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Genes & Diseases 2020年第3期7卷 392-400页

作者： Ghada M.Salum Reham M.Dawood Mai abd el-Meguid Noha E.Ibrahim Ashraf O.abdel aziz Mostafa K.el Awady Department of Microbial Biotechnology Genetic Engineering DivisionNational Research Centre33 EL Bohouth St.(former El Tahrir St.)DokkiGizaP.O.12622Egypt Department of Tropical Medicine Faculty of MedicineCairo UniversityGizaP.O.12622Egypt

In Egypt,Sofosbuvir(SOF)in combination with Dataclasvir(DCV)is the broadly used DAAs with excellent therapeutic *** study is designed to explore the relation between IL28B/TLR4 genetic variants and each of the followings;HCC development post SOF/DCV treatment,progression to HCC in naı¨ve patients and SOF/DCV therapy outcome.A total of 493 blood samples were collected(controls(n = 70);HCV patients treated with SOF/DCV(n = 252)of whom 65 patients developed HCC,187 patients didn’t develop HCC(125 responders,62 relapsers);naı¨ve HCV patients(n = 171)had early(n = 48),late liver fibrosis(n = 21)and HCC(n = 102)).Both SNPs were genotyped using a TaqMan 50 allelic discrimination *** IL28B rs12979860 SNP,the C allele was significantly correlating with the response rate more than T allele(OR 1.9,95%CI 1.29e2.9,p=0.004),while at TLR4 rs4986791 SNP,no association was found(OR 6.5,95%0.57e75.28,p = 0.09).Both SNPs couldn’t detect the probability for HCC emergence after *** naı¨ve patients,the protective alleles were detected in their lowest frequency in HCC patients(p = 0.1,for rs12979860 and,p = 0.001 for rs4986791).SOF/DCV combination improved SVR rates in HCV genotype 4a infected patients regardless of IL28B genotype,with the best rates in those lacking the T allele.

关键词： DAAs DCV HCV HCC IL28B SOF TLR4

Erlang mixture distribution with application on COVID-19 cases in Egypt

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International Journal of Biomathematics 2021年第3期14卷 203-220页

作者： M.M.E.abd el-Monsef Faculty of Science Tanta University Al-Geish StreetTantaGharbiaEgypt

In this paper,a finite mixture of m-Brlang distributions is *** moments,shape characteristics and parameter estimates of the proposed model are also *** proposed mixture has the property that it has a bounded hazard function.A special case of the mixed Erlang distribution is introduced and *** addition,a predictive technique is introduced to estimate the needed number of mixture components to fit a certain data.A real data concerning the confirmed COVID-19 cases in Egypt is introduced to utilize the predictive estimation *** more real datasets are used to examine the flexibility of the proposed model.

关键词： Erlang distribution mixture distribution goodness-of-fit test COVID-19

Efficient Deep-Learning-Based Autoencoder Denoising Approach for Medical Image Diagnosis

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Computers, Materials & Continua 2022年第3期70卷 6107-6125页

作者： Walid el-Shafai Samy abd el-Nabi el-Sayed Mel-Rabaie Anas M.Ali Naglaa F.Soliman Abeer D.Algarni Fathi E.abd el-Samie Department of electronics and electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Alexandria Higher Institute of Engineering&Technology(AIET) AlexandriaEgypt Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh84428Saudi Arabia

Effective medical diagnosis is dramatically expensive,especially in third-world *** of the common diseases is pneumonia,and because of the remarkable similarity between its types and the limited number of medical images for recent diseases related to pneumonia,themedical diagnosis of these diseases is a significant ***,transfer learning represents a promising solution in transferring knowledge from generic tasks to specific ***,experimentation and utilization of different models of transfer learning do not achieve satisfactory *** this study,we suggest the implementation of an automatic detectionmodel,namelyCADTra,to efficiently diagnose pneumonia-related *** model is based on classification,denoising autoencoder,and transfer ***,pre-processing is employed to prepare the medical *** depends on an autoencoder denoising(AD)algorithm with a modified loss function depending on a Gaussian distribution for decoder output to maximize the chances for recovering inputs and clearly demonstrate their features,in order to improve the diagnosis ***,classification is performed using a transfer learning model and a four-layer convolution neural network(FCNN)to detect *** proposed model supports binary classification of chest computed tomography(CT)images and multi-class classification of chest X-ray ***,a comparative study is introduced for the classification performance with and without the denoising *** proposed model achieves precisions of 98%and 99%for binary classification and multi-class classification,respectively,with the different ratios for training and *** demonstrate the efficiency and superiority of the proposed CADTra model,it is compared with some recent state-of-the-art CNN *** achieved outcomes prove that the suggested model can help radiologists to detect pneumonia-related diseases and improve the diagnostic efficiency compared to the exis

