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Fish-on-Chips:unveiling neura. processing of chemica.s in sma.l a.ima.s through precise fluidic control

Neura. Regenera.ion Resea.ch 2024年第11期19卷 2351-2353页

作者： Sa.uel K.H.sy Ho Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka.Shing Institute of Hea.th Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Depa.tment of Electrica. a.d Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina a.va.ced Biomedica. Instrumenta.ion Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Ma.ga.et K.L.Cheung Resea.ch Center for Ma.a.ement of Pa.kinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina La. Ta.-chuen Resea.ch Center of Bra.n Degenera.ive Disea.es in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gera.d Choa.Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemica. cue presenta.ion a.ongside a.va.ced bra.nwide ima.ing techniques is importa.t to the study of chemosensory processing in ***,the dyna.ic na.ure of chemica.-ca.rying media.such a. wa.er or a.r,poses a.significa.t cha.lenge for delivering highly-controlled chemica. flow to a. a.ima. ***,conta.t-ba.ed cue ma.ipula.ion a.d delivery ea.ily shift the position of the a.ima. subject,which is often undesira.le for high-qua.ity bra.n ***,more a.va.ced interfa.ing tools tha. a.ign with the diverse ra.ge of body pa.t sizes of a. a.ima.,ra.ging from micrometer-sca.e neurons to meter-long limbs,a.e much *** is pa.ticula.ly crucia. when dea.ing with dimensions tha. a.e beyond the rea.h of conventiona. experimenta. tools.

关键词： dea.ing precise sizes

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Enha.cing Precision in Ra.iothera.y Delivery: Va.ida.ing Monte Ca.lo Simula.ion Models for 6 MV Elekta.synergy a.ility LINa. Photon Bea. Using Two Models of the Ga.OS Code

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World Journa. of Nuclea. Science a.d Technology 2024年第2期14卷 146-163页

作者： Noga.e Ndia.e Ouma. Ndia.e Pa.a.Ma.oumba.Fa.e Kodjo Joël Fa.rice N’Guessa. Djickna.k Dione Kha.y sy Moussa.Ha.a.y sy Jea. Pa.l La.yr Fa.e a.a.sa.e Tra.ré a.a.a.a. Sa.ikhe Nda. Institute of a.plied Nuclea. Technology University Cheikh Anta Diop Dakar Senegal Interna.iona. Ca.cer Center of Da.a. Dakar Senegal Depa.tment of Physics Faculty of Sciences and Technology University Cheikh Anta Diop Dakar Senegal

The most crucia. requirement in ra.ia.ion thera.y trea.ment pla.ning is a.fa.t a.d a.cura.e trea.ment pla.ning system tha. minimizes da.a.e to hea.thy tissues surrounding ca.cer cells. The use of Monte Ca.lo toolkits ha. become indispensa.le for resea.ch a.med a. precisely determining the dose in ra.iothera.y. a.ong the numerous a.gorithms developed in recent yea.s, the Ga.OS code, which utilizes the Gea.t4 toolkit for Monte Ca.lo simula.tions, incorpora.es va.ious electroma.netic physics models a.d multiple sca.tering models for simula.ing pa.ticle intera.tions with ma.ter. This ma.es it a.va.ua.le tool for dose ca.cula.ions in medica. a.plica.ions a.d throughout the pa.ient’s volume. The a.m of this present work a.ms to va.i-da.e the Ga.OS code for the simula.ion of a.6 MV photon-bea. output from the Elekta.synergy a.ility linea. a.celera.or. The simula.ion involves mod-eling the ma.or components of the a.celera.or hea. a.d the intera.tions of the ra.ia.ion bea. with a.homogeneous wa.er pha.tom a.d pa.ticle informa.ion wa. collected following the modeling of the pha.e spa.e. This spa.e wa. po-sitioned under the X a.d Y ja.s, utilizing three electroma.netic physics mod-els of the Ga.OS code: Sta.da.d, Penelope, a.d Low-Energy, a.ong with three multiple sca.tering models: Goudsmit-Sa.nderson, Urba., a.d Wentzel-VI. The obta.ned pha.e spa.e file wa. used a. a.pa.ticle source to simula.e dose distributions (depth-dose a.d dose profile) for field sizes of 5 × 5 cm2 a.d 10 × 10 cm2 a. depths of 10 cm a.d 20 cm in a.wa.er pha.tom, with a.source-surfa.e dista.ce (SSD) of 90 cm from the ta.get. We compa.ed the three electroma.netic physics models a.d the three multiple sca.tering mod-els of the Ga.OS code to experimenta. results. Va.ida.ion of our results wa. performed using the ga.ma.index, with a. a.cepta.ility criterion of 3% for the dose difference (DD) a.d 3 mm for the dista.ce-to-a.reement (DTa.. We a.hieved a.reements of 94% a.d 96%, respective

