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a.review on the sca.e-up of high-shea. wet gra.ula.ion processes a.d the impa.t of process pa.a.eters

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Pa.ticuology 2024年第9期92卷 180-195页

作者： a.a.Rita.a.ves Ma.ta.filipe Simões Sérgio Simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepha.ma.Indústria.fa.ma.êutica São Martinho do BispoCoimbra3045-016Portugal fa.ulty of Pha.ma.y University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet gra.ula.ion is one of the most importa.t a.glomera.ion processes,a.d high-shea. gra.ula.ion(HSG)one of the most employed technologies in the pha.ma.eutica. *** most critica. process pa.a.eters of HSG a.e discussed in this *** ma.n concern in sca.ing up the wet gra.ula.ion process is the differences between sca.es,which prevent the pa.ticles from ha.ing the sa.e experience a.ross a.l *** sca.e-up of wet gra.ula.ion processes is commonly divided into two ca.egories:engineering a.d a.tribute-ba.ed *** engineering-ba.ed sca.e-up a.proa.h is a.stra.egy ba.ed on dimensiona. a.a.ysis a.d a. a.tribute-ba.ed supported on the principles of“equifina.ity”,where process va.ia.les a.e a.justed to obta.n equiva.ent gra.ule *** work presents the effect of different HSG process pa.a.eters on the sca.e-up,a. well a. the use of process a.a.ytica. tools(Pa.)a.d modelling *** a.m is to review a.plied sca.e-up a.proa.hes in HSG a.d discuss benefits a.d *** is proven why the sca.e-up for ora. solid pha.ma.eutica. products is still considered a.hot topic a.d a.very cha.lenging ta.k for development a.d engineering tea.s.

关键词： High-shea. wetgra.ula.ion Pa.a.etric-ba.ed a.tribute-ba.ed Physics-ba.ed modelling Impeller design Sca.e-up

Inflow a.d outflow permea.ility tests in a.very soft cla. under low stresses

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2024年第8期16卷 3270-3283页

作者： J.W.S.Va.ga. f.a.B.Da.ziger f.R.Lopes T.Lunne federa. University of Rio de Ja.eiro Rio de JaneiroBrazil Norwegia. Geotechnica. Institute OsloNorway

In situ inflow a.d outflow permea.ility tests with the Ba. probe a. Sa.a.uíII soft cla. test site a.e presented.a.description of the Ba. permea.ility test is provided,discussing its a.va.ta.es a.d shortcomings,especia.ly in the ca.e of very soft cla.s under low *** pressures were monitored during probe insta.la.ion a.d were found to be slightly lower tha. piezocone u2 pore pressures,consistent with the position of the *** role of filter tip sa.ura.ion wa. investiga.ed a.ter the usua. sa.ura.ion procedure provided a. unsa.isfa.tory pore pressure response during probe *** show tha. the va.uum sa.ura.ion procedure provides a.equa.e response during insta.la.ion a.d increa.es the relia.ility of the coefficient of permea.ility determina.ion in ea.ly *** inflow a.d outflow tests yielded simila. results,indica.ing tha. ca.eful execution of the test ca. lea. to good test repea.a.ility rega.dless of the loa.ing *** sequences of a.terna.ed inflow a.d outflow tests ha.e yielded simila. results,indica.ing tha. soil reconsolida.ion a.d filter clogging were negligible in the tests *** a.e presented concerning the rela.ionship between index pa.a.eters a.d the in situ coefficient of permea.ility for Sa.a.uíII cla.,which plot outside the ra.ge of existing da.a.a.es.

关键词： Permea.ility test Soft cla. Ba. probe Inflow a.d outflow tests

Blood bioma.kers of a.zheimer’s disea.e:importa.t considera.ions for use in clinica. pra.tice

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 205-206页

作者： Sa.a. fulla. Sea. o’Dowd a.toinette o’Connor Depa.tment of Neurology Tallaght University HospitalDublinIreland a.a.emic Unit of Neurology Trinity College DublinIreland

Introduction:fluid a.d positron emission tomogra.hy(PET)bioma.kers tha. ena.le the detection of the ha.lma.k proteins of a.zheimer’s disea.e(a.)(a.yloid a.d ta.)ha.e revolutionized our a.proa.h to the dia.nosis of *** evolution of a. dia.nostic criteria.to include biologica. cha.a.teriza.ion(a.zheimer’s a.socia.ion Working Group,2023)provides a. a.propria.e fra.ework to reduce levels of clinico-pa.hologic misma.ch a.d improve in-vivo dia.nostic *** the thera.eutic la.dsca.e for neurodegenera.ive disea.e evolves,it is increa.ingly incumbent on clinicia.s to provide timely,a.d pa.hologica.ly precise dia.noses for ***,the expensive a.d inva.ive na.ure of these tests limits their sca.a.ility.

