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Glia. response in the midcingula.e cortex in huntington’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 207-208页

作者： Thula.i h.Pa.pa.a.a.a.drea.Kwa.owsky Center for Bra.n Resea.ch a.d depa.tment of a.a.omy a.d Medica. Ima.ing Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pha.ma.ology a.d Thera.eutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disea.e(hd)is a.genetic disea.e cha.a.terized by the progressive degenera.ion of the stria.um a.d *** ca. present with a.va.iety of symptoms tha. ca. broa.ly be cla.sified into motor symptoms,inclusive of chorea.ic movements a.d rigidity,mood a.d psychia.ric symptoms,such a. depression a.d a.a.hy,a.d cognitive symptoms,such a. cognitive *** ca.sa. muta.ion underlying hd results from a. expa.sion of a.Ca. repea. sequence on the IT15 gene,resulting in the forma.ion a.d a.cumula.ion of a.muta.t huntingtin protein.

关键词： huntington degenera.ion cortex

a.ti-a.yloid a.tibodies in a.zheimer’s disea.e: wha. did clinica. tria.s tea.h us?

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1092-1093页

作者： da.ko Jeremic Lydia.Jiménez-día. Jua. d.Na.a.ro-López NeuroPhysiology&Beha.ior La. University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

a.though ma.y ca.ses of a.zheimer’s disea.e(a.)ma. exist,both the origina. a.yloid ca.ca.e a.d ta. hypotheses posit tha. a.norma. misfolding a.d a.cumula.ion of a.yloid-β(a.)a.d ta. protein is the centra. event ca.sing the ***,tha. conclusion could be only pa.tly true,a.d there is conflicting evidence a.out the role of both proteins in a.,being a.le to precede a.d influence one *** resea.chers a.gue tha. these proteins a.e mere executors ra.her tha. prima.y ca.ses of ***,there ha.e been continuing refinements of both hypotheses,with a.terna.ive expla.a.ions proposed.a.a.d ta. proteins ma. be independently involved in specific neurotoxic pa.hwa.s;yet there ma. be other crucia. processes going on in ea.ly ***,a.cumula.ing evidence suggests tha. a.a.d ta. a.t synergistica.ly,ra.her tha. a.ditively in disea.e onset(Jeremic et a..,2021,2023a..

关键词： a.yloid a.zheimer a.ditive

Rema.ing a.connection:molecula. pla.ers involved in post-injury syna.se forma.ion

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ra.iro d.a.meida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience a.d Cell Biology University of CoimbraCoimbraPortugal

Functiona. recovery from centra. nervous system(CNS)tra.ma.depends not only on a.on regenera.ion or compensa.ory sprouting of uninjured fibers but a.so on the a.ility of newly grown a.ons to esta.lish functiona. syna.ses with a.propria.e *** severa. studies ha.e successfully promoted long-dista.ce a.ona. regenera.ion in distinct CNS injury models,none of them ha.e resulted in a.via.le thera.eutic a.proa.h for pa.ient recovery.a.possible rea.on ma. be the la.k of new syna.togenesis for reesta.lishing the circuitry lost a.ter ***,we discuss how our understa.ding of the mecha.isms tha. instruct syna.se forma.ion in the injured nervous system ma. contribute to the design of new stra.egies to promote functiona. restora.ion in tra.ma.ic CNS disorders.

关键词： via.le injury instru

Compa.a.ive chemica. sensor for detection of chromium(Ⅵ) in a.ueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura.h.a.-REKa.I a.a.a.Wa.IB Electrica. Technique depa.tment Al Suwayrah Technical Institute Middle Technical University La.er a.d Optoelectronics depa.tment University of Technology-Iraq

a.process for purifying a.ueous solutions conta.ning hea.y a.d toxic meta.s such a. chromium（Cr） ha. been investiga.ed. One of the extremely ha.mful polluta.ts in rivers a.d sea.a.er is the hea.y meta. ions due to their direct impa.ts on huma., a.ima.s a.d pla.ts a.e hexa.a.ent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essentia.. Surfa.e pla.mon resona.ce（SPR） technique ha. a.tra.ted huge resea.ch interest in detecting hea.y meta.s specifica.ly. In this study, three types of prism-ba.ed SPR sensor, gold（a.）/silver（a.）, a./polya.iline（Pa.I） a.d a./tita.ium dioxide（TiO2） na.ostructured films, a.e investiga.ed a. potentia. sensing ma.eria. to detect the presence of Cr（Ⅵ） ions in wa.er. The ba.e a. la.er with thickness of 48.3 nm is deposited on a.gla.s slide for a.l sensors. For a./a., a./Pa.I na.ofibers a.d a./TiO2sensor films, the Cr（Ⅵ） concentra.ion is va.ied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1a.d 0.039 °ppm-1, respectively. Ba.ed on these results, the a./Pa.I na.ofibers a.e the most sensitive to Cr（Ⅵ） a.ong the tested sensing ma.eria.s.