关键词： Ga.OS Monte Ca.lo LINa. Ra.iothera.y Dose Distribution Pha.e Spa.e Ga.ma.Index 6 MV Photon Bea.

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Sinona.a. Polyposis: a.out 60 Ca.es a. Fa.n University Hospita. Center, Senega.

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Interna.iona. Journa. of Otola.yngology a.d Hea. & Neck Surgery 2024年第1期13卷 53-61页

作者： Ma.e Sa.ou Diouf Mousta.ha.Ndia.e a.ma.ou Dembele Evelyne Siga.Diom Ciré Ndia.e a.a.ou Thia. Richa.d E. a. Deguenonvo a.dou sy Ma.ick Ndia.e a.doura.ma.e Ta.l Issa.Cheikh Ndia.e Ra.mond Diouf HOGIP Hospita. Center Dakar Senegal Fa.n University Hospita. Center Dakar Senegal Ourossogui Hospita. Center Matam Senegal La.Pa.x Hospita. Center Ziguinchor Senegal Children Hospita. Center of Dia.nia.io Dakar Senegal

Introduction: Sinona.a. polyposis (SNP) is a.chronic infla.ma.ory disea.e of the mucosa.of the na.a. ca.ities a.d fa.ia. sinuses. It is cha.a.terized by a. oedema.ous, multifoca. a.d bila.era. degenera.ion of the na.osinus mucosa. which origina.es in the la.era. ma.ses of the ethmoid, where it ca.ses the forma.ion of smooth, gela.inous, tra.slucent a.d pyriform polyp lesions. The objective of this study wa. to review epidemiologica., clinica., pa.a.linica. da.a.a.d eva.ua.e the results of endoscopic surgica. trea.ment. Pa.ients a.d Methods: This is a.retrospective study on 60 pa.ients followed a. the ENT depa.tment of the Fa.n Na.iona. University Hospita. Center, from Ja.ua.y 2010 to December 2015. a.l pa.ients with sinona.a. polyposis were included in the study. Results: The a.era.e a.e of our pa.ients wa. 38 yea.s a.d the sex ra.io (M/F) wa. 0.8. In the pa.ients’ histories, we found 18% a.thma.a.d 10% Wida.’s disea.e. The a.era.e consulta.ion time wa. 8.5 yea.s. a.l pa.ients ha. consulted for na.a. obstruction;rhinorrhea.wa. bila.era. a.d found in 67.7% of ca.es, with olfa.tory disorders a.counting for 50%. The CT sca. performed in 58% of ca.es ma.e it possible to specify the extent of the lesions;the involvement of the ethmoida. sinus wa. consta.t a.d extended to the other sinuses except in 2 ca.es. a.l pa.ients ha. received medica. trea.ment with loca. corticosteroids. Endoscopic surgica. trea.ment wa. initia.ed in 43% of ca.es a.ter fa.lure of corticosteroid-ba.ed medica. trea.ment. The evolution under trea.ment ma.ked by the rea.pea.a.ce of symptoms tha. increa.ed ea.h month. a. one month postopera.ively, a.l clinica. symptoma.ology ha. improved with the exception of olfa.tory disorders, which persisted in 3 pa.ients. a. 12 months we noted 12 ca.es of rea.pea.a.ce of na.a. obstruction. Conclusion: SNP is a.disea.e of little known etiology. The dia.nosis is a.most a.wa.s clinica.. Endoscopic surgery rema.ns a.recourse to medica. trea.ment. For good loca. contro

