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a.ti-proma.tigote a.tivity of the a.a.on Pla.ts

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Journa. of Pha.ma.y a.d Pha.ma.ology 2017年第9期5卷 654-660页

作者： Silva.Silva. J. V Monteiro, R. C. S. Brigido, H. P. C Va.e, V. V Silvestre, J. V. Silva. N. C. S Silveira.F.T marinho, a. M. R Dola.ela. M. F Progra.a.de Pos-Gra.ua.a. em Ciencia. Fa.ma.dutica. Universidade Federal do Para Belem 66075-110 Brasil Progra.a.de Pos-Gra.ua.a. em lnova.a. Fa.ma.eutica Universidade Federal do Para Belem 66075-110 Brasil Fa.ulda.e de Ciencia. Fa.ma.eutica. Universidade Federal do Parr Belem 66075-11 O Brasil Instituto Eva.dro Cha.a. Br 316 Km 7 Ananindeua 67030-000 Brasil Fa.ulda.e de Qulmica Universidade Federal do Para Belem 66075-110 Brasil

This study eva.ua.ed in vitro a.tivity of etha.ol extra.t, fra.tions, a.d isola.ed substa.ce from a.a.on species a.a.nst proma.tigotes of L. a.a.onensis. The etha.ol extra.ts were concentra.ed a.d fra.tiona.ion. The a.ti-proma.tigote a.tivity wa. eva.ua.ed through the cell via.ility a.sessment method （MTT）. The etha.ol extra.t, fra.tions, a.d isola.ed substa.ce from Hima.a.thus a.ticula.us a.d Pa.a.a.cornia.a.cicula.a.were ina.tive in proma.tigote ofL. a.a.onensis, a. the etha.ol extra.t ofPhysa.is a.gula.a. The hexa.e fra.tions from different pa.ts ofMontricha.dia.linifera.showed a.ti-proma.tigote a.tivity proba.ly due to the presence of steroids a.d terpenes. a.l species in studies were ina.tive, except ofM. linifera. The few pola. constituents ca. be responsible for the a.tivity. Therefore, the isola.ion a.d purifica.ion of the a.tive on L. a.a.onensis proma.tigotes a.e urgently required.

关键词： Leishma.ia hima.a.thus a.ticula.us pa.a.a.comia.fa.cicula.a montricha.dia.linifera physa.is a.gula.a.

Zircon U-Pb a.d Lu-Hf isotope constra.nts on a.chea. crusta. evolution in Southea.tern Guya.a.Shield

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Geoscience Frontiers 2019年第4期10卷 1477-1506页

作者： Joa. marinho Milhomem Neto Jea.-Michel La.on Progra.a.de Pos-gra.ua.a. em Geologia.e Geoquimica.PPGG Instituto de Geociencias-IGUniversidade Federal do Para-UFPA66075-110BelemParaBrazil La.ora.ório de Geologia.Isotópica.Pa.á-Iso IG-UFPA66075-110BelémParáBrazil

The southea.tern Guya.a.Shield,northea.t a.a.onia. Cra.on,in the north of Bra.il,is pa.t of a.widesprea. orogenic belt developed during the Tra.sa.a.onia. orogenic cycle(2.26-1.95 Ga.tha. includes a.la.ge a.chea. continenta. la.dma.s strongly reworked during the Tra.sa.a.onia. orogeny,na.ed a.a.a.*** consists ma.nly of a.high-gra.e meta.orphic gra.ulitic-migma.itic-gneiss complex,of Meso-to Neoa.chea. a.e a.d Rhya.ia. gra.itoids a.d supra.rusta. *** the first time,coupled U-Pb a.d Lu-Hf isotope da.a.were obta.ned on zircon by La.ICP-MS from five tectono-stra.igra.hic units of the a.chea. ba.ement a.d one Pa.eoproterozoic intrusive rock,in order to investiga.e the ma.n episodes of crusta. growth a.d ***-rock Sm-Nd isotope da.a.were compa.ed to the zircon Lu-Hf *** ma.n ma.ma.ic episodes were defined by U-Pb zircon da.ing,two in the Mesoa.chea.(~3.19 Ga.a.d 2.85 Ga.a.d one in the Neoa.chea.(~2.69-2.65 Ga..SubchondriticεHf(t)va.ues obta.ned for a.most a.l investiga.ed units indica.e tha. crusta. reworking processes were predomina.t during the forma.ion of rocks tha. toda. ma.e up the a.a.a.***-TDMC model a.es,ra.ging from2.99 Ga.to 3.97 Ga.indica.e tha. a. lea.t two importa.t periods of ma.tle extra.tion a.d continenta. crust forma.ion occurred during the a.chea. in southea.tern Guya.a.Shield,a. older one in the Eoa.chea.(~4.0 Ga.a.d a.younger one in the Mesoa.chea.(~3.0-3.1 Ga..The la.ter is recognized a. a. importa.t period of crusta. a.cretion *** recognition of a. Eoa.chea. episode to the southea.tern most pa.t of the Guya.a.Shield is unprecedented a.d wa. not recorded by whole-rock Sm-Nd da.a.which were restricted to the Meso-Pa.eoa.chea.(2.83 Ga.to 3.51 Ga..This finding revea.s t ha. continenta. crust genera.ion in the a.a.onia. Cra.on bega. a. lea.t 500 Ma.ea.lier tha. previously suggested by the SmNd systema.ics.

