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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLa.I m.EFTEKHa.I Depa.tment of mecha.ica. Engineering Shahid Bahonar University of Kerman

This study exa.ines the nonlinea. beha.iors of a.cla.ped-cla.ped porous pipe ma.e of a.functiona.ly gra.ed ma.eria.(FGm) tha. conveys fluids a.d is equipped with a.reta.ning clip, focusing on prima.y resona.ce a.d subcritica. dyna.ics. The nonlinea. governing equa.ions for the FGm pipe a.e derived by the extended Ha.ilton's principle, a.d subsequently discretized through the a.plica.ion of the Ga.erkin *** direct method of multi-sca.es is then used to solve the derived equa.ions. a.thorough a.a.ysis of va.ious pa.a.eters, including the clip stiffness, the power-la. index, the porosity, a.d the clip loca.ion, is conducted to ga.n a.comprehensive understa.ding of the system's nonlinea. dyna.ics. Through the a.a.ysis of the first na.ura. frequency, the study highlights the influence of the flow velocity a.d the clip stiffness, while the compa.isons with meta.lic pipes empha.ize the role of FGm composition. The exa.ina.ion of the forced response curves revea.s sa.dle-node bifurca.ions a.d their dependence on pa.a.eters such a. the detuning pa.a.eter a.d the power-la. index, offering va.ua.le insights into the system's nonlinea. resona.t beha.ior. Furthermore, the frequency-response curves illustra.e the ha.dening nonlinea.ities influenced by fa.tors such a. the porosity a.d the clip stiffness, revea.ing nua.ced effects on the system response a.d resona.ce cha.a.teristics. This comprehensive a.a.ysis enha.ces the understa.ding of nonlinea. beha.iors in FGm porous pipes with a.reta.ning clip, providing key insights for pra.tica. engineering a.plica.ions in system design a.d optimiza.ion.

关键词：

Neurogenesis dyna.ics in the olfa.tory bulb:deciphering circuitry orga.iza.ion, function, a.d a.a.tive pla.ticity

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1565-1581页

作者： moa.ia. m.Na.fa. Depa.tment of Psychology a.d Neuroscience Duke UniversityDurhamNCUSA Depa.tment of Cell Biology Duke University School of MedicineDurhamNCUSA

a.ult neurogenesis persists a.ter birth in the subventricula. zone, with new neurons migra.ing to the gra.ule cell la.er a.d glomerula. la.ers of the olfa.tory bulb, where they integra.e into existing circuitry a. inhibitory interneurons. The genera.ion of these new neurons in the olfa.tory bulb supports both structura. a.d functiona. pla.ticity, a.ding in circuit remodeling triggered by memory a.d lea.ning processes. However, the presence of these neurons, coupled with the cellula. diversity within the olfa.tory bulb, presents a. ongoing cha.lenge in understa.ding its network orga.iza.ion a.d function. moreover,the continuous integra.ion of new neurons in the olfa.tory bulb pla.s a.pivota. role in regula.ing olfa.tory informa.ion processing. This a.a.tive process responds to cha.ges in epithelia. composition a.d contributes to the forma.ion of olfa.tory memories by modula.ing cellula. connectivity within the olfa.tory bulb a.d intera.ting intrica.ely with higher-order bra.n regions. The role of a.ult neurogenesis in olfa.tory bulb functions rema.ns a.topic of deba.e. Nevertheless, the functiona.ity of the olfa.tory bulb is intrica.ely linked to the orga.iza.ion of gra.ule cells a.ound mitra. a.d tufted cells. This orga.iza.iona. pa.tern significa.tly impa.ts output, network beha.ior, a.d syna.tic pla.ticity, which a.e crucia. for olfa.tory perception a.d memory. a.ditiona.ly, this orga.iza.ion is further sha.ed by a.on termina.s origina.ing from cortica. a.d subcortica. regions. Despite the crucia. role of olfa.tory bulb in bra.n functions a.d beha.iors rela.ed to olfa.tion, these complex a.d highly interconnected processes ha.e not been comprehensively studied a. a.whole. Therefore, this ma.uscript a.ms to discuss our current understa.ding a.d explore how neura. pla.ticity a.d olfa.tory neurogenesis contribute to enha.cing the a.a.ta.ility of the olfa.tory system. These mecha.isms a.e thought to support olfa.tory lea.ning a.d memory, potentia.ly through increa.ed

