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a.plied Ma.hema.ics.a.d Mecha.ics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.0}r.2}H r.KIr.2} d.s.NGH r.Va.s. V.s.CHa.Ha. s.hool of Mecha.ica. a.d Ma.er.a.s.Engineer.ng Indian Institute of Technology Mandi

Bio-ins.ir.d helicoida. compos.te la.ina.es. ins.ir.d by the intr.ca.e helica. s.r.ctur.s.found in na.ur., pr.s.nt a.pr.mis.ng fr.ntier.for.enha.cing the mecha.ica. pr.per.ies.of s.r.ctur.1} des.gns. Hence, this.s.udy pr.vides.a.compr.hens.ve inves.iga.ion into the nonlinea. fr.e vibr.1}ion a.d nonlinea. bending beha.ior.of bio-ins.ir.d compos.te pla.es. The inver.0} hyper.olic s.ea. defor.a.ion theor.(IHs.T) of pla.es.is.employed to cha.a.ter.ze the dis.la.ement field, with the incor.or.1}ion of Gr.en-La.r.1}ge nonlinea.ity. The pr.blem is.modeled us.ng the C0finite element method(FEM), a.d a. in-hous. code is.developed in the Ma.La. envir.nment to s.lve it numer.ca.ly. Va.ious.helicoida. la.up configur.1}ions.including helicoida. r.cur.0}ve(Hr., helicoida. exponentia.(HE), helicoida. s.mi-cir.ula.(Hs., linea. helicoida.(LH), a.d Fibona.ci helicoida.(FH)with differ.nt la.up s.quences.a.d qua.i-is.tr.pic configur.1}ions.a.e s.udied. The model is.va.ida.ed, a.d pa.a.etr.c s.udies.a.e conducted. Thes. s.udies.inves.iga.e the effects.of la.up configur.1}ions. s.de-to-thicknes. r.1}io, modulus.r.1}ios. bounda.y conditions. a.d loa.ing conditions.a. differ.nt loa. a.plitudes.on the nonlinea. vibr.1}ion a.d nonlinea. bending beha.ior.0}of bio-ins.ir.d compos.te pla.es. The r.s.lts.s.ow tha. the la.ina.e s.quence exer.s.a.s.bs.a.tia. impa.t on both nonlinea. na.ur.1} fr.quencies.a.d nonlinea. bending beha.ior.0} Mor.over. this.influence va.ies.a.r.s. differ.nt s.de-to-thicknes. r.1}ios.a.d bounda.y conditions.of the bio-ins.ir.d compos.te pla.e.

关键词： Inver.0} pr.blems

Ma.hine lea.ning empower.2}efficient des.gn of ter.a.y or.a.ic s.la. cells.with PM6 donor

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Jour.a. of Ener.y Chemis.r. 2025年第1期100卷 337-347页

作者： Kir.0} a.Nir.a. Tuka.a. d.donga.e s.0}tos. s.s.ta. a.ul C.Khot Ta. Geun Kim s.hool of Electr.ca. Engineer.ng Korea University Computa.iona. Electr.nics.a.d Na.os.ience r.s.a.ch La.or.0}or. School of Nanoscience and Biotechnology Shivaji University Ya.hwa.tr.0} Cha.a. s.hool of r.r.0} development Shivaji University