关键词： U-Pb-Lu-Hf isotopes Zircon a.chea. crusta. evolution Southea.tern Guya.a Shield a.a.onia. Cra.on

Impa.t of hepa.itis C ora. thera.y in porta. hypertension

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World Journa. of Ga.troenterology 2017年第26期23卷 4669-4674页

作者： Diogo Liba.io Rui Ta.o marinho Depa.tment of Ga.troenterology Instituto Português de Oncologia do Porto Depa.tment of Ga.troenterology a.d Hepa.ology Centro Hospitalar de Lisboa Norte/Hospital Santa Maria Fa.ulty of Medicine University of Lisbon

Chronic hepa.itis C is a.lea.ing ca.se of morbidity a.d morta.ity, ma.nly rela.ed to fibrosis/cirrhosis a.d porta. hypertension. Direct a.tivira. a.ents a.e highly effective a.d sa.e a.d ca. now cure > 90% of the pa.ients. Susta.ned vira. response (SVR) a.ter interferon-ba.ed regimens ha. been a.socia.ed with improvement in liver function, fibrosis a.d porta. hypertension in a.significa.t proportion of pa.ients, a.though a.point of no return seems to exist from which vira. elimina.ion is no longer ca.a.le of preventing porta. hypertension progression a.d liver decompensa.ion. Indeed, a.though SVR is a.socia.ed with improvement of hepa.ic venous pressure gra.ients a.d therefore a.decrea.ed risk of de novo esopha.ea. va.ices, severa. studies show tha. vira. clea.a.ce does not elimina.e the risk of va.icea. progression, liver decompensa.ion a.d dea.h in pa.ients with pre-esta.lished porta. hypertension. a.though evidence a.out the effects of direct a.tivira. a.ents (Da.s) on clinica.ly significa.t outcomes is still sca.ce a.d with short follow-up, Da.s ca. decrea.e the burden of the disea.e if pa.ients a.e timely trea.ed before significa.t fibrosis a.d porta. hypertension develops. Studies with longer follow-up a.e wa.ted to esta.lish the rea. ma.nitude of hepa.itis C trea.ment on porta. hypertension. Future studies should a.so focus on predictors of porta. hypertension resolution since it ca. influence ma.a.ement a.d a.oid unnecessa.y monitoring

关键词： Hepa.itis C Porta. hypertension Direct a.tivira. a.ents Cirrhosis Fibrosis Interferon

Long-term response to a.eluma. a.d ma.a.ement of oligoprogression in Merkel cell ca.cinoma.a.ca.e report

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World Journa. of Clinica. Ca.es 2021年第18期9卷 4829-4836页

作者： Inês Leão Joa.a.marinho Telma.Costa Depa.tment of Oncology Centro Hospitalar Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal

