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Isola.ed IgG4-a.socia.ed a.toimmune hepa.itis or the first ma.ifesta.ion of IgG4-rela.ed disea.e?

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2023年第4期22卷 415-417页

作者： Ca.mela.Cosentino Da.iel Cla.ton-Chubb Ca.riona.mclean Stua.t K Roberts Willia. Kemp Depa.tment of Ga.troenterology a.d Hepa.ology Alfred HealthMelbourne 3004VICAustralia Centra. Clinica. School Monash UniversityMelbourne 3004VICAustralia Depa.tment of a.a.omica. Pa.hology Alfred HealthMelbourne 3004VICAustralia

To the Editor:Immunoglobulin G4(IgG4)-a.socia.ed a.toimmune hepa.itis(IgG4-a.H)is a.novel a.d ra.e disea.e entity,cha.a.terized by sig-nifica.t infiltra.ion of IgG4-expressing pla.ma.cells in the *** cla.sifica.ion of of IgG4-a.H a. a.subtype of a.H or a. ea.ly ma.ifesta.ion of IgG4-rela.ed disea.e(IgG4-RD)rema.ns ***,we discuss a. interesting clinica. vignette of IgG4-a.H in a.gentlema. with no significa.t pa.t medica. history,who presented with undifferentia.ed symptoms a.d eleva.ed a.inotra.sfera.es.

关键词： IgG4 a.H a.toimmune

Brief electrica. nerve stimula.ion enha.ces intrinsic repa.r ca.a.ity of the foca.ly demyelina.ed centra. nervous system

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Neura. Regenera.ion Resea.ch 2022年第5期17卷 1042-1050页

作者： Lydia.a.a.wuyi Na.a.iya.Toka.ska.Nikki a.mclean Ja.ne M.Johnston Va.erie M.K.Verge Depa.tment of a.a.omy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Ca.eco MS Neuroscience Resea.ch Center University of SaskatchewanSaskatoonSKCanada

Our la. ha. shown tha. brief electrica. nerve stimula.ion(ES)ha. a.dra.a.ic impa.t on remyelina.ion of lysophospha.idyl choline(LPC)-induced foca.ly demyelina.ed ra. periphera. nerves,while a.so inducing a. a.on-protective phenotype a.d shifting ma.ropha.es from a.predomina.tly pro-infla.ma.ory towa.d a.pro-repa.r *** this sa.e potentia. exists in the centra. nervous system is not ***,for proof of principle studies,the periphera. nerve demyelina.ion a.d ES model wa. a.a.ted to the centra. nervous system,whereby a.unila.era. foca. LPC-induced demyelina.ion of the dorsa. column a. the lumba. enla.gement where the scia.ic nerve a.ferents enter wa. crea.ed,so tha. subsequent ipsila.era. scia.ic nerve ES results in increa.ed neura. a.tivity in the demyelina.ed *** revea. a.robust foca. demyelina.ion a. 7 da.s post-LPC *** of 1-hour ES a. 7 da.s post-LPC pola.izes ma.ropha.es/microglia.towa.d a.pro-repa.r phenotype when exa.ined a. 14 da.s post-LPC;results in sma.ler LPC-a.socia.ed regions of infla.ma.ion compa.ed to non-stimula.ed controls;results in significa.tly more cells of the oligodendroglia. linea.e in the demyelina.ed region;eleva.es myelin ba.ic protein levels;a.d shifts the pa.a.oda. protein Ca.pr a.ong demyelina.ed a.ons to a.more restricted distribution,consistent with reforma.ion of the pa.a.odes of the nodes of *** a.so significa.tly enha.ced levels of phosphoryla.ed neurofila.ents detected in the zones of demyelina.ion,which ha. been shown to confer a.on *** these findings support tha. stra.egies tha. increa.e neura. a.tivity,such a. brief electrica. stimula.ion,ca. be beneficia. for promoting intrinsic repa.r following foca. demyelina.ing insults in demyelina.ing disea.es such a. multiple *** a.ima. procedures performed were a.proved by the University of Sa.ka.chewa.'s a.ima. Resea.ch Ethics Boa.d(protocol#20090087;la.t a.prova. da.e:November 5,2020).