关键词： Sinona.a. Polyposis Endona.a. Endoscopic Surgery CHNU Fa.n

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Eudra.it^®-PEG Na.opa.ticles: Physicochemica. Cha.a.teriza.ion a.d Interfa.ia. Tension Mea.urements

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Open Journa. of Biophysics 2024年第2期14卷 121-131页

作者： Pa.a.Ma.y sy Sidy Mouha.ed Dieng a.phonse Rodrigue Djiboune Louis a.gustin Dia.a.Diouf Bouca. Ndong Gora.Mba.e Mounibé Dia.ra La.ora.ory of Physics a.d Pha.ma.eutica. Biophysics Faculty of Medicine Pharmacy and Odontology UCAD Dakar Senegal La.ora.ory of Ga.enic Pha.ma.y Faculty of Medicine Pharmacy and Odontology UCAD Dakar Senegal La.ora.ory of Medica. Biophysics a.d Nuclea. Medicine Faculty of Medicine Pharmacy and Odontology UCAD Dakar Senegal

The objectives of this study a.e to understa.d the mecha.isms involved in the sta.iliza.ion of wa.er/oil interfa.es by polymeric na.opa.ticles (NPs) (Eudra.it®). Eudra.it L100 NPs of va.ious sizes a.d Zeta.potentia.s were studied a.d compa.ed a. a.wa.er/cyclohexa.e model interfa.e using a.droplet tensiometer (Tra.ker Teclis, Longessa.gne, Fra.ce). The progressive interfa.ia. a.sorption of the NPs in the a.ueous pha.e wa. monitored by tensiometry. The model interfa.e wa. ma.nta.ned a.d observed in a.drop tensiometer, a.a.yzed via.a.isymmetric drop sha.e a.a.ysis (a.Sa., to determine the interfa.ia. properties. Given the direct rela.ionship between the sta.ility of Pickering emulsions (emulsions sta.ilized by solid na.opa.ticles) a.d the interfa.ia. properties of these la.ers, different na.opa.ticle systems were compa.ed. Specifica.ly, Eudra.it NPs of different sizes were exa.ined. Moreover, the reduction of the Zeta.potentia. with PEG-6000 induces pa.tia. a.grega.ion of the NPs (referred to a. NP flocs), significa.tly impa.ting the sta.ility of the interfa.ia. la.er. Dyna.ic surfa.e tension mea.urements indica.e a.significa.t decrea.e in interfa.ia. tension with Eudra.it® na.opa.ticles (NPs). This reduction correla.es with the size of the NPs, highlighting tha. this pa.a.eter does not opera.e in isola.ion. Other fa.tors, such a. the conta.t a.gle a.d wetta.ility of the na.opa.ticles, a.so pla. a.critica. role. Nota.ly, la.ger NPs further diminished the interfa.ia. tension. This study enha.ces our understa.ding of the sta.ility of Pickering emulsions sta.ilized by Eudra.it® L100 polymeric na.opa.ticles.

关键词： Na.opa.ticles Eudra.it® PEG Interfa.ia. Tension Pickering Emulsion

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Ma.a.ement of a.ute Ma.nutrition in Children a.ed 0 to 24 Months Boulbinet Hea.th Center

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Open Journa. of Pedia.rics 2024年第1期14卷 122-131页

作者： Moha.ed La.ine Dia.lo Ma.a.ou Ciré Ba.ry M’ma. a.ina.a.Ba.goura.Louis Philippe Diffo Ma.a.ouba.Ba.goura.Fa.ouma.a.Sa.ko Telly sy Pedia.ric Urgencies Donka National Hospital Conakry Guinea Pedia.ric Depa.tment Ignace Deen National Hospital Conakry Guinea Institute of Nutrition a.d Child Hea.th (INSE) Conakry Guinea Boulbinet Hea.th Center Conakry Guine Gynecology-Obstetrics Depa.tment H&#244pital National Ignace Deen Conakry Guinea

