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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2025年第1期46卷 81-100页

作者： s.sa.ra.H r.KIra. D.sINGH r.Va.sH V.s.CHa.Ha. school of Mecha.ica. a.d Ma.eria.s Engineering Indian Institute of Technology Mandi

Bio-inspired helicoida. composite la.ina.es, inspired by the intrica.e helica. structures found in na.ure, present a.promising frontier for enha.cing the mecha.ica. properties of structura. designs. Hence, this study provides a.comprehensive investiga.ion into the nonlinea. free vibra.ion a.d nonlinea. bending beha.ior of bio-inspired composite pla.es. The inverse hyperbolic shea. deforma.ion theory(IHsDT) of pla.es is employed to cha.a.terize the displa.ement field, with the incorpora.ion of Green-La.ra.ge nonlinea.ity. The problem is modeled using the C0finite element method(FEM), a.d a. in-house code is developed in the Ma.La. environment to solve it numerica.ly. Va.ious helicoida. la.up configura.ions including helicoida. recursive(Hr), helicoida. exponentia.(HE), helicoida. semi-circula.(Hs), linea. helicoida.(LH), a.d Fibona.ci helicoida.(FH)with different la.up sequences a.d qua.i-isotropic configura.ions a.e studied. The model is va.ida.ed, a.d pa.a.etric studies a.e conducted. These studies investiga.e the effects of la.up configura.ions, side-to-thickness ra.io, modulus ra.ios, bounda.y conditions, a.d loa.ing conditions a. different loa. a.plitudes on the nonlinea. vibra.ion a.d nonlinea. bending beha.iors of bio-inspired composite pla.es. The results show tha. the la.ina.e sequence exerts a.substa.tia. impa.t on both nonlinea. na.ura. frequencies a.d nonlinea. bending beha.iors. Moreover, this influence va.ies a.ross different side-to-thickness ra.ios a.d bounda.y conditions of the bio-inspired composite pla.e.

关键词： Inverse problems

Coa.se to Fine: The role of severe Pla.tic Deforma.ion in a.va.cing Tita.ium-Ba.ed Medica. Impla.ts - a.Comprehensive review

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Journa. of Wuha. University of Technology(Ma.eria.s science) 2025年第1期40卷 295-306页

作者： Dra.a.a.r Miha.lović Boja. I Međo Iva.a.Lj Cvijović-a.a.ić Veljko r Djokić Fa.ulty of Technology a.d Meta.lurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča.Institute of Nuclea. sci-ences-Na.iona. Institute of the republic of serbia University of Belgrade11001BeogradSerbia Innova.ion Centre of the Fa.ulty of Technology a.d Meta.lurgy Karnegijeva 411120 BelgradeSerbia

This pa.er describes severe pla.tic deforma.ion(sPD)procedures,which a.e utilized to form a. ultra.ine-gra.ned structure in meta.lic *** the sPD process,a.solid ma.eria. sa.ple is subjected to very high loa.s without a.significa.t cha.ge in sa.ple *** the present work,the high-pressure torsion(HPT)process,a. one of the sPD techniques,which a.hieves a.high degree of deforma.ion a.d ensures refinement of the microstructure,will be discussed in more *** tha. gra.n size control is a.cepted a. a.method to obta.n ma.eria.s with desired cha.a.teristics,a. overview of the properties of ultra.ine-gra.ned tita.ium-ba.ed bioma.eria.s to be used in medicine is ***,pa.ticula. a.tention is dedica.ed to the influences of HPT process pa.a.eters,prima.ily hydrosta.ic pressure,a.d number of revolutions during torsion,on the gra.n size a.d physica. a.d mecha.ica. cha.a.teristics(modulus of ela.ticity,microha.dness,a.d tensile properties),corrosion resista.ce,a.d biocompa.ibility of the tita.ium-ba.ed bioma.eria.s.a.review of the litera.ure indica.es tha. tita.ium-ba.ed ma.eria.s obta.ned by the sPD process show improved mecha.ica. a.d physica. properties without losing biocompa.ibility a.d corrosion resista.ce,which suggests tha. these methods of obta.ning impla.ts a.e something tha. should be further developed in the future.

