检索结果-南通市图书馆

Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

Neural Regeneration Research 2025年第1期20卷 41-53页

作者： Alessio Canovai Pete A.williams Department of Biology University of PisaPisaItaly Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden

Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/*** quinone is present in the diet being available in foodstuffs,conferring the potential of this compound to be supplemented by dietary *** quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction,growth,and immunity resulting from the dietary absence of pyrroloquinoline quinone,and as such,pyrroloquinoline quinone has been considered as a“new vitamin.”Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established,the wide range of benefits for health provided has been reported in many *** this respect,pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts,thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian *** the regulation of different metabolic mechanisms,pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and *** quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration,although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully ***,we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological *** addition,we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.

关键词： metabolism mitochondria neurodegenerative disease neuroprotection pyrroloquinoline quinone retinal diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple sclerosis is at a checkpoint: advancing the program

引用

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica L.williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

单侧髌股关节不稳病人对侧无症状关节的影像特点

引用

国际医学放射学杂志 2015年第1期 77-77页

作者： S.Demehri G.K.Thawait a.a.williams A.Kom Pel J.J.Elias J.A.Carrino Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine

目的验证以下假说:在4D CT下显示单侧髌股关节不稳病人对侧无症状关节存在骨关节炎异常形态学及影像特征。材料与方法本回顾性研究获得了伦理委员会的批

关键词：髌股关节不稳对侧单侧关节运动器官无症状病人

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hubble telescope 30 years in orbit:personal reflections

引用

Research in Astronomy and Astrophysics 2020年第4期20卷 1-6页

作者： Robert williams Space Telescope Science Institute&University of California/Santa Cruz CA 95064USA

With an initial requirement to make observations a minimum of 5–10 years,Hubble Space Telescope(HST)has continued to operate well for 30 *** has relied upon five servicing missions to repair and replace essential *** the final Space Shuttle mission 10 years ago,it has avoided major breaks in its operation,with the only serious effects of aging in space being a progressive deterioration in the performance of the gyroscopes and sensitivity of the instrument detectors.A number of factors were important in making HST a scientific ***-breaking discoveries have been made with HST-the most important being the discovery of cosmic *** HST operation ceases,future observations in space should be assured with successful operation of major missions now planned by NASA,ESA,and the Chinese and Japanese Space Agencies.

关键词： HST cosmic acceleration Hubble constant supernovae

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Large scale manufacture of magnetic polymer particles using membranes and microfluidic devices

引用

China Particuology 2007年第1期5卷 26-42页

作者： Richard A. williams Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Clarendon Road Leeds LS2 9JT United Kingdom

Magnetic polymer particles have found applications in diverse areas such as biomedical treatments, diagnosis and separation technology. These applications require the particles to have controlled sizes and narrow size distributions to gain better control and reproducibility in use. This paper reviews recent developments in the preparation of magnetic polymer particles at nano- and micro-scales by encapsulating magnetic components with dissolved or in situ formed polymers. Particle manufacture using emulsification and embedment methods produces magnetic polymer particles at micro-scale dimensions. However, the production of particles in this range using conventional emulsification methods affords very limited control over particle sizes and polydispersity. We report on alternative routes using membrane and microfluidics emulsification techniques, which have a capability to produce monodisperse emulsions and polymer microspheres （with coefficients of variation of less than 10%） in the range from submicrometer to a few 100 μm. The performance of these manufacturing methods is assessed with a view to future applications.

关键词： Magnetic polymer particles Membrane emulsification Microfluidics emulsification Large scale manufacture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fibonacci Type Semigroups

引用

Algebra Colloquium 2014年第4期21卷 647-652页

作者： Gerald williams Department of Mathematical Sciences University of Essex Colchester Essex C04 3SQ UK

We study “Fibonacci type” groups and semigroups. By establishing asphericity of their presentations we show that many of the groups are infinite. We combine this with Adjan graph techniques and the classification of the finite Fibonacci semigroups （in terms of the finite Fibonacci groups） to extend it to the Fibonacci type semigroups.

