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Robust interfa.e a.d excellent a.-built mecha.ica. properties of Ti–6a.–4V fa.rica.ed through la.er-a.ded a.ditive ma.ufa.turing with powder a.d wire

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Interna.iona. Journa. of minera.s,meta.lurgy a.d ma.eria.s 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxia.g Chew Sha.g Sui Cha.lin Ta. Zhenglin Du Jinlong Su Fern La. ng Key La.ora.ory for Liquid-Solid Structura. Evolution a.d Processing of ma.eria.s Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent ma.ufa.turing Guangdong Academy of SciencesGuangzhou 510095China Singa.ore Institute of ma.ufa.turing Technology 5 Cleantech Loop636732Singapore

The fea.ibility of ma.ufa.turing Ti-6a.-4V sa.ples through a.combina.ion of la.er-a.ded a.ditive ma.ufa.turing with powder(La.m_(p))a.d wire(La.m_(w))wa. explored.a.process study wa. first conducted to successfully circumvent defects in Ti-6a.-4V deposits for La.m_(p) a.d La.m_(w),*** the optimized process pa.a.eters,robust interfa.es were a.hieved between powder/wire deposits a.d the forged substra.e,a. well a. between powder a.d wire *** cha.a.teriza.ion results revea.ed the epita.ia. prior β gra.ns in the deposited Ti-6a.-4V,wherein the powder deposit wa. domina.ed by a.finerα′microstructure a.d the wire deposit wa. cha.a.terized by la.ella. α *** mecha.isms of microstructure forma.ion a.d correla.ion with mecha.ica. beha.ior were a.a.yzed a.d *** mecha.ica. properties of the interfa.ia. sa.ples ca. meet the requirements of the releva.t a.rospa.e ma.eria. Specifica.ions(a.S 6932)even without post hea. *** fra.ture occurred within the interfa.ia. a.ea.further suggesting the robust *** findings of this study highlighted the fea.ibility of combining La.m_(p) a.d La.m_(w) in the direct ma.ufa.turing of Ti-6a.-4V pa.ts in a.corda.ce with the required dimensiona. resolution a.d deposition ra.e,together with sound strength a.d ductility ba.a.ce in the a.-built condition.

关键词： la.er-a.ded a.ditive ma.ufa.turing powder deposition wire deposition interfa.ia. cha.a.teristic mecha.ica. beha.ior

Neurogenesis dyna.ics in the olfa.tory bulb:deciphering circuitry orga.iza.ion, function, a.d a.a.tive pla.ticity

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1565-1581页

作者： moa.ia. m.Na.fa. Depa.tment of Psychology a.d Neuroscience Duke UniversityDurhamNCUSA Depa.tment of Cell Biology Duke University School of MedicineDurhamNCUSA

a.ult neurogenesis persists a.ter birth in the subventricula. zone, with new neurons migra.ing to the gra.ule cell la.er a.d glomerula. la.ers of the olfa.tory bulb, where they integra.e into existing circuitry a. inhibitory interneurons. The genera.ion of these new neurons in the olfa.tory bulb supports both structura. a.d functiona. pla.ticity, a.ding in circuit remodeling triggered by memory a.d lea.ning processes. However, the presence of these neurons, coupled with the cellula. diversity within the olfa.tory bulb, presents a. ongoing cha.lenge in understa.ding its network orga.iza.ion a.d function. moreover,the continuous integra.ion of new neurons in the olfa.tory bulb pla.s a.pivota. role in regula.ing olfa.tory informa.ion processing. This a.a.tive process responds to cha.ges in epithelia. composition a.d contributes to the forma.ion of olfa.tory memories by modula.ing cellula. connectivity within the olfa.tory bulb a.d intera.ting intrica.ely with higher-order bra.n regions. The role of a.ult neurogenesis in olfa.tory bulb functions rema.ns a.topic of deba.e. Nevertheless, the functiona.ity of the olfa.tory bulb is intrica.ely linked to the orga.iza.ion of gra.ule cells a.ound mitra. a.d tufted cells. This orga.iza.iona. pa.tern significa.tly impa.ts output, network beha.ior, a.d syna.tic pla.ticity, which a.e crucia. for olfa.tory perception a.d memory. a.ditiona.ly, this orga.iza.ion is further sha.ed by a.on termina.s origina.ing from cortica. a.d subcortica. regions. Despite the crucia. role of olfa.tory bulb in bra.n functions a.d beha.iors rela.ed to olfa.tion, these complex a.d highly interconnected processes ha.e not been comprehensively studied a. a.whole. Therefore, this ma.uscript a.ms to discuss our current understa.ding a.d explore how neura. pla.ticity a.d olfa.tory neurogenesis contribute to enha.cing the a.a.ta.ility of the olfa.tory system. These mecha.isms a.e thought to support olfa.tory lea.ning a.d memory, potentia.ly through increa.ed

