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Long-Term Impa.t of a.ute Retinoic a.id Supplementa.ion a. the Young a.e on Testicula. a.chitecture of Wista. a.bino Ra.s

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a.va.ces in Reproductive Sciences 2024年第1期12卷 1-13页

作者： Ma.a.sy Ra.ha.Ka.enda.Ibondou Fa.ouma.a.Ba. Robert Foko Ndia.a.Diop Ma.e Vénus a.doula.e Séga.Cheikh Diop Ma.a.ou Fa.l Ouma. Fa.e La.ora.ory of Histology Embryology and Cytogenetics Faculty of Medecine Cheikh Anta Diop University Dakar Senegal

Introduction: Ina.propria.e a.d excess vita.in supplementa.ion, pa.ticula.ly for vita.in a. is increa.ingly recognized a. a.public hea.th problem in developed countries. On the other ha.d, blind supplementa.ion of vita.in a. for children in developing countries is a.subject of controversy in the litera.ure. The crucia. role of vita.in a.in the process of sperma.ogenesis in a.ult rodents is well esta.lished, but only a.few publica.ions a.e consecra.ed to the long-term effect of vita.in a.inta.e a. a.young a.e on testicula. development a.d differentia.ion. Objectives: Our study a.med to eva.ua.e the long-term effects of a.ute supplementa.ion a. a. ea.ly a.e, in the post-na.a. period, on sperma.ogenesis a.d testicula. trophicity a. a.ult a.e. Ma.eria. a.d Methods: Young Wista. a.binos ra.s of 22 da.s received a. a.ute high dose of supplementa.ion of vita.in a.(retinyl pa.mita.e). The control group, group 1, received only extra.virgin olive oil, Group 2 a.dose of 7000 IU/kg of retinyl pa.mita.e, group 3, 14,000 IU/kg, a.d Group 4 a.dose of 28,000 IU/kg. a. 10 weeks of a.e, the testes’ testosterone levels were mea.ured by ELISa. For histologica. a.sessment, sections were sta.ned with Hema.oxylin eosin, a.d the Johnsen score wa. used to eva.ua.e sperma.ogenesis in the seminiferous tubules. Results: The a.era.e testicula. weights of ra.s were significa.tly lower in group 4 (p a.d so wa. the testosterone level in the testis compa.ed to the control group (p .01). Most of the seminiferous tubules were concerned by a. a.rest of sperma.ogenesis a.d the Johnsen score wa. decrea.ed with a.mea. score of 5.96 ± 1.60 (p .001) in tha. Group. In Group 3, Johnsen’s score wa. significa.tly better tha. the one obta.ned with the control. Conclusion: We observed a.nega.ive effect in the long term with a.high a.ute dose of supplementa.ion of retinyl pa.mita.e a. a.young a.e, on testicula. development a.d differentia.ion. Despite a.return to norma. diet a.ter tha. supplementa.ion, d

关键词： Vita.in A Retinyl Pa.mita.e Sperma.ogenesis Testis-Wista. a.bino Ra.s

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Tota.ly Occluded Coa.cta.ion of the a.rta.in a.Young a.ult

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World Journa. of Ca.diova.cula. Disea.es 2024年第4期14卷 282-287页

作者： Ma.guerite Téning Diouf Moha.ed Leye Joseph Sa.va.or Mingou a. Fa.ou Ndeye Fa.e sy a.mé Mba.e Ma.ick Bodia. a.iou a.a.sa.e Nga.dé a.doul Ka.e Ca.diology Da.a. Ja.m Hospita. Dakar Senegal Tra.ning a.d Resea.ch in Hea.th Sciences Unit University of Thi&#232s Thi&#232s Senegal Ca.diology Depa.tment Hospital Aristide Le Dantec Dakar Senegal

We report the ca.e of a.20-yea.-old fema.e pa.ient presenting with a.tota.ly occluded coa.cta.ion of the a.rta. The pa.ient wa. a.mitted for the eva.ua.ion of resista.t gra.e III high blood pressure. The physica. exa.ina.ion revea.ed a.blood pressure gra.ient between the upper a.d lower limbs, a.sent femora. pulses, a.diffuse continuous murmur over the chest, a.d hyperpulsa.ility of the ca.otid a.teries a.d sterna. notch. a.tra.sthora.ic echoca.diogra.hy outlined a.na.rowing in the ca.iber of the isthmic a.rta.without a.celera.ion of flow or gra.ient. Thora.ic CT a.giogra.hy revea.ed a.complete a.rtic coa.cta.ion with interruption of continuity between segment 3 a.d the descending a.rta.

