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Ionic liquid-based transparent membrane-coupled human lung epithelium-on-a-chip demonstrating PM0.5 pollution effect under breathing mechanostress

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Bio-Design and Manufacturing 2024年第5期7卷 624-636页

作者： Bilgesu kaya Ozlem Yesil-Celiktas Department of Bioengineering Faculty of EngineeringEge UniversityIzmir 35100Türkiye Translational Pulmonary Research Center(EgeSAM) Ege UniversityIzmir 35100Türkiye

The plausibility of human exposure to particulate matter(PM)has witnessed an increase within the last several *** of different sizes has been discovered in the atmosphere given the role of dust transport in weather and climate *** a regulator,the lung epithelium orchestrates the innate response to local ***,we developed a lung epithelium-ona-chip platform consisting of easily moldable polydimethylsiloxane layers along with a thin,flexible,and transparent ionic liquid-based poly(hydroxyethyl)methacrylate gel *** epithelium was formed through the culture of human lung epithelial cells(Calu-3)on this *** mechanical stress at the air–liquid interface during inhalation/exhalation was recapitulated using an Arduino-based servo motor system,which applied a uniaxial tensile strength from the two sides of the chip with 10%strain and a frequency of 0.2 ***,the administration of silica nanoparticles(PM0.5)with an average size of 463 nm to the on-chip platform under static,dynamic,and dynamic+mechanical stress(DMS)conditions demonstrated the effect of environmental pollutants on lung *** viability and release of lactate dehydrogenase were determined along with proinflammatory response through the quantification of tumor necrosis factor-α,which indicated alterations in the epithelium.

关键词： Ionic liquid-based membrane Lung Epithelial barrier Mechanostress Organ-on-chip Silica particles

Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1517-1522页

作者： Işın kaya Medical Genetics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BACKGROUND Nonallelic homologous recombination(NAHR)of segmental duplications or low copy repeats(LCRs)result in DNA gain/loss and play an important role in the origin of genomic *** SUMMARY A 3-year-old boy was referred for genetic *** genomic hybrid-ization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal *** Genomic imbalances caused by NAHR in LCRs result in deletion and duplication syndromes.

关键词： Wolf-Hirschhorn syndrome Silver-Russell syndrome Recurrent rearrangements Case report

Design of a large-scale model for wind tunnel test of a multiadaptive flap concept

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Chinese Journal of Aeronautics 2024年第2期37卷 58-80页

作者： Mürüvvet Sinem SICIM DEMIRCI Rosario PECORA Metin Orhan kaya Aeronautical Engineering Department Istanbul Technical UniversityIstanbulTurkey Industrial Engineering Department University of Naples Federico IINapoliItaly

The design and application of morphing systems are ongoing issues compelling the aviation *** Clean Sky-program represents the most significant aeronautical research ever launched in Europe on advanced technologies for greening next-generation *** primary purpose of the program is to develop new concepts aimed at decreasing the effects of aviation on the environment,increasing reliability,and promoting eco-friendly *** ambitions are pursued through research on enabling technologies fostering noise and gas emissions reduction,mainly by improving aircraft aerodynamic *** the Clean Sky framework,a multimodal morphing flap device was designed based on tight industrial requirements and tailored for large civil aircraft *** flap is deployed in one unique setting,and its cross section is morphed differently in take-off and landing to get the necessary extra lift for the specific flight ***,during the cruise,the tip of the flap is deflected for load control and induced drag *** manufacturing the first flap prototype,a high-speed(Ma=0.3),large-scale test campaign(geometric scale factor 1:3)was deemed necessary to validate the performance improvements brought by this novel system at the aircraft *** the other hand,the geometrical scaling of the flap prototype was considered impracticable due to the unscalability of the embedded mechanisms and actuators for shape ***,a new architecture was conceived for the flap model to comply with the scaled dimensions requirements,withstand the relevant loads expected during the wind tunnel tests and emulate the shape transition capabilities of the true-scale *** strategies were developed to effectively morph the model during wind tunnel tests while ensuring the robustness of each morphed configuration and maintaining adequate stiffness levels to prevent undesirable deviations from the intended aerodynamic ***,

关键词： Morphing structures Smart aircraft Morphing flap Adaptive systems Finger-like ribs Wind tunnel tests Large-scale morphing archi-tectures Variable camber airfoil