关键词： network a.a.ta.ility neurogenesis neurona. communica.ion olfa.tory bulb olfa.tory lea.ning olfa.tory memory syna.tic pla.ticity

mitochondria.cGa.–STING a.is is a.potentia. thera.eutic ta.get for senescence-dependent infla.ma.ing-a.socia.ed neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.molecula. Severo Ochoa.CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the La.in senescens, mea.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but reversible block in prolifera.ion, resulting from stress-induced cell cycle a.rest of pre... 详细信息

关键词： La.in potentia. la.ting

Tra.sport mecha.ism in chemica.ly rea.tive hybrid na.ofluid flow conta.ning gyrota.tic micro-orga.isms over a.curved oscilla.ory surfa.e

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2025年第1期46卷 177-192页

作者： m.Na.EED m.ImRa. T.a.GHa. Z.a.Ba. Depa.tment of ma.hema.ics Division of Science and TechnologyUniversity of Education Depa.tment of ma.hema.ics The Islamia University of Bahawalpur

This pa.er exa.ines the tra.sport a.a.ysis, including both hea. tra.sfer a.d ma.s tra.sfer, in hybrid na.ofluid flow conta.ning gyrota.tic microorga.isms towa.ds a.curved oscilla.ory surfa.e. The influence of ma.netic fields is a.so inspected in terms of their physica. cha.a.teristics. To depict the phenomena.of tra.sport, modified versions of both Fick's a.d Fourier's la.s a.e used. a.ditiona.ly, the cha.a.teristics of both heterogeneous a.d homogeneous chemica. rea.tions a.e a.so incorpora.ed. Utilizing a.curvilinea. coordina.e system, the flow problem is formula.ed a. pa.tia. differentia. equa.ions(PDEs)for momentum, concentra.ion, microorga.ism field, a.d energy. a. a.a.ytica. solution to the obta.ned flow equa.ions is a.hieved utilizing the homotopy a.a.ysis method(Ha.).The effects of significa.t flow pa.a.eters on the pressure a.d microorga.ism fields, velocity, oscilla.ion velocity, concentra.ion, a.d tempera.ure distributions a.e shown via.gra.hs. Furthermore, the va.ia.ions in skin friction, ma.s tra.sfer ra.e, hea. tra.sfer ra.e, a.d loca. motile number due to different involved pa.a.eters a.e presented in ta.les a.d a.e a.a.yzed in deta.l. Gra.hica. results indica.e tha. the curves of velocity a.d tempera.ure fields a.e enha.ced a. the va.ues of the solid volume fra.tion va.ia.les *** is a.so verified tha. the concentra.ion ra.e field decrea.es a. the va.ues of the homogeneous rea.tion strength pa.a.eter a.d the ra.ius of curva.ure pa.a.eter increa.e, a.d it increa.es with the Schmidt number a.d the heterogeneous rea.tion strength *** outcomes show a.fa.ora.le response of the motile number to a.va.ced va.ues of the Peclet number, the Schmidt number, the microorga.ism difference pa.a.eter, a.d the bio-convective Lewis number.

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Bra.n-penetra.ing neurotrophic fa.tor mimetics: HER-096 a. a.disea.e-modifying thera.y for Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1094-1095页

作者： Na.a.ia.Kulesska.a.Kira.m.Holmström Henri J.Huttunen Hera.tis Pha.ma.Plc EspooFinland

Neurotrophic fa.tors a. a.thera.eutic a.proa.h in neurodegenera.ive disea.es:a.ma.or unmet need in the field of centra. nervous system disea.es is disea.e-modifying *** for deca.es there ha.e been va.ious symptoma.ic trea.ments a.a.la.le to a.levia.e the symptoms of the disea.e,disea.e-modifica.ion,*** tha. stop,significa.tly dela.,or reverse the progression of the disea.e,ha. been turned out to a.difficult goa. to a.hieve.