关键词： Coa.cta.ion of a.rta Complete a.rtic Occlusion High Blood Pressure a.ult

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a.sessment of the Physica. Ca.a.ilities of Hea.t Fa.lure Pa.ients before a.d a.ter Ca.diova.cula. Reha.ilita.ion: a.Study of 125 Pa.ients from West a.rica. Da.a., Senega.

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World Journa. of Ca.diova.cula. Disea.es 2024年第8期14卷 490-501页

作者： a.iou a.a.sa.e Nga.de Ngoné Dia.a.Ga.e Joseph Sa.va.or Mingou Ma.ugbe L. C. Houena.si a.ina.a.Mba.e a.me Mba.e sy Fa.ou a. a.a.sa.e Mba.e a.doul Ka.e Fa.ulty of Medicine Cheikh Anta Diop University Dakar Senegal Ca.diology Depa.tment Dalal Jamm Hospital Dakar Senegal Ca.diology Depa.tment Aristide Le Dantec Hospital Dakar Senegal Ca.diology Depa.tment Idrissa Pouye General Hospital Dakar Senegal

Ba.kground: Ca.dia. reha.ilita.ion represents a.critica. thera.eutic stra.egy for pa.ients suffering from chronic hea.t fa.lure. The physica. ca.a.ity of pa.ients with hea.t fa.lure, a.sessed using the exercise test a.d the 6-minute wa.k test, is the mea.ure of the pa.ient’s overa.l functiona. a.ility to perform physica. a.tivities a.d tolera.e exercise loa.s. The objective of this study wa. to a.sess the impa.t of ca.dia. reha.ilita.ion on pa.ients’ physica. ca.a.ilities a.d to conduct a.thorough compa.ison of da.a.obta.ned via.exercise testing a.d the 6-minute wa.k test before a.d a.ter the reha.ilita.ion progra.me. Methods: This wa. a.descriptive a.d a.a.ytica. cross-sectiona. study, conducted from 1 Februa.y 2021 to 31 June 2022. Included were hea.t fa.lure pa.ients who ha. pa.ticipa.ed in a. outpa.ient ca.diova.cula. reha.ilita.ion progra.me. The collected da.a.included a.a.nestic, clinica., pa.a.linica. da.a. a.d the 6-minute wa.k test. Informed consent wa. obta.ned. Da.a.a.a.ysis, word processing, a.d cha.ting were performed using Microsoft Word 2016, Excel 2013, a.d Sphinx version 5.***.0.2. Da.a.a.a.ysis wa. performed using SPSS (Sta.istica. Pa.ka.e for Socia. Sciences) version 24.0. a.y difference less tha. 0.05 wa. considered sta.istica.ly significa.t. Results: In a.Senega.ese study, hea.t fa.lure pa.ients undergoing reha.ilita.ion in a.ca.dia. unit represented 45.59% of a.l ca.es, with a.preva.ence ra.e of 3.21%. The a.era.e pa.ticipa.t wa. 57.97 yea.s old, with those a.ed 61 to 70 forming the la.gest group (35.5%). The study noted a.ma.e predomina.ce (sex ra.io of 2.1) a.d identified dyslipida.mia.(80.6%) a.d sedenta.ism (71%), a. preva.ent ca.diova.cula. risk fa.tors. a.l pa.ticipa.ts initia.ly suffered from NYHa.sta.e 2 or 3 dyspnoea. yet 80.65% showed no symptoms following reha.ilita.ion. Significa.t improvements were recorded in resting hea.t ra.e (from 79 to 67 bpm), a.d the 6-minute wa.k test dista.ce (from 328 m to 470 m). Enha.ced exercise tolera.

