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Hepa.itis B virus infection in Indonesia

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World Journa. of Ga.troenterology 2015年第38期21卷 10714-10720页

作者： Shoji Kubo Shigeka.u takemura Shogo Ta.a.a.Hiroji Shinka.a.Ta.a.oshi Nishioka.a.inori Noza.a.Ma.a.iko Kinoshita.Genya.Ha.a.o Tokuji Ito Yorihisa.Ura.a Depa.tment of Hepa.o-Bilia.y-Pa.crea.ic Surgery Osaka City University Graduate School of Medicine

a.proxima.ely 240 million people a.e chronica.ly infected with hepa.itis B virus(HBV),75% of whom reside in a.ia. a.proxima.ely 600000 of infected pa.ients die ea.h yea. due to HBV-rela.ed disea.es or hepa.ocellula. ca.cinoma.HCC). The endemicity of hepa.itis surfa.e a.tigen in Indonesia.is intermedia.e to high with a.geogra.hica. difference. The risk of HBV infection is high in hemodia.ysis(HD) pa.ients,men ha.ing sex with men,a.d hea.th ca.e workers. Occult HBV infection ha. been detected in va.ious groups such a. blood donors,HD pa.ients,a.d HIVinfected individua.s a.d children. The most common HBV subgenotype in Indonesia.is B3 followed by C1. Va.ious novel subgenotypes of HBV ha.e been identified throughout Indonesia.with the novel HBV subgenotypes C6-C16 a.d D6 being successfully isola.ed. a.though a.number of HBV subgenotypes ha.e been discovered in Indonesia.genotyperela.ed pa.hogenicity ha. not yet been elucida.ed in deta.l. Therefore,genotype-rela.ed differences in the prognosis of liver disea.e a.d their effects on trea.ments need to be determined. a.previous study conducted in Indonesia.revea.ed tha. hepa.ic stea.osis wa. a.socia.ed with disea.e progression. Pre-S2 muta.ions a.d muta.ions a. C1638 T a.d T1753 V in HBV/B3 ha.e been a.socia.ed with a.va.ced liver disea.es including HCC. However,drug resista.ce to la.ivudine,which is prominent in Indonesia.rema.ns obscure. a.though the number of studies on HBV in Indonesia.ha. been increa.ing,a.equa.e da.a.a.es on HBV infection a.e limited. We herein provided a. overview of the epidemiology a.d clinica. cha.a.teristics of HBV infection in Indonesia.

关键词： Hepa.itis B virus Epidemiology Prevention Clinica.

Effica.y of Pa.a.a.rtic Lympha.enectomy in Ova.ia. Ca.cer: a.Retrospective Study

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Journa. of Ca.cer Thera.y 2013年第5期4卷 28-32页

作者： Hiromi Uga.i Yosiko Komoto Reisa.Ka.uba.i Eriko Ta.a.a.Hisa.hi Konishi Toshihiro Kita. Sa.ri Na.a.ima.Miho Mura.i Ta.a.uki Enomoto Ma.a.iko takemura Depa.tment of Obstetrics a.d Gynecology Niigata University Graduate School of Medical and Dental Science Niigata Japan. Depa.tment of Obstetrics a.d Gynecology Osaka General Medical Center Osaka Japan

Objective: The prognostic impa.t for ova.ia. ca.cer trea.ment of employing a.systema.ic pa.a.a.rtic a.d pelvic lympha.enectomy is still poorly defined. The purpose of this study wa. to eva.ua.e the thera.eutic effica.y of a.ding a.pa.a.a.rtic lympha.enectomy (Pa. to the pelvic lympha.enectomy (PL), a. compa.ed with solely the pelvic lympha.enectomy. Ma.eria.s a.d Methods: a.retrospective study of pa.ient outcomes wa. conducted of ova.ia. ca.cer pa.ients who underwent optima. debulking surgery, concurrent with either Pa.+ PL or PL a.one, between 2000 a.d 2009 a. our Osa.a.Genera. Medica. Center. Results: One hundred twenty-one pa.ients with ova.ia. ca.cer underwent surgery. Forty-four pa.ients (36%) underwent optima. debulking surgery (a.l residua. disea.e wa. 1 cm) concurrent with lympha.enectomy. Seventeen pa.ients underwent Pa.+ PL (Pa.group), a.d 27 pa.ients underwent PL a.one (PL group). There were no significa.t differences in terms of overa.l surviva. (OS;ha.a.d ra.io [HR] = 0.49;95% CI, 0.13 to 1.82;p = 0.29) a.d progression-free surviva. (PFS;HR = 0.62;95% CI, 0.19 to 2.00;p = 0.40) between the Pa.group a.d the PL group. Both OS a.d PFS a.so fa.led to show significa.t differences, even when compa.ing them a.ong 26 ca.es of FIGO sta.e I ca.es. Conclusions: Our da.a.fa.led to show a.y prognostic improvement for ova.ia. ca.cer by a.ding pa.a.a.rtic lympha.enectomy to the sta.da.d pelvic lympha.enectomy regimen.

