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Prevention of Hea.ing Loss by a.tera.ion of the Systemic Immune System

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a.va.ces in a.ing Resea.ch 2019年第2期8卷 29-41页

作者： H. Iwa. M. Ina.a.D. B. Va. K. Suzuki T. Sa.a.a.i Y. Yun Y. Koba.a.hi a. kanda Depa.tment of Otola.yngology Head and Neck Surgery Kansai Medical University Osaka Japan First Depa.tment of Medicine Kansai Medical University Osaka Japan

a.though congenita. sensorineura. hea.ing loss (SHL) in the bila.era. cochlea. ma.nly results from genetic a.norma.ities, chronic SHL progressing in la.er life is often influenced by systemic immune disturba.ces, including a.toimmunity, chronic infla.ma.ion, a.d immunosenescence. We ha.e investiga.ed the rela.ionship between the inner ea. a.d systemic immunity a.d reviewed the possibilities to prevent SHL, including a.toimmune SHL a.d a.e-rela.ed SHL. We a.so demonstra.ed two lymphocyte popula.ions, interleukin 1 receptor type II (IL-1R2)-positive T cells (T1R2) a.d na.ura.ly occurring regula.ory T cells (nTregs) in CD4+ T cells, which increa.e with a.ing, suppress host immune function a.d promote orga. degenera.ion. a.tera.ions in systemic immunity by fewer microbia. a.tigen cha.lenges in the living environment, elimina.ion of immune suppressive lymphocytes, or immune rejuvena.ion with a.reconstituted thymus ma. contribute not only to renew the cochlea. function in SHL, but a.so to extend the hea.thy life of functiona. orga.s in a.vigorous a.d youthful body, one of huma.ity’s grea.est drea.s.

关键词： a.toimmune Sensorineura. Hea.ing Loss a.e-Rela.ed Sensorineura. Hea.ing Loss Infla.ma.ion Immune Senescence Interleukin 1 Receptor Type II-Positive T Cells Na.ura.ly Occurring Regula.ory T Cells Immune Rejuvena.ion Thymus

Usefulness of Newly Devised Clomiphene Citra.e a.ministra.ion Method Compa.ed with the Conventiona. Method in Ovula.ion a.d Pregna.cy

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Open Journa. of Obstetrics a.d Gynecology 2024年第4期14卷 637-649页

作者： Ma.oto Ka.a.ura.Misa.i a.iya.a.Remi Na.a.ima.Eri Sa.oi Yoko Oga.i Rieko kanda Depa.tment of Obstetrics a.d Gynecology Kohseichuo General Hospital Tokyo Japan

Objective: Since not a.l women wish to conceive a.child through a.gressive trea.ment, we investiga.ed the usefulness of modified repea.ed intra.yclic clomiphene citra.e (CC) thera.y (repea.ed CC thera.y) a. a.newly devised a.ministra.ion method. Methods: We eva.ua.ed the effects of CC a.ministra.ion on menstrua. cycle length a.d retrospectively compa.ed ovula.ion a.d pregna.cy in 220 women who received CC a. our hospita.. Pa.ients in the conventiona. method group received 50 mg per da. for five da.s, sta.ting on the fifth da. of menstrua.ion (withdra.a. bleeding). Groups with a.d without menstrua. cycle shortening a.ter conventiona. CC a.ministra.ion were compa.ed. The repea.ed CC thera.y group wa. a.so compa.ed with the non-shortened group. Repea.ed CC thera.y wa. a.ministered for the first five da.s a. in the conventiona. method, a.d a.second five-da. repea. trea.ment wa. a.ministered a.ter a. interva. of five to seven da.s. Pregna.cy ra.es, including indirect pregna.cies, were eva.ua.ed by three different methods. Results: Ovula.ion a.d pregna.cy ra.es were significa.tly better in the shortened group tha. in the non-shortened group (P a.d P = 0.010, respectively). Even in the non-shortened group, ovula.ion a.d pregna.cy ra.es including indirect pregna.cies were significa.tly improved when ovula.ion wa. observed with repea.ed CC thera.y (P a.d P = 0.022, respectively). Conclusions: For pa.ients whose menstrua. cycle wa. not improved or shortened, repea.ed CC thera.y a. the newly devised CC a.ministra.ion method is useful a. the next step a.ter the conventiona. CC a.ministra.ion method.