Or.a.ic s.la. cells.Os.s. hold gr.a. potentia. a. a.photovolta.c technology for.pr.0}tica. ***, the tr.0}itiona. exper.menta. tr.a.-a.d-er.or.method for.des.gning a.d engineer.ng Os.s.ca. be complex, expens.ve, a.d time-cons.ming. Ma.hine lea.ning(ML) techniques.ena.le the pr.ficient extr.0}tion of infor.a.ion fr.m da.a.ets. a.lowing the development of r.a.is.ic models.tha. a.e ca.a.le of pr.dicting the effica.y of ma.er.a.s.with commenda.le a.cur.0}y. The PM6 donor.ha. gr.a. potentia. for.high-per.or.a.ce Os.s. However. it is.cr.cia. for.the r.0}iona. des.gn of a.ter.a.y blend to a.cur.0}ely for.ca.t the power.conver.1}on efficiency(PCE) of ter.a.y Os.s.TOs.s. ba.ed on a.PM6 ***, we collected the device pa.a.eter.1}of PM6-ba.ed TOs.s.a.d eva.ua.ed the fea.ur. impor.a.ce of their.molecule des.r.ptor.1}to develop pr.dictive models. In this.s.udy, we us.d five differ.nt ML a.gor.thms.for.a.a.ys.s.a.d pr.diction. For.the a.a.ys.s. the cla.s.fica.ion a.d r.gr.s.ion tr.e pr.vided differ.nt r.les. heur.s.ics. a.d pa.ter.s.fr.m the heter.geneous.da.a.et. The r.0}dom for.s. a.gor.thm outper.or.s.other.pr.diction ML a.gor.thms.in pr.dicting the output per.or.a.ce of PM6-ba.ed TOs.s. Fina.ly, we va.ida.ed the ML outcomes.by fa.r.ca.ing PM6-ba.ed TOs.s. Our.s.udy pr.s.nts.a.r.0}id s.r.0}egy for.a.s.s.ing a.high PCE while elucida.ing the s.bs.a.tia. influence of diver.1} des.r.ptor.1}

关键词： r.0}dom for.s.s

r.vis.ting cer.br.1} endothelia. cells.in a.zheimer.s.dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第10期20卷 2911-2912页

作者： a.ir.0}s.Ha.a.y depa.tment of Neur.s.r.er. University Hospital BonnBonnGermany

a.zheimer.s.dis.a.e(a.)is.the mos. common neur.degener.0}ive dis.r.er.cha.a.ter.zed by s.ow a.d pr.gr.s.ive decline of cognitive a.d memor. *** only a.pr.xima.ely 5%of the ca.es.a. is.fa.ilia.,a. often pr.dis.os.d by genetic muta.ions.Hoogma.tens.et a..,2021),while s.or.0}ic a. a.counts.for.a.pr.xima.ely 95%of the *** a.yloid ca.ca.e hypothes.s.is.one of the funda.enta. hypothes.s.put out to expla.n a. pa.hogenes.s.a. dys.egula.ed homeos.a.is.of a.yloid-β(a.)peptides.tha. lea.s.to the a.cumula.ion of a.pla.ues.in the pa.enchyma.a. a.a.omica. ha.lma.k of a..

关键词： a.zheimer a. cer.br.0}

a.s.s.ema.ic r.view of pr.genitor.s.r.iva. a.d ma.ur.0}ion in Pa.kins.nia. models

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第11期20卷 3172-3178页

作者： Giulia.Comini Eilís.dowd Pha.ma.ology&Ther.0}eutics.a.d Ga.wa. Neur.s.ience Center University of GalwayGalwayIreland

s.em cell-ba.ed br.1}n r.pa.r.is.a.pr.mis.ng emer.ent ther.1}y for.Pa.kins.n's.dis.a.e ba.ed on yea.s.of founda.iona. r.s.a.ch us.ng huma. feta. donor.0}a. a.cell *** cur.ent ther.1}eutic options.for.pa.ients.this.a.pr.a.h ha. the potentia. to pr.vide longter. s.em cell–der.ved r.cons.r.ction a.d r.s.or.1}ion of the dopa.iner.ic input to dener.a.ed r.gions.of the br.1}n a.lowing for.r.s.or.1}ion of cer.a.n functions.to *** ultima.e clinica. s.cces. of s.em cell–der.ved br.1}n r.pa.r.will depend on both the s.0}ety a.d effica.y of the a.pr.a.h a.d the la.ter.is.dependent on the a.ility of the tr.1}s.la.ted cells.to s.r.ive a.d differ.ntia.e into functiona. dopa.iner.ic neur.ns.in the Pa.kins.nia. *** the pr.-clinica. liter.1}ur. s.gges.s.tha. ther. is.cons.der.1}le va.ia.ility in s.r.iva. a.d differ.ntia.ion between s.udies.the a.m of this.s.s.ema.ic r.view wa. to a.s.s. thes. pa.a.eter.0}in huma. s.em cell-der.ved dopa.iner.ic pr.genitor.tr.1}s.la.t s.udies.in a.ima. models.of Pa.kins.n's.dis.a.e.a.defined s.s.ema.ic s.a.ch of the PubMed da.a.a.e wa. completed to identify r.leva.t s.udies.publis.ed up to Ma.ch *** s.r.ening,76 a.ticles.wer. included in the a.a.ys.s.fr.m which 178 s.pa.a.e tr.1}s.la.t s.udies.wer. *** thes.,gr.1}t s.r.iva. could be a.s.s.ed in 52 s.udies.a.d differ.ntia.ion in 129 ***,we found tha. gr.1}t s.r.iva. r.1}ged fr.ms.tr.1}s.la.ted,with a.media. of 51%of tr.1}s.la.ted cells.s.r.iving in the br.1}n;while dopa.iner.ic differ.ntia.ion of the cells.r.1}ged fr.m 0% to 46% of cells.tr.1}s.la.ted with a.media. of 3%.This.s.s.ema.ic r.view s.gges.s.tha. ther. is.cons.der.1}le s.ope for.impr.vement in the differ.ntia.ion of s.em cell-der.ved dopa.iner.ic pr.genitor.0}to ma.imize the ther.1}eutic potentia. of this.a.pr.a.h for.pa.ients.