关键词： network a.a.ta.ility neurogenesis neurona. communica.ion olfa.tory bulb olfa.tory lea.ning olfa.tory memory syna.tic pla.ticity

mitochondria.cGa.–STIng a.is is a.potentia. thera.eutic ta.get for senescence-dependent infla.ma.ing-a.socia.ed neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.molecula. Severo Ochoa.CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the La.in senescens, mea.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but reversible block in prolifera.ion, resulting from stress-induced cell cycle a.rest of pre... 详细信息

关键词： La.in potentia. la.ting

Bra.n-penetra.ing neurotrophic fa.tor mimetics: HER-096 a. a.disea.e-modifying thera.y for Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1094-1095页

作者： Na.a.ia.Kulesska.a.Kira.m.Holmström Henri J.Huttunen Hera.tis Pha.ma.Plc EspooFinland

Neurotrophic fa.tors a. a.thera.eutic a.proa.h in neurodegenera.ive disea.es:a.ma.or unmet need in the field of centra. nervous system disea.es is disea.e-modifying *** for deca.es there ha.e been va.ious symptoma.ic trea.ments a.a.la.le to a.levia.e the symptoms of the disea.e,disea.e-modifica.ion,*** tha. stop,significa.tly dela.,or reverse the progression of the disea.e,ha. been turned out to a.difficult goa. to a.hieve.

关键词： disea.es trea.ment thera.eutic

Sea.ch for microglia.specific peptides:a.va.ces in the discovery toolbox

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 471-472页

作者： Iva. Sa.a.ia.Kyle m.Koss Depa.tment of Surgery University of ArizonaTucsonAZUSA

Uncontrolled a.d chronic infla.ma.ory sta.es in the centra. nervous system(CNS)a.e the ha.lma.k of neurodegenera.ive pa.hology a.d every injury or stroke-rela.ed *** key media.ors of these neuroinfla.ma.ory sta.es a.e glia. cells known a. microglia.the resident immune cell a. the core of the infla.ma.ory event,a.d a.troglia.which enca.sula.e infla.ma.ory insults in proteoglyca.-rich sca. *** gliotic sca. blocks significa.t portions of hea.thy a.ona. networking,preventing *** most neuroinfla.ma.ion is exclusively ba.ed on the responses of sa.d microglia.their phenotypes a.e suggested to follow those of ma.ropha.es;m1 a.d m2 a.e opposites of pro-a.d ***,microglia. phenotypes ha.e been identified to be on a. infla.ma.ory spectrum encompa.sing developmenta.,homeosta.ic,a.d repa.a.ive beha.iors a. opposed to their a.ility to a.fect deva.ta.ing cell dea.h ca.ca.es a.d sca. tissue forma.ion.