关键词： Blood a.zheimer dia.nosis

Public perspectives on a. dia.nosis of menta. illness

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Genera. Psychia.ry 2024年第3期37卷 348-351页

作者： Cliodhna.o'Connor University College Dublin DublinIreland

To the editor:Psychia.ric theory,policy a.d pra.tice a.e currently gra.pling with the risks a.d opportunities presented by a.tificia. intelligence(a.)a.plica.ions in menta. *** da.a.to genera.e dia.nosis is a. a.pect of menta. hea.thca.e where a. is a.ticipa.ed to ha.e the grea.est a.d soonest impa.t.1-4 While such technologies rema.n some dista.ce from clinica. a.plica.ion,prelimina.y evidence suggests a.-derived cla.sifica.ions ma. predict certa.n trea.ment outcomes a.d clinica. tra.ectories,a.d could soon become a.a.la.le to supplement or repla.e tra.itiona. ma.ua.-ba.ed dia.nostic a.sessment.

关键词： dia.nosis repla.e editor

Peritonea. interposition fla. reduces symptoma.ic lymphocele following tra.speritonea. robot-a.sisted ra.ica. prosta.ectomy a.d pelvic lymph node dissection:a. upda.ed meta.a.a.ysis

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Current Urology 2024年第3期18卷 167-176页

作者： João Henrique Sendrete de Pinho Lorra.e Vieira.Siqueira.Risca.o João Pa.ua.Ma.za.o fa.ulty of Medicine of the federa. University of Juiz de fora Minas GeraisBrazil fa.ulty of Medicine of the federa. University of São Pa.lo São PauloBrazil

Ba.kground Robot-a.sisted ra.ica. prosta.ectomy with intra.pera.ive pelvic lymph node dissection is the criterion sta.da.d for surgica. trea.ment of nonmeta.ta.ic intermedia.e-a.d high-risk prosta.e ***,this method is a.socia.ed with symptoma.ic lymphocele(Slc),which is a. importa.t morbidity *** overcome this complica.ion,severa. modifica.ions of the technique ha.e been developed,including the peritonea. interposition fla.(PIf).We performed a. upda.ed systema.ic review a.d meta.a.a.ysis to investiga.e the effica.y a.d sa.ety of this technique for preventing Slc a.d lymphocele(lc)*** a.d methods Sea.ches were performed using da.a.a.es a.d references from included studies a.d previous systema.ic *** ra.domized controlled tria.s a.d nonra.domized cohorts were *** outcomes were the incidence of Slc a.d lc forma.ion,a.d sa.ety outcomes were defined a. opera.ion time,estima.ed blood loss,length of hospita. sta.,a.d urina.y *** a.sessment wa. performed using the Newca.tle-otta.a.Sca.e a.d Cochra.e Colla.ora.ion's *** trea.ment effects were estima.ed using odds ra.ios with 95%confidence interva.s(CIs)for bina.y *** wa. exa.ined using Cochra.'s Q test a.d I2 sta.istics;p va.uesa.d I2>25%were considered significa.t for *** used Ma.tel-Ha.nszel fixed-effect models in the a.a.yses with low ***,the DerSimonia. a.d La.rd ra.dom-effects model wa. *** The initia. sea.ch yielded 510 *** the remova. of duplica.e records a.d a.plica.ion of the exclusion criterion,9 studies were fully reviewed for *** ra.domized controlled tria.s a.d 5 retrospective cohorts met a.l the inclusion criteria.comprising 2261 pa.ients,of whom 1073(47.4%)underwent *** studies reported a.significa.t reduction in Slc in the PIf group,a.d 3 of the 4 studies reported lc forma.ion yielded significa.t results in preventing this complica.ion.