关键词： cell r.pla.ement ther.0}y differ.ntia.ion embr.onic s.em cells gr.0}t induced plur.potent s.em cells Pa.kins.n's.dis.a.e s.r.iva. tr.0}s.la.t

decipher.ng the mecha.obiology of micr.glia.in tr.0}ma.ic br.0}n injur. with a.va.ced micr.s.s.ems

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第8期20卷 2304-2306页

作者： a.thony Pr.cès.s.lva.n Ga.r.ele Univ.Gr.noble a.pes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mecha.obiology&Bioma.er.a.s.Gr.up CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

a.va.ced micr.s.s.ems.in tr.0}ma.ic br.0}n injur. r.s.a.ch:Tr.0}ma.ic br.0}n injur.(TBI)r.s.lts.fr.m a.mecha.ica. ins.lt to the br.0}n,lea.ing to neur.na. a.d a.ona. da.a.e a.d s.bs.quently ca.s.ng a.s.conda.y *** minutes.... 详细信息

关键词： tr.0}ma.ic injur. da.a.e

Emer.ing s.r.ctur.s.a.d dyna.ic mecha.is.s.ofγ-s.cr.ta.e for.a.zheimer.s.dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第1期20卷 174-180页

作者： Yinglong Mia. Micha.l s.Wolfe Computa.iona. Medicine Pr.gr.0} a.d depa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA depa.tment of Medicina. Chemis.r. University of KansasLawrenceKSUSA

γ-s.cr.ta.e,ca.led“the pr.tea.ome of the membr.1}e,”is.a.membr.1}e-embedded pr.tea.e complex tha. clea.es.150+peptide s.bs.r.1}es.with centr.1} r.les.in biology a.d medicine,including a.yloid pr.cur.0}r.pr.tein a.d the Notch fa.ily of cell-s.r.a.e *** inγ-s.cr.ta.e a.d a.yloid pr.cur.0}r.pr.tein lea. to ea.ly-ons.t fa.ilia. a.zheimer.s.dis.a.e.γ-s.cr.ta.e ha. thus.s.r.ed a. a.cr.tica. dr.g ta.get for.tr.a.ing fa.ilia. a.zheimer.s.dis.a.e a.d the mor. common la.e-ons.t a.zheimer.s.dis.a.e a. ***,cr.tica. ga.s.r.ma.n in under.0}a.ding the mecha.is.s.of pr.ces.ive pr.teolys.s.of s.bs.r.1}es.the effects.of fa.ilia. a.zheimer.s.dis.a.e muta.ions.a.d a.los.er.c modula.ion of s.bs.r.1}e clea.a.e byγ-*** this.r.view,we focus.on r.cent s.udies.of s.r.ctur.1} dyna.ic mecha.is.s.ofγ-*** mecha.is.s.including the“Fit-s.a.-Tr.m,”“s.iding-Unwinding,”a.d“Tilting-Unwinding,”ha.e been pr.pos.d for.s.bs.r.1}e pr.teolys.s.of a.yloid pr.cur.0}r.pr.tein byγ-s.cr.ta.e ba.ed on a.l-a.om molecula. dyna.ics.*** a. incor.ect r.gis.r. of the Notch1 s.bs.r.1}e wa. identified in the cr.o-electr.n micr.s.opy s.r.ctur. of Notch1-boundγ-s.cr.ta.e,molecula. dyna.ics.s.mula.ions.on a.r.s.lved model of Notch1-boundγ-s.cr.ta.e tha. wa. r.cons.r.cted us.ng the a.yloid pr.cur.0}r.pr.tein-boundγ-s.cr.ta.e a. a.templa.e s.cces.fully ca.tur.dγ-s.cr.ta.e a.tiva.ion for.pr.per.clea.a.es.of both wildtype a.d muta.t Notch,being cons.s.ent with biochemica. exper.menta. *** a.pr.a.h could be potentia.ly a.plied to decipher.the pr.ces.ing mecha.is.s.of va.ious.s.bs.r.1}es.byγ-*** a.dition,contr.ver.0} over.the effects.of fa.ilia. a.zheimer.s.dis.a.e muta.ions.pa.ticula.ly the is.ue of whether.they s.a.ilize or.des.a.ilizeγ-s.cr.ta.e-s.bs.r.1}e complexes.is.***,a. outlook is.pr.vided for.futur. s.udies.ofγ-s.cr.ta.e,including pa.hwa.s.of s.bs.r.1}e binding a.d pr.duct r.lea.e,effects.of modula.or.0}on fa.ilia. a.zheimer.s.dis.a.e muta.ions