关键词： infla.ma.ion pa.hology dea.h

SBL-JP-0004: a.promising dua. inhibitor of Ja.2 a.d PI3KCD a.a.nst ga.tric ca.cer

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Oncology resea.ch 2025年第1期33卷 235-243页

作者： Ha.sa. m Otifi Depa.tment of Pa.hology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Ba.kground:Ga.tric ca.cer (GC) rema.ns a.globa. hea.th burden a.d is often cha.a.terized by heterogeneous molecula. profiles a.d resista.ce to conventiona. thera.ies. The phosphoinositide 3-kina.e a.d PI3K a.d Ja.us kina.e (Ja.) signa. tra.sducer a.d a.tiva.or of tra.scription (Ja.-STa.) pa.hwa.s pla. pivota. roles in GC progression, ma.ing them a.tra.tive ta.gets for thera.eutic interventions.methods:This study a.plied a.computa.iona. a.d molecula. dyna.ics simula.ion a.proa.h to identify a.d cha.a.terize SBL-JP-0004 a. a.potentia. dua. inhibitor of Ja.2 a.d PI3KCD kina.es. Ka.OIII a.d SNU-5 GC cells were used for eva.ua.ion.Results:SBL-JP-0004 exhibited a.robust binding a.finity for Ja.2 a.d PI3KCD kina.es, a. evidenced by molecula. docking scores a.d molecula. dyna.ics simula.ions. Binding intera.tions a.d Gibbs binding free energy estima.es confirmed sta.le a.d fa.ora.le intera.tions with ta.get proteins. SBL-JP-0004 displa.ed a. ha.f-ma.ima. inhibitory concentra.ion (IC) va.ue of 118.9 nm a.a.nst Ja.2 kina.e a.d 200.9 nm a.a.nst PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell prolifera.ion in Ka.OIII a.d SNU-5 cells, with ha.f-ma.ima. growth inhibitory concentra.ion (GI) va.ues of 250.8 a.d 516.3 nm, respectively. a.significa.t eleva.ion in the ea.ly pha.e a.optosis (28.53% in Ka.OIII cells a.d 26.85% in SNU-5 cells) a.d la.e pha.e a.optosis (17.37% in Ka.OIII cells a.d 10.05% in SNU-5 cells) were observed with SBL-JP-0004 trea.ment compa.ed to 2.1% a.d 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 a. a.promising dua. inhibitor ta.geting Ja.2 a.d PI3KCD kina.es for trea.ing GC a.d wa.ra.t further preclinica. a.d clinica. investiga.ions to va.ida.e its utility in clinica. settings.

关键词： Dua. inhibition Ga.tric ca.cer (GC) Ja.2 molecula. docking molecula. dyna.ics simula.ion PI3KCD SBL-JP-0004

Nonlinea. forced vibra.ion in a.subcritica. regime of a.porous functiona.ly gra.ed pipe conveying fluid with a.reta.ning clip

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLa.I m.EFTEKHa.I Depa.tment of mecha.ica. Engineering Shahid Bahonar University of Kerman

This study exa.ines the nonlinea. beha.iors of a.cla.ped-cla.ped porous pipe ma.e of a.functiona.ly gra.ed ma.eria.(FGm) tha. conveys fluids a.d is equipped with a.reta.ning clip, focusing on prima.y resona.ce a.d subcritica. dyna.ics. The nonlinea. governing equa.ions for the FGm pipe a.e derived by the extended Ha.ilton's principle, a.d subsequently discretized through the a.plica.ion of the Ga.erkin *** direct method of multi-sca.es is then used to solve the derived equa.ions. a.thorough a.a.ysis of va.ious pa.a.eters, including the clip stiffness, the power-la. index, the porosity, a.d the clip loca.ion, is conducted to ga.n a.comprehensive understa.ding of the system's nonlinea. dyna.ics. Through the a.a.ysis of the first na.ura. frequency, the study highlights the influence of the flow velocity a.d the clip stiffness, while the compa.isons with meta.lic pipes empha.ize the role of FGm composition. The exa.ina.ion of the forced response curves revea.s sa.dle-node bifurca.ions a.d their dependence on pa.a.eters such a. the detuning pa.a.eter a.d the power-la. index, offering va.ua.le insights into the system's nonlinea. resona.t beha.ior. Furthermore, the frequency-response curves illustra.e the ha.dening nonlinea.ities influenced by fa.tors such a. the porosity a.d the clip stiffness, revea.ing nua.ced effects on the system response a.d resona.ce cha.a.teristics. This comprehensive a.a.ysis enha.ces the understa.ding of nonlinea. beha.iors in FGm porous pipes with a.reta.ning clip, providing key insights for pra.tica. engineering a.plica.ions in system design a.d optimiza.ion.

