

作者： Zohreh Emami Bistgani Allen V.barker Masoud Hashemi Isfahan Agricultural and Natural Resources Research and Education Center Agricultural Research Education and Extension Organization(AREEO)Isfahan 81748-35117Iran Stockbridge School of Agriculture University of MassachusettsAmherstMA 01002USA

Drought poses a significant challenge,restricting the productivity of medicinal and aromatic *** strain induced by drought can impede vital processes like respiration and photosynthesis,affecting various aspects of plants’growth and *** response to this adversity,medicinal plants employ mechanisms such as morphological and structural adjustments,modulation of drought-resistant genes,and augmented synthesis of secondary metabolites and osmotic regulatory substances to alleviate the *** water scarcity can lead to leaf wilting and may ultimately result in plant *** cultivation and management of medicinal plants under stress conditions often differ from those of other *** is because the main goal with medicinal plants is not only to increase the yield of the above-ground parts but also to enhance the production of active ingredients such as essential *** elucidate these mechanisms of drought resistance in medicinal and aromatic plants,the current review provides a summary of recent literature encompassing studies on the morphology,physiology,and biochemistry of medicinal and aromatic plants under drought conditions.

关键词： Drought stress Medicinal and aromatic plants Phytochemistry Physiology

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管壁形态、血流及管壁剪切应力:周围血管病的MR表现

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国际医学放射学杂志 2014年第3期 302-303页

作者： M.S.Galizia a.barker Y.Liao J.Collins J.Carr M.M.McDermot M.Markl 秦乃姗 Department Biomedical Engineering McCormick School of EngineeringNorthwestern University737 N.Michigan Avenue Suite 1600ChicagoIL 60611USA

摘要目的二维(2D)相位对比(PC)MRI与三方向速率编码评价动脉粥样硬化斑块对股动脉血流动力学的影响。方法收集1年内患有外周动脉疾病且踝肱指数<1.00的病人

关键词： MR PC 血流管壁剪切应力剪应力

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Change in Functional Status from Preoperative to One Year Postoperative in Patients Who Have Undergone Elective Open-Heart Surgery: A Repeated-Measures Study

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World Journal of Cardiovascular Diseases 2024年第6期14卷 421-433页

作者： A. Kate MacPhedran David barker Mark Marbey Kieran Fogarty Physical Therapy Program Morosky College of Health Professions and Sciences Gannon University Erie PA USA Interdisciplinary Health Sciences PhD Program College of Health and Human Sciences Western Michigan University Kalamazoo MI USA Organizational Learning and Leadership PhD Program College of Humanities Education and Social Sciences Gannon University Erie PA USA Cardiac Surgery Services AHN Saint Vincent Health Center Erie PA USA

Purpose: Although patient-related factors affect surgical outcomes, preoperative functional status is not measured by any cardiac risk score. Functional status can, however, be objectively measured using validated outcome tools such as the Late-Life Function and Disability Instrument (LLFDI). The purpose of this study was to determine 1) if there was a change over time in functional status, as measured by the LLFDI, in patients who underwent elective cardiac surgery, and if so, 2) what specific aspect(s) of functional status changed. Methods: A prospective longitudinal study of one year was conducted on elective cardiac surgery patients (n = 43) using the self-reported LLFDI, which measures Disability Frequency (frequency of participation in social tasks), Disability Limitation (ability to participate in social tasks) and Function Total (ease in performing routine activities). Higher scores indicate increased function and decreased disability. LLFDI scores were compared at three times (preoperative, six-week and one-year postoperative) using repeated measures ANOVA. Post hoc pairwise comparison was conducted for specific interactions. Results: Both Function Total and Disability Frequency significantly changed over time (p = 0.047 and p = 0.013, respectively). Specifically, patients’ function level was significantly higher one-year postoperative compared to preoperative (M difference = +3.48, SE = 1.48, p = 0.026). Likewise, Disability Frequency scores were significantly higher (i.e. more active) at one-year postoperative versus preoperative (M difference= +5.98, SE = 2.19, p = 0.033). Disability Limitation scores were not significantly different between any time points (p > 0.05). Conclusion: By one-year postoperative, patients demonstrated increased ease in their routine physical activities and were more participatory in social life tasks. Individuals who underwent elective cardiac surgery took more than six weeks to detect notable improvement in functional status,

关键词： Functional Status Elective Cardiac Surgery Late-Life Function and Disability Instrument

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4D-flow MRI评估TIPS术后对门体动脉血流的影响

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国际医学放射学杂志 2015年第6期 596-596页

作者： Z.Stankovic M.Rssle W.Euringer M.Schultheiss R.Salem a.barker 陈丽华 Department of Diagnostic Radiology and Medical Physics University Medical Center Freiburg

摘要目的 4D flow MRI是一种无创、无对比剂增强成像技术,旨在利用其评估经颈静脉肝内门体分流术(TIPS)后门体动脉血流动力学的改变。方法 11例TIPS植入术后病人纳

关键词：动脉血流 MRI flow MRI 门体 TIPS

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Monitoring the 2008 cold surge and frozen disasters snowstorm in South China based on regional ATOVS data assimilation

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Science China Earth Sciences 2010年第8期53卷 1216-1228页

