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Tra.sloca.or protein a.d neurodegenera.ion: insights from a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1090-1091页

作者： a.pit kumar Pra.ha. Ra.ner Rupprecht Gerha.d Ra.mes Klinik für a.a.sthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Gra.ua.e School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Depa.tment of Psychia.ry a.d Psychothera.y University RegensburgRegensburgGermany

The 18 kDa.tra.sloca.or protein(TSPO)loca.ed on the outer mitochondria. membra.e regula.es severa. key cellula. processes including mitochondria. homeosta.is,cholesterol tra.sport,a.optosis,cell prolifera.ion,a.d ma.ntena.ce of mitochondria. hea.th(Rupprecht et a..,2022,2023).TSPO is expressed in both periphera. orga.s a.d the centra. nervous system,with a.more pronounced expression in tissues tha. produce *** ma.n rea.on why TSPO ha. ga.nered so much a.tention is beca.se it pla.s a.key role in neurosteroidogenesis by tra.sferring cholesterol from the outer to the inner mitochondria. membra.e,which is the ra.e-limiting step in neurosteroid synthesis.a.cholesterol-recognizing a.ino a.id consensus doma.n ha. been identified in the cytosolic C terminus of the TSPO protein by both in vitro a.d site-directed muta.enesis experiments(Li et a..,2001).However,the role of TSPO in the process of neurosteroid synthesis ha. been cha.lenged by severa. studies,pa.ticula.ly TSPO knockout models,which suggest tha. TSPO remova. does not a.fect the phenotype or the system’s via.ility(Tu et a..,2014).However,liga.ds ta.geting TSPO ha.e been shown to enha.ce levels of neurosteroids which suggests tha. neurosteroidogenesis is one of the ma.or functiona. roles media.ed by the TSPO protein.

关键词： cholesterol orga.s

Breeding Sorghum Using Induced Muta.ions: Future Prospect for Na.ibia

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a.erica. Journa. of Pla.t Sciences 2018年第13期9卷 2696-2707页

作者： Ma.ia.a.a.hon Wa.ga.a. a.hok kumar Gra.e Na.desora.Ka.gueehi Hussein Shimelis Lydia.N. Horn Fa.ma.Sa.su Ja.a.na.F. N. a.dowa Directora.e of Resea.ch a.d Tra.ning Ministry of Agriculture Water and Forestry Windhoek Namibia Depa.tment of a.riculture a.d Na.ura. Resources Sciences Namibia University of Science and TechnologyWindhoek Namibia Interna.iona. Crops Resea.ch Institute for the Semi-a.id Tropics (ICRISa.) Hyderabad India School of a.riculture Earth and Environmental Sciences University of KwaZulu-Natal Pietermaritzburg South Africa Multidisciplina.y Resea.ch Centre University of Namibia Windhoek Namibia Pla.t Breeding a.d Genetics Section Department of Nuclear Sciences and Applications International Atomic Energy Agency (IAEA) Vienna International Centre Vienna Austria

In a.id a.d semi-a.id regions of the world sorghum sta.ds out a. a.clima.e cha.ge-rea.y crop with high potentia. for the production of food, feed, fodder, fiber a.d fuel in the fa.e of increa.ing huma. popula.ion. The present review highlights induced muta.ion breeding technique a. a.potentia. tool for improving sorghum in Na.ibia. The review discussed the following issues;crop improvement using muta.ens, muta.t screening, selection a.d eva.ua.ion, impa.t of induced muta.ion breeding, fa.tors for declining production a.d future implica.ion of sorghum muta.ion breeding. In Na.ibia. severe drought stress resulting in tota. crop fa.lure ha. become frequent. This is pa.tly a.consequence of fa.mers growing crop va.ieties which ca.not withsta.d impa.t of drought. a. such Na.ibia.ha. limited drought tolera.t va.ieties a.a.la.le for the diverse a.ro-ecologies. Fa.mers keep growing the fa.ilia. la.dra.es which performs well in good ra.nfa.l yea.s but fa.ls to produce sta.le yield with irregula. a.d erra.ic ra.nfa.l. Thus, breeding new sorghum va.ieties of high yield a.d qua.ity combined with multiple a.ronomic tra.ts including pest a.d disea.e resista.ce a.d high efficiency in nutrient a.d wa.er use is needed. Induced muta.ion is one of the breeding methods utilized worldwide to supplement conventiona. breeding for developing superior va.ieties with desira.le tra.ts in different crops. Development of high yielding, drought tolera.t, a.d dwa.f sorghums with ea.ly ma.urity ena.les effective utiliza.ion of a.a.la.le soils moisture a.d in optimizing pla.t density for a.hieving higher yield in fa.mers’ fields. Recombina.ion breeding through exploita.ion of na.ura. genetic va.ia.ility a.d muta.ion breeding to reduce the pla.t height without disturbing a.ronomic superiority of elite lines is recommended for sorghum improvement in Na.ibia.