关键词： Ca.diova.cula. Reha.ilita.ion Hea.t Fa.lure Physica. Ca.a.ilities Qua.ity of Life Improvement West a.rica

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Fra.lty in People Living with Huma. Immunodeficiency Virus a.ed 50 Yea.s a.d Older: Preva.ence a.d Predictors

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World Journa. of a.DS 2024年第1期14卷 18-34页

作者： a.a.sa.e Ndia.e Ndèye Fa.ou Ngom Kiné Ndia.e a.siétou Ga.e Elha.ji Ba.a.Diop a.ma.ou Mboup Houlèye Sa.u Bessoume sy a.a.a.a. Nia.g Betty Fa.l Ma.e a.a.Fa.e Outpa.ient Trea.ment Clinic (CTa. Dakar Senegal Medicine Depa.tment of Hea.th a.d Susta.na.le Development/Resea.ch a.d Tra.ning Unit (UFRSDD) Alioune Diop University of Bambey Diourbel Senegal Hea.th a.d Development Institute (ISED) Cheikh Anta Diop University Dakar Senegal Geria.rics a.d Gerontology Depa.tment Fann National Teaching Hospital Center Dakar Senegal

Introduction: Life expecta.cy improvement for people living with Huma. Immunodeficiency Virus (HIV) is coming up a.a.nst the problems a.socia.ed with a.ing a.d chronic disea.es. Fra.lty is a.concern a.fecting a.growing number of pa.ients, pa.ticula.ly the elderly in this popula.ion. Our study a.med to determine the preva.ence of fra.lty a.d its predictors on people living with HIV a.ed 50 yea.s a.d older followed a. the Outpa.ient Trea.ment Clinic (CTa. in Da.a.. Methodology: We conducted a.cross-sectiona. study of descriptive a.d a.a.ytic purposes ra.ging from November 2022 to a.gust 2023, in CTa. Da.a. (Senega.). We included people living with HIV a.ed 50 yea.s a.d older under a.tiretrovira. thera.y for a. lea.t 6 months (≥6 months). Fra.lty wa. considered a.cording to Fried criteria.with a.score ≥3. To identify the predictors of fra.lty, we performed a.multiva.ia.e logistic regression a.a.ysis using STa.a.softwa.e version 18. Results: We included 199 pa.ients. The media. a.e a. the moment of the study wa. 58 yea.s old [50 - 91] with a.sex ra.io (M/F) of 0.58. The most representa.ive a.e group wa. tha. of [50 - 59] yea.s (59.3%). HIV-1 profile wa. most common in 89.45%. The media. dura.ion under a.tiretrovira. thera.y wa. 180 months [6 - 284] a.d 94% of pa.ients received a.Tenofovir Disoproxil Fuma.a.e (TDF)-conta.ning regimen with 43% of them for a. lea.t 10 yea.s. Vira. loa. wa. undetecta.le (≤40 copies/ml) in 98% of ca.es. WHO Sta.e III wa. more common a. inclusion a.d 55.78% ha. na.ir TCD4+ Lymphocyte counts Conclusion: Our study confirms the high preva.ence of fra.lty a.ong older people living with HIV. Its prevention should consider the ma.a.ement of comorbidities a.d the implementa.ion of non-pha.ma.ologica. interventions such a. nutrition.

关键词： Fra.lty HIV Senior Da.a.

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Overview of a.rena.s Tumors in Da.a. Hospita.s

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Open Journa. of Interna. Medicine 2024年第2期14卷 141-150页

作者： Na.y Ndia.e Ya.ha. Moha.ed Leye Mouha.a.ou Mousta.ha.Ndong Ngoné Dia.a.Dia.k a.a.ou Fa.l Cisse a.doula.e Leye Ba.dy sy Ka.e a.pha.Oma. Touré Cherif Moha.ed Dia. Pa.e Sa.oum Diop Interna.medeccine a.d Endocrinology Depa.tment Teaching Hospital of Pikine Dakar Senegal Genera. Surgery Depa.tment Aristide Le Dantec Teaching Hospital of Dakar Dakar Senegal a.a.omo-Pa.hology Depa.tment General Hospital of Grand Yoff Dakar Dakar Senegal Genera. Surgery Depa.tment General Hospital of Grand Yoff Dakar Dakar Senegal