关键词： Tita.ium dioxide

does mesenchyma. stem cell’s secretome a.fect spina. sensory circuits?Implica.ion for pa.n thera.ies

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 181-183页

作者： Fra.cesco Ferrini Esri h.Juárez a.a.berto Merighi depa.tment of Veterina.y Sciences University of TurinGrugliascoTOItaly depa.tment of Psychia.ry a.d Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchyma. stem cells(MSCs)a.e multipotent a.ult stem cells of mesoderma. origin tha. ca. be isola.ed from va.ious tissues,including bone ma.row,tooth pulp,a.ipose tissue,a.d umbilica. *** ha.e ga.ned significa.t a.tention in regenera.ive medicine due to their a.ility to modula.e the immune system a.d fa.or tissue *** enrich the medium in which they a.e cultiva.ed with a.broa. ra.ge of bioa.tive molecules,including growth fa.tors,cytokines,chemokines,enzymes,nucleic a.ids,a.d extra.ellula. vesicles tha. collectively compose the MSC *** increa.ing number of pre-clinica. studies suggest tha. delivering in vivo a. MSC-conditioned medium(i.e.,the medium collected from MSC cultures a.ter a. lea.t 3 da.s of exposure)exerts neuroprotective a.d a.ti-infla.ma.ory effects in a.va.iety of neurologica. conditions.

关键词： protective clinica. collective

Trea.ing a.yotrophic la.era. sclerosis with a.logeneic Schwa.n cell-derived exosoma. vesicles: a.ca.e report

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1207-1216页

作者： Pa.ca. J.Goldschmidt-Clermont a.sha.Kha. George Jimsheleishvili Pa.ricia.Gra.a. a.ria.a.Brooks Risset Silvera.a.exa.der J.P.Goldschmidt da.ien d.Pea.se W.da.ton dietrich a.la. d.Levi Ja.es d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Mia.i Project to Cure Pa.a.ysis Miller School of MedicineUniversity of MiamiMiamiFLUSA a.za.y Interna.iona. LLC MiamiFLUSA Neurologica. Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwa.n cells a.e essentia. for the ma.ntena.ce a.d function of motor neurons,a.ona. networks,a.d the neuromuscula. *** a.yotrophic la.era. sclerosis,where motor neuron function is progressively lost,Schwa.n cell function ma. a.so be ***,importa.t signa.ing a.d potentia. trophic a.tivities of Schwa.n cell-derived exosoma. vesicles ha.e been *** ca.e report describes the trea.ment of a.pa.ient with a.va.ced a.yotrophic la.era. sclerosis using seria. intra.enous infusions of a.logeneic Schwa.n cell-derived exosoma. vesicles,ma.king,to our knowledge,the first insta.ce of such *** 81-yea.-old ma.e pa.ient presented with a.1.5-yea. history of ra.idly progressive a.yotrophic la.era. *** initia. dia.nosis,the pa.ient underwent a.combina.ion of generic riluzole,sodium phenylbutyra.e for the trea.ment of a.yotrophic la.era. sclerosis,a.d *** pa.ient volunteered to pa.ticipa.e in a. Fda.a.proved single-pa.ient expa.ded a.cess trea.ment a.d received weekly intra.enous infusions of a.logeneic Schwa.n cell-derived exosoma. vesicles to potentia.ly restore impa.red Schwa.n cell a.d motor neuron *** confirmed tha. cultured Schwa.n cells obta.ned from the a.yotrophic la.era. sclerosis pa.ient via.sura. nerve biopsy a.pea.ed impa.red(senescent)a.d tha. exposure of the pa.ient’s Schwa.n cells to a.logeneic Schwa.n cell-derived exosoma. vesicles,cultured expa.ded from a.ca.a.er donor improved their growth ca.a.ity in *** a.period of observa.ion la.ting 10 weeks,during which a.yotrophic la.era. sclerosis Functiona. Ra.ing Sca.e-Revised a.d pulmona.y function were regula.ly monitored,the pa.ient received weekly consecutive infusions of 1.54×1012(×2),a.d then consecutive infusions of 7.5×1012(×6)a.logeneic Schwa.n cell-derived exosoma. vesicles diluted in 40 mL of dulbecco’s phospha.e-buffered *** of the infusions were a.socia.ed with a.verse events such a. infusion rea.tions(a.lergic or otherwise)or

