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Rice science 2024年第4期31卷 449-462,I0027-I0030页

作者： anuradha KUMARI Wusirika RAMAKRISHNA Department of Biochemistry Central University of PunjabPunjab 151401India

Tissue culture techniques were used to produce large amounts of bioactive compounds with medicinal potential, overcoming space and time constraints for cancer prevention. Rice callus suspension cultures(RCSC) and seed extracts prepared from aromatic rice varieties were used to evaluate the cytotoxic impact on human colon and lung cancer cell lines, as well as a normal control cell line, using Taxol as a positive control. RCSC and seed extracts from two Indian aromatic rice varieties were applied at different concentrations to treat the cancer cell lines and normal lung fibroblasts over varying time intervals. Apoptosis was assessed in 1:5 dilutions of the A549 and HT-29 cell lines treated with RCSC for 72 h, using propidium iodide staining and flow cytometry. RCSC showed a more potent cytotoxic effect than seed extracts with minimal effect on the normal cell line, in contrast to Taxol. Confocal microscopy and flow cytometry further confirmed the apoptotic effect of RCSC. Gas chromatography-mass spectrometry-based metabolic profiling identified metabolites involved in cytotoxicity and highlighted altered pathways. RCSC is proposed as an alternative source for the development of novel anticancer drugs with reduced side effects.

关键词： anticancer cytotoxicity metabolite profiling plant tissue culture rice callus suspension culture secondary metabolite

Importance of Sexual Dimorphism of the Maxillary Sinus and Mandibular Inter Coronoid Distance of Vijayawada City Population in Andhra Pradesh:An Original Research

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Journal of Forensic Science and Medicine 2021年第3期7卷 91-95页

作者： Supraja S a.anuradha Vijaysrinivas Guduru Mohammad Asif Kiresur Mohan Kumar Pasupuleti P.Vignatha Department of Oral and Maxillofacial Pathology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Department of Oral and Maxillofacial Pathology St.Joseph Dental CollegeEluruAndhra PradeshIndia Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Private Practitioner VijayawadaAndhra PradeshIndia

Background:Mass fatality incidents occur due to environmental,medical,vehicle,industrial,or terrorist events that can involve large numbers of *** of these victims is of utmost importance in these ***-beam computed tomography(CBCT)may be helpful in some forensic contexts,offering several advantages for postmortem forensic ***:The research study aims to evaluate the sexual dimorphism of the maxillary sinus and inter coronoid distance to estimate sex by using *** and Methods:In 40 CBCT scans of 20 males and 20 females,maxillary sinuses height,width and inter coronoid distances of mandible were measured for forensic *** high quality,reconstructed images ofbilateral maxillary sinuses,height,and width were measured,and in mandible,inter coronoid was measured in axial *** were tabulated and analyzed using an unpaired r-test and discriminant function analysis used to compare difierences in the measured parameters between males and ***:Mean values of inter coronoid in males and females are(♂=88.1,♀=78.1).The maxillary sinus right side height and width(♂=32.2,♀=24.6)(♂=19.7,♀=19.6)left side height and width(♂=32.7,♀=23.6)(♂=18.1,♀=17.8),respectively.A statistically significant(P<0.05)difference was found in maxillary sinus and inter coronoid distance between males and *** showed significantly larger dimensions of maxillary sinus and inter coronoid distance in males compared to *** correct predictive accuracy rate of sex detennination was 100% in females and 90% in males with overall accuracy of 95%.Conclusion:The present study showed the importance of maxillary sinus dimensions and inter coronoid distance in sex estimation using cone-beam computed tomography in forensic medicine.

关键词： Cone-beam computed tomography inter coronoid distance maxillary sinus

Prospective randomized study to evaluate and compare the post-procedural sexual function in patients undergoing semi-rigid ureterorenoscopy for distal ureteric stones in three different operating room settings

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Asian Journal of Urology 2024年第2期11卷 331-338页

作者： Gajanan S.Bhat anuradha Shastry Sexual Medicine TSS Shripad Hegde Kadave Institute of Medical SciencesSirsiKarnatakaIndia Department of Urology Andrology and Sexual MedicineTSS Shripad Hegde Kadave Institute of Medical SciencesSirsiKarnatakaIndia