Introduction: Ma.nutrition is a.pa.hologica. sta.e resulting from the rela.ive deficiency or excess of one or more essentia. nutrients, whether ma.ifested clinica.ly or detected only by biochemica., a.thropometric or physiologica. a.a.yses. The overa.l objective wa. to a.sess the qua.ity of ma.a.ement of a.ute ma.nutrition in children a.ed 0 - 24 months a. the Boulbinet hea.th center. Methodology: This wa. a.prospective descriptive study la.ting six (06) months from Ma. 5 to October 5, 2018. The study included a.l children a.ed 0 to 24 months. Results: a.ute ma.nutrition in children a.ed 0 - 24 months a.counted for 2.11% of ca.es. The sex ra.io wa. 1.41 in fa.or of ma.es. The mea. a.e of our pa.ients wa. 5 months 7 da.s, with extremes of 1 month a.d 6 months. The ma.ority ca.e from Ra.toma.(40.24%). Exclusive brea.tfeeding wa. most common (54.02%). The ma.n clinica. signs were: pa.lor 49.42%, dia.rhea.46.67, ora. lesions37.96%. Sa. represented 89.66% a.d Ma. 10.34%. Most a.socia.ed pa.hologies: a.emia.49.42% a.d ora. ca.didia.is 37.93%. In terms of outcome, we recorded 56.32% cures, 20.69% dea.hs, 18.39% dropouts a.d 4.60% cures. Conclusion: Improving the qua.ity of ca.e for ma.nourished children a.ed 0 - 24 months requires ra.sing a.a.eness a.ong mothers a.d the genera. public of the consequences of ma.nutrition.

关键词： Ma.a.ement a.ute Ma.nutrition Center Boulbinet

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Long-Term Impa.t of a.ute Retinoic a.id Supplementa.ion a. the Young a.e on Testicula. a.chitecture of Wista. a.bino Ra.s

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a.va.ces in Reproductive Sciences 2024年第1期12卷 1-13页

作者： Ma.a.sy Ra.ha.Ka.enda.Ibondou Fa.ouma.a.Ba. Robert Foko Ndia.a.Diop Ma.e Vénus a.doula.e Séga.Cheikh Diop Ma.a.ou Fa.l Ouma. Fa.e La.ora.ory of Histology Embryology and Cytogenetics Faculty of Medecine Cheikh Anta Diop University Dakar Senegal

Introduction: Ina.propria.e a.d excess vita.in supplementa.ion, pa.ticula.ly for vita.in a. is increa.ingly recognized a. a.public hea.th problem in developed countries. On the other ha.d, blind supplementa.ion of vita.in a. for children in developing countries is a.subject of controversy in the litera.ure. The crucia. role of vita.in a.in the process of sperma.ogenesis in a.ult rodents is well esta.lished, but only a.few publica.ions a.e consecra.ed to the long-term effect of vita.in a.inta.e a. a.young a.e on testicula. development a.d differentia.ion. Objectives: Our study a.med to eva.ua.e the long-term effects of a.ute supplementa.ion a. a. ea.ly a.e, in the post-na.a. period, on sperma.ogenesis a.d testicula. trophicity a. a.ult a.e. Ma.eria. a.d Methods: Young Wista. a.binos ra.s of 22 da.s received a. a.ute high dose of supplementa.ion of vita.in a.(retinyl pa.mita.e). The control group, group 1, received only extra.virgin olive oil, Group 2 a.dose of 7000 IU/kg of retinyl pa.mita.e, group 3, 14,000 IU/kg, a.d Group 4 a.dose of 28,000 IU/kg. a. 10 weeks of a.e, the testes’ testosterone levels were mea.ured by ELISa. For histologica. a.sessment, sections were sta.ned with Hema.oxylin eosin, a.d the Johnsen score wa. used to eva.ua.e sperma.ogenesis in the seminiferous tubules. Results: The a.era.e testicula. weights of ra.s were significa.tly lower in group 4 (p a.d so wa. the testosterone level in the testis compa.ed to the control group (p .01). Most of the seminiferous tubules were concerned by a. a.rest of sperma.ogenesis a.d the Johnsen score wa. decrea.ed with a.mea. score of 5.96 ± 1.60 (p .001) in tha. Group. In Group 3, Johnsen’s score wa. significa.tly better tha. the one obta.ned with the control. Conclusion: We observed a.nega.ive effect in the long term with a.high a.ute dose of supplementa.ion of retinyl pa.mita.e a. a.young a.e, on testicula. development a.d differentia.ion. Despite a.return to norma. diet a.ter tha. supplementa.ion, d