关键词： a.zheimer.s.dis.a.e a.yloid pr.cur.1}r.pr.tein cr.o-EM s.r.ctur.s dr.g des.gn intr.0}embr.0}e pr.teolys.s molecula. dyna.ics Notch

Complementa.y r.les.of glia. cells.in gener.0}ing r.gion-s.ecific neur.infla.ma.or. r.s.ons.s.a.d pha.ocytos.s.in Pa.kins.n’s.dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第10期20卷 2917-2918页

作者： Leyr. a.er.a.Ma.ia.s.a.mer.ch Univer.0}da. de Na.a.r. Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMa.Univer.1}da. de Na.a.r. PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neur.infla.ma.ion is.a.s.cia.ed with Pa.kins.n’s.dis.a.e:r.a.tive glios.s.a.d neur.infla.ma.ion a.e ha.lma.ks.of Pa.kins.n’s.dis.a.e(Pd),a.multis.s.em neur.degener.0}ive dis.r.er.cha.a.ter.zed by a.pr.gr.s.ive los. of dopa.iner.ic *** ha. long been cons.der.d a.mer. cons.quence of neur.na. los.,but whether.it pr.motes.Pd or.is.a.key pla.er.in dis.a.e pr.gr.s.ion r.ma.ns.to be *** leukocyte a.tigen.

关键词： infla.ma.ion leukocyte gener.0}ing

Under.0}a.ding a.tivity of butyr.1}e a. a.cellula. level

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第8期20卷 2323-2324页

作者： Pr.0}ti Cha.r.0}or.y a.gela.s.La.r. Ma.qua.ie Univer.2}ty Motor.Neur.n dis.a.e r.s.a.ch Centr. Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyr.0}e is.a.s.or.-cha.n fa.ty a.id of four.ca.bons.in length tha. is.a.by-pr.duct pr.duced by the micr.bia. fer.enta.ion of dieta.y fiber.a.d undiges.ed ca.bohydr.0}es.within the *** the yea.s.butyr.0}e ha. a.tr.0}ted ... 详细信息

关键词： ca.bons butyr.0}e fiber

Micr.glia. dys.unction a.d genetic r.s. for.neur.degener.0}ive dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第5期20卷 1401-1402页

作者： debr.0}s.Ma.dona.d Ja. Penney depa.tment of Biomedica. s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neur.degener.0}ive dis.r.er.1}s.ch a. a.zheimer.s.a.d Pa.kins.n's.dis.a.es.a.r. incr.a.ing in pr.va.ence a. wor.d popula.ions.*** tr.mendous.pr.gr.s. ha. been ma.e,our.under.1}a.ding of the mecha.is.s.tha. under.ie the development of thes. dis.a.es.r.ma.ns.fa. fr.m com *** tr.ubling,des.ite the gr.wing emotiona. a.d fina.cia. toll being to ken by neur.degener.0}ive dis.r.er.1}exis.ing tr.a.ment options.a.e limited a.mos. exclus.vely to thos. tha. help ma.a.e s.mptoms.but tha. la.k the a.ility to a.ter.the pr.gr.s.ion of the dis.a.e(Liu et a..,2022).

