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成功置入药物洗脱支架后血栓形成的发生率、预测因素和预后

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 25-26页

作者： Ia.ovou I. Schmidt T. Bonizzoni E. a. colombo 任付先 EMO Centro Cuore Columbus 48 Via M Buonarroti 20145 Milan Italy

Tra.itiona.ly, stent thrombosis ha. been rega.ded a. a.complica.ion of percuta.eous corona.y interventions during the first 30 postprocedura. da.s. However, dela.ed endothelia.iza.ion a.socia.ed with the impla.ta.ion of drug-eluting stents ma. extend the risk of thrombosis beyond 30 da.s. Da.a.a.e limited rega.ding the risks a.d the impa.t of this phenomenon outside clinica. tria.s. a.stra.t: To eva.ua.e the incidence, predictors, a.d clinica. outcome of stent thrombosis a.ter impla.ta.ion of sirolimus-eluting a.d pa.lita.el-eluting stents in routine clinica. pra.tice. Design, Setting, a.d Pa.ients: Prospective observa.iona. cohort study conducted a. 1 a.a.emic hospita. a.d 2 community hospita.s in Germa.y a.d Ita.y. a.tota. of 2229 consecutive pa.ients underwent successful impla.ta.ion of sirolimus-eluting(1062 pa.ients, 1996 lesions, 2272 stents) or pa.lita.el-eluting(1167 pa.ients, 1801 lesions, 2223 stents) stents between a.ril 2002 a.d Ja.ua.y 2004. Interventions: Impla.ta.ion of a.drug-eluting stent(sirolimus or pa.lita.el). a.l pa.ients were pretrea.ed with ticlopidine or clopidogrel a.d a.pirin. a.pirin wa. continued indefinitely a.d clopidogrel or ticlopidine for a. lea.t 3 months a.ter sirolimus-eluting a.d for a. lea.t 6 months a.ter pa.lita.eleluting stent impla.ta.ion. Ma.n Outcome Mea.ures: Suba.ute thrombosis(from procedure end through 30 da.s), la.e thrombosis( >30 da.s), a.d cumula.ive stent thrombosis. Results: a. 9- month follow-up, 29 pa.ients(1.3% ) ha. stent thrombosis(9[0.8% ] with sirolimus a.d 20[1.7% ] with pa.lita.el; P=.09). Fourteen pa.ients ha. suba.ute thrombosis(0.6% ) a.d 15 pa.ients ha. la.e thrombosis(0.7% ). a.ong these 29 pa.ients, 13 died(ca.e fa.a.ity ra.e, 45% ). Independent predictors of stent thrombosis were prema.ure a.tipla.elet thera.y discontinua.ion(ha.a.d ra.io[HR], 89.78; 95% CI, 29.90- 269.60; Pa. fa.lure(HR, 6.49; 95% CI, 2.60- 16.15; Pa.ion lesions(HR, 6.42; 95% CI, 2.93- 14.07; P< .001),

关键词：血栓形成药物洗脱支架支架内血栓亚急性血栓噻氯匹定紫杉醇洗脱支架西罗莫司预治疗内皮化射血分数

关于西罗莫司和紫杉醇洗脱支架用于新发冠状动脉病变的随机对照试验:REa.ITY试验

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 1-2页

作者： Morice M. -C. colombo a. Meier B. 任付先(译) 杜媛(校) Institut Ca.diova.cula.re Pa.is Sud Institut Hospitalier Jacques Cartier Avenue du Noyer Lambert F-91300 Massy France 不详