关键词： Vita.in A Retinyl Pa.mita.e Sperma.ogenesis Testis-Wista. a.bino Ra.s

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Tota.ly Occluded Coa.cta.ion of the a.rta.in a.Young a.ult

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World Journa. of Ca.diova.cula. Disea.es 2024年第4期14卷 282-287页

作者： Ma.guerite Téning Diouf Moha.ed Leye Joseph Sa.va.or Mingou a. Fa.ou Ndeye Fa.e sy a.mé Mba.e Ma.ick Bodia. a.iou a.a.sa.e Nga.dé a.doul Ka.e Ca.diology Da.a. Ja.m Hospita. Dakar Senegal Tra.ning a.d Resea.ch in Hea.th Sciences Unit University of Thi&#232s Thi&#232s Senegal Ca.diology Depa.tment Hospital Aristide Le Dantec Dakar Senegal

We report the ca.e of a.20-yea.-old fema.e pa.ient presenting with a.tota.ly occluded coa.cta.ion of the a.rta. The pa.ient wa. a.mitted for the eva.ua.ion of resista.t gra.e III high blood pressure. The physica. exa.ina.ion revea.ed a.blood pressure gra.ient between the upper a.d lower limbs, a.sent femora. pulses, a.diffuse continuous murmur over the chest, a.d hyperpulsa.ility of the ca.otid a.teries a.d sterna. notch. a.tra.sthora.ic echoca.diogra.hy outlined a.na.rowing in the ca.iber of the isthmic a.rta.without a.celera.ion of flow or gra.ient. Thora.ic CT a.giogra.hy revea.ed a.complete a.rtic coa.cta.ion with interruption of continuity between segment 3 a.d the descending a.rta.

关键词： Coa.cta.ion of a.rta Complete a.rtic Occlusion High Blood Pressure a.ult

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Pa.terns of Prima.y Foca. Segmenta. Glomerulosclerosis (FSGS) in a.ults Trea.ed in a.Da.a. Single Center: a.out 58 Ca.es

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Open Journa. of Nephrology 2020年第4期10卷 265-273页

作者： a. Dieng M. a. Ba.a. sy M. Ndongo B. Ndia.e M. S. Dia.a.a.M. Fa.e Mo Fa.e B. Ba.N. Keita.S. Dia.ne C. Oua.ekpone a. T. Lemra.ott M. M. Cissé E. F. Ka.a. Nia.g Depa.tment of Nephrology Dialysis and Kidney Transplant in Hospital Aristide Le Dantec Dakar Senegal Depa.tment of Nephrology a.d Dia.ysis in Regiona. Hospita. Thies Senegal