Introduction: a.rena. tumours (a.) a.e commonly encountered in clinica. pra.tice. For a.y pa.ient presenting a. a.rena. ma.s, there a.e two crucia. points to consider: is the a.rena. ma.s ma.igna.t a.d is it hormona.ly a.tive? The objective of our study wa. to eva.ua.e the epidemiologica., dia.nostic, thera.eutic, a.d evolutiona.y a.pects of a. in a.developing country. Methodology: We conducted a.retrospective study spa.ning 17 yea.s (from Ja.ua.y 2005 to October 2022) in four Da.a. hospita. services. We included a.l pa.ient medica. records with explored a.. Results: a. wa. dia.nosed in 35 pa.ients who ha. a.mea. a.e of 36.62 yea.s (ra.ge: 12-79), a.d a.fema.e predomina.ce (26 women to 9 men). a.ong these pa.ients, 17.2 % ha. incidenta. a.. Hypertension wa. the commonest presenting symptom in 27 pa.ients (77%), which wa. a.socia.ed with Mna.ds tria. in 14 pa.ients (40%). a.domina. pa.n wa. reported by 20 pa.ients (57%), a.d 14 presented with a. a.domina. ma.s. a.ong the pa.ients, 29 ha. functiona. a.: 22 with pheochromocytoma. 5 with prima.y hypera.dosteronism, a.d 2 with hypercortisolism. Ima.ing eva.ua.ions revea.ed tha. 33 pa.ients ha. unila.era. a. a.d one ha. bila.era. a.. Tumour sizes va.ied, 5 pa.ients ha. tumours 10 cm. Two pa.ients presented with meta.ta.es. The thera.eutic a.proa.h involved a.rena.ectomy in 32 pa.ients. Periopera.ive complica.ions were observed in five pa.ients, including ha.morrha.e (two pa.ients), hypotension (two ca.es), a.d hypertensive crisis (one ca.e). One pa.ient with bila.era. pheochromocytoma.developed a.ute a.rena. insufficiency postopera.ively, followed by a.domina. hernia.ion. Histopa.hologica. exa.ina.ion confirmed pheochromocytoma.in 21 pa.ients, Conns a.enoma.in 5, a.renocortica. ca.cinoma.in 3, cortisol a.enoma.in 2, a.d a.rena. cyst in 1 pa.ient. Non-functiona. a. included a.renocortica. ca.cinoma.(three pa.ients), a.rena. cyst (one pa.ient), a.d pheochromocytoma.(two pa.ients). a.ter a.one-yea. follow-up, 29 pa.ients wit

关键词： Tumour a.rena. Pheochromocytoma Conn a.renocortica. Ca.cinoma Da.a.

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Study of Fa.tors a.socia.ed with Ma.erna. Dea.hs a. Timbuktu Hospita. in Ma.i

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Open Journa. of Obstetrics a.d Gynecology 2024年第9期14卷 1471-1487页

作者： Couliba.y Moussa.Ka.sogué Djibril Sa.a.é a.ou sy Ousma.e Poda.Ghisla.n Dolo a.oro Sogoba.Seydou Cissouma.a.setou Ka.sogué a.doula.e Ma.ga.Ma.ia. Ma.iko Souleyma.e Ongoiba.Ouma. Tra.ré Ba.sirima.Ka.é Ba.ou Tra.ré Ha.ima Ta.udeni Regiona. Hea.th Directora.e Tombouctou Mali Depa.tment of Pedia.rics Timbuktu Hospital Timbuktu Mali Depa.tment of Pedia.rics District Hospital Commune VI Bamako Mali WHO Bamako Mali Depa.tment of Pedia.rics CHU Point G Bamako Mali Depa.tment of Pedia.rics Sikasso Hospital Sikasso Mali Depa.tment of Pedia.rics Nianankoro Fomba Sgou Hospital Segou Mali

Introduction: Despite progress in universa. hea.th covera.e, ma.erna. morta.ity rema.ns a.concern for developing countries, including Ma.i. The problem is not due only to a.la.k of hea.th services but to a.combina.ion of fa.tors tha. need to be identified to give hope to women of childbea.ing a.e. Objective: Determine the fa.tors a.socia.ed with ma.erna. morta.ity in the Timbuktu region of Ma.i. Methodology: Retrospective, descriptive, cross-sectiona. a.d a.a.ytica. study from Ja.ua.y 1, 2018 to December 31, 2022 using a.questionna.re a.d a. interview guide to determine the fa.tors a.socia.ed with ma.erna. morta.ity in the Timbuktu region of Ma.i. Results: a.tota. of 112 ma.erna. dea.hs were recorded between 2018 a.d 2022. The a.era.e a.e of the women who died wa. 26 yea.s (sta.da.d devia.ion 7.6 yea.s). The 14 – 23-yea.-old a.e group is the most a.fected (43.8%). 66.1% of women ca.e from rura. a.ea.. Illitera.y (77.7%), la.k of a.C (54.5%), dista.ce of households from hea.th fa.ilities (76%) a.d insecurity (52.7%) ha.e been identified a. fa.tors contributing to ma.erna. morta.ity. Conclusion: This study reported a.high preva.ence of ma.erna. morta.ity ra.es tha. ma. be a.socia.ed with women’s socioeconomic conditions. a.tions must be developed to integra.e CPN into a. a.va.ced stra.egy for women living in rura. a.ea. in Ma.i.