Personalized medicine and opioid use disorder

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World Journal of Psychiatry 2024年第9期14卷 1285-1288页

作者： Dilek kaya-Akyüzlü Institute of Forensic Sciences Ankara UniversityAnkara 06590Türkiye

Opioid use disorder(OUD)is a major public health problem affecting millions of people *** OUD is a chronic and relapsing disorder,a variety of pharmacological and non-pharmacological interventions are ***-assisted treatment of OUD generally relies on competition for opioid receptors against the addictive *** mechanisms of this competition are to block or inactivate the opioid receptor or activate the receptor with a substance that is intermittent or long *** and buprenorphine are two United States Food and Drug Administration-approved medications that have long-term positive effects on the health of opioid-dependent *** clinical studies of drugs generally demonstrate efficacy in thousands of people and toxicity is excluded,it cannot be predicted whether the given drug will cause side effects in one of the patients at the treatment *** differences can be explained by many biological and environmental *** in genes encoding drug metabolism or cellular drug targets significantly explain the variability in drug response between ***,for the effects of candidate genes to be accepted and included in individual treatment protocols,it is important to repeat studies on individuals of different ethnic backgrounds and prove a similar effect.

关键词： Opioid use disorder Genetic vulnerability Treatment failures Personalized medicine Pharmacogenetics

Changes in Calcareous Nannofossil Assemblages and Paleoenvironmental Interpretation of the Early Miocene Lice Formation, Kahramanmara? Basin, Turkey, East Mediterranean

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 1021-1034页

作者： Caner kayaÖZER Muazez Esra ORHAN Uğur TEMİZ Yozgat Bozok University DivanlıRoadYozgat 66900Turkey

This study investigated the calcareous nannofossil assemblages in detail from the early Miocene aged Lice Formation outcropping in the Kahramanmara? basin. The biostratigraphy of calcareous nannofossils was outlined and paleoenvironmental features determined. In 81 samples taken from three measured sections in the region, 17 calcareous nannofossil genus and 48 nannofossil species were identified. These calcareous nannofossil genus and species identified the Lice Formation as being in the CNM4 nannofossil biozone. The abundance and diversity of early Miocene calcareous nannofossil species varied in the measured sections, with the samples generally moderate-poor, apart from a few samples. The relative abundance of individuals of Cyclicargolithus floridanus, Coccolithus pelagicus, Reticulofenestra hagii and Sphenolithus moriformis species, with paleoecological importance identified in the study region, indicate that in early Miocene times, the basin in which the Lice Formation deposited was meso-eutrophic with excess nutrient input, temperate and generally stable shallow marine conditions.

关键词： paleoecology nannofossil Burdigalian East Mediterranean

Correlation of work function and stacking fault energy through Kelvin probe force microscopy and nanohardness in diluteα-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit Türe Ali Arslan kaya Hüseyin Aydin Jiang Peng Servet Turan Eskisehir Technical University Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman University Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey Hüseying Aydın TUBITAK MRCTurkey Jiang Peng Chongqing UniversityChina Eskisehir Technical University Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of the Group 2A elements with magnesium have been studied through the dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** investigation incorporated the difference in the‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in the *** was shown that the nano-hardness of the solid-solutionα-Mg phase changed in the order of Mg-Ca>Mg-Sr>***,it was shown,by also considering the nano-hardness levels,that SFE of a solid-solution is closely correlated with its‘Work Function'***-hardness measurements on the eutectics andΔWF difference between eutectic phases enabled an assessment of the relative bond strength and the pertinent electronic structures of the eutectics in the three *** withΔWF and at least qualitative verification of those computed SFE values with some experimental measurement techniques were considered important as those computational methods are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by this investigation,if the results of measurement techniques can be qualitatively correlated with those of the computational methods,it can be possible to evaluate the electronic structures in alloys,starting from binary systems,going to ternary and then multi-elemental *** investigation has shown that such a qualitative correlation is *** all,the SFE values are not treated as absolute values but rather become essential in comparative investigations when assessing the influences of alloying elements at a fundamental level,that is,free electron density *** study indicated that the principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental methods,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Short range order Miedema Nanoindentation Eutectics

Microstrip Patch Antenna with an Inverted T-Type Notch in the Partial Ground for Breast Cancer Detections