Ba.KGROUND Merkel cell ca.cinoma.MCC)is a.ra.e a.d a.gressive cuta.eous neuroendocrine neopla.ia.with high risk of recurrence a.d meta.ta.is a.d poor *** checkpoint inhibitors,like the a.ti-progra.med dea.h-liga.d 1 a.ent a.eluma.,were recently a.proved for the trea.ment of a.va.ced ***,herein,report the first ca.e of a.va.ced MCC with oligoprogression ma.a.ed with a.eluma. a.d loca. ra.ica. *** SUMMa.Y a.61-yea.-old ma. wa. presented to the hospita. with spora.ic fever a.d a. exuda.ive ma.odorous ma.s(10 cm of dia.eter),loca.ed on the right glutea. *** fina. dia.nosis wa. MCC,cT4N3M1c(a.CC,TNM sta.ing 8th edition,2017),with inva.ion of a.ja.ent muscle,in-tra.sit meta.ta.is,a.d bone *** sta.ted chemothera.y(cispla.in a.d etoposide),a.d a.ter six cycles,the ma.n tumor increa.ed,evidencing disea.e *** months la.er,the pa.ient sta.ted second line trea.ment with a.eluma.(under a. ea.ly a.cess progra.).a.ter two cycles of trea.ment,the lesion sta.ted to decrea.e,a.hieving a.ma.or *** progression wa. documented a.ter 16 ***,a. the tumor beca.e resecta.le,sa.va.e surgery wa. performed,while keeping the systemic trea.ment with *** the pa.ient developed bila.era. pneumonia.immunothera.y wa. *** tha. 2.5 yea.s a.ter surgery(la.t 19 mo without systemic thera.y),the pa.ient ma.nta.ns complete loca. response a.d sta.le bone *** This report highlights the effica.y a.d long-term response of a.eluma. on the ma.a.ement of a.chemothera.y resista.t a.va.ced MCC,with evidence of oligoprogression,in combina.ion with loca. ra.ica. trea.ment.

关键词： Merkel cell ca.cinoma Unresecta.le tumor a.eluma. Oligoprogression Surgery Chemothera.y Ca.e report

Hepa.itis C,stigma.a.d cure

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World Journa. of Ga.troenterology 2013年第40期19卷 6703-6709页

作者： Rui Ta.o marinho Da.id Pires Ba.reira Depa.tment of Ga.troenterology a.d Hepa.ology Hospita. Sa.ta.Ma.ia Medical School of Lisbon1649-035 LisboaPortugal

The infection with hepa.itis C virus(HCV)is one of the most importa.t globa. chronic vira. infections *** is estima.ed to a.fect a.ound 3%of the world popula.ion,a.out 170-200 million *** pa.t of the infections a.e a.ymptoma.ic,the pa.ient ca. be a.chronic ca.rier for deca.es without knowing *** most severe consequences of the chronic infection a.e liver cirrhosis a.d hepa.ocellula. ca.cinoma.which a.pea.s in 20%-40%of the pa.ients,lea.ing to hepa.ic fa.lure a.d *** HCV wa. discovered 25 yea.s a.o in 1989,is a.RNa.virus a.d cla.sified by the World Hea.th Orga.iza.ion a. a. oncogenic *** ca.cinoma.is one of the most importa.t ca.cers,the fifth worldwide in terms of *** ha. been increa.ing in the Ocidenta. world,ma.nly due to chronic hepa.itis *** C is not only a.liver disea.e a.d a.ca.se of cirrhosis,but a.so a.menta.,psychologica.,fa.ilia.,a.d socia. *** stigma.tha. the infected person sometimes ca.ries is tremendous ha.ing multiple *** ma.n ca.se is la.k of a.equa.e informa.ion,even in the hea.th professiona.s ***,besides the"dra.a.of being infected,hea.th professiona.s,fa.ily,society a.d the infected pa.ients,must be a.a.e of the cha.ce of rea. cure a.d tota. a.d definitive elimina.ion of the *** trea.ment for hepa.itis C ha. begun in the la.t 80′s with a.percenta.e of cure of 6%.Step by step the effica.y of the thera.y for hepa.itis C is ra.idly increa.ing a.d nowa.a.s with the very new medica.ions,the so ca.led Direct a.tivira. a.ents-Da.s of new genera.ion,is a.ound 80%-90%.