关键词： degener.0}ive dis.a.es

Br.0}n-der.ved neur.tr.phic fa.tor.s.gna.ing in the neur.mus.ula. junction dur.ng developmenta. a.ona. competition a.d s.na.s. elimina.ion

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor.Ciller.s.Ma.é La.a.Jus.-Bor.às.Ma.ta.Ba.a.yà-s.gur.3}a.eks.0}dr.3}Polis.chuk La.r.3}Na.a. Ma.ta.Tomàs.Ca.olina.s.lver.3}s.món Ma.el M.s.0}ta.é Ma.ia.a.La.uza Unita. d’His.ologia.i Neur.biologia.UHNeur.b) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

dur.ng the development of the ner.ous.s.s.em,ther. is.a. over.r.duction of neur.ns.a.d *** competition between neighbor.ng ner.e endings.a.d s.na.s.s.per.or.ing differ.nt a.tivity levels.lea.s.to their.elimina.ion or.*** ha.e extens.vely s.udied the involvement of the br.4}n-der.ved neur.tr.phic fa.tor.Tr.pomyos.n-r.la.ed kina.e B r.ceptor.neur.tr.phic r.tr.gr.4}e pa.hwa.,a. the neur.mus.ula. junction,in the a.ona. development a.d s.na.s. elimina.ion pr.ces. ver.0}s.the s.na.s. *** pur.os. of this.r.view is.to des.r.be the neur.tr.phic influence on developmenta. s.na.s. elimina.ion,in r.la.ion to other.molecula. pa.hwa.s.tha. we a.d other.0}ha.e found to r.gula.e this.*** pa.ticula.,we s.mma.ize our.publis.ed r.s.lts.ba.ed on tr.4}s.itter.r.lea.e a.a.ys.s.a.d a.ona. counts.to s.ow the differ.nt involvement of the pr.s.na.tic a.etylcholine mus.a.inic a.tor.ceptor.0}coupled to downs.r.a. s.r.ne-thr.onine pr.tein kina.es.a.a.d C(PKa.a.d PKC)a.d volta.e-ga.ed ca.cium cha.nels.a. differ.nt ner.e endings.in developmenta. *** dyna.ic cha.ges.tha. occur.s.multa.eous.y in s.ver.4} ner.e ter.ina.s.a.d s.na.s.s.conver.e a.r.s. a.pos.s.na.tic s.te,influence ea.h other.a.d r.quir. ca.eful s.udies.to individua.ize the mecha.is.s.of s.ecific *** des.r.be a. a.tivity-dependent ba.a.ce(r.la.ed to the extent of tr.4}s.itter.r.lea.e)between the pr.s.na.tic mus.a.inic s.btypes.a.d the neur.tr.phin-media.ed Tr.B/p75NTr.pa.hwa.s.tha. ca. influence the timing a.d fa.e of the competitive inter.4}tions.between the differ.nt a.on *** downs.r.a. dis.la.ement of the PKa.PKC a.tivity r.4}io to lower.va.ues.both in competing ner.e ter.ina.s.a.d a. pos.s.na.tic s.tes.pla.s.a.r.leva.t r.le in contr.lling the elimina.ion of s.per.umer.4}y ***,ca.cium entr. thr.ugh L-a.d P/Q-s.btypes.of volta.e-ga.ed ca.cium cha.nels.both cha.nels.a.e pr.s.nt,together.with the N-type cha.nel in developing ner.e ter.ina.s.contr.butes.to r.d

关键词： a.etylcholine r.lea.e a.enos.ne r.ceptor. a.ona. competition br.0}n-der.ved neur.tr.phic fa.tor ca.cium cha.nels motor.end-pla.e mus.a.inic a.etylcholine r.ceptor. pos.na.a. s.na.s. elimina.ion s.r.ne kina.es tr.pomyos.n-r.la.ed kina.e r.ceptor.