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1301-1322页

作者： Nure Alam Chowdhury Lulu Wang Md Shazzadul Islam Linxia Gu Mehmet kaya Department of Biomedical Engineering and Science Florida Institute of TechnologyMelbourneFL 32901USA Biomedical Device Innovation Center Shenzhen Technology UniversityShenzhen518118China Department of Electrical and Computer Engineering International Islamic University MalaysiaJalan GombakSelangor53100Malaysia

This study designs a microstrip patch antenna with an inverted T-type notch in the partial ground to detect tumorcells inside the human *** size of the current antenna is small enough(18mm×21mm×1.6mm)todistribute around the breast *** operating frequency has been observed from6–14GHzwith a minimumreturn loss of−61.18 dB and themaximumgain of current proposed antenna is 5.8 dBiwhich is flexiblewith respectto the size of *** the distribution of eight antennas around the breast phantom,the return loss curveswere observed in the presence and absence of tumor cells inside the breast phantom,and these observations showa sharp difference between the presence and absence of tumor *** simulated results show that this proposedantenna is suitable for early detection of cancerous cells inside the breast.

关键词： Antenna microwave wideband cancer breast phantom tumor detection

The ability of biostimulants and copper-containing fungicide to protect cotton against chilling stress

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Journal of Cotton Research 2024年第3期7卷 223-230页

作者： ERGIN Nurgül KULAN Engin Gokhan HARMANCI Pinar kaya Mehmet Demir Faculty of Agriculture and Natural Sciences Department of Field CropsBilecik Seyh Edebali UniversityBilecikTürkiye Faculty of Agriculture Department of Field CropsEskisehir Osmangazi UniversityEskisehirTürkiye

Background Cotton(Gossypium hirsutum L.),adapted to tropical and subtropical regions of the world,is highly sensitive to low temperatures throughout its life *** objective of this study was to evaluate the mitigating effects of different doses of animal-derived(0.25%,0.50%,and 1.00% Isabion■),seaweed-based(0.165%,0.330%,and 0.660% Proton■)biostimulants,as well as a copper(Cu)-containing fungicide application,on cotton cultivar Lazer seedlings at the four true leaves(V4)*** plants were exposed to a low temperature of 5℃for 48 h,and the changes in morphological(seedling fresh and dry weight,plant height,and stem diameter)and physiological parameters(leaf temperature,chlorophyll content,relative water content,electrolyte leakage,and relative injury)were *** The results revealed that chilling stress reduced plant growth,while biostimulants helped protect the plants and overcome the adverse effects of *** chilling stress,there was a considerable reduction in seedling fresh weight(SFW),seedling dry weight(SDW),plant height(PH),stem diameter(SD),leaf temperature(LT),and relative water content(RWC).Cotton seedlings treated with the animal-derived biostimulants showed significantly enhanced SFW,SDW,PH,SD,LT,chlorophyll content(Chl),electrolyte leakage(EL),and relative injury(RI),although there were no positive changes in *** significant differences in the morphological traits were observed among the doses of seaweed *** SDW,PH,EL,and RI,the best results were obtained with the application of a fungicide containing *** These results show the efficiency of the biostimulant and fungicide treatments in mitigating low-temperature stress in cotton *** a copper-containing fungicide to cotton seedlings helped to counteract the negative effects of low-temperature stress and to protect the plants from damage by maintaining electrolyte *** the biostimulant applications,all levels of animal-derive

关键词： Gossypium hirsutum L. Cold stress Electrolyte leakage

Deciphering the implications of MAFLD and MASLD definitions in the NAFLD population:results from a single-center biopsy study

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Chinese Medical Journal 2024年第5期137卷 616-618页

作者： Eda kaya Yusuf Yilmaz Department of Internal Medicine Ruhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochum 44892Germany Institute of Gastroenterology Marmara Universityİstanbul 34840Turkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRize 53100Turkey

To the Editor:The nomenclature for steatotic liver disease has been a topic of debate since *** conventional expression,non-alcoholic fatty liver disease(NAFLD),was introduced in 1980 to describe the occurrence of steatosis in the absence of other hepatic ***,in recent years,there has been a growing movement to phase out and retire this *** 2020,Eslam et al^([1])proposed a new definition—metabolic(dysfunction)associated fatty liver disease(MAFLD)—redefining the disease to include hepatic steatosis along with other factors such as diabetes,obesity,overweight,or meeting the criteria for metabolic dysfunction.

关键词： NAFLD liver MAF