关键词： Clomiphene Citra.e Infertility Menstrua. Cycle Ovula.ion Induction

a.ult-Type Gra.ulosa.Cell Tumor with Simila. Clinica. Findings Seen during Ova.ia. Cystectomy Performed a. the Sa.e Time a. La.a.oscopic Ova.ia. Drilling for Polycystic Ova.ia. Syndrome: a. Extremely Ra.e Ca.e

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Open Journa. of Obstetrics a.d Gynecology 2024年第8期14卷 1197-1206页

作者： Remi Na.a.ima.Risa.Koba.a.hi Ma.ie Ka.a. Eriko Sa.a.oto Miho Ma.suda.Rieko kanda Ma.oto Ka.a.ura Depa.tment of Obstetrics a.d Gynecology Kohseichuo General Hospital. Tokyo Japan

Polycystic ova.y syndrome (PCOS) is a.ma.or ca.se of a.ovula.ory infertility. La.a.oscopic ova.ia. drilling (LOD) is a.trea.ment for PCOS tha. a.lows the la.a.oscopic identifica.ion of other intra.a.domina. lesions a.d the provision of dia.nostic trea.ment. This study reports a.ca.e of PCOS with a. ova.ia. ma.s in which LOD wa. a.gressively used a.d a.gra.ulosa.cell tumor (GCT) wa. found. a.34-yea.-old woma. with seconda.y a.enorrhea.a.d irregula. menstrua. cycles presented to the emergency depa.tment with a.domina. pa.n of unknown etiology. Ima.ing studies revea.ed a.6-cm left ova.ia. ma.s with a. interna. a.pea.a.ce suggestive of a.hemorrha.e. The pa.ient’s seconda.y a.enorrhea.wa. subsequently dia.nosed a. PCOS, a.d LOD wa. performed to preserve her fertility. Simulta.eously, a.cystectomy wa. performed to eva.ua.e the tumor in the left ova.y;the dia.nosis wa. a.ult-type GCT. a.though concomita.t GCT a.d PCOS a.e extremely ra.e, the two conditions ha.e simila. clinica. ma.ifesta.ions. In women of reproductive a.e, the impa.t of surgery on future fertility should be considered, a.d the initia. surgica. technique should be chosen ca.efully.

关键词： Polycystic Ova.y Syndrome La.a.oscopic Ova.ia. Drilling Gra.ulosa.Cell Tumor

Photometric Studies of EV Cnc a.d a. Cnc in the Open Cluster M67

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Resea.ch in a.tronomy a.d a.trophysics 2024年第8期24卷 196-211页

作者： Ma.a.ha.Ra.i G. K.Srira. Deblina.La.iri Vija.a.a. Depa.tment of a.tronomy Osmania UniversityHyderabad 500007India

Conta.t bina.ies a. va.ious sta.es of evolution unveil va.ious opera.ing mecha.isms tha. drive *** report the photometric a.d period va.ia.ion a.a.ysis of two conta.t bina.ies EV Cnc a.d a. Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope a.d utilized TESS a.d Kepler *** photometric solutions of EV Cnc a.d a. Cnc revea.ed a.ma.s ra.io of q~0.41 a.d~0.15 with a. inclina.ion of i=42°a.d87°*** solutions suggest tha. EV Cnc is proba.ly a.semi-deta.hed a.d a. Cnc is a.deep low-ma.s ra.io conta.t *** study of O-C va.ia.ion a.a.ysis indica.es tha. for both systems,the period is increa.ing which suggests the ma.s tra.sfer is occurring from seconda.y to *** the ca.e of a. Cnc a.d ba.ed on simula.ions by ra.domly va.ying the time of minima.to fit the LITE solution,we noted the third body orbita. period to be a.ound P_(3)=26.82±2.54 yr,which is different from ea.lier reported va.ues a.d conclude tha. future observa.ions a.e required to confirm this *** compa.e these two systems with other simila. conta.t bina.ies to get a. estima.e of the fina. configura.ion of the respective systems.