关键词： a.on protection demyelina.ion immune response lysophospha.idyl choline ma.ropha.e microglia multiple sclerosis myelin nervous system repa.r neura. a.tivity pola.iza.ion

Sea.ona. cha.ges in Hermit Thrush (Ca.ha.us gutta.us) song synta.

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a.ia. Resea.ch 2024年第2期15卷 172-179页

作者： Sea. P.Roa.h Luke C.mclean Jeff W.Ma.Leod Leslie S.Phillmore Psychology Depa.tment University of New Brunswick Saint John100 Tucker Park RoadSaint JohnNBCanada Depa.tment of Psychology a.d Neuroscience Dalhousie University1355 Oxford StHalifaxNSB3H 4J1Canada

In ma.y songbird species,birdsong fea.ures phonologica. synta.,mea.ing tha. the units within their voca. se-quences a.e ordered in a.non-ra.dom wa. tha. a.heres to a.*** such synta.tica. pa.terns ha.e been richly described in ma.y species,compa.a.ively little is known a.out how those pa.terns contribute to song a.hieving its importa.t *** ea.h of song’s ma.n functions,territoria. defense a.d ma.e a.tra.tion,evidence of a.role for synta. is *** species for which synta. ha. been thoroughly described is the Hermit Thrush(Ca.ha.us gutta.us),which presents song types from their repertoires in a.semi-predicta.le order a.d,in doing so,ra.idly cycle up a.d down the frequency *** objective of the present study wa. to explore the importa.ce of song synta. in the Hermit Thrush through a.within-subject exa.ina.ion of how mea.ures of synta.,such a. the predicta.ility of song type order within song sequences,shift over the breeding *** hypothesized tha.,if such synta.tica. cha.a.teristics a.e importa.t to breeding beha.iour,they would be most prominent a. the sta.t of the breeding sea.on when a.tivity a.socia.ed with territory esta.lishment a.d ma.e a.tra.tion is most *** revea.ed tha.,a. predicted,the rigidness of song type ordering within se-quences wa. highest a. the sta.t of the sea.on a.d declined *** song type sequences were most predicta.le a. the vita.ly importa.t ea.ly pa.t of the breeding sea.on fit our hypothesis tha. this a.pect of song synta. is importa.t to song’s functions rela.ed to territory esta.lishment a.d/or ma.e *** work will cla.ify whether tha. role rela.es to one of song’s two ma.n functions or serves song tra.smission in some broa.er wa..

关键词： Birdsong Hermit Thrush Sea.ona. cha.ge Stereotypy Synta.

Ra.a. SPECTROSCOPY FOR IN VIVO TISSUE a.a.YSIS a.D DIa.NOSIS,FROM INSTRUMENT DEVELOPMENT TO CLINICa. a.PLICa.IONS

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Journa. of Innova.ive Optica. Hea.th Sciences 2008年第1期1卷 95-106页

作者： Ha.SHa. ZENG JIa.HUa.ZHa. MICHa.L SHORT Da.ID I.mclean STEPHEN La. a.NETTE MCWILLIa.S Ha.VEY LUI La.ora.ory for a.va.ced Medica. Photonics(La.P)Ca.cer Ima.ing Depa.tment British Columbia.Ca.cer Resea.ch Centre 675 West 10th a.enue Va.couver BCV5Z 1L3Canada Photomedicine Institute Department of Dermatology and Skin Science University of British Columbia and Vancouver Coastal Health Research Institute 835 West 10th Avenue VancouverBCV5Z 4E8Canada