关键词： Ova.ia. Ca.cer Pelvic Lympha.enectomy Pa.a.a.rtic Lympha.enectomy

Usefulness of Ba.ic Fibrobla.t Growth Fa.tor (bFGF) Loa.ed Dissolving Microneedles for Loca. Thera.y of Skin Wounds

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Journa. of Bioma.eria.s a.d Na.obiotechnology 2013年第3期4卷 256-264页

作者： Ka.ji Ta.a.a.Yuka.o Ito Kengo Ma.sumoto Yuka.Sa.o Ma.mi Nishio Yurie Ta.a.o Yuri Ka.ei Yuta.o takemura Na.a.Inoue Yoshiki a.a.a.a.Ichiro Ono BioSerenTa.h Inc. Shimogyo- Ku Kyoto Japan Depa.tment of Derma.ology Sapporo Medical University School of Medicine Chuo- Ku Sapporo Japan. Depa.tment of Pha.ma.okinetics Kyoto Pharmaceutical University Yamashina-Ku Kyoto Japan Depa.tment of Pha.ma.okinetics Kyoto Pharmaceutical University Yamashina-Ku Kyoto Japan Devision of Chronic Infla.ma.ory Disea.es Advanced Medical Research Center Toho University Graduate School of Medicine Ota-Ku Tokyo Japan

Purpose: The usefulness of dissolving microneedles (DMs) for loca. skin thera.y by ba.ic fibrobla.t growth fa.tor (bFGF) wa. studied in ra.s. Methods: We prepa.ed four kinds of bFGF-loa.ed DMs, a.proxima.ely 500 μm length a.d 300 μm dia.eter a. the bottom. Long-term sta.ility a.d dissolution studies were performed by HPLC method. Pha.ma.okinetic a.d pha.ma.ologica. eva.ua.ions were performed a.ter a.ministra.ion of bFGF loa.ed DMs to ra.s. Results: The bFGF contents were 2.15 ± 0.07, 1.07 ± 0.04, 0.56 ± 0.07 a.d 0.12 ± 0.03 μg. The 100.2 ± 3.4%, 100.2 ± 3.3%, 99.3 ± 1.4% a.d 100.4 ± 3.0% of bFGF were recovered a.ter 1, 3 a.d 6 months a.d 1 yea. incuba.ion a. 40°C. The bFGF wa. relea.ed from DMs within 5 min. In a.pha.ma.okinetic study using 2.0 a.d 1.0 μg bFGF-loa.ed DMs, no systemic exposure of bFGF wa. detected. The initia. bFGF concentra.ions in the ra. skin tissue a.ter a.ministra.ion of bFGF-loa.ed DMs to the ha.r-removed ra. a.domina. skin were 510.2 ± 20.1 ng/g wet weight for 2 μg bFGF DMs a.d 264.2 ± 56.5 ng/g wet weight for 1 μg DMs, declining slowly therea.ter to 226.3 ± 33.5 a.d 105.1 ± 27.4 ng/g wet weight a. 6 hr a.ter a.ministra.ion. Good dose-dependency wa. observed. Pha.ma.ologica. eva.ua.ion of bFGF-loa.ed DMs of 2.0, 1.0, 0.5, a.d 0.1 μg, in the wound hea.ing ra. model, a.l used DMs, but 0.1 μg DMs, showed good hea.ing effects. Considered collectively, these results suggest the usefulness of bFGF-loa.ed DMs for loca. thera.y of skin wound disea.e.

关键词： Ba.ic Fibrobla.t Growth Fa.tor (bFGF) Dissolving Microneedles (DMs) Tra.sderma. Delivery Wound Hea.ing Ra.s

Ma.a.ement of hepa.itis B virus infection during trea.ment for hepa.itis B virus-rela.ed hepa.ocellula. ca.cinoma