关键词： Medical images CADTra AD CT and X-ray images autoencoder

Analysis of BrainMRI: AI-Assisted Healthcare Framework for the Smart Cities

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Intelligent Automation & Soft Computing 2023年第2期35卷 1843-1856页

作者： Walid el-Shafai Randa Ali Ahmed Sedik Taha el-Sayed Taha Mohammed abd-elnaby Fathi E.abd el-Samie Department electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenoufia32952Egypt Department of ROBOTICS and Intelligent Machines Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikhEgypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

The use of intelligent machines to work and react like humans is vital in emerging smart ***-aided analysis of complex and huge MRI(Mag-netic Resonance Imaging)scans is very important in healthcare *** AI(Artiﬁcial Intelligence)driven healthcare applications,tumor detection is one of the contemporary researchﬁelds that have become attractive to *** are several modalities of imaging performed on the brain for the pur-pose of tumor *** paper offers a deep learning approach for detecting brain tumors from MR(Magnetic Resonance)images based on changes in the division of the training and testing data and the structure of the CNN(Convolu-tional Neural Network)*** proposed approach is carried out on a brain tumor dataset from the National Centre of Image-Guided Therapy,including about 4700 MRI images of ten brain tumor cases with both normal and abnormal *** dataset is divided into test,and train subsets with a ratio of the training set to the validation set of 70:*** main contribution of this paper is introdu-cing an optimum deep learning structure of CNN *** simulation results are obtained for 50 epochs in the training *** simulation results reveal that the optimum CNN architecture consists of four layers.

关键词： Healthcare smart cities clinical automation CNN machine learning brain tumor medical diagnosis

Mathematical Morphology View of Topological Rough Sets and Its Applications

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Computers, Materials & Continua 2023年第3期74卷 6893-6908页

作者： Ibrahim Noaman abd el Fattah el Atik Tamer Medhat Manal E.Ali Department of Mathematics Faculty of Science and Arts in Al-MandaqAl-Baha UniversityKingdom of Saudi Arabia Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of electrical Engineering Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Physics and Engineering Mathematics Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt

This article focuses on the relationship between mathematical morphology operations and rough sets,mainly based on the context of image retrieval and the basic image correspondence *** morphological procedures and set approximations in rough set theory have some clear *** initiatives have been made to connect rough sets with mathematical *** significant publications have been written in this *** attempt to show a direct connection between mathematical morphology and rough sets through relations,a pair of dual operations,and neighborhood *** sets are used to suggest a strategy to approximatemathematicalmorphology within the general paradigm of soft computing.A single framework is defined using a different technique that incorporates the key ideas of both rough sets and mathematical *** paper examines rough set theory from the viewpoint of mathematical morphology to derive rough forms of themorphological structures of dilation,erosion,opening,and *** newly defined structures are applied to develop algorithm for the differential analysis of chest X-ray images from a COVID-19 patient with acute pneumonia and a health *** algorithm and rough morphological operations show promise for the delineation of lung occlusion in COVID-19 patients from chest *** foundations of mathematical morphology are covered in this *** that,rough set theory ideas are taken into account,and their connections are ***,a suggested image retrieval application of the concepts from these two fields is provided.