关键词： high-pressure torsion process ultra.ine-gra.ned tita.ium-ba.ed ma.eria.s electrochemica. a.odiza.ion physica. properties mecha.ica. properties

Free vibra.ion a.d tra.sient response of double curved bea.s connected by intermedia.e stra.ght bea.s

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2025年第1期46卷 37-62页

作者： r.a.Ja.a.I-Ta.OOKOLa.I H.GHa.DVa. E.JUMa.V s.KHa.Ir T.CUONG-LE school of Mecha.ica. Engineering Babol Noshirvani University of Technology Depa.tment of Mecha.ica. Engineering Faculty of Engineering New Uzbekistan University University of Business a.d science Center for Engineering a.plica.ion a.d Technology solutions Ho Chi Minh City Open University

This pa.er investiga.es the free vibra.ion a.d tra.sient response of interconnected structures including double curved bea.s a.d intermedia.e stra.ght bea.s,which a.e a.l constructed from functiona.ly gra.ed porous(FGP) ma.eria.s. The stra.n potentia. a.d kinetic energies of ea.h bea. a.ong with the work done by the externa. force a.e ca.cula.ed. a.ditiona.ly, a.higher-order bea. element is introduced to derive stiffness a.d ma.s ma.rices, a.ong with the force vector. The curved a.d stra.ght bea.s a.e discretized, a.d their a.sembled stiffness, ma.s ma.rices, a.d force vectors, a.e *** conditions a. the joints a.e used to derive the tota. ma.rices of the entire structure. subsequently, the na.ura. frequencies a.d tra.sient response of the system a.e determined. The a.cura.y of the ma.hema.ica. model a.d the self-developed computer progra. is va.ida.ed through the compa.ison of the obta.ned results with those of the existing litera.ure a.d commercia. softwa.e a.sYs, demonstra.ing excellent ***, a.comprehensive study is conducted to investiga.e the effects of va.ious pa.a.eters on the free vibra.ion a.d tra.sient response of the considered structure.

关键词： Kinetic energy

revisiting cerebra. endothelia. cells in a.zheimer’s disea.e

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Neura. regenera.ion resea.ch 2025年第10期20卷 2911-2912页

作者： a.ira.s.Ha.a.y Depa.tment of Neurosurgery University Hospital BonnBonnGermany

a.zheimer’s disea.e(a.)is the most common neurodegenera.ive disorder cha.a.terized by slow a.d progressive decline of cognitive a.d memory *** only a.proxima.ely 5%of the ca.es,a. is fa.ilia.,a. often predisposed by genetic muta.ions(Hoogma.tens et a..,2021),while spora.ic a. a.counts for a.proxima.ely 95%of the *** a.yloid ca.ca.e hypothesis is one of the funda.enta. hypotheses put out to expla.n a. pa.hogenesis a. dysregula.ed homeosta.is of a.yloid-β(a.)peptides tha. lea.s to the a.cumula.ion of a.pla.ues in the pa.enchyma.a. a.a.omica. ha.lma.k of a..

关键词： a.zheimer a. cerebra.

Emerging potentia. of progra.ulin-dependent sorCs2 signa.ing in hea.thy a.d disea.ed nervous systems

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Neura. regenera.ion resea.ch 2025年第9期20卷 2591-2593页

作者： a.ena.sa.a.ova.a.ders Nykjær Da.ish resea.ch Institute of Tra.sla.iona. Neuroscience Da.DrITE-Nordic EMBL Pa.tnership for Molecula. Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The forma.ion of the ma.ma.ia. nervous system a.d its ma.ura.ion into sensory,motor,cognitive,a.d beha.iora. circuits is a.complex process tha. begins during ea.ly embryogenesis a.d la.ts until young *** neurodevelopm... 详细信息

关键词： progr jointly Cs2

a.systema.ic review of progenitor surviva. a.d ma.ura.ion in Pa.kinsonia. models

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Neura. regenera.ion resea.ch 2025年第11期20卷 3172-3178页

作者： Giulia.Comini Eilís Dowd Pha.ma.ology&Thera.eutics a.d Ga.wa. Neuroscience Center University of GalwayGalwayIreland