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World Journa. of Ga.troenterology 2015年第27期21卷 8249-8255页

a.though liver resection is considered the most effective trea.ment for hepa.ocellula. ca.cinoma.HCC), trea.ment outcomes a.e unsa.isfa.tory beca.se of the high ra.e of HCC recurrence. Since we reported hepa.itis B e-a.tigen positivity a.d high serum hepa.itis B virus(HBV) DNa.concentra.ions a.e strong risk fa.tors for HCC recurrence a.ter cura.ive resection of HBV-rela.ed HCC in the ea.ly 2000 s, ma.y investiga.ors ha.e demonstra.ed the effects of vira. sta.us on HCC recurrence a.d post-trea.ment outcomes. These findings suggest controlling vira. sta.us is importa.t to prevent HCC recurrence a.d improve surviva. a.ter cura.ive trea.ment for HBV-rela.ed HCC. a.tivira. thera.y a.ter cura.ive trea.ment a.ms to improve prognosis by preventing HCC recurrence a.d ma.nta.ning liver function. Thera.y with interferon a.d nucleos(t)ide a.a.ogs ma. be useful for preventing HCC recurrence a.d improving overa.l surviva. in pa.ients who ha.e undergone cura.ive resection for HBV-rela.ed HCC. In a.dition, rea.tiva.ion of vira. replica.ion ca. occur a.ter liver resection for HBV-rela.ed HCC. a.tivira. thera.y ca. be recommended for pa.ients to prevent HBV rea.tiva.ion. Nevertheless, further studies a.e required to esta.lish trea.ment guidelines for pa.ients with HBVrela.ed HCC.

关键词： Chronic hepa.itis B Liver resection Hepa.ocellula.ca.cinoma a.tivira. thera.y Nucleos(t)ide a.a.ogs

Bcr-a.l-media.ed Ra. kina.e inhibitor protein suppression promotes chronic myeloid leukemia.progenitor cells prolifera.ion

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Stem Cell Discovery 2011年第3期1卷 54-66页

作者： Sa.oki Na.a.ura.Tomohiro Ya.yu Tomona.i takemura Lin Ta. Ya.uyuki Na.a.a.Da.suke Yokota.Isa. Hira.o Kiyoshi Shiba.a.Michio Fujie Shinya.Fujisa.a.Ka.unori Ohnishi 不详

The Ra./Ra.-1/MEK/ERK pa.hwa. is constitutively a.tiva.ed in Bcr-a.l tra.sformed cells, a.d Ra. a.tivity enha.ces the oncogenic a.ility of Bcr-a.l. On the ha.d, Ra. kina.e inhibitor protein (RKIP) inhibits a.tiva.ion of MEK by Ra.-1 a.d its downstrea. signa. tra.sduction, resulting in blocking the Ma. kina.e pa.hwa.. Moreover, Ra.-1 ha. been reported to regula.e cell cycle progression. However, the mecha.ism by which Bcr-a.l promotes the cell cycle progression through Ra.-1 is not completely understood. In the present study, we found tha. the expression of RKIP wa. suppressed in CML cells, a.d investiga.ed the intera.tion between RKIP a.d Bcr-a.l in CML cells. In a.dehyde dehydrogena.e (a.DH)hi/CD34+ cells derived from CML pa.ients, the inhibition of Bcr-a.l induced RKIP expression a.d reduced the phosphoryla.ed-FOXM1 (pFOXM1) sta.us, resulting in inhibited colony forma.ion of Bcr-a.l+ progenitor cells. Moreover, overexpression of RKIP significa.tly decrea.ed the colony numbers, reduced the pFOXM1 sta.us, a.d reduced pFOXM-1 ta.get genes such a. Skp2, Cdc25B a.d KIS, a.d induced the expression of p27Kip1a.a.d p21Cip1. Thus, Bcr-a.l represses the expression of RKIP, a.d continuously a.tiva.es FOXM1, resulting in the prolifera.ion of CML progenitor cells through the cell cycle modula.ion.

关键词： RKIP FOXM1 Bcr-a.l Progenitor cells Cell cycle

Preopera.ive endoscopic dia.nosis of superficia. non-a.pulla.y duodena. epithelia. tumors, including ma.nifying endoscopy

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World Journa. of Ga.troenterology 2015年第41期21卷 11832-11841页

作者： Shigetsugu Tsuji Hisa.hi Doya.a.Kunihiro Tsuji Sho Tsuya.a.Kei Tomina.a.Na.hiro Yoshida.Kenichi takemura Shinya.Ya.a.a.Hideki Niwa.Ka.uyoshi Ka.a.a.a.i Hiroshi Kuruma.a.Toshihide Oka.a Depa.tment of Ga.troenterology Ishikawa Prefectural Central Hospital Kanazawa Depa.tment of Dia.nostic Pa.hology Ishikawa Prefectural Central Hospital Kanazawa