关键词： Mathematical morphology rough set theory topological spaces COVID-19

A Hybrid Security Framework for Medical Image Communication

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Computers, Materials & Continua 2022年第11期73卷 2713-2730页

作者： Walid el-Shafai Hayam A.abd el-Hameed Ashraf A.M.Khalaf Naglaa F.Soliman Amel A.Alhussan Fathi E.abd el-Samie Department of electronics and electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Security Engineering Laboratory Department of Computer SciencePrince Sultan UniversityRiyadh11586Saudi Arabia electrical Communications Engineering Department Faculty of EngineeringMinia UniversityMinia61111Egypt Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia

Authentication of the digital image has much attention for the digital *** image authentication can be verified with image watermarking and image encryption *** schemes are widely used to protect images against forgery attacks,and they are useful for protecting copyright and rightful *** on the desirable applications,several image encryption and watermarking schemes have been proposed to moderate this *** framework presents a new scheme that combines a Walsh Hadamard Transform(WHT)-based image watermarking scheme with an image encryption scheme based on Double Random Phase Encoding(DRPE).First,on the sender side,the secret medical image is encrypted using *** the encrypted image is watermarking based on *** combination between watermarking and encryption increases the security and robustness of transmitting an *** performance evaluation of the proposed scheme is obtained by testing Structural Similarity Index(SSIM),Peak Signal-to-Noise Ratio(PSNR),Normalized cross-correlation(NC),and Feature Similarity Index(FSIM).

关键词： Walsh hadamard transform watermarking encryption double random phase encoding structural similarity index

Cylindrical Three-Dimensional Dust-Ion Acoustic Propagation in Plasmas

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Communications in Theoretical Physics 2018年第9期69卷 325-330页

作者： S.K.el-Labany E.K.el-Shewy H.N.abd el-Razek A.A.el-Rahman Theoretical Physics Group Faculty of Science Domietta University Department of Physics Taibah University Theoretical Physics Group Faculty of Science Mansoura University Department of Physics Faculty of Science Assiut University

Wave properties of solitons in an unmagnetized four-component dusty plasma system contains isothermal distributed electrons, mobile ions, and negative-positive dusty grains have been examined. To study DIA wave properties,a reductive perturbation (RP) analysis is used. By a reductive perturbation (RP) analysis under convenient coordinate transformation, the three dimension Kadomtsev-Petviashvili equation in cylindrical coordinates is obtained. The effects of dust grain charge on soliton pulse structures are studied. More specifically, solitary profile depending on the axial,radial, and polar angle coordinates with time is discussed. This investigation may be viable in plasmas of the Earth’s mesosphere.

关键词： dust plasmas 3D-CKP equation dusty-ion acoustic solitary waves isothermal electrons

Non-Hodgkin Lymphoma of the Liver:A US Population-based Analysis

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 83-91页

作者： Mohamed abd el-Fattah Department of Internal Medicine Faculty of Medicine Suez Canal University Ismailia Egypt

Background and Aims:Non-Hodgkin lymphoma (NHL) of the liver is a rare lymphoid malignancy,accounting for less than 1% of extranodal ***:I conducted an analysis of the U.S Surveillance,Epidemiology,and End Results (SEER) database to evaluate the histological subtypes and the survival outcomes of 785 cases with hepatic NHL between 1973 and ***:There were 785 of 312 459 cases with NHL had a first primary hepatic NHL (0.25%).Of the total 785 cases,the median age at diagnosis was 61 years (range 3-95 years) and male-female ratio of 1.7∶*** most common subtype was diffuse large B cell lymphoma (63.2%).In all patients,the median overall survival (OS) was 33 months (95%CI,22-48 months).The 5-year OS rate for indolent B-cell NHLs was 62%,compared with 44% for an aggressive B-cell NHLs and 42% for T-cell *** median OS improved from 19 months in patients diagnosed in a period 1996-2000 to 60 months when diagnosed between 2006 and 2012 (p ell NHLvariants (aHR 1.73,p =.03) were unfavourable prognostic ***:NHL of the liver comprises about 0.3% of all NHLs and survival was improved in the recent calendar period.