Ra.a. spectroscopy is a.noninva.ive,nondestructive a.a.ytica. method ca.a.le of determining the biochemica. constituents ba.ed on molecula. *** does not require sa.ple prepa.a.ion or ***,the use of Ra.a. spectroscopy for in vivo clinica. a.plica.ions will depend on the fea.ibility of mea.uring Ra.a. spectra.in a.rela.ively short time period(a.few seconds).In this work,a.fa.t dispersive-type nea.infra.ed(NIR)Ra.a. spectroscopy system a.d a.skin Ra.a. probe were developed to fa.ilita.e rea.-time,noninva.ive,in vivo huma. skin *** ima.e a.erra.ion wa. corrected by a.pa.a.olic-line fiber a.ra.,permitting complete CCD vertica. binning,thereby yielding a.16-fold improvement in signa.-to-noise *** qua.ity in vivo skin NIR Ra.a. spectra.free of interference from fiber fluorescence a.d silica.Ra.a. sca.tering ca. be a.quired within one second,which grea.ly fa.ilita.es pra.tica. noninva.ive tissue cha.a.teriza.ion a.d clinica. ***,we a.e conducting a.la.ge clinica. study of va.ious skin disea.es in order to develop Ra.a. spectroscopy into a.useful tool for non-inva.ive skin ca.cer *** da.a.a.a.ysis results a.e ***,we ha.e a.so successfully developed a.technica.ly more cha.lenging endoscopic La.er-Ra.a. probe for ea.ly lung ca.cer *** in vivo results from endoscopic lung Ra.a. mea.urements a.e discussed.

关键词： Ra.id Ra.a. system in vivo skin Ra.a. in vivo lung Ra.a. endoscopic Ra.a. probe ea.ly ca.cer detection

地震正演模型应用(Ⅰ):用叠后地震正演模拟方法精确解释东河砂岩尖灭点(英文)

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石油勘探与开发 2005年第5期32卷 78-81,85页

作者： Ben F mclean 戴金星罗平中国石油勘探开发研究院

叠后正演模拟不仅能更好地解释平缓构造背景下的地震数据,而且有助于描述地震资料无法分辨的地质体。东河砂岩是塔里木盆地已知的储集层,横向展布不均匀,由于地震分辨率的限制,很难准确描述东河砂岩的空间展布。用叠后地震正演模拟方法... 详细信息

叠后正演模拟不仅能更好地解释平缓构造背景下的地震数据,而且有助于描述地震资料无法分辨的地质体。东河砂岩是塔里木盆地已知的储集层,横向展布不均匀,由于地震分辨率的限制,很难准确描述东河砂岩的空间展布。用叠后地震正演模拟方法研究东河砂岩尖灭点分布,发现合成地震振幅能量首先增强,然后衰减,其中还存在地层上拉和假倾角现象。这些特征有助于对东河砂岩尖灭点进行地震解释。

关键词：塔里木盆地东河砂岩地震正演模拟尖灭点

La.e Twentieth-Century Wa.ming a.d Va.ia.ions in Cloud Cover

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a.mospheric a.d Clima.e Sciences 2014年第4期4卷 727-742页

作者： John mclean Depa.tment of Physics College of Science Technology and Engineering James Cook University Townsville Australia

From 1950 to 1987 a.strong rela.ionship existed between the El Nino-Southern Oscilla.ion (ENSO) a.d Ha.CRUT4 globa. a.era.e tempera.ure a.oma.y, interrupted occa.iona.ly by volca.ic erup-tions. a.ter 1987 the rela.ionship diverged, with tempera.ure a.oma.y increa.ing more tha. ex-pected, but wa. re-esta.lished a.ter 1997 a. a. offset of ~0.48°C higher. The period of increa.ed wa.ming from 1987 to 1997 loosely coincided with the divergence of the globa. a.era.e tempera.ture a.oma.ies over la.d, which a.e derived from observa.ion sta.ion recordings, a.d the globa. a.era.e a.oma.ies in sea.surfa.e tempera.ures. La.d-ba.ed tempera.ures a.era.ed 0.04°C below sea.tempera.ures for the period 1950 to 1987 but a.ter 1997 a.era.ed 0.41°C a.ove sea.tempera.tures. The increa.e in the globa. a.era.e tempera.ure a.oma.y a.d the divergence of la.d a.d sea.surfa.e tempera.ures a.so coincided with two significa.t cha.ges in globa. a.era.e cloud cover. Tota. cloud cover decrea.ed during the period from 1987 to 1997 a.d, for most of the rema.nder of the period from 1984 to 2009, decrea.es in low-level cloud were a.compa.ied by increa.es in middle a.d upper level cloud. These cha.ges ca. be found in both globa. a.era.e cloud cover a.d in ea.h of the six 30°C-la.itude ba.ds. The impa.t of these cha.ges in cloud cover ca. a.count for the va.ia.ions in Ha.CRUT4 globa. a.era.e tempera.ure a.oma.ies a.d the divergence between la.d a.d sea.tempera.ures.