关键词： Breeding Induced Muta.ion Na.ibia Sorghum

18F-FDGPET/CT对局部进展性乳腺癌病人新辅助化疗早期反应的评价作用

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国际医学放射学杂志 2009年第4期32卷 409-410页

作者： a. kumar R. kumar V. Seenu S.D. Gupta.M. Cha.la.a. Ma.hotra.范璐（译）刘筠（校） E-81 A nsari Nagar （east） A IIMS Campus New Delhi 110020 India. 不详

我们评估^18F—FDG PET／CT对于乳腺癌病人新辅助化疗（Na.T）2个周期后反应的评价作用。23例女性局部进展性乳腺癌病人纳入本研究。Na.T2个周期后，根据临床检查、CT和^18F—FDG PET／CT评价早期反应。以Na.T6个周期后手术病理结果作... 详细信息

我们评估^18F—FDG PET／CT对于乳腺癌病人新辅助化疗（Na.T）2个周期后反应的评价作用。23例女性局部进展性乳腺癌病人纳入本研究。Na.T2个周期后，根据临床检查、CT和^18F—FDG PET／CT评价早期反应。以Na.T6个周期后手术病理结果作为参照。治疗前PET／CT显示23例病人共有26个病灶。原发性肿瘤大小为1．90～11．60cm，FDG最大标准摄取值（SUVma.）为3．6～38．6（平均11．7）。Na.T2个周期后行PET／CT检查，原发性肿瘤大小为0．0—7．6cm，

关键词： FDG PET/CT 局部进展性乳腺癌新辅助化疗治疗反应评价

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远程监控服装在人员监控上的应用

国际纺织导报 2011年第8期39卷 66-67,76页

作者： L. a. kumar T. Ra.a.ha.dra. I. Vennila.刘晨（译）赵莉（校） PSG技术学院（印度）不详

探讨了远程监控服装(TG)采用的监控人员身体状况的系统。TG由电导、光导纤维织成的网和普通的机织或刺绣织物整合而成,普通织物所选用的纤维和纱线能满足服用舒适性和耐用性。最初的TG传感服是用于改进野战医院伤员的鉴别归类(根据紧迫... 详细信息

探讨了远程监控服装(TG)采用的监控人员身体状况的系统。TG由电导、光导纤维织成的网和普通的机织或刺绣织物整合而成,普通织物所选用的纤维和纱线能满足服用舒适性和耐用性。最初的TG传感服是用于改进野战医院伤员的鉴别归类(根据紧迫性和救活的可能性等可在战场上决定优先治疗的人员的方法)。

关键词：远程监控服装射入定位受伤分析 POF 传感器

Telemedicine a.d public hea.th–pea.ls a.d pitfa.ls

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World Journa. of Methodology 2025年第2期15卷 177-179页

作者： Ra.jeet kumar Sinha.Sony Sinha.Pra.eek Nisha.t a.vind kumar Morya.a.shi Singh Depa.tment of Community Medicine Patna Medical CollegePatna 800004BiharIndia Depa.tment of Ophtha.mology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Depa.tment of Ophtha.mology ESIC Medical CollegePatna 801103BiharIndia Depa.tment of Ophtha.mology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Depa.tment of Ophtha.mology Guru Nanak Eye CenterNew Delhi 110001India

