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Recombinant outer membrane protein F-B subunit of LT protein as a prophylactic measure against Pseudomonas aeruginosa burn infection in mice

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World Journal of Methodology 2015年第4期5卷 230-237页

作者： Hassan Heydari Farsani Iraj Rasooli Seyed latif Mousavi Gargari Shahram Nazarian Shakiba Darwish Alipour Astaneh Department of Biology Shahed University Molecular Microbiology Research Center Shahed University Department of Biology Faculty Of Science Imam Hussein University Faculty of Biotechnology University of Semnan

AIM: To study immunogenicity of outer membrane protein F(Opr F) fused with B subunit of LT(LTB), against Pseudomonas aeruginosa(P. aeruginosa). METHODS: The Opr F, a major surface exposed outer membrane protein that is antigenically conserved in various strains of P. aeruginosa, is a promising immunogen against P. aeruginosa. In the present study recombinant Opr F and Opr F-LTB fusion gene was cloned, expressed and purified. BALB/c mice and rabbits were immunized using recombinant Opr F and Opr F-LTB and challenged at the burn site with P. aeruginosa lethal dose of 104 CFU. The protective efficacy of rabbit anti Opr F Ig G against P. aeruginosa burn infection was investigated by passive immunization. RESULTS: It has been well established that the LTB is a powerful immunomodulator with strong adjuvant activity. LTB as a bacterial adjuvant enhanced immunogenicity of Opr F and anti Opr F Ig G titer in serum was increased. Experimental findings showed significantly higher average survival rate in burned mice immunized with Opr F-LTB than immunized with Opr F or the control group. Rabbits anti Opr F Ig G brought about 75% survival of mice following challenge with P. aeruginosa. Post challenge hepatic and splenic tissues of mice group immunized with Opr F-LTB had significantly lower bacterial load than those immunized with Opr F or the control groups. CONCLUSION: These results demonstrate that LTBfused Opr F might be a potential candidate protein for a prophylactic measure against P. aeruginosa in burn infection.

关键词： Pseudomonas aeruginosa Outer membrane protein F B subunit of LT Immunization Burn

腐植酸施用方法对绿豆产量及其构成因子的影响

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腐植酸 2016年第6期 36-40页

作者： Muhammad Waqas Bashir Ahmad Muhammad Arif Fazal Munsif Abdul latif Khan Muhammad Amin Sang-Mo Kang Yoon-Ha Kim In-Jung Lee 刘雪娇茹雪峰高同国韩国庆北大学应用生物科学学院巴基斯坦开伯尔-普什图农业大学白沙瓦25000 巴基斯坦开伯尔-普什图农业推广学院布内尔999010 阿曼尼兹瓦大学生物科学与化学学院尼兹瓦518103 美国密苏里大学植物科学学院和大豆生物技术国家中心(NCSB) 哥伦比亚999076 河北农业大学生命科学学院保定071001 保定市清苑区第一中学保定071100

为了探索腐植酸(HA)的施用方法,在白沙瓦开伯尔-普什图省农业大学的农业研究农场内进行了完全随机区组设计试验,并设置3次重复。HA的施用方法分为浸种、叶片喷施和土壤施用3种。HA的施用方法对绿豆单株结荚数、每荚粒数、千粒重和籽粒... 详细信息

为了探索腐植酸(HA)的施用方法,在白沙瓦开伯尔-普什图省农业大学的农业研究农场内进行了完全随机区组设计试验,并设置3次重复。HA的施用方法分为浸种、叶片喷施和土壤施用3种。HA的施用方法对绿豆单株结荚数、每荚粒数、千粒重和籽粒产量具有显著影响,而对绿豆生物量影响不大。每公顷土地施用3 kg HA能显著提高绿豆结荚率、千粒重和产量;而土壤中加入1 kg/hm^2和2 kg/hm^2 HA,浓度为0、1%、2%的HA浸种和0.01%、0.05%、0.1%的HA叶面喷施3种方法所得到的结果在统计学上相似。由此得出结论:3种施用HA的方法均能显著提高绿豆产量及其构成因子。

关键词：绿豆腐植酸浸种叶面喷施土壤施用产量

Nat Med:靶向两分子或有助于彻底治愈白血病

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir latif Ming Xu H Leighton Grimes Mohammad Azam Division of Experimental Hematology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Department of Medicine University of Cincinnati Cincinnati Ohio USA Department of Anesthesia and Critical Care University of Chicago Chicago Illinois USA Division of Immunobiology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA Division of Pathology Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA.