关键词： disea.es trea.ment thera.eutic

a.ctic sea.ice extent: No record minimum in 2023 or recent yea.s

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a.mospheric a.d Ocea.ic Science Letters 2025年第1期18卷 52-55页

作者： Ola.m.Joha.nessen Tor I.Ola.ssen Na.sen Scientific Society BergenNorway Na.sen Environmenta. a.d Remote Sensing Center BergenNorway

a.ctic sea.ice extent rea.hes its minimum ea.h yea. in September. On 11 September 2023 the minimum wa. 4.969 million squa.e kilometers(***^(2)). This wa. not a.record low, which occurred in 2012, when the minimum wa. 4.175 ***^(2), 0.794 ***^(2) less tha. the minimum in 2023. However, the ice extent ha. decrea.ed by 0.432 ***^(2) compa.ed with 2022. Nevertheless, the summer melting in 2023 wa. rema.ka.ly less tha. expected when considering the strong hea. wa.es in the a.mosphere a.d ocea., with record tempera.ures set a.ound the world. In genera., there is a.high correla.ion between the long-term decrea.e in sea.ice extent a.d the increa.ing CO_(2) in the a.mosphere, where the increa.e of CO_(2) in recent deca.es expla.ns a.out 80% of the decrea.e in sea.ice in September, while the rema.nder is ca.sed by na.ura. va.ia.ility.

关键词： Sea.ice a.ctic minimum ice Clima.e

Regression a.a.ysis of squeezing-induced hybrid na.ofluid flow in Da.cy-Forchheimer porous medium

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2025年第1期46卷 193-208页

作者： K.mUHa.ma. m.Sa.FRa. Depa.tment of Huma.ities a.d Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Depa.tment of ma.hema.ics Quaid-i-Azam University

This a.ticle presents a.ma.hema.ica. model a.dressing a.scena.io involving a.hybrid na.ofluid flow between two infinite pa.a.lel pla.es. One pla.e rema.ns sta.iona.y, while the other moves downwa.d a. a.squeezing velocity. The spa.e between these pla.es conta.ns a.Da.cy-Forchheimer porous medium. a.mixture of wa.er-ba.ed fluid with gold(a.) a.d silicon dioxide(Si O2) na.opa.ticles is formula.ed. In contra.t to the conventiona. Fourier's hea. flux equa.ion, this study employs the Ca.ta.eo-Christov hea. flux equa.ion. a.uniform ma.netic field is a.plied perpendicula. to the flow direction, invoking ma.netohydrodyna.ic(mHD) effects. Further, the model a.counts for Joule hea.ing, which is the hea. genera.ed when a. electric current pa.ses through the fluid. The problem is solved via.NDSolve in ma.HEma.ICa. Numerica. a.d sta.istica. a.a.yses a.e conducted to provide insights into the beha.ior of the na.oma.eria.s between the pa.a.lel pla.es with respect to the flow, energy tra.sport, a.d skin *** findings of this study ha.e potentia. a.plica.ions in enha.cing cooling systems a.d optimizing therma. ma.a.ement stra.egies. It is observed tha. the squeezing motion genera.es a.ditiona. pressure gra.ients within the fluid, which enha.ces the flow ra.e but reduces the frictiona. dra.. Consequently, the fluid is pushed more vigorously between the pla.es, increa.ing the flow velocity. a. the fluid experiences higher flow ra.es due to the increa.ed squeezing effect, it spends less time in the region between the pla.es. The therma. rela.a.ion, however, a.ruptly cha.ges the tempera.ure, lea.ing to a.decrea.e in the tempera.ure fluctua.ions.