We hereby comment on the interesting systema.ic review by Grewa. et a. where they ha.e provided a. overa.l picture of the current sta.us of a.a.la.le tele-hea.th progra.s in the United Sta.es with empha.is on the a.a.on *** a.a.ysis is a. a.precia.le effort in discovering the fea.ures a.a.la.le a.d fea.ures la.king in these tele-hea.th *** concept of tele-hea.th origina.ed to curta.l the need for physica. a.tenda.ce of pa.ients a. hea.th clinics,a.d ha. been beneficia. during the corona.irus disea.e 2019 *** implore tha. the pea.ls a.d pitfa.ls of these progra.s ha.e to be understood by policyma.ers prior to forming a.consensus rega.ding the a.a.la.ility,a.cessibility a.d a.forda.ility of these progra.s a. methods of hea.thca.e *** prolifera.ion of tele-hea.th progra.s in their current form ma. pose threa.s to pa.ient a.d provider sa.ety a.d medicolega. ***,pa.ients a.d providers must work together to improve them to meet their expecta.ions a.d ena.le them to provide the best ca.e for the a.ling public.

关键词： Telemedicine Remote a.cess a.a.la.ility a.cessibility a.forda.ility Ethics Priva.y Medicolega. lia.ility

Drought Resista.t Rice: a. Integra.ed Crop Improvement Stra.egy

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分子植物育种 2007年第2期5卷 211-212页

作者： R. Serra. J. Ca.rns G. a.lin a. kumar J. Bernier D. Bra. K. McNa.ly H. Leung P. Herve R. Bruskiewich J. Bennett Interna.iona. Rice Resea.ch Institute DAPO 7777 Metro Manila Philippines

Rice physiologica. sensitivity to drought a.d its impa.t on crop productivity in wa.er-limited environments a.e well-documented (O'Toole, 2004). However, rice yields in drought-prone ra.nfed lowla.ds a.d most

关键词：干旱耐受能力稻子种植

Insights into ga.trointestina. ma.ifesta.ion of huma. immunodeficiency virus:a.na.ra.ive review

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World Journa. of Virology 2025年第1期14卷 51-62页

作者： Pra.iksha.Moliya.a.mol Singh Na.deep Singh Vika.h kumar a.la. Soha. Depa.tment of Tra.spla.t Hepa.ology University of Nebraska Medical CenterOmahaNE 69198United States Depa.tment of Medicine Tristar Centennial Medical CenterNashvilleTN 37203United States Depa.tment of Medicine Government Medical CollegeAmritsar 143001PunjabIndia Depa.tment of Ga.troenterology a.d Hepa.ology Creighton University School of MedicinePhoenixAZ 85012United States

Huma. immunodeficiency virus(HIV)modifies CD4-positive cells,resulting in immunodeficiency a.d a.wide ra.ge of ga.trointestina.(GI)*** burden of HIV-rela.ed GI illnesses ha. significa.tly evolved with the widesprea. use of a.tiretrovira. thera.y(a.T).While a.T ha. effectively reduced the occurrence of opportunistic infections,it ha. led to a. increa.e in thera.y-rela.ed GI *** esopha.ea. conditions in HIV pa.ients include ga.troesopha.ea. reflux disea.e,idiopa.hic esopha.ea. ulcers,herpes simplex virus,cytomega.ovirus(CMV),a.d ca.dida. ***’s sa.coma.a.ha.lma.k of a.quired immunodeficiency syndrome,ma. a.fect the entire GI *** a.d peptic ulcer disea.e a.e a.so frequently seen in pa.ients with ***,often linked to both opportunistic infections a.d a.T,requires ca.eful *** dia.rhea.often a.sign of colitis ca.sed by ba.teria. infections such a. Shigella.or Clostridium difficile,is *** bowel lymphoma.a.though ra.e,is increa.ing in *** disorders,including proctitis,fissures,a.d a.a. squa.ous cell ca.cinoma.a.e pa.ticula.ly releva.t in homosexua. men,underlining the importa.ce of timely *** review comprehensively explores the epidemiology,pa.hogenesis,a.d trea.ment considera.ions for the va.ious GI disorders a.socia.ed with HIV,highlighting the importa.ce of a.cura.e dia.nosis a.d effective trea.ment to improve outcomes for HIV-infected pa.ients.

关键词： Huma. immunodeficiency virus Opportunistic infections a.tiretrovira. trea.ment Ga.trointestina.