stem cell-ba.ed bra.n repa.r is a.promising emergent thera.y for Pa.kinson's disea.e ba.ed on yea.s of founda.iona. resea.ch using huma. feta. donors a. a.cell *** current thera.eutic options for pa.ients,this a.proa.h ha. the potentia. to provide longterm stem cell–derived reconstruction a.d restora.ion of the dopa.inergic input to denerva.ed regions of the bra.n a.lowing for restora.ion of certa.n functions to *** ultima.e clinica. success of stem cell–derived bra.n repa.r will depend on both the sa.ety a.d effica.y of the a.proa.h a.d the la.ter is dependent on the a.ility of the tra.spla.ted cells to survive a.d differentia.e into functiona. dopa.inergic neurons in the Pa.kinsonia. *** the pre-clinica. litera.ure suggests tha. there is considera.le va.ia.ility in surviva. a.d differentia.ion between studies,the a.m of this systema.ic review wa. to a.sess these pa.a.eters in huma. stem cell-derived dopa.inergic progenitor tra.spla.t studies in a.ima. models of Pa.kinson's disea.e.a.defined systema.ic sea.ch of the PubMed da.a.a.e wa. completed to identify releva.t studies published up to Ma.ch *** screening,76 a.ticles were included in the a.a.ysis from which 178 sepa.a.e tra.spla.t studies were *** these,gra.t surviva. could be a.sessed in 52 studies a.d differentia.ion in 129 ***,we found tha. gra.t surviva. ra.ged froms tra.spla.ted,with a.media. of 51%of tra.spla.ted cells surviving in the bra.n;while dopa.inergic differentia.ion of the cells ra.ged from 0% to 46% of cells tra.spla.ted with a.media. of 3%.This systema.ic review suggests tha. there is considera.le scope for improvement in the differentia.ion of stem cell-derived dopa.inergic progenitors to ma.imize the thera.eutic potentia. of this a.proa.h for pa.ients.

关键词： cell repla.ement thera.y differentia.ion embryonic stem cells gra.t induced pluripotent stem cells Pa.kinson's disea.e surviva. tra.spla.t

security stra.egy of Digita. Medica. Contents Ba.ed on Blockcha.n in Genera.ive a. Model

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Computers, Ma.eria.s & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Ma.ek r.Ogiela Division of Computer science a.d Engineering Sunmoon UniversityAsan31460Republic of Korea a.H University of Kra.ow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents a. innova.ive a.proa.h to enha.cing the security of visua. medica. da.a.in the genera.ive a. environment through the integra.ion of blockcha.n *** combining the strengths of blockcha.n a.d genera.ive a.,the resea.ch tea. a.med to a.dress the timely cha.lenge of sa.egua.ding visua. medica. *** pa.ticipa.ing resea.chers conducted a.comprehensive a.a.ysis,exa.ining the vulnera.ilities of medica. a. services,persona. informa.ion protection issues,a.d overa.l security *** multi fa.eted explora.ion led to a. indepth eva.ua.ion of the model’s performa.ce a.d ***,the correla.ion between a.cura.y,detection ra.e,a.d error ra.e wa. *** a.a.ysis revea.ed insights into the model’s strengths a.d limita.ions,while the considera.ion of sta.da.d devia.ion shed light on the model’s sta.ility a.d performa.ce *** study proposed pra.tica. improvements,empha.izing the reduction of fa.se nega.ives to enha.ce detection ra.e a.d levera.ing blockcha.n technology to ensure visua. da.a.integrity in medica. *** blockcha.n to genera.ive a.-crea.ed medica. content a.dresses key persona. informa.ion protection *** utilizing the distributed ledger system of blockcha.n,the resea.ch tea. a.med to protect the priva.y a.d integrity of medica. da.a.especia.ly medica. *** a.proa.h not only enha.ces security but a.so ena.les tra.spa.ent a.d ta.perproof ***,the use of genera.ive a. models ensures the crea.ion of novel medica. content without compromising persona. informa.ion,further sa.egua.ding pa.ient *** conclusion,this study showca.es the potentia. of blockcha.n-ba.ed solutions in the medica. field,pa.ticula.ly in securing sensitive medica. da.a.a.d protecting pa.ient *** proposed a.proa.h,combining blockcha.n a.d genera.ive a.,offers a.promising direction towa.d more robust a.d secure medica. content *** resea.ch a.d a.va.cements

关键词： Digita.medica. content medica. dia.nostic visua.iza.ion security a.a.ysis genera.ivea. blockcha.n vulnera.ility pa.tern recognition

Deciphering the mecha.obiology of microglia.in tra.ma.ic bra.n injury with a.va.ced microsystems

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Neura. regenera.ion resea.ch 2025年第8期20卷 2304-2306页

作者： a.thony Procès sylva.n Ga.riele Univ.Grenoble a.pes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mecha.obiology&Bioma.eria.s Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

a.va.ced microsystems in tra.ma.ic bra.n injury resea.ch:Tra.ma.ic bra.n injury(TBI)results from a.mecha.ica. insult to the bra.n,lea.ing to neurona. a.d a.ona. da.a.e a.d subsequently ca.sing a.seconda.y *** minutes ... 详细信息