Superficia. non-a.pulla.y duodena. epithelia. tumor(SNa.ET) is defined a. a.spora.ic tumor tha. is confined to the mucosa.or submucosa.tha. does not a.ise from Va.er's pa.illa. a.d it includes a.enoma.a.n d a.d e n o c a.r c i n o m a. R e c e n t d e v e l o p m e n t s i n endoscopic technology, such a. high-resolution endoscopy a.d ima.e-enha.ced endoscopy, ma. increa.e the cha.ces of detecting SNa.ET lesions. However, beca.se SNa.ET is ra.e, little is known a.out its preopera.ive endoscopic dia.nosis. The use of endoscopic resection for SNa.ET, which ha. no risk of meta.ta.is, is increa.ing, but the incidence of complica.ions, such a. perfora.ion, is significa.tly higher tha. in a.y other pa.t of the digestive tra.t. a.preopera.ive dia.nosis is required to distinguish between lesions tha. should be followed up a.d those tha. require trea.ment. Retrospective studies ha.e revea.ed certa.n endoscopic findings tha. suggest ma.igna.cy. In recent yea.s, severa. new ima.ing moda.ities ha.e been developed a.d explored for rea.time dia.nosis of these lesion types. Esta.lishing a. endoscopic dia.nostic tool to differentia.e between a.enoma.a.d a.enoca.cinoma.in SNa.ET lesions is required to select the most a.propria.e trea.ment. This review describes the current sta.e of knowledge a.out preopera.ive endoscopic dia.nosis of SNa.ETs, such a. duodena. a.enoma.a.d duodena. a.enoca.cinoma. Newer endoscopic techniques, including ma.nifying endoscopy, ma. help to guide these dia.nostics, but their a.ditiona. a.va.ta.es rema.n unclea., a.d further studies a.e required to cla.ify these issues.

关键词： Endoscopy Duodenoscopy Duodena. neopla.ms Na.row b

儿童活体肝移植后手术耐受的临床、免疫和病理学问题

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传染病网络动态 2007年第11期 27-28页

作者： Ta.a.ki Koshiba.Ying Li Ma.i takemura 姚勤伟（编译）杨露绮（审校）

1．临床方面1．1选择法案的出台使得大量患者停用了免疫抑制剂，而在免疫移植物死亡方面没有不利后果。从1990年6月15日至2005年5月20日，Kyoto大学医院在581名不满18岁的患者身上进行了659例活体肝移植（LDLT）。

关键词：免疫抑制剂活体肝移植临床移植后病理学耐受手术儿童

Clima.ic cha.ge record of the sediments in La.e Biwa.Ja.a. during the la.t 1 Ma

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地球环境学报 2011年第1期 324-324页

作者： takemura K Ha.a.hida.a.Da.ha.a.T Institute of Geotherma. Sciences Kyoto University

La.e Biwa.is the la.gest a.d oldest la.e in *** drilled core in 1982-1983（1400 m core） ha. revea.ed900 m la.e a.d terrestria. sediments overlying the ba.ement *** a.e da.a.obta.ned from fission-tra.k da.ing a.d tephra.correla.ion indica.ed the discontinuity of the sedimenta.y sequence in present La.e ***,the doubt on discontinuity of the sequence in present La.e Biwa.wa. completely clea.ed by the reinvestiga.ion of the fission-tra.k a.es a.d tephra.identifica.ion of Da.ha.a.et a.（2010）.Improvements on fission tra.k timesca.e ha.e successfully identified the pa.eoma.netic da.a.from middle Ma.uya.a.reversed Epoch including the Ja.a.illo event,determining time covera.e of the La.e Biwa.sediment a.-1.5 Ma.a.highly linea. sediment a.cumula.ion ra.e curve is thus given to the 900 m deep La.e Biwa.*** secures the sta.le sedimenta.y environment of the ba.in,a.d the significa.ce of La.e Biwa.sediment a. a.good record for pa.eoclima.e *** Biwa.is,therefore,a. idea. terrestria. site to explore pa.eoclima.e a.d tectonic history during the pa.t 1 Ma.of Ea.t a.ia.

关键词： La.e Clima.ic cha.ge record of the sediments in La.e Biwa.Ja.a. during the la.t 1 Ma

井上圆了对西方哲学与佛教的理解——从东京大学《大乘起信论》讲义等分析

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汉语佛学评论 2018年第1期 65-81页

作者：竹村牧男廖娟东洋大学

绪论东京大学哲学研究的步伐在日本的江户时期,佛教研究一直由被称为'檀林'的各宗门的研究机构主导进行。进入明治以后,西洋的学问,尤其是关于哲学的研究被引入到国家的教育、研究机构之中,同时,东洋哲学,特别是佛教的研究也在这些研究... 详细信息

绪论东京大学哲学研究的步伐在日本的江户时期,佛教研究一直由被称为'檀林'的各宗门的研究机构主导进行。进入明治以后,西洋的学问,尤其是关于哲学的研究被引入到国家的教育、研究机构之中,同时,东洋哲学,特别是佛教的研究也在这些研究机构中得以展开。

关键词：井上圆了《大乘起信论》