关键词： Hepa.itis C Chronic Thera.y Hepa.ocellula. ca.cinoma Hepa.ic cirrhosis Interferon-a.pha Riba.irin Socia. stigma Depression

Muckle-Wells syndrome: ma.ifesta.ions a.d dia.nosis in four genera.ions of a.Portuguese fa.ily

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World Journa. of Pedia.rics 2020年第5期16卷 541-542页

作者： Sora.a.Ra.uel Loureiro a.evedo Da.iela.Filipa.marinho Peixoto Rheuma.ology Depa.tment Unidade Local de Satúde Do Alto MinhoHospital Conde Bertiandos4990-041Ponte de LimaPortugal

Severa. medica. conditions ca. present a. fever a.d ra.h in children,including infections,hypersensitivity rea.tions a.d immune-media.ed disea.es[1].Cryopyrin-a.socia.ed periodic syndrome(Ca.S)is a.group of inherited a.toinfla.ma.ory disorders ca.sed by ga.n-of-function muta.ions in the NLRP3 gene(CIa. 1).Ca.S encompa.s a.spectrum of disea.es including Muckle-Wells syndrome(MWS).The a.39V muta.ion is considered a.disea.e-ca.sing muta.ion,a.though clinica. phenotypes ca. be diverse[2].MWS is cha.a.terized by recurrent episodes of fever,urtica.ia. ra.h,a.thra.gia.a.thritis,a.d more ra.ely,ora. ulcers,folliculitis,or erythema.nodosum[3].

关键词： dia.nosis Ca.S fever

Pha.or-doma.n Dyna.ic Model of a.ymmetric Current Injection Controller for Converter-interfa.ed Genera.or

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Journa. of Modern Power Systems a.d Clea. Energy 2021年第6期9卷 1269-1278页

作者： Victor a.F.a.meida.Gla.co N.Ta.a.to José M.T.marinho Electrica. Engineering Depa.tment of the Federa. University of Rio de Ja.eiro(COPPE/UFRJ) Petrobra. S.a.

This pa.er presents a.controller model of a.ymmetric current injection for converter-interfa.ed genera.ors suita.le for root-mea.-squa.e(RMS)pha.or-doma.n,funda.enta.frequency,three-pha.e,a.d dyna.ic simula.ion *** effectiveness of the proposed controller is a.sessed with simula.ions in test systems with high percenta.e of converter-interfa.ed *** simula.ions focus on the opera.ion of protection rela.s tha. use nega.ive-sequence qua.tities in their directiona. *** pa.er a.so presents a.d compa.es two stra.egies to limit rea.tive nega.ive-sequence currents,a.d a.tive a.d rea.tive positive-sequence currents.a.tutoria. test system a.d a.regiona. system pa.t of the a.tua. Bra.ilia. Interconnected Power System a.e used to a.sess the correctness of the proposed controller in three-pha.e funda.enta.-frequency RMS dyna.ic simula.ions.

关键词： Converter-interfa.ed genera.or three-pha.e model power system protection nega.ive-sequence current injection nega.ive-sequence current protection unba.a.ced fa.lt three-pha.e root-mea.-squa.e(RMS)dyna.ic simula.ion

La.e Cryogenia.-Edia.a.a. ma.ma.ism in southern Borborema.Province,NE Bra.il:a.es,sources,petrogenesis,a.d tectonic setting

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Geoscience Frontiers 2023年第6期14卷 70-101页

作者： Fábio Sa.tos Pereira.Herbet Conceição Ma.ia.de Lourdes Silva.Rosa.Moa.yr Moura.marinho Colombo Celso Ga.ta.Ta.sina.i João marinho Milhomem Neto Jea.-Michel La.on Progra.a.de Pós-Gra.ua.ão em Geologia.e Geoquímica.PPGG) Instituto de GeociênciasUniversidade Federal do Pará(UFPA)66075-110 BelémParáBrazil Progra.a.de Pós-Gra.ua.ão em Geociência. e a.álise de Ba.ia.(PGa.) Universidade Federal de Sergipe(UFS)49100-000 São CristóvãoSergipeBrazil Instituto de Geociência. Universidade Federal da Bahia(UFBA)40170-290 SalvadorBahiaBrazil Instituto de Geociência. Universidade de São Paulo(USP)05508-900 São PauloBrazil La.ora.ório de Geologia.Isotópica.Pa.á-Iso) IG-UFPA66075-110 BelémParáBrazil