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能... 详细信息

科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。

关键词：白血病治愈 Nat Med 分子信号蛋白治疗效果国际学术期刊

Evaluation of the Toxicity of Stone Hair Dye ＆ Paraphenylenediamine by MTT Bioassays in Vitro

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Journal of Chemistry and Chemical Engineering 2010年第5期4卷 36-40页

作者： Hatem Abdel Moniem Ahmed Fathy Fahim Abdul latif Adel Mohamed Kamal El-Dean Ragaa Mohamed Abdel Maaboud Kamal Mohamed EI-Shaieb Eugenio Vilanova Carmen Estevan Assiut Lab.of Medico-legal Department Ministry of JusticeAssuit BranchEgypt Chemistry Department Faculty of ScienceMinia UniversityEI-Minia 61519Egypt Chemistry Department Faculty of ScienceAssiut UniversityAssiut 71516Egypt Department of Forensic Medicine&Toxicology Faculty of MedicineAssiut UniversityAssiut 71516Egypt Institute of Bioengineering Unit of Toxicology and Chemical SafetyUniversity Miguel Hernhndez of Elche(Alicante)Spain

Synthesis and Characterization of Mesomorphic Behaviour of New Mesogenic Compounds Incorporating Cholesteryl Ester Moiety Connected to 1,3,4-Oxadiazole

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Journal of Chemistry and Chemical Engineering 2011年第10期5卷 946-955页

作者： Ivan H. R. Tomi Maha T. S. Al-Mahdawi Isam A. latif Fawwaz I. Khlili Ammar H. AI-Dujaili Department of Chemistry College of Science AI-Mustansiriya University Baghdad Iraq Department of Chemistry College of Education Ibn AI-Haitham University of Baghdad Baghdad Iraq Department of Chemistry Faculty of Science University of Jordan Amman Jordan

The synthesis and characterization of new series of liquid crystals containing cholesteryl moiety connected via an ester linkage to 1,3,4-oxadiazole are reported. The molecular structures of the intermediates and target compounds were confirmed by elemental analyses and FT-IR, 1H NMR and mass spectrometry. The mesomorphic behaviors were investigated by polarizing optical microscopy (POM) attached with hot stage and differential scanning calorimetry (DSC). Enantiotropic smectic 1, smectic A, blue phase and cholesteric mesophases are exhibited by the newly synthesized compounds.

关键词：胆固醇酯化合物恶二唑合成连接基团行为表征

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在一个小学群体的远视及其受教育程度

世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 13-13页

作者： Williams W. R. latif A. H. A. Hannington L. Watkins D. R. 郭战宏 Children’s Centre Royal Glamorgan Hospital Llantrisant CF72 8XR United Kingdom Dr.

Background: Vision screening addresses the visual impairments that impact on child development. Tests of long-sightedness are not found in most school screening programmes. The evidence linking mild-moderate hyperopia and lack of progress in school is insufficient, although strengthened by recent findings of developmental problems in infants. Aims: To report on the relation between hyperopia and education test results in a cohort of primary school children. Methods: A total of 1298 children, aged 8 years, were screened for hyperopia on the basis of fogging test results. School test results (NFER and SATs) were compared between groups categorised by referral status and refractive error. Results: A total of 166 (12.8%)-fogging test failures were referred for ophthalmic assessment. Ophthalmic tests on 105 children provided an accurate diagnosis of vision defects, for reference to their education scores. Fifty per cent of the children examined by optometrists required an intervention (prescription change, glasses prescribed, or referral). Mean (95%CI) NFER scores of children with refractive errors (summed for both eyes) >+3D (98.4, 93.0-103.8, n = 32) or >+1.25D (best eye) (99.3, 93.0-105.6, n = 26) were lower than the respective scores of children with a less positive refractive state (104.8, 100.7-108.9, n = 43) (103.6, 99.7-107.4, n = 49), the non-referred group, and total sample. The SATs results followed a similar trend. A high proportion of the fogging test failures (16%) and confirmed hyperopes (29%) had been referred to an educational psychologist, and the latter group contributed substantially to the poor education scores. Conclusions: The results of this study provide further evidence for a link between hyperopia and impaired literacy standards in children.

关键词：屈光异常中度远视儿童发育雾视试验屈光状态儿童文化配镜试验结果验光师小正

心脏化学交换饱和转移MRI示踪大鼠细胞疗法细胞存活或排斥的研究

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国际医学放射学杂志 2017年第2期 209-209页

作者： A.L.Pumphrey S.Ye Z.Yang J.Simkin J.C.Gensel A.Abdel-latif 陈繁陈艳丽 Saha Cardiovascular Research Center University of Kentucky

摘要目的阐明心脏化学交换饱和转移(CEST)MRI能否连续、无创性地探测大鼠心肌植入后细胞存活或排斥状态。材料与方法该研究符合国家卫生机构关于实验动物使

关键词：饱和转移化学交换大鼠 MRI 示踪细胞存活细胞疗法心脏