关键词： Fibonacci group Fibonacci semigroup cyclic presentation asphericity Adjangraph

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Landmarks in the application of electrical tomography in particle science and technology

引用

Particuology 2010年第6期8卷 493-497页

作者： Richard A.williams Institute of Particle Science and Engineering School of ProcessEnvironmental and Materials EngineeringUniversity of LeedsLeedsWest YorkshireLS2 9JTUK

Selected milestones in the development and use of electrical tomography in powder conveying, slurry processing and multi-phase flow are highlighted. The ability to map concentration in opaque mixtures under process-realistic conditions was a major innovation for the method and has had far reaching implications. Subsequent developments have enabled velocity information to be abstracted resulting in the ability to measure component flux and motion.

关键词： Computational fluid dynamics Fault condition and maloperation Flow measurement Flow regime identification Particle concentration Process control Process safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anosov and expanding attractors

引用

Science China Mathematics 2020年第9期63卷 1929-1934页

作者： Robert F.williams Department of Mathematics University of Texas at AustinAustinTX 78705USA Institute for Advanced Study PrincetonNJ 08540USA

An earlier conjecture is settled with an immersion of a 2-dimensional branched *** obstructions in linear algebra and tiling theory are studied rst.

关键词： Anosov expanding attractor Cantor set ber bundle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correction of disturbed pathophysiology of hepatic failure by albumin dialysis

引用

Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 19-24页

作者： Roger williams Institute of Hepatology University College London Medical School 69-75 Chenies MewsLondonWC1E 6HXUK

Introduction In my presentation to the 4th International Symposium on Hepatic Failure and Artificial Liver Support in Chongqing on which this paper is based, I was specifically asked to address the question of whether albumin dialysis, as in the Molecular Adsorbents Recirculating System (MARS) did correct known abnormalities of the disturbed pathophysiology in liver failure. Before doing this

关键词： albumin dialysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A risk scoring system for seafood supply chain breaches and examination of freshwater fish imported to Australia

引用

Food Quality and Safety 2021年第3期5卷 256-270页

作者： Michelle williams Marta Hernandez-Jover Thomas williams Shokoofeh Shamsi School of Animal and Veterinary Sciences&Graham Centre for Agricultural Innovation Charles Sturt UniversityWagga WaggaNSWAustralia

Legislative changes have altered the way imported edible seafood is inspected in *** onus of responsibility has been placed on exporting countries to provide documentary evidence of adherence to internally recognized food safety *** to global trade agreements,any additional safety tests applied to freshwater fish imported into Australia must be ***,the aim of this study was to develop a risk scoring method to provide justification for identifying countries as'Freshwater fish high risk'and to examine the seafood they export to Australia for seafood supply chain *** ng was con ducted using six predictor variables,identified in the literature as important contributors to seafood supply chain breaches,to achieve the outcome variable,Country considered'Freshwater fish high ***-seven fish fillets(9.55 kg)of the same species were examined from the third highest scoring country(Country 20)and 562(5.6 kg)whole fish from the sixth highest scoring country(Country 22).Country 20 had supply chain breaches of 28 macroscopic yellow cysts in one *** hundred and thirteen parasites and other supply chain breaches were identified in fish from Country 22,in eluding retai ned liver(91 per cent),visible mud(11 per cent),a variety of debris(16 per cent)and,depending on the commodity code,these fish were imported to Australia under full intestine(90 per cent),retained gills(89 per cent),and partial intestine(9 per cent).Three serious physical hazards were recovered from the edible portion of three'consumer-ready' fish and snails of Genus Lymnaea and Indoplanorbis were recovered from gill mud also from'consumer-readyz *** study showed variable results from the scoring system and vast differences in seafood supply chain breaches between the third and sixth highest scoring countries.

关键词： Imported seafood supply chain breaches parasites.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：