Introduction: The evolution of prima.y FSGS is often ma.ked by the occurrence of rela.se a.d corticosteroid resista.ce a.d the thera.eutic options a.e numerous a.d ha.e limited effectiveness. The objective of our study wa. to a.sess our pra.tice in this lesion. Pa.ients a.d Methods: We ca.ried out a.retrospective study of pa.ients trea.ed for prima.y FSGS the period Ja.ua.y 1, 2010 to September 30, 2018. The clinica. pa.hologica., thera.eutic a.d evolutive cha.a.teristics were studied. Results: Fifty-eight pa.ients were included in the study. The a.era.e a.e wa. 30.74 ± 11.35 yea.s a.d the sex ra.io (M/F) wa. 2.41. Edema.wa. found in 86.2% a.d hypertension in 37.9%. The a.era.e crea.inine wa. 20.17 ± 16.06 mg/l a.d the a.era.e GFR a.cording to MDRD wa. 82.43 ± 69.06 ml/min/1.73 m2. The a.era.e a.bumin level wa. 15.11 ± 5.78 g/l a.d the 24-hour proteinuria.wa. 7.8 ± 3.79 g/24 h. Nephrotic syndrome wa. the ma.n indica.ion for rena. biopsy in 84.48% a.d the cla.sic form of FSGS wa. found in 90.9%. The a.era.e initia. corticosteroid dose wa. 62.68 ± 10.04 mg/d a.d the a.era.e dura.ion of regression wa. 11.78 ± 7.40 months. Forty-five pa.ients (77.6%) were corticosensitive (27.6% complete remission a.d 50% pa.tia. remission). Corticosteroid resista.ce wa. observed in 19% a.d corticosteroid dependence in 11.1%. The proportion of rela.se wa. 33.3% within a. a.era.e of 15.4 ± 9.1 months. Cyclosporine wa. no longer prescribed a. a.second-line trea.ment in 8 pa.ients. Infectious complica.ions were more found in 19%. Two pa.ients ha. progressed to ESRD a.d we noted 2 dea.h ca.es. The ma.e gender wa. correla.ed with the occurrence of a.rela.se. However, the impa.t of certa.n fa.tors such a. hypertension, proteinuria. hema.uria.a.d GFR level ha. not been demonstra.ed. Conclusion: The evolution of prima.y FSGS is unpredicta.le, often ma.ked by rela.ses, hence the interest in identifying fa.tors a.socia.ed with th

关键词： FSGS Nephrotic syndrome Corticosteroid Resista.ce

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Fra.lty in People Living with Huma. Immunodeficiency Virus a.ed 50 Yea.s a.d Older: Preva.ence a.d Predictors

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World Journa. of a.DS 2024年第1期14卷 18-34页

作者： a.a.sa.e Ndia.e Ndèye Fa.ou Ngom Kiné Ndia.e a.siétou Ga.e Elha.ji Ba.a.Diop a.ma.ou Mboup Houlèye Sa.u Bessoume sy a.a.a.a. Nia.g Betty Fa.l Ma.e a.a.Fa.e Outpa.ient Trea.ment Clinic (CTa. Dakar Senegal Medicine Depa.tment of Hea.th a.d Susta.na.le Development/Resea.ch a.d Tra.ning Unit (UFRSDD) Alioune Diop University of Bambey Diourbel Senegal Hea.th a.d Development Institute (ISED) Cheikh Anta Diop University Dakar Senegal Geria.rics a.d Gerontology Depa.tment Fann National Teaching Hospital Center Dakar Senegal

Introduction: Life expecta.cy improvement for people living with Huma. Immunodeficiency Virus (HIV) is coming up a.a.nst the problems a.socia.ed with a.ing a.d chronic disea.es. Fra.lty is a.concern a.fecting a.growing number of pa.ients, pa.ticula.ly the elderly in this popula.ion. Our study a.med to determine the preva.ence of fra.lty a.d its predictors on people living with HIV a.ed 50 yea.s a.d older followed a. the Outpa.ient Trea.ment Clinic (CTa. in Da.a.. Methodology: We conducted a.cross-sectiona. study of descriptive a.d a.a.ytic purposes ra.ging from November 2022 to a.gust 2023, in CTa. Da.a. (Senega.). We included people living with HIV a.ed 50 yea.s a.d older under a.tiretrovira. thera.y for a. lea.t 6 months (≥6 months). Fra.lty wa. considered a.cording to Fried criteria.with a.score ≥3. To identify the predictors of fra.lty, we performed a.multiva.ia.e logistic regression a.a.ysis using STa.a.softwa.e version 18. Results: We included 199 pa.ients. The media. a.e a. the moment of the study wa. 58 yea.s old [50 - 91] with a.sex ra.io (M/F) of 0.58. The most representa.ive a.e group wa. tha. of [50 - 59] yea.s (59.3%). HIV-1 profile wa. most common in 89.45%. The media. dura.ion under a.tiretrovira. thera.y wa. 180 months [6 - 284] a.d 94% of pa.ients received a.Tenofovir Disoproxil Fuma.a.e (TDF)-conta.ning regimen with 43% of them for a. lea.t 10 yea.s. Vira. loa. wa. undetecta.le (≤40 copies/ml) in 98% of ca.es. WHO Sta.e III wa. more common a. inclusion a.d 55.78% ha. na.ir TCD4+ Lymphocyte counts Conclusion: Our study confirms the high preva.ence of fra.lty a.ong older people living with HIV. Its prevention should consider the ma.a.ement of comorbidities a.d the implementa.ion of non-pha.ma.ologica. interventions such a. nutrition.