The Sergipa.o Orogenic System(SOS)in southern Borborema.Province(NE Bra.il)hosts voluminous Neoproterozoic plutonism rela.ed to the Bra.ilia.o/Pa.-a.rica. *** pa.er presents comprehensive whole-rock geochemica. da.a.tita.ite U-Pb a.es,a.d the first combined zircon U-Pb a.d Lu-Hf isotope results for plutonic rocks from the Ma.ururéDoma.n to constra.n their sources,petrogenesis,a.d tectonic *** ma.ma.ic episodes a.e recognized a.d record the evolutiona.y sta.es of the orogen.(i)Ea.ly-collisiona. ma.ma.ism(643–628 Ma.comprises ga.bros a.d diorites with minor tona.ites cha.a.terized by well-developed tectonic folia.ion a.d evidence of solid-sta.e *** rocks a.e ma.nesia.,high-K ca.c-a.ka.ine,LILE-a.d LREE-enriched a.d provide subchondriticε_(Hf)(t)va.ues(6.5 to4.7)a.d Orosiria. Hf-T^(C)_(DM)model a.es(1.83–1.94 Ga..Such fea.ures indica.e deriva.ion from a.lithospheric ma.tle source meta.oma.ized by incorpora.ing crusta. components through subduction processes prior to ma.ma.genera.ion,possibly rela.ed to the Rhya.ia. Orogeny(2.20–1.96 Ga..Extensive mixing/mingling between ba.a.tic a.d crust-derived ma.ma. took pla.e a. lower crusta. depths,producing coeva. hybrid diorites a.d qua.tz-diorites.(ii)Syn-collisiona. ma.ma.ism(630–624 Ma.encompa.ses biotite-a.d muscovite-bea.ing gra.odiorites a.d monzogra.ites,preserving their structures pa.a.lel to the schistosity of the country *** rocks a.e leucocra.ic,wea.ly meta.uminous to pera.uminous,a.d conta.n a.unda.t surmica.eous *** fea.ures a.d geochemica. composition suggest a. origin rela.ed to the pa.tia. melting of gra.wa.ke protoliths with a.subordina.e igneous component.(iii)La.e-collisiona. ma.ma.ism(625–600 Ma.includes undeformed a.d isotropic monzonites a.d gra.odiorites,which trunca.e the regiona. *** rocks a.e consistently meta.uminous a.d ma.nesia.,showing a.finities with the high-K ca.c-a.ka.ine to shoshonite *** element modeling with su

关键词： Bra.ilia.o/Pa.-a.rica. Orogeny Western Gondwa.a Zircon a.d tita.ite U-Pb da.ing Hf isotope da.a Ma.ma.source

Mecha.isms a.d consequences of COVID-19 a.socia.ed liver injury: Wha. ca. we a.firm?

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World Journa. of Hepa.ology 2020年第8期12卷 413-422页

作者： Ca.los a.tunes Brito Fa.io marinho Ba.ros Edmundo Pessoa.Lopes Depa.tment of Interna. Medicine Center of Medical Sciences of Federal University of PernambucoRecifePernambuco 50740600Brazil Clinica. Hospita. of Federa. University of Perna.buco RecifePernambuco 50740900Brazil Post-gra.ua.ion Progra. of Tropica. Medicine of Federa. University of Perna.buco RecifePernambuco 50670901Brazil a.toimmune Resea.ch Institute RecifePernambuco 52011010Brazil Português Hospita. of Perna.buco RecifePernambuco 52010075Brazil

Since the first reports of corona.irus disea.e 2019(COVID-19)ca.es in December 2019 in China.numerous pa.ers ha.e been published describing a.high frequency of liver injury a.socia.ed with severe a.ute respira.ory syndrome corona.irus 2 infection,ma.y of them proposing a.link between these findings a.d pa.ient *** in serum a.inotra.sfera.e levels(ra.ging from 16%to 62%)a.d bilirubin levels(ra.ging from 5%to 21%)ha.e been reported a.d seem to be more often observed in pa.ients with severe forms of *** a.solute cha.ges in these pa.a.eters a.e frequently seen,other va.ia.les,such a. the ra.io a.ove the upper limit of norma.,the onset of liver injury a. a.complica.ion in severe ca.es a.d histopa.hologica. findings,reinforce tha. liver cha.ges a.e of dubious clinica. releva.ce in the course of this *** fa.tors must a.so be considered in these a.a.yses,such a. the repercussions of hemodyna.ic cha.ges,the presence of thrombotic events,a.d,ma.nly,the possible drug-induced liver injury with the current,yet off-la.el,*** pa.er a.med to a.a.yze the currently a.a.la.le da.a.on liver injury in pa.ients with COVID-19.

关键词： COVID-19 Sa.S-CoV-2 Liver injury Liver enzymes Drug induced liver injury Pa.demic