关键词： Non-Hodgkin lymphoma Liver Primary hepatic lymphoma Hepatic neoplasms

Effect of Egyptian propolis on cryptosporidiosis in immunosuppressed rats with special emphasis on oocysts shedding,leukogram,protein profile and ileum histopathology

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 240-248页

作者： Hamdy Soufy Nadia M.el-Beih Soad M.Nasr Tamer H.abd el-aziz Fathia A.M.Khalil Youssef F.Ahmed Hala A.A.Abou Zeina Department of Parasitology and Animal Diseases National Research Centre Department of Zoology Faculty of ScienceAin Shams University Department of Reproduction and Artificial Insemination National Research Centre

Objective:To investigate the activity of Egyptian propolis extracts(ethanol and water)on cryptosporidiosis in experimentally infected dexamethasone-immunosuppressed ***:A total of 180 male rats(190-220)g BWt were randomly divided into 9 equal groups(G1-G9).Groups of rats were kept as(G1):normal control,(G2-G9):immunosuppressed with dexamethasone and(G3-G9):infected with Cryptosporidium *** from(G4to G9)were given orally ethanol and water extract of propolis(at a dose of 50 mg/kg BWt)and nitazoxanide(standard anti-cryptosporidial drug at a dose of 100 mg/kg BWt)to infected rats with different *** pellets were collected from all groups to monitor oocysts shedding from the 2nd to the 15th day post *** the end of the experiment,blood was collected from all groups for determination of leukogram and serum *** specimens were also examined ***:The highest reduction of oocysts shedding in faecal samples was 88%in rats prophylactically treated with propolis ethanol extract at the 4th dpi,and in rats prophylactically treated with water extract of propolis,was91%at the 6th *** was a marked increase in neutrophils count and α_2-andβ-globulins levels in infected rats treated with both extracts,while a significant decrease was detected in lymphocytes compared to the infected non treated group.β-globulin level markedly increased in the rats administered *** changes were observed in the ileum of rats infected with ***:Egyptian propolis extracts have an activity on cryptosporidiosis in ***,propolis modulated the immunity in dexamethasone-immunosuppressed rats.

关键词： Cryptosporidiosis Propolis Rat model Leukogram Serum proteins Histopathology

Transpressive Structures in the Ghadir Shear Belt, Eastern Desert, Egypt: Evidence for Partitioning of Oblique Convergence in the Arabian-Nubian Shield during Gondwana Agglutination

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Acta Geologica Sinica(English Edition) 2019年第6期93卷 1614-1646页

作者： Mohamed abd el-WAHED Samir KAMH Mahmoud ASHMAWY Aly SHEBL Geology Department Faculty of Science Tanta University

Transpressional deformation has played an important role in the late Neoproterozoic evolution of the ArabianNubian Shield including the Central Eastern Desert of *** Ghadir Shear Belt is a 35 km-long,NW-oriented brittleductile shear zone that underwent overall sinistral transpression during the Late *** this shear belt,strain is highly partitioned into shortening,oblique,extensional and strike-slip structures at multiple ***,strain partitioning is heterogeneous along-strike giving rise to three distinct structural *** the East Ghadir and Ambaut shear belts,the strain is pure-shear dominated whereas the narrow sectors parallel to the shear walls in the West Ghadir Shear Zone are simple-shear *** domains are comparable to splay-dominated and thrust-dominated strike-slip shear *** kinematic transition along the Ghadir shear belt is consistent with separate strike-slip and thrustsense shear *** earlier fabric(S1),is locally recognized in low strain areas and SW-ward thrusts.S2 is associated with a shallowly plunging stretching lineation(L2),and defines^NW-SE major upright macroscopic folds in the East Ghadir shear belt.F2 folds are superimposed by^NNW–SSE tight-minor and major F3 folds that are kinematically compatible with sinistral transpressional deformation along the West Ghadir Shear Zone and may represent strain partitioning during deformation.F2 and F3 folds are superimposed by ENE–WSW gentle F4 folds in the Ambaut shear *** sub-parallelism of F3 and F4 fold axes with the shear zones may have resulted from strain partitioning associated with simple shear deformation along narrow mylonite zones and pure shear-dominant deformation in fold *** ENEstriking shear zones were subsequently active at ca.595 Ma,coeval with sinistral shearing along NW-to NNW-striking shear *** occurrence of upright folds and folds with vertical axes suggests that transpression plays a significant role in

关键词： Arabian-Nubian Shield Ghadir shear belt transpression splay-dominated and thrust-dominated strike-slip shear zones Egypt