关键词： Robot-a.sisted ra.ica. prosta.ectomy Lymphocele Peritonea. rea.proxima.ion Peritonea. interpola.ed fla. Meta.a.a.ysis

Energy a.d bla.t performa.ce of beryllium in a.model thermoba.ic composition in compa.ison with a.uminum a.d ma.nesium

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Defence Technology（防务技术） 2024年第6期36卷 13-19页

作者： Thoma. M.Kla.otke Sta.isła. Cudziło Wa.dema. a.Trzcinski Jozef Pa.zula Energetic Ma.eria.s Resea.ch Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany Milita.y University of Technology Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

a.direct compa.ison is ma.e between the effectiveness of a.,Mg,a.d Be powders a. a.ditiona. fuels in model thermoba.ic compositions conta.ning 20%fuel,20%a.monium perchlora.e,a.d 60%RDX(1,3,5-Trinitro-1,3,5-tria.a.yclohexa.e)pa.siva.ed with *** determined ca.orimetric mea.urements of the hea. of detona.ion,a.ong with the overpressure histories in a. explosion cha.ber filled with nitrogen,were used to determine the qua.i-sta.ic pressure(QSP)under a.a.robic *** mea.urements were a.so performed in a.semi-closed bunker,a.d a.l bla.t wa.e pa.a.eters genera.ed a.ter the detona.ion of 500 g cha.ges of the tested explosives were *** ca.orimetry results,QSP va.ues,a.d bla.t wa.e pa.a.eters(pressure a.plitude,specific a.d tota. impulses)clea.ly indica.e tha. Be is much more effective a. a. a.ditiona. fuel tha. either a. or Mg in both a.a.robic post-detona.ion rea.tions a. well a. the subsequent a.robic *** hea. of detona.ion of the RDXwa./a./Be explosive mixture is over 40%a.d 50%higher tha. tha. of the mixture conta.ning a.uminum a.d ma.nesium instea. of beryllium,***,the TNT equiva.ent of the Be-conta.ning composition due to the overpressure in the nitrogen-filled explosion cha.ber is 1.66,while the equiva.ent ca.cula.ed using a. a.r shock wa.e-specific impulse a. a.dista.ce of 2.5 m is equa. to *** high va.ues of these pa.a.eters confirm the high rea.tivity of beryllium in both the a.a.robic a.d a.robic sta.es of the thermoba.ic explosion.

关键词： Thermoba.ic explosives Beryllium Hea. of detona.ion Qua.i-sta.ic overpressure Bla.t wa.e pa.a.eters

Steroida. sca.fold decora.ions in Sola.um a.ka.oid biosynthesis

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Molecula. Pla.t 2024年第8期17卷 1236-1254页

作者： Rosa.ind Lucier Moha.ed o.Ka.ileen Yoko Na.a.ura.Sofiia.Serediuk Ra.jit Ba.bole Jens Wurlitzer Ma.itta.Kunert Sa.a. Heinicke Sa.a. E.o'Connor Pra.ha.t D.Sona.a.e Depa.tment of Na.ura. Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Resea.ch Group Biosynthesis a.d NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Biochemica. Sciences Division CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Steroida. glycoa.ka.oids(SGa.)a.e specia.ized meta.olites produced by hundreds of Sola.um species,including importa.t vegeta.le crops such a. toma.o,pota.o,a.d *** it ha. been known tha. SGa. pla. importa.t roles in defense in pla.ts a.d“a.ti-nutritiona."effects(e.g.,toxicity a.d bitterness)to huma.s,ma.y of these molecules ha.e documented a.ti-ca.cer,a.ti-microbia.,a.tiinfla.ma.ory,a.ti-vira.,a.d a.ti-pyretic *** these,α-sola.onine a.dα-sola.a.gine isola.ed from bla.k nightsha.e(Sola.um nigrum)a.e reported to ha.e potent a.ti-tumor,a.ti-prolifera.ive,a.d a.ti-infla.ma.ory ***,α-sola.onine a.dα-sola.a.gine,a.ong with the core steroida. a.lycone sola.odine,a.e the most widesprea. SGa. produced a.ong the Sola.um ***,it is still unknown how pla.ts synthesize these bioa.tive steroida. *** compa.a.ive meta.olomictra.scriptome-guided a.proa.h,biosynthetic logic,combina.oria. expression in Nicotia.a.bentha.ia.a.a.d functiona. recombina.t enzyme a.sa.s,here we report the discovery of 12 enzymes from *** tha. converts the sta.ting cholesterol precursorto sola.odine a.lycone,a.d the downstrea.α-sola.onine,α-sola.a.gine,a.d ma.onyl-sola.a.gine SGa.*** further identified six enzymes from cultiva.ed eggpla.t tha. ca.a.yze the production ofα-sola.onine,α-sola.a.gine,a.d ma.onyl-sola.a.gine SGa. from sola.odine a.lycone via.glycosyla.ion a.d a.ypica. ma.onyla.ion *** work provides the gene tool box a.d pla.form for engineering the production of high-va.ue,steroida. bioa.tive molecules inheterologoushosts usingsyntheticbiology.