关键词： (sta.s)bina.ies(including multiple) close-(sta.s)bina.ies eclipsing-sta.s a.tivity

Kerogen Kinetic Distributions a.d Simula.ions Provide Insights into Petroleum Tra.sforma.ion Fra.tion (TF) Profiles of Orga.ic-Rich Sha.es

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Journa. of Ea.th Science 2024年第3期35卷 747-757页

作者： Da.id a.Wood DWa.Energy Limited Lincoln LN59JPUnited Kingdom

Two hundred a.d fifty single first-order a.rhenius rea.tions a.e simula.ed to genera.e S2 pyrogra.s a. three hea.ing ra.es 25,15,a.d 5°C·*** a.tiva.ion energy(E)a.d pre-exponentia. fa.tor(a.of the rea.tions simula.ed follow a.long-esta.lished trend of those va.ia.le va.ues displa.ed by sha.es a.d *** cha.a.teristics of the tra.sforma.ion fra.tion(TF)profiles(product genera.ion window tempera.ures)of the simula.ed single rea.tions a.e compa.ed to the TF profiles of recorded sha.e pyrogra.s genera.ed by multiple rea.tions with different E-a.va.ues lying nea. the defined E-a.*** simila.ities a.d differences a.e observed between the TF profile va.ues of the two *** simila.ities support the sprea. of E-a.va.ues involved in sha.e pyrogra. best *** differences a.e most likely expla.ned by the complexity of the multiple kerogen first-order a.d second-order rea.tions contributing to the recorded sha.e pyrogra.s versus the simplicity a.d crispness of the single first-order rea.tions *** results a.so justify the va.idity of using the previously described“va.ia.le E-a.pyrogra.-fitting method”of multi-hea.ing-ra.e sha.e pyrogra.s ena.ling optimizers to choose multiple rea.tions from a. unlimited ra.ge of E-a.*** contra.t,further doubt is ca.t on the va.idity of the consta.t-a.pyrogra.-fitting method used by the Ea.y%Ro technique,in tha. a.distribution of rea.tions with a.single a.va.ue is unlikely to represent the complex va.iety of kerogen ma.era.s observed in sha.e *** profiles genera.ed by the va.ia.le E-a.pyrogra.-fitting method lie close to the esta.lished E-a.trend a.d a.e likely to provide more rea.istic TF genera.ion window tempera.ures tha. TF profiles genera.ed by the consta.t-a.pyrogra.-fitting method.

关键词： tra.sforma.ion fra.tion profiles simula.ed S2 pyrogra.s multiple hea.ing ra.es kerogen/sha.e kinetics S2 pyrogra. fitting techniques kerogen petroleum resea.ch.

Fa.ry病患者皮肤中神经酰胺三己糖苷堆积免疫电镜检测

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 42-42页

作者： Ka.ekura.T. Fukushige T. kanda a. 刘艳 Depa.tment of Derma.ology Kagoshima University Graduate School of Medical and Dental Sciences 8- 35- 1 Sakuragaoka Kagoshima 890- 8520 Japan

Ba.kground: Fa.ry disea.e is cha.a.terized by the systemic a.cumula.ion of glycosphingolipids, pa.ticula.ly in the lysosomes of va.cula. endothelia. cells of most orga.s due to the deficient a.tivity of α - ga.a.tosida.e a. The ma.or glycolipid a.cumula.ed in tissue is globotria.sylcera.ide (GL- 3). To da.e, no direct detection of GL- 3 by immunoelectron microscopy ha. been reported. Objectives: To exa.ine whether GL- 3 is a.cumula.ed exclusively in lysosomes of cuta.eous cells using a. a.ti- GL- 3 monoclona. a.tibody (ma.) a.d immunoelectron microscopy. Methods: Skin specimens from seven pa.ients with Fa.ry disea.e were exa.ined immunohistochemica.ly by light a.d electronmicroscopy using a. a.ti- GL- 3ma.. Results: By light microscopy, the cytopla.m of va.cula. endothelia. cells, eccrine gla.d cells, a.d perineurium wa. sta.ned with mouse a.ti- GL- 3 a.tibody. Electronmicroscopica.ly, positive signa.s for GL- 3 were limited to dila.ed lysosomes in the cytopla.m of endothelia. cells, pericytes, eccrine gla.d cells, derma. fibrobla.ts a.d perineurium. Conclusions: Our results demonstra.e tha. the cytopla.mic deposit in Fa.ry disea.e wa. GL- 3 a.d the a.cumula.ed GL- 3 wa. loca.ized essentia.ly to lysosomes.

关键词： Fa.ry病免疫电镜溶酶体汗腺细胞糖鞘脂血管内皮细胞神经束膜单克隆抗体免疫组化检查周细胞

Crimina. or bysta.der: ima.inib a.d second prima.y ma.igna.cy in GIST pa.ients

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Chinese Journa. of Ca.cer Resea.ch 2013年第5期25卷 490-492页

作者： Ta.suo kanda Sa.jo Genera. Hospita.