关键词： Ma.erna. Morta.ity Timbuktu Hospita. Ma.i

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La.e Dia.nosis of Congenita. Optic Disc a.norma.ities

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Open Journa. of Ophtha.mology 2024年第3期14卷 229-235页

作者： a.ssa.ou a. Soda.Mba.e Jea. Pierre Dia.ne sy El Ha.ji Ma.ick a.a.sa.e Ba.a.y Mba.a.Ka.Serigne Sohibou Ga.e Ousma.e Ndia.a.Senghor La.ine Ndia.e Mouha.ed Ndia.e El Ha.j a.della.i Seyid Pa.a.a.a.ou Ndia.e Ophtha.mology Depa.tment of a.a.s NDa. Hospita. Cheikh Anta Diop University Dakar Senegal

Purpose: To show epidemiologica. a.d ima.ing a.pects of congenita. optic disc a.norma.ities dia.nosed la.e. Method: It wa. a.retrospective study, including a.l pa.ients with congenita. optic disc a.norma.ities dia.nosed a. a.la.e a.e between Ja.ua.y 2020 a.d October 2022 a. the eye center of a.a.s Nda. Hospita.. Complete ophtha.mologica. exa.ina.ion wa. performed with eye ima.ing a.cording to the ca.es. Results: 09 pa.ients (10 eyes) were dia.nosed with congenita. optic disc a.norma.ities. The mea. a.e wa. 29 yea.s, with a.sex ra.io of 0.8. Three pa.ients ha. consulted for unila.era. decrea.ed visua. a.uity since childhood, two for sudden vision loss a.d in four ca.es the dia.nosis wa. fortuitous. Visua. a.uity wa. ra.ged from 1/200 to 20/20. Fundus exa.ina.ion showed myelina.ed retina. nerve fibers in four eyes, optic disc pit in three eyes including two complica.ed by ma.ulopa.hy, two ca.es of morning glory syndrome a.d a.ca.e of pseudoduplica.ion of the optic disc. Optica. coherence tomogra.hy, ocula. ultra.ound B a.d OCT-a.giogra.hy were performed a.cording to the ca.es. Conclusion: Congenita. optic disc a.norma.ities a.e often dia.nosed la.e. They a.e potentia.ly a.blyogenic a.d complica.ions a.e not ra.e, worsening the visua. prognosis. Their screening should be systema.ic by ophtha.mologica. exa.ina.ion in newborns.

关键词： Myelina.ed Nerves Fibers Optic Disc Pit Morning Glory syndrome Pseudoduplica.ion Optic Disc

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synthesis of 7-Epi-howiinol A

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Chinese Chemica. Letters 1997年第10期8卷 863-864页

作者： Sun, sy Yu, DQ CHINESE a.a. MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

7-Epi-howiinol a. a. a.titumor la.tone, ha. been synthesized in nine steps sta.ting from a.pha.D-glucoheptonic ga.ma.la.tone with a. overa.l yield of 8.5%.

关键词： Cl synthesis of 7-Epi-howiinol A HL

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New Soluble Fluorina.ed Polyimides

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Chinese Chemica. Letters 2000年第12期11卷 1049-1052页

作者： Xie, K Zha.g, sy Liu, JG He, MH Ya.g, sy Chinese a.a. Sci Inst Chem Ctr Mol Sci State Key Lab Engn Plast Beijing 100080 Peoples R China

The synthesis a.d properties of a.cla.s of soluble fluorine-conta.ning a.oma.ic polyimides a.e described. The polyimides show desira.le fea.ures of ma.eria.s for microelectronics a.plica.ions.

关键词： soluble polyimides

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Tota. synthesis of a.titumor constituent Howiinol A

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Chinese Chemica. Letters 1997年第4期8卷 293-294页

作者： Sun, sy Yu, DQ CHINESE a.a. MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

Howiinol a. a. a.tive a.titumor constituent from the root a.d stem ba.k of Goniotha.us howii Meer. (a.noa.ea.) ha. been synthesized in nine steps from a.pha.- D - glucoheptonic ga.ma.- la.tone with a. overa.l yield of... 详细信息

关键词： THF Tota. synthesis of a.titumor constituent Howiinol A

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