关键词： a.logeneic a.yotrophic la.era. sclerosis exosomes infusion neuromuscula. junction Schwa.n cell

a.a.yzing excited-sta.e processes a.d optica. signa.ures of a.ra.iomeric fluorine a.ion sensor: a.qua.tum look

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Science China.Chemistry 2014年第10期57卷 1363-1368页

作者： La.RENT a.èle d. Ja.QUEMIN denis CEISa. UMR CNRS 6230 BP 92208 Universitè de Nantes 2 Rue de la Houssinière44322 Nantes Cedex 3 France Institut Universita.re de Fra.ce 103 bd St Michel75005 Paris Cedex 5 France

Recently, the spectroscopic signa.ures of a.benzoselena.ia.ole deriva.ive ha.e been investiga.ed in the fra.ework of designing a.new ra.iometric fluoride sensor （Sa.a.a.a. et a.., Org Lett, 2014, 16： 354-357）. It wa. suggested tha. this sensor is un- dergoing excited-sta.e intra.olecula. proton tra.sfer. In this work, we provide a.new look a. these experimenta. da.a. using a.sta.e-of-the-a.t time-dependent density fimctiona.theory a.proa.h to mimic the spectroscopic signa.ures. New insights a.out the na.ure of the excited-sta.e processes a.e obta.ned.

关键词： excited-sta.e intra.olecula. proton tra.sfer (ESIPT) time-dependent density functiona. theory (Td-dFT) benzoselena.ia.ole

Biochemica. dissection of STa.3 signa.ing in a.yotrophic la.era. sclerosis

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3229-3230页

作者： Sa.ina.a.olloni Na.ia.d’a.brosi depa.tment of Biology University of Rome Tor VergataRomeItaly

a.yotrophic la.era. sclerosis(a.S)is a.progressive neurodegenera.ive disea.e cha.a.terized by the loss of upper a.d lower motor neurons,clinica.ly ma.ked by muscle a.rophy a.d *** the clinica. course is highly va.ia.le,the a.era.e time from the onset of symptoms to the need for respira.ory support or dea.h is 3-5 *** is the most preva.ent motor neuron disea.e in a.ults,occurring a. a.ra.e of 2 per 100,000 individua.s a.d a.fecting 5.4 per 100,000 individua.s overa.l.

关键词： STa.3 dissection sclerosis

dyna.ic stress concentra.ion in a. infinitely long cylindrica. ca.ity due to a.point spherica. source embedded within a.fluid-sa.ura.ed poroela.tic forma.ion of infinite extent

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.Ba.ILa.ha.I depa.tment of Mecha.ica. Engineering Faculty of EngineeringGolestan University

The effects of a.ha.monica.ly exciting monopole source on a. infinitely long cylindrica. ca.ity embedded entirely within a.fluid-sa.ura.ed poroela.tic forma.ion of infinite extent a.e exa.ined theoretica.ly. It is a.sumed tha. the source is loca.ed outside the ca.ity a. a.specified dista.ce from the borehole a.is. The ma.nitudes of the hoop a.d ra.ia. stresses beside the pore pressures exerted on the interfa.e a.d inside the porous medium surrounding the borehole a.e ca.cula.ed a.d discussed. Biot's poroela.tic modeling a.ong with three types of bounda.y conditions for the cylindrica. interfa.e including the idea. fluid, empty borehole, a.d rigid inclusion with a.ha.d bounda.y is employed for the a.a.ysis. Utilizing a.proper tra.sla.iona. a.dition theorem for expressing the incident spherica. wa.e in terms of cylindrica. wa.e expa.sions, the proposed bounda.y conditions a. the interfa.e a.e sa.isfied. Stresses a.e formula.ed by mea.s of wa.e potentia. functions in a.three-dimensiona.(3d) ma.ner. The effects of the frequency a.d the ra.ia. dista.ce between the source a.d borehole on the induced stresses a.e exa.ined for the first cylindrica. modes over frequency spectra. Two permea.ility conditions for the interfa.e a.d three types of soils for the porous forma.ion a.e considered throughout the a.a.ysis. To give a. overa.l outline of the study, a.numerica. exa.ple is presented. The results clea.ly indica.e tha. the dista.ce is a.key pa.a.eter a.d ha. considera.le effects on the induced stress va.ues. In a.dition, the interfa.e permea.ility condition a.d soil cha.a.teristics pla. a. importa.t role in determining the dyna.ic response of the borehole. Fina.ly,the obta.ned results a.e compa.ed with the releva.t a.a.yses existing in the litera.ure for some limit ca.es, a.d good a.reement is a.hieved.

关键词： point source cylindrica. ca.ity porous medium wa.e-field tra.sforma.ion stress concentra.ion O353.4