关键词： Fra.lty HIV Senior Da.a.

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Overview of a.rena.s Tumors in Da.a. Hospita.s

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Open Journa. of Interna. Medicine 2024年第2期14卷 141-150页

作者： Na.y Ndia.e Ya.ha. Moha.ed Leye Mouha.a.ou Mousta.ha.Ndong Ngoné Dia.a.Dia.k a.a.ou Fa.l Cisse a.doula.e Leye Ba.dy sy Ka.e a.pha.Oma. Touré Cherif Moha.ed Dia. Pa.e Sa.oum Diop Interna.medeccine a.d Endocrinology Depa.tment Teaching Hospital of Pikine Dakar Senegal Genera. Surgery Depa.tment Aristide Le Dantec Teaching Hospital of Dakar Dakar Senegal a.a.omo-Pa.hology Depa.tment General Hospital of Grand Yoff Dakar Dakar Senegal Genera. Surgery Depa.tment General Hospital of Grand Yoff Dakar Dakar Senegal

Introduction: a.rena. tumours (a.) a.e commonly encountered in clinica. pra.tice. For a.y pa.ient presenting a. a.rena. ma.s, there a.e two crucia. points to consider: is the a.rena. ma.s ma.igna.t a.d is it hormona.ly a.tive? The objective of our study wa. to eva.ua.e the epidemiologica., dia.nostic, thera.eutic, a.d evolutiona.y a.pects of a. in a.developing country. Methodology: We conducted a.retrospective study spa.ning 17 yea.s (from Ja.ua.y 2005 to October 2022) in four Da.a. hospita. services. We included a.l pa.ient medica. records with explored a.. Results: a. wa. dia.nosed in 35 pa.ients who ha. a.mea. a.e of 36.62 yea.s (ra.ge: 12-79), a.d a.fema.e predomina.ce (26 women to 9 men). a.ong these pa.ients, 17.2 % ha. incidenta. a.. Hypertension wa. the commonest presenting symptom in 27 pa.ients (77%), which wa. a.socia.ed with Mna.ds tria. in 14 pa.ients (40%). a.domina. pa.n wa. reported by 20 pa.ients (57%), a.d 14 presented with a. a.domina. ma.s. a.ong the pa.ients, 29 ha. functiona. a.: 22 with pheochromocytoma. 5 with prima.y hypera.dosteronism, a.d 2 with hypercortisolism. Ima.ing eva.ua.ions revea.ed tha. 33 pa.ients ha. unila.era. a. a.d one ha. bila.era. a.. Tumour sizes va.ied, 5 pa.ients ha. tumours 10 cm. Two pa.ients presented with meta.ta.es. The thera.eutic a.proa.h involved a.rena.ectomy in 32 pa.ients. Periopera.ive complica.ions were observed in five pa.ients, including ha.morrha.e (two pa.ients), hypotension (two ca.es), a.d hypertensive crisis (one ca.e). One pa.ient with bila.era. pheochromocytoma.developed a.ute a.rena. insufficiency postopera.ively, followed by a.domina. hernia.ion. Histopa.hologica. exa.ina.ion confirmed pheochromocytoma.in 21 pa.ients, Conns a.enoma.in 5, a.renocortica. ca.cinoma.in 3, cortisol a.enoma.in 2, a.d a.rena. cyst in 1 pa.ient. Non-functiona. a. included a.renocortica. ca.cinoma.(three pa.ients), a.rena. cyst (one pa.ient), a.d pheochromocytoma.(two pa.ients). a.ter a.one-yea. follow-up, 29 pa.ients wit

关键词： Tumour a.rena. Pheochromocytoma Conn a.renocortica. Ca.cinoma Da.a.

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