Objective:To evaluate and compare the effect of semi-rigid ureterorenoscopy on post-procedural sexual function with three different operating room ***:In this prospective randomized study,consecutive sexually active patients with normal pre-operative sexual function undergoing uncomplicated semi-rigid ureterorenoscopy for distal ureteric stones were randomized into three groups,with three different operating room ***-related anxiety and sexual function were assessed pre-operatively using Amsterdam Preoperative Anxiety and Information Scale and Brief Sexual Function Inventory(in males)and Female Sexual Function Index-6(in females),*** the participants were stented following the procedure,and the stent was removed after 3 ***-procedural sexual function and general discomfort were assessed and compared between three groups at 1 week,3 weeks,and 12 *** effect of surgery-related anxiety,preoperative sexual function,age,and general discomfort(including stent-related discomfort)on post-procedural sexual function were analyzed using multiple regression analysis.A p-value of less than 0.05 was considered statistically ***:Totally,327 eligible patients were randomized into three *** group of patients who underwent the procedural with a screen separating the operating area from the patient vision,while the patient could watch the endoscopy through a separate monitor,had better post-procedural sexual function compared to those who had total vision of the operating area as well as to those whose eyes were *** difference was statistically *** post-procedural reduction in sexual function could not be attributed to in situ stent ***:Our study showed that semi-rigid ureterorenoscopy can have significant negative effect on sexual function,which can be reduced with proper preoperative counseling and an ideal operating room settings.

关键词： Semi-rigid ureterorenoscopy Post-procedural sexual dysfunction Preoperative counselling Operating room setting

SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration

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Neural Regeneration Research 2024年第6期19卷 1385-1392页

作者： Aditi Singh anuradha Venkatakrishnan Chimata Prajakta Deshpande Soumya Bajpai Anjali Sangeeth Mrigendra Rajput Amit Singh Department of Biology University of Dayton Premedical Program University of Dayton Center for Tissue Regeneration and Engineering at Dayton (TREND) University of Dayton The Integrative Science and Engineering Center University of Dayton Center for Genomic Advocacy (TCGA) Indiana State University

Infection caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV2) virus, responsible for the coronavirus disease 2019(COVID-19) pandemic, induces symptoms including increased inflammatory response, severe acute respiratory syndrome(SARS), cognitive dysfunction like brain fog, and cardiovascular defects. Long-term effects of SARS-CoV2 COVID-19 syndrome referred to as post-COVID-19 syndrome on age-related progressive neurodegenerative disorders such as Alzheimer’s disease remain understudied. Using the targeted misexpression of individual SARS-CoV2 proteins in the retinal neurons of the Drosophila melanogaster eye, we found that misexpression of nonstructural protein 3(Nsp3), a papain-like protease, ablates the eye and generates dark necrotic spots. Targeted misexpression of Nsp3 in the eye triggers reactive oxygen species production and leads to apoptosis as shown by cell death reporters, terminal deoxynucleotidyl transferase(TdT) dUTP Nick-end labeling(TUNEL) assay, and dihydroethidium staining. Furthermore, Nsp3 misexpression activates both apoptosis and autophagy mechanism(s) to regulate tissue homeostasis. Transient expression of SARS-CoV2 Nsp3 in murine neuroblastoma, Neuro-2a cells, significantly reduced the metabolic activity of these cells and triggers cell death. Misexpression of SARS-CoV2 Nsp3 in an Alzheimer’s disease transgenic fly eye model(glass multiple repeats [GMR]>amyloid β42) further enhances the neurodegenerative rough eye phenotype due to increased cell death. These findings suggest that SARS-CoV2 utilizes Nsp3 protein to potentiate cell death response in a neurodegenerative disease background that has high pre-existing levels of neuroinflammation and cell death.

关键词： Alzheimer's disease apoptosis autophagy COVID-19 Drosophila necrosis Neuro-2a cells neurodegeneration post COVID-19 syndrome SARS-CoV2

Highly efficient fiber to Si waveguide free-form coupler for foundry-scale silicon photonics

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Photonics Research 2024年第5期12卷 1055-1066页

作者： LUIGI RANNO JIA Xu BRIAN SIA COSMIN POPESCU DREW WENINGER SAMUEL SERNA SHAOLIANG YU LIONEL C.KIMERLING anuradha AGARWAL TIAN GU JUEJUN HU Department of Materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Centre for Micro-&Nano-Electronics(CMNE) Nanyang Technological UniversitySingapore 639798Singapore Department of Physics Photonics and Optical EngineeringBridgewater State UniversityBridgewaterMassachusetts 02324USA Zhejiang Laboratory Hangzhou 311100China Materials Research Laboratory Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA

As silicon photonics transitions from research to commercial deployment,packaging solutions that efficiently couple light into highly compact and functional sub-micrometer silicon waveguides are imperative but remain *** 220 nm silicon-on-insulator(SOI)platform,poised to enable large-scale integration,is the most widely adopted by foundries,resulting in established fabrication processes and extensive photonic component *** development of a highly efficient,scalable,and broadband coupling scheme for this platform is therefore of paramount *** two-photon polymerization(TPP)and a deterministic free-form micro-optics design methodology based on the Fermat’s principle,this work demonstrates an ultraefficient and broadband 3-D coupler interface between standard SMF-28 single-mode fibers and silicon waveguides on the 220 nm SOI *** coupler achieves a low coupling loss of 0.8 dB for the fundamental TE mode,along with 1 dB bandwidth exceeding 180 *** broadband operation enables diverse bandwidthdriven applications ranging from communications to ***,the 3-D free-form coupler also enables large tolerance to fiber misalignments and manufacturing variability,thereby relaxing packaging requirements toward cost reduction capitalizing on standard electronic packaging process flows.

关键词： fiber waveguide enable

Redefining gaming addictive behavior:influence of media,psychological dimensions and clinical implications

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Clinical Research Communications 2024年第3期7卷 1-12页

作者： anuradha Sathiyaseelan Sathiyaseelan Balasundaram Bishal Patangia Veda Anita Dandamudi Adithya Ramesh Department of Psychology School of Social ScienceCHRIST(Deemed to be University)Bengaluru 560029India. School of Business and Management CHRIST(Deemed to be University)Bengaluru 560029India.

This review critically examines gaming addiction within the contexts of media psychology and addiction *** outlines a continuum of gaming behavior,from casual play to addiction,characterized by loss of control,prioritizing gaming over other activities,and negative life *** inclusion of gaming disorder in International Classification of Disease 11 and its provisional status in Diagnostic and Statistical Manual of Mental Disorder 5 highlight growing clinical and societal *** review explores neural correlates of gaming addiction,such as activation in reward-related brain regions,drawing parallels with substance *** highlights how media and marketing promote gaming behaviors potentially leading to addiction,raising ethical concerns about game design and *** review systematically analyzes the negative physical,mental,social,and occupational impacts of gaming *** advocates for a balanced approach emphasizing awareness,therapeutic interventions,and responsible media practices,while also proposing areas for future research and policy development to mitigate the risks of excessive gaming.

关键词： gaming addiction media psychology addiction theory ICD-11 DSM-5

Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis

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Chinese Journal of Integrative Medicine 2023年第9期29卷 818-824页

作者： Sahar Idris anuradha Mishra Mohammad Khushtar Faculty of Pharmacy Integral UniversityDasauliLucknow226026Uttar PradeshIndia Amity Institute of Pharmacy LucknowAmity University Uttar PradeshNoida201313India

Objective To quantify phytochemicals using liquid chromatography and mass spectroscopy(LCMS)analysis and explore the therapeutic effect of Aesculus hippocastanum L.(AH)seeds ethanolic extract against gastric ulcers in *** Preliminary phytochemical testing and LCMS analysis were performed according to standard *** treatment,the animals were divided into 7 groups including normal control,ulcer control,self-healing,AH seeds low and high doses,ranitidine and per se *** were orally administered with 10 mg/kg of indomethacin,excluding the normal control group(which received 1%carboxy methyl cellulose)and the per se group(received 200 mg/kg AH seeds extract).The test group rats were then given 2 doses of AH seeds extract(100 and 200 mg/kg,respectively),while the standard group was given ranitidine(50 mg/kg).On the 11th day,rats in all groups were sacrificed,and their stomach was isolated to calculate the ulcer index,and other parameters such as blood prostaglandin(PGE2),tissue superoxide dismutase(SOD),catalase(CAT),malonyldialdehyde(MDA),and glutathione(GSH).All isolated stomach tissues were analyzed for histopathological *** The phytochemical examination shows that the AH seeds contain alkaloids,flavonoids,saponins,phenolic components,and *** analysis confirms the presence of quercetin and *** AH seeds extract showed significant improvement in gastric mucosa conditions after indomethacin-induced gastric lesions(P<0.01).Further marked improvement in blood PGE2 and antioxidant enzymes,SOD,CAT,MDA and GSH,were observed compared with self-healing and untreated ulcer-induced groups(P<0.01).Histopathology results confirmed that AH seeds extract improved the mucosal layer and gastric epithelial membrane in treated groups compared to untreated ulcer-induced *** LCMS report confirms the presence of quercetin and rutin in AH seeds ethanolic *** therapeutic effect of AH seeds extract against indomethacin

关键词： Aesculus hippocastanum L. pharmacological action phytochemical physicochemical analysis liquid chromatography and mass spectroscopy analysis gastro-protective activity

Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1711-1725页

作者： Ramya Dhandapani Swaminathan Sethuraman Uma Maheswari Krishnan anuradha Subramanian Centre for Nanotechnology&Advanced Biomaterials School of Chemical&BiotechnologySASTRA Deemed UniversityThanjavur 613401India

Circulating tumor clusters(CTC)disseminating from the primary tumor are responsible for secondary tumor formation where the conventional treatments such as chemotherapy and radiotherapy does not prevent the metastasis at locally advanced stage of breast *** this study,a smart nanotheranostic system has been developed to track and eliminate the CTCs before it can colonize at a new site,which would reduce metastatic progression and increase the five-year survival rate of the breast cancer *** multiresponsive(magnetic hyperthermia and pH)nanomicelles incorporated with NIR fluorescent superparamagnetic iron oxide nanoparticles were developed based on self-assembly for dual modal imaging and dual toxicity for spontaneous killing of CTCs in blood stream.A heterogenous tumor clusters model was developed to mimic the CTCs isolated from breast cancer *** nanotheranostic system was further evaluated for the targeting property,drug release kinetics,hyperthermia and cytotoxicity against developed CTC model in *** vivo model in BALB/c mice equivalent to stageⅢandⅣhuman metastatic breast cancer was developed to evaluate the biodistribution and therapeutic efficacy of micellar nanotheranostic *** CTCs in blood stream and low distant organ metastasis after treatment with the nanotheranostic system demonstrates its potential to capture and kill the CTCs that minimize the secondary tumor formation at distant sites.

关键词： Self-assembly Hybrid nanotheranostic system Circulating tumor clusters Advanced breast cancer Cancer stem cells Heterogenous clusters SPIONs NIR Metastasis CD44

Therapeutic Application,Phytoactives and Pharmacology of Tinospora cordifolia:An Evocative Review

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Chinese Journal of Integrative Medicine 2023年第6期29卷 549-555页

作者： Rabiya Ahsan anuradha Mishra Badruddeen Badar Mohammad Owais Vijayshwari Mishra Research Scholar Faculty of PharmacyIntegral UniversityLucknowUP226022India Department of Pharmacology Amity Institute of PharmacyLucknowAmity University Uttar PradeshSector 125Noida201313India Research Scholar Rameshwaram Institute of TechnologyLucknowIndia

Tinospora cordifolia(Guduchi or Gurjo),a herbaceous vine or climbing deciduous shrub,is consider as an important medicine in the Ayurvedic system of medication,which is available in India,China,Myanmar,Bangladesh and *** is the family of this *** have a variety of properties to treat various ailments such as fevers,jaundice,diabetes,dysentery,urinary infections,and skin *** compound has been subjected to many chemicals,pharmacological,pre-clinical,or clinical investigations and some new therapeutic potential effects have been *** review aims to summarize the critical information concerning in areas of chemical constituents,chemical structure,and pharmacokinetic activities such as anti-diabetic,anticancer,immune-modulatory,antivirus(especially in silico study about COVID-19),antioxidant,antimicrobial,hepatoprotective and its effect on cardiovascular and neurological disorders as well as rheumatoid *** traditional herb needs more experimental study on the clinical,pre-clinical study,and clinical efficacy of these compounds for the prevention and treatment of COVID-19 and needs large-scale clinical studies to prove the clinical efficacy of this compound,especially in stress-related diseases and other neuronal disorders.

关键词： Tinospora cordifolia Guduchi menispermaceae pharmacology

OKRA (HIBISCUS ESCULENTUS) AND FENUGREEK (TRIGONELLA FOENUM GRACEUM) MUCILAGE:CHARACTERIZATION AND APPLICATION AS FLOCCULANTS FOR TEXTILE EFFLUENT TREATMENTS

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Chinese Journal of Polymer Science 2008年第6期26卷 679-687页

作者： Rajani Srinivasan anuradha Mishra Blackland Research and Extension Centre Texas A&M University System720East Blackland RoadTempleTX76502USA Department of Chemistry University Institute of Engineering and TechnologyCSJM UniversityKanpur-208 024India

The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was *** polysaccharides were used for removal of solids (suspended solids (SS) and total dissolved solids (TDS)) and dyes from real textile effluents and aqueous solutions of different class of synthetic *** of varying polysaccharide concentration,contact time and pH on removal of pollutant from the textile...

关键词： Fenugreek Okra Natural polysaccharides Flocculation Wastewater treatment Textile effluent Bridging Hibiscus esculentus Trigonella foenum graceum.