Niiga.a.University Hospita. is a.regiona. center institution of ca.cer thera.y where ma.y pa.ients with ga.trointestina. stroma. tumors （GISTs） a.e visiting to seek the la.est *** the time Ⅰ wa. trea.ing GIST pa.ients there with ima.inib,a.tyrosine kina.e inhibitor,a.sma.l concern wa. ra.sed：Ⅰ successively encountered pa.ients who were newly dia.nosed a. ha.ing ma.igna.t neopla.ms during the course of their *** the 70 GIST pa.ients who were enrolled in our prospective study of ima.inib thera.y,seven suffered from second prima.y ma.igna.cies （SPMs）.One fema.e GIST pa.ient who suffered from a.va.ced esopha.ea. ca.cer died of the SPM,wherea. the rema.ning six pa.ients continued with their ima.inib thera.y a.d their prognoses were not a.fected by their SPMs.I reported on the risk of SPMs in GIST pa.ients under ima.inib thera.y to a. interna.iona. journa. of clinica. oncology （1）.a. the pa.ient cohort of our study wa. so sma.l in number to a.ply to sta.istica. a.a.ysis,our observa.ion wa. no more tha. a.clinica. a.ert.

关键词： GIST ima.inib a.d second prima.y ma.igna.cy in GIST pa.ients Crimina. or bysta.der

Experimenta. a.d numerica. study on hydrodyna.ics of ripa.ia. vegeta.ion

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Journa. of Hydrodyna.ics 2014年第5期26卷 796-806页

作者： UOTa.I Ta.uya.kanda Keiichi MICHIOKU Kohji Kobe City Burea. KobeJapan Depa.tment of Civil Engineering Akashi National College of TechnologyAkashiJapan Depa.tment of Civil a.d Environmenta. Engineering Hosei UniversityShinjukuTokyoJapan

Recently, ma.y cha.nelized rivers tend to be hea.ily vegeta.ed due to regime shifts in hydrologica., fluvia. a.d ecologica. processes. Dense vegeta.ion in a.river frequently obstructs a.flood flow a.d reduces conveya.ce ca.a.ity of cha.nels. On the other ha.d, river vegeta.ion provides va.ious ecologica. services such a. ha.ita.s for va.ious species a.d life, na.ura. cycle of orga.ic a.d inorga.ic substa.ces, etc.. It is of engineering importa.ce to understa.d vegeta.ion hydrodyna.ics in order to preserve vegeta.ion na.ure a.d keep a.certa.n level of flow conveya.ce ca.a.ity. In view tha. willows tend to be densely vegeta.ed a.ong the shoreline of floodpla.ns or sa.dba.s, a.field mea.urement, a.physica. model experiment a.d a.numerica. a.a.ysis were ca.ried out for investiga.ing hydrodyna.ics in a. open cha.nel with ripa.ia. vegeta.ion. Discussion wa. ma.e focusing on flow a.d shea. la.er structures developed a.ound the vegeta.ion ca.opy.

关键词： open cha.nel ripa.ia. vegeta.ion dra. force velocity profile la.ora.ory experiment hydrodyna.ic model

Rodent biology a.d ecologica.ly ba.ed rodent ma.a.ement(EBRM)-25 yea.s of progress through promoting multidisciplina.y resea.ch

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Integra.ive Zoology 2024年第1期19卷 2-7页

作者： Gra.t R. SINGLETON Lyn a. HINDS Rhodes Ma.UNDI Steven R. BELMa.N Na.ura. Resources Institute University of Greenwich Kent UK CSIRO Hea.th a.d Biosecurity Canberra ACT Australia a.rica. Centre of Excellence for Innova.ive Rodent Pest Ma.a.ement a.d Biosensor Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Ma.a.ement Sokoine University of Agriculture Morogoro Tanzania

“During rodent outbrea. yea.s in ea.tern a.rica.lo-ca.ly,more tha. 80%of the potentia. ha.vest ma. be lost,but even in non-outbrea. periods,rodents ca.se chronic da.a.e to crops….The pest rodent story in a.rica.in-volves severa. species embedded in a.broa. a.d va.ia.le la.dsca.e with highly va.ia.le densities.”(Leirs et a..2010).

关键词： da.a.e crops