作者： DALE M.barker National Center for Atmospheric Research BoulderColoradoUSA

In January 2008, South China experienced extremely low temperatures, heavy snowstorms, and severe frosts (2008 Frost Disaster, for short), which led to (partial) failures of observations from ground stations and ground radars resulting in a lack of necessary emergency information. To compensate for the failure of ground observations and to provide timely disaster information, the National Satellite Meteorological Center of China (NSMC) established a snow storm monitoring system for the 2008 Frost Disaster, which was based on the WRF Three Dimension Variational Assimilation and Forecast system (with NOAH as the land surface sub-process model) cooperatively developed by NSMC and the National Center for Atmospheric Research (NCAR), US. This system made full use of ATOVS and NCEP data to provide estimates of snow water equivalent every 6 hours during the storm. In this study, the ATOVS assimilation based snowstorm monitoring scheme was explored in detail, while the modeled results with and without ATOVS assimilation were compared against related observations. Results showed that the coupling of ATOVS assimilation into the proposed monitoring system evidently delineates weather characteristics of the snowstorm process more accurately, and demonstrated the feasibility of the system for snowstorm monitoring and forecasting. Through theoretical analyses and case discussion, this study proposes a reliable and practicable scheme to provide timely and accurate information on snow spatial distribution and temporal development for disaster mitigation, and illustrates a new application of ATOVS data.

关键词： 2008 cold surge and frozen disaster in South China ATOVS data assimilation snow depth snowstorm monitoring

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Comparisons of corrosion behaviour for X65 and low Cr steels in high pressure CO2-saturated brine

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Journal of Materials Science & Technology 2020年第6期41卷 21-32页

作者： Yong Hua Sikiru Mohammed Richard barker Anne Neville Institute of Functional Surfaces School of Mechanical Engineering University of Leeds Leeds LS2 9JT United Kingdom

Appropriate materials for injection pipelines and tubing for carbon dioxide geologic storage is fundamental to ensure asset integrity and save *** paper evaluates the corrosion behaviour of X65,1Cr,3Cr and 5Cr,which have the potential to be injection pipeline/tubing *** influence of steel Cr content on the general and localised corrosion behaviour was investigated at time periods from 6 to 192 h at 60℃and 100 *** evolution,morphology and chemistry of corrosion products on the surface of each material were evaluated using a combination of scanning electron microscopy,energy dispersive X-ray spectroscopy and X-ray diffraction and related to their overall corrosion *** indicate that prior to the formation of protective films on the steel surfaces,the resistance of the materials to corrosion increase with increasing Cr content(Corrosion resistance:X651Cr>3Cr>5Cr).In terms of the corrosion products on X65,both inner amorphous and outer crystalline corrosion layers consist of *** the Cr-containing steels,the outer layer also comprises FeCO3,but the inner layer is enriched with Cr,and is predominantly amorphous Cr(OH)*** extent of localised corrosion(determined using surface profilometry)is noticeably less for X65 compared to the Cr-containing *** paper raises questions about the benefits that low Cr steels offer towards extending component design life compared to carbon steel under the test conditions considered here.

关键词： Carbon dioxide Corrosion X65 Low-Cr steels Iron carbonate Chromium hydroxide

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EXISTENCE AND STABILITY OF VISCOUS SHOCK PROFILES FOR 2-D ISENTROPIC MHD WITH INFINITE ELECTRICAL RESISTIVITY

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Acta Mathematica Scientia 2010年第2期30卷 447-498页

作者： Blake barker Olivier Lafitte Kevin Zumbrun Department of Mathematics Indiana University LAGA Institut GalileeUniversite Paris 1393 430 Villetaneuse and CEA SaclayDM2S/DIR91 191 Gif sur Yvette CedexFrance

For the two-dimensional Navier-Stokes equations of isentropic magnetohydrodynamics （MHD） with γ-law gas equation of state, γ≥ 1, and infinite electrical resistivity, we carry out a global analysis categorizing all possible viscous shock profiles. Precisely, we show that the phase portrait of the traveling-wave ODE generically consists of either two rest points connected by a viscous Lax profile, or else four rest points, two saddles and two nodes. In the latter configuration, which rest points are connected by profiles depends on the ratio of viscosities, and can involve Lax, overcompressive, or undercompressive shock profiles. Considered as three-dimensional solutions, undercompressive shocks axe Lax-type （Alfven） waves. For the monatomic and diatomic cases γ= 5/3 and γ=7/5, with standard viscosity ratio for a nonmagnetic gas, we find numerically that the the nodes are connected by a family of overcompressive profiles bounded by Lax profiles connecting saddles to nodes, with no undercompressive shocks occurring. We carry out a systematic numerical Evans function analysis indicating that all of these two-dimensional shock pro- files are linearly and nonlinearly stable, both with respect to two- and three-dimensional perturbations. For the same gas constants, but different viscosity ratios, we investigate also cases for which undercompressive shocks appear; these are seen numerically to be stable as well, both with respect to two-dimensional and （in the neutral sense of convergence to nearby Riemann solutions） three-dimensional perturbations.

关键词： stability of viscous shock waves Evans function magnetohydrodynamics

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Change in Functional Status from Preoperative to One Year Postoperative in Patients Who Have Undergone Elective Open-Heart Surgery: A Repeated-Measures Study

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World Journal of Cardiovascular Diseases（心血管病） 2024年第6期 421页

作者： A.Kate MacPhedran David barker Mark Marbey Kieran Fogarty

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Physiology of medicinal and aromatic plants under drought stress

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The Crop Journal 2024年第2期 330页

作者： Zohreh Emami Bistgani Allen V.barker Masoud Hashemi

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