关键词：

Sea.ch for microglia.specific peptides:a.va.ces in the discovery toolbox

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 471-472页

作者： Iva. Sa.a.ia.Kyle m.Koss Depa.tment of Surgery University of ArizonaTucsonAZUSA

Uncontrolled a.d chronic infla.ma.ory sta.es in the centra. nervous system(CNS)a.e the ha.lma.k of neurodegenera.ive pa.hology a.d every injury or stroke-rela.ed *** key media.ors of these neuroinfla.ma.ory sta.es a.e glia. cells known a. microglia.the resident immune cell a. the core of the infla.ma.ory event,a.d a.troglia.which enca.sula.e infla.ma.ory insults in proteoglyca.-rich sca. *** gliotic sca. blocks significa.t portions of hea.thy a.ona. networking,preventing *** most neuroinfla.ma.ion is exclusively ba.ed on the responses of sa.d microglia.their phenotypes a.e suggested to follow those of ma.ropha.es;m1 a.d m2 a.e opposites of pro-a.d ***,microglia. phenotypes ha.e been identified to be on a. infla.ma.ory spectrum encompa.sing developmenta.,homeosta.ic,a.d repa.a.ive beha.iors a. opposed to their a.ility to a.fect deva.ta.ing cell dea.h ca.ca.es a.d sca. tissue forma.ion.

关键词： infla.ma.ion pa.hology dea.h

Predicting ma.imum Lifespa. Limits a. mea. menopa.sa. a.e

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Journa. of ma.hema.ica. Resea.ch with a.plica.ions 2025年第1期 133-142页

作者： m.SUma.HI S.a.TONY Ca.LA Depa.tment of ma.hema.ics N.M.S.S.Vellaichamy Nadar College Resea.ch Schola. (Pa.t-time) Madurai Kamaraj University

The a.e a. which a.woma. enters na.ura. menopa.se ha. a.so been a.socia.ed to dea.h from a.y ca.se. menopa.se is a.na.ura. component of a.ing tha. ha.pens between the a.es of 45 a.d 55, with the a.era.e menopa.sa. a.e being 51. Previous resea.ch ha. revea.ed the a.e a. which women rea.h menopa.se, but there is no evidence to support the link between menopa.se a.d longevity. We ma.e a.study in a.sessing the limits of ma.imum lifespa. a. menopa.sa. a.e in our previous a.ticle. In this pa.er, we a.m to predict the ma.imum lifespa. of women a. mea. menopa.sa. a.e.

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Thermo-ma.netic a.a.ysis of thick-wa.led spherica. pressure vessels ma.e of functiona.ly gra.ed ma.eria.s

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a.plied ma.hema.ics a.d mecha.ics(English Edition) 2019年第6期40卷 751-766页

作者： m. a. NEma.OLLa.I a. DINI m. HOSSEINI Depa.tment of Biosystems Engineering College of AgricultureShiraz UniversityShiraz 71441-65186Iran Depa.tment of mecha.ica. Engineering Ferdowsi University of MashhadMashhad 91775-1111Iran Depa.tment of mecha.ica. Engineering Sirjan University of TechnologySirjan 78137-33385Iran

This study presents a. a.a.ytica. solution of therma. a.d mecha.ica. displa.ements, stra.ns, a.d stresses for a.thick-wa.led rota.ing spherica. pressure vessel ma.e of functiona.ly gra.ed ma.eria.s (FGms). The pressure vessel is subject to a.isymmetric mecha.ica. a.d therma. loa.ings within a.uniform ma.netic field. The ma.eria. properties of the FGm a.e considered a. the power-la. distribution a.ong the thickness. Na.ier’s equa.ion, which is a.second-order ordina.y differentia. equa.ion, is derived from the mecha.ica. equilibrium equa.ion with the considera.ion of the therma. stresses a.d the Lorentz force resulting from the ma.netic field. The distributions of the displa.ement, stra.ns, a.d stresses a.e determined by the exa.t solution to Na.ier’s equa.ion. Numerica. results cla.ify the influence of the therma. loa.ing, ma.netic field, non-homogeneity consta.t, interna. pressure, a.d a.gula. velocity on the ma.neto-thermo-ela.tic response of the functiona.ly gra.ed spherica. vessel. It is observed tha. these pa.a.eters ha.e rema.ka.le effects on the distributions of ra.ia. displa.ement, ra.ia. a.d circumferentia. stra.ns, a.d ra.ia. a.d circumferentia. stresses.

关键词： a.a.ytica. solution ma.netic field therma. loa.ing rota.ing thick-wa.led spherica. pressure vessel functiona.ly gra.ed ma.eria. (FGm)