Irreversible electropora.ion for meta.ta.ic pa.crea.ic ca.cinoma.with liver meta.ta.is:Wha. does the evidence sa.

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World Journa. of Clinica. Ca.es 2025年第3期13卷 30-34页

作者： Ra.it Sea. a.a.h Ba.a.ia.Bita. kumar Cha.topa.hya. Nila.ja.Sikda. Depa.tment of Genera. Surgery IPGME&R and SSKM HospitalKolkata 700020West BengalIndia Huma. Genetics Unit Indian Statistical InstituteKolkata 700108West BengalIndia Esta.rine a.d Coa.ta. Studies Founda.ion Howrah 711101India

Irreversible electropora.ion is a.promising non-therma. a.la.ion method tha. ha. been shown to increa.e overa.l surviva. in loca.ly a.va.ced pa.crea.ic ca.cer in some ***,higher qua.ity studies with proper controls a.d ra.domiza.ion a.e required to esta.lish its superiority when a.ded with neoa.juva.t chemothera.y over the current ma.a.ement of choice,which is chemothera.y *** studies a.e required before esta.lishment of a.y surviva. benefit in meta.ta.ic pa.crea.ic ca.cinoma.a.d such evidence is la.king a. present.

关键词： Irreversible electropora.ion Loca.ly a.va.ced pa.crea.ic ca.cinoma Meta.ta.ic pa.crea.ic ca.cinoma a.va.ced pa.crea.ic ca.cinoma Chemothera.y

Congruent Fea.ure Selection Method to Improve the Effica.y of Ma.hine Lea.ning-Ba.ed Cla.sifica.ion in Medica. Ima.e Processing

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 357-384页

作者： Mohd a.jum Na.ufel Kra.em Hong Min a.hit kumar Dutta.Yousef Ibra.im Da.a.keh Depa.tment of Computer Engineering Aligarh Muslim UniversityAligarh202002India College of Computer Science King Khalid UniversityAbha61413Saudi Arabia School of Computing Gachon UniversitySeongnam13120Republic of Korea Depa.tment of Computer Science a.d Informa.ion Systems College of Applied SciencesAlMaarefa UniversityRiyadh13713Saudi Arabia Depa.tment of Computer Engineering a.d Informa.ion College of Engineering in Wadi AlddawasirPrince Sattam bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia

Ma.hine lea.ning(ML)is increa.ingly a.plied for medica. ima.e processing with a.propria.e lea.ning *** a.plica.ions include a.a.yzing ima.es of va.ious orga.s,such a. the bra.n,lung,eye,etc.,to identify specific fla.s/disea.es for *** prima.y concern of ML a.plica.ions is the precise selection of flexible ima.e fea.ures for pa.tern detection a.d region *** of the extra.ted ima.e fea.ures a.e irreleva.t a.d lea. to a. increa.e in computa.ion ***,this a.ticle uses a. a.a.ytica. lea.ning pa.a.igm to design a.Congruent Fea.ure Selection Method to select the most releva.t ima.e *** process tra.ns the lea.ning pa.a.igm using simila.ity a.d correla.ion-ba.ed fea.ures over different textura. intensities a.d pixel *** simila.ity between the pixels over the va.ious distribution pa.terns with high indexes is recommended for disea.e ***,the correla.ion ba.ed on intensity a.d distribution is a.a.yzed to improve the fea.ure selection ***,the more congruent pixels a.e sorted in the descending order of the selection,which identifies better regions tha. the ***,the lea.ning pa.a.igm is tra.ned using intensity a.d region-ba.ed simila.ity to ma.imize the cha.ces of ***,the proba.ility of fea.ure selection,rega.dless of the textures a.d medica. ima.e pa.terns,is *** process enha.ces the performa.ce of ML a.plica.ions for different medica. ima.e *** proposed method improves the a.cura.y,precision,a.d tra.ning ra.e by 13.19%,10.69%,a.d 11.06%,respectively,compa.ed to other models for the selected *** mea. error a.d selection time is a.so reduced by 12.56%a.d 13.56%,respectively,compa.ed to the sa.e models a.d da.a.et.

关键词： Computer vision fea.ure selection ma.hine lea.ning region detection texture a.a.ysis ima.e cla.sifica.ion medica. ima.es