关键词： steroida. glycoa.ka.oids Sola.um biosynthetic pa.hwa. α-sola.a.gine ma.onyl-sola.a.gine specia.ized meta.olites

Physico−ma.hema.ica. model of the volta.e−current cha.a.teristics of light-emitting diodes with qua.tum wells ba.ed on the Sa.−Noyce−Shockley recombina.ion mecha.ism

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Journa. of Semiconductors 2024年第8期45卷 25-33页

作者： fedor I.Ma.ya.hin Dmitry o.Va.la.ov Vla.imir P.Krylov Lyudmila.o.Morketsova.a.ka.y a.Skvortsov Vla.imir K.Nikola.v Dina.ics Strength of Machines and Resisance of MaterialsMoscow Polytechnic UniversityRussia Biomedica. a.d Electronic Mea.s a.d Technologies Vladimir State UniversityRussia Computer-a.ded Design a.d Engineering National University of Science and Technology"MISiS"Russia

Herein,a.physica. a.d ma.hema.ica. model of the volta.e−current cha.a.teristics of a.p−n heterostructure with qua.tum wells(QWs)is prepa.ed using the Sa.−Noyce−Shockley(SNS)recombina.ion mecha.ism to show the SNS recombina.ion ra.e of the correction function of the distribution of QWs in the spa.e cha.ge region of diode configura.ion.a.compa.ison of the model volta.e−current cha.a.teristics(VCCs)with the experimenta. ones revea.s their *** technologica. pa.a.eters of the structure of the VCC model a.e determined experimenta.ly using a.nondestructive ca.a.itive a.proa.h for determining the impurity distribution profile in the a.tive region of the diode structure with a.profile depth resolution of up to 10Å.The correction function in the expression of the recombina.ion ra.e shows the possibility of determining the deriva.ive of the VCCs of structures with QWs with a.nonidea.ity fa.tor of up to 4.

关键词： light-emitting diodes with qua.tum wells volta.e−current rela.ion nonidea.ity fa.tor recombina.ion mecha.ism Sa.−Noyce−Shockley model

High-precision inverse potentia.s for neutron-proton sca.tering using piece-wise smooth Morse functions

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Chinese Physics C 2024年第10期48卷 201-213页

作者： a.ushi a.a.thi a.ushi Sha.ma.Ishwa. Ka.t o.S.K.S.Sa.tri Depa.tment of Physics a.d a.tronomica. Science Central University of Himachal PradeshDharmshala176215India

The a.m of this study is to construct inverse potentia.s for va.ious ℓ-cha.nels of neutron-proton sca.tering using a.piece-wise smooth Morse function a. a.*** pha.e equa.ions for single-cha.nel sta.es a.d the coupled equa.ions of multi-cha.nel sca.tering a.e solved numerica.ly using the 5^(th) order Runge-kutta.*** employ a.piece-wise smooth reference potentia. comprising three Morse functions a. the initia. *** a.ma.hine lea.ning-ba.ed genetic a.gorithm,we optimize the model pa.a.eters to minimize the mea.-squa.ed error between simula.ed a.d a.ticipa.ed pha.e *** a.proa.h yields inverse potentia.s for both single a.d multicha.nel sca.tering,a.hieving convergence to a.mea.-squa.ed error≤10^(-3).The resulting sca.tering lengths"a.(0)"a.d effective ra.ges"r"for ^(3)S_(1) a.d ^(1)S_(0) sta.es,expressed a.[a.(0),r],a.e found to be[5.445(5.424),1.770(1.760)]a.d[–23.741(–23.749),2.63(2.81)],respectively;these va.ues a.e in excellent a.reement with experimenta. ***,the ca.cula.ed tota. sca.tering cross-sections a.e highly consistent with their experimenta. counterpa.ts,ha.ing a.percenta.e error of less tha. 1%.This computa.iona. a.proa.h ca. be ea.ily extended to obta.n intera.tion potentia.s for cha.ged pa.ticle sca.tering.

关键词： inverse potentia.s neutron-proton sca.tering piece-wise smooth Morse function pha.e function method reference potentia. a.proa.h genetic a.gorithm