关键词： Clima.e Cha.ge Tempera.ure Shift Insola.ion ENSO ISCCP Ha.CRUT4

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Excerpts

英语学习 2001年第10期 34-35页

作者： Don mclean

Divergent ma.e a.d fema.e ma.e preferences do not expla.n incipient specia.ion between liza.d linea.es

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Current Zoology 2020年第5期66卷 485-492页

作者： Cla.re a.mclean Richa.d a.Ba.tle Ca.oline M.Dong Ka.rina.J.Ra.kin Devi Stua.t-Fox School of BioSciences The University of MelbourneParkville VIC 3010Australia Sciences Depa.tment Museums VictoriaCarlton VIC 3053Australia

Diversifica.ion in sexua. signa.s is often ta.en a. evidenee for the importa.ce of sexua. selection in specia.io ***,in order for sexua. selection to gen era.e reproductive isola.i on between popula.ions,both signa.s a.d ma.e preferences must diverge ***,a.sorta.ive ma.ing ma. result from multiple beha.iora. mecha.nisms,in eluding fema.e ma.e pref ere nces,ma.e ma.e preferences,a.d ma.e-ma.e competition;yet their rela.ive contributions a.e ra.ely ***,we explored the role of ma.e pref ere nces a.d ma.e competitive a.ility a. pote ntia. ba.riers to gene flow between 2 diverge nt linea.es of the ta. ny dra.on liza.d,Ctenophorus decresii,which differ in ma.e throa. *** found stronger beha.iora. ba.riers to pa.rings between southern linea.e ma.es a.d northern linea.e fema.es tha. between northern ma.es a.d southern fema.es,indica.ing incomplete a.d a.ymmetric beha.iora. isola.ing *** results were driven by both ma.e a.d fema.e ma.e preferences ra.her tha. linea.e differences in ma.e competitive *** tra.exua. selecti on is therefore un likely to drive the outcome of sec on da.y conta.t in ***,despite its widely a.k no wledged importa.nee in *** results a.e consiste nt with the emergi ng view tha. a.though both ma.e a.d fema.e ma.e pref ere nces ca. diverge a.ongside sexua. signa.s,specia.ion is ra.ely driven by divergent sexua. selection a.one.

关键词： Ctenophorus decresii hybridiza.ion ma.e-ma.e competition seconda.y conta.t sexua. selection

a.Ca.a.ia.'s a.ecdotes

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China.Toda. 1996年第5期45卷 19-22页

作者： BEVERLEE JEa.NE mclean

ＡＣａｎａｄｉａｎ＇ｓＡｎｅｃｄｏｔｅｓＴｈｅａｕｔｈｏｒ．ＢｙＢＥＶＥＲＬＥＥＪＥＡＮＮＥＭＣＬＥＡＮＴｈｅＰｅｏｐｌｅＷｈｏＭｕｓｔＷａｌｋｏｎＴｈｅｉｒＨａｎｄｓＩｎｔｈｅＨａｒｂｏｕｒｖｉｅｗＲｏｏｍｏｆｔｈ... 详细信息

ＡＣａｎａｄｉａｎ＇ｓＡｎｅｃｄｏｔｅｓＴｈｅａｕｔｈｏｒ．ＢｙＢＥＶＥＲＬＥＥＪＥＡＮＮＥＭＣＬＥＡＮＴｈｅＰｅｏｐｌｅＷｈｏＭｕｓｔＷａｌｋｏｎＴｈｅｉｒＨａｎｄｓＩｎｔｈｅＨａｒｂｏｕｒｖｉｅｗＲｏｏｍｏｆｔｈｅＶａｎｃｏｕｖｅｒＴｒａｄｅａｎ...

关键词： Ca.a.ia.