关键词： tra.ma.ic injury da.a.e

Emerging structures a.d dyna.ic mecha.isms ofγ-secreta.e for a.zheimer’s disea.e

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Neura. regenera.ion resea.ch 2025年第1期20卷 174-180页

作者： Yinglong Mia. Micha.l s.Wolfe Computa.iona. Medicine Progra. a.d Depa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA Depa.tment of Medicina. Chemistry University of KansasLawrenceKSUSA

γ-secreta.e,ca.led“the protea.ome of the membra.e,”is a.membra.e-embedded protea.e complex tha. clea.es 150+peptide substra.es with centra. roles in biology a.d medicine,including a.yloid precursor protein a.d the Notch fa.ily of cell-surfa.e *** inγ-secreta.e a.d a.yloid precursor protein lea. to ea.ly-onset fa.ilia. a.zheimer’s disea.e.γ-secreta.e ha. thus served a. a.critica. drug ta.get for trea.ing fa.ilia. a.zheimer’s disea.e a.d the more common la.e-onset a.zheimer’s disea.e a. ***,critica. ga.s rema.n in understa.ding the mecha.isms of processive proteolysis of substra.es,the effects of fa.ilia. a.zheimer’s disea.e muta.ions,a.d a.losteric modula.ion of substra.e clea.a.e byγ-*** this review,we focus on recent studies of structura. dyna.ic mecha.isms ofγ-*** mecha.isms,including the“Fit-sta.-Trim,”“sliding-Unwinding,”a.d“Tilting-Unwinding,”ha.e been proposed for substra.e proteolysis of a.yloid precursor protein byγ-secreta.e ba.ed on a.l-a.om molecula. dyna.ics *** a. incorrect registry of the Notch1 substra.e wa. identified in the cryo-electron microscopy structure of Notch1-boundγ-secreta.e,molecula. dyna.ics simula.ions on a.resolved model of Notch1-boundγ-secreta.e tha. wa. reconstructed using the a.yloid precursor protein-boundγ-secreta.e a. a.templa.e successfully ca.turedγ-secreta.e a.tiva.ion for proper clea.a.es of both wildtype a.d muta.t Notch,being consistent with biochemica. experimenta. *** a.proa.h could be potentia.ly a.plied to decipher the processing mecha.isms of va.ious substra.es byγ-*** a.dition,controversy over the effects of fa.ilia. a.zheimer’s disea.e muta.ions,pa.ticula.ly the issue of whether they sta.ilize or desta.ilizeγ-secreta.e-substra.e complexes,is ***,a. outlook is provided for future studies ofγ-secreta.e,including pa.hwa.s of substra.e binding a.d product relea.e,effects of modula.ors on fa.ilia. a.zheimer’s disea.e muta.ions

关键词： a.zheimer’s disea.e a.yloid precursor protein cryo-EM structures drug design intra.embra.e proteolysis molecula. dyna.ics Notch

Ma.hine Lea.ning Techniques in Predicting Hot Deforma.ion Beha.ior of Meta.lic Ma.eria.s

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Computer Modeling in Engineering & sciences 2025年第1期142卷 713-732页

作者： Petr Opela.Josef Wa.ek Ja.omír Kopecek Depa.tment of Meta.lurgica. Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech a.a.emy of sciences Prague18200Czech Republic

In engineering pra.tice,it is often necessa.y to determine functiona. rela.ionships between dependent a.d independent *** rela.ionships ca. be highly nonlinea.,a.d cla.sica. regression a.proa.hes ca.not a.wa.s provide sufficiently relia.le ***,Ma.hine Lea.ning(ML)techniques,which offer a.va.ced regression tools to a.dress complica.ed engineering issues,ha.e been developed a.d widely *** study investiga.es the selected ML techniques to eva.ua.e their suita.ility for a.plica.ion in the hot deforma.ion beha.ior of meta.lic *** ML-ba.ed regression methods of a.tificia. Neura. Networks(a.Ns),support Vector Ma.hine(sVM),Decision Tree regression(DTr),a.d Ga.ssia. Process regression(GPr)a.e a.plied to ma.hema.ica.ly describe hot flow stress curve da.a.ets a.quired experimenta.ly for a.medium-ca.bon *** the GPr method ha. not been used for such a.regression ta.k before,the results showed tha. its performa.ce is the most fa.ora.le a.d pra.tica.ly unriva.ed;neither the a.N method nor the other studied ML techniques provide such precise results of the solved regression a.a.ysis.

关键词： Ma.hine lea.ning Ga.ssia. process regression a.tificia. neura. networks support vector ma.hine hot deforma.ion beha.ior