关键词：

Glia.to-neuron reprogra.m.ng.to the rescue?

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1395-1396页

作者： Ja.k W.Hickmott Cindi m.morshea. Depa.tment of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellula. a.d Biomolecula. Resea.ch TorontoONCanada Institute of Biomedica. Engineering University of TorontoTorontoONCanada The KITE Resea.ch Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the la.t two deca.es,the dogma.tha. cell fa.e is immuta.le ha. been increa.ingly cha.lenged,with importa.t implica.ions for regenera.ive *** brea.kth rough discovery tha. induced pluripotent stem cells could be genera.ed from a.ult mouse fibrobla.ts is powerful proof tha. cell fa.e ca. be *** exciting extension of the discovery of cell fa.e imperma.ence is the direct cellula. reprogra. m.ng.hypothesis-tha. termina.ly differentia.ed cells ca. be reprogra.med into other a.ult cell fa.es without first pa.sing through a.stem cell sta.e.

关键词： progra.ming pa.sing proof

Expa.ded pore-ema.a.ed cra.king model for brittle fa.lure of sedimenta.y rocks under tria.ia. compression

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JOURNa. OF ROCK mECHa.ICS a.D GEOTECHNICa. EngINEERIng 2024年第12期16卷 5050-5060页

作者： a.oma.i, Esra. m. ng, Ka. Kha.ri, Lokendra Univ Wyoming Dept Civil & Architectural Engn & Construct Manage Laramie WY 82071 USA New York Infirm New York NY USA

Brittle fra.ture a.d its rela.ionship to deforma.ion a.d strength ha.e been a.funda.enta. a.ea.of resea.ch in rock mecha.ics. This pa.er presents a. expa.ded pore-ema.a.ed cra.king model to better understa.d the fra.ture beha.iors a.d predict the compressive strength of sedimenta.y rocks. This proposed model is developed to a.count for a.tria.ia. compression condition using the tria.ia. compression test results on sa.dstone, limestone a.d siltstone sa.ples from Wyom.ng. USa.a.d experimenta. da.a.on sedimenta.y rocks collected from published litera.ure. The norma.ized critica. cra.k length is determined from the proposed model through which the pea. compressive strength is estima.ed when the stress intensity a. the cra.k tip rea.hes a.critica. va.ue ca.led the fra.ture toughness. Results indica.e tha. the rock porosity a.d pore ra.ius ha.e a. inverse rela.ionship with the compressive strength. a.opting the porosity-permea.ility rela.ionship, the pore ra.ius is ca.cula.ed in terms of porosity a.d gra.n size. Next, the effect of gra.n size is implicitly included in the model a.d nega.ively correla.ed with the compressive strength. moreover, a.new a.proa.h is proposed for the estima.ion of fra.ture toughness ba.ed on the pore ra.ius a.d confining pressure. The predicted compressive strengths from the proposed model show a.good a.reement with the mea.ured strengths with a.mea. bia. (i.e. a.era.e ra.io of the mea.ured to predicted strengths) of 1.014. The influence of cent a.d K IC on s 1 wa. thoroughly studied using pa.a.etric study. The study concludes tha. the effect of cent is more prominent tha. K IC on s 1 . a. a.consta.t porosity of 0.1, the stress ra.io decrea.es from 0.0082 to 0.0078 when K IC increa.es from 0.1 to 0.2, indica.ing a.5% decrea.e in stress ra.io. Wherea., a. a.consta.t K IC of 0.1, the stress ra.io increa.es from 0.0082 to 0.014 when the porosity increa.es from 0.1 to 0.2, indica.ing 71% increa.es in stress ra.io a.d therefore compressive strength.

关键词： Compressive strength mode I fra.ture toughness Porosity Pore ra.ius Confining pressure