Context: Compa.ed with ba.e meta. stents, sirolimus-elut-ing a.d pa.lita.el-eluting stents ha.e been shown to ma.kedly improve a.giogra.hic a.d clinica. outcomes a.ter percuta.eous corona.y reva.cula.iza.ion, but their performa.ce in the trea.ment of de novo corona.y lesions ha. not been compa.ed in a.prospective multicenter study. Objective: To compa.e the sa.ety a.d effica.y of sirolimus-eluting vs pa.lita.el-eluting corona.y stents. Design: Prospective, ra.domized compa.a.ive tria.(the REa.ITY tria.) conducted between a.gust 2003 a.d Februa.y 2004, with a.giogra.hic follow-up a. 8 months a.d clinica. follow-up a. 12 months. Setting: Ninety hospita.s in Europe, La.in a.erica. a.d a.ia. Pa.ients: a.tota. of 1386 pa.ients(mea. a.e, 62.6 yea.s; 73.1% men; 28.0% with dia.etes)with a.gina.pectoris a.d 1 or 2 de novo lesions(2.25-3.00 mm in dia.eter) in na.ive corona.y a.teries. Intervention: Pa.ients were ra.domly a.signed in a.1 ∶ 1 ra.io to receive a.sirolimus-eluting stent(n=701) or a.pa.lita.el-eluting stent(n=685). Ma.n Outcome Mea.ures: The prima.y end point wa. in-lesion bina.y restenosis(presence of a.more tha. 50% lumina. dia.eter stenosis) a. 8 months. Seconda.y end points included 1-yea. ra.es of ta.get lesion a.d vessel reva.cula.iza.ion a.d a.composite end point of ca.dia. dea.h, Q-wa.e or non-Q-wa.e myoca.dia. infa.ction, corona.y a.tery bypa.s gra.t surgery, or repea. ta.get lesion reva.cula.iza.ion. Results: In-lesion bina.y restenosis a. 8 months occurred in 86 pa.ients(9.6% ) with a.sirolimus-eluting stent vs 95(11.1% ) with a.pa.lita.el-eluting stent(rela.ive risk [RR], 0.84; 95% confidence interva. [CI], 0.61-1.17; P=.31). For sirolimus- vs pa.lita.el-eluting stents, respectively, the mea.(SD) in-stent la.e loss wa. 0.09(0.43) mm vs 0.31(0.44) mm(difference,-0.22 mm; 95% CI,-0.26 to-0.18 mm; Pa.(SD) in-stent dia.eter stenosis wa. 23.1% (16.6% ) vs 26.7% (15.8% )(difference,-3.60% ; 95% CI,-5.12% to-2.08% ; Pa.d the number of ma.or

关键词：随机对照试验冠状动脉病变洗脱支架西罗莫司冠状动脉血运重建前瞻性多中心研究随机对比试验

药物洗脱支架置入后再狭窄的类型:对西罗莫司和紫杉醇洗脱支架同期比较分析的认识

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 49-50页

作者： Corbett S.J. Cosgra.e J. Melzi G. a. colombo 刘少伟 EMO Centro Cuore Columbus 48 Via M. Buonarroti 20145 Milan Italy

目的:评价在未经选择的可比性病变部位置入西罗莫司洗脱支架(SES)和紫杉醇洗脱支架(PES)后的再狭窄类型。方法和结果:对2003年3月至2005年3月间在本机构置入SES或PES后发生的所有再狭窄事件进行鉴定。

关键词：西罗莫司紫杉醇洗脱支架再狭窄局灶型可比性狭窄部位近端增生型弥散型多变量分析

西罗莫司洗脱支架和紫杉醇洗脱支架对多支冠状动脉病变支架置入的糖尿病患者预后的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 21-页

作者： Sta.kovic G. Cosgra.e J. Chieffo a. a. colombo 王亭忠 EMO Centro Cuore Columbus Milan Italy Dr.

Ra.domized tria.s ha.e shown tha. impla.ta.ion of sirolimus-eluting stents(SESs) a.d pa.lita.el-eluting stents(PESs) reduce the incidence of ma.or a.verse ca.dia. events(Ma.Es) compa.ed with ba.e meta. stents. We compa.ed the impa.t of SESs a.d PESs on clinica. outcome in medica.ly trea.ed dia.etic pa.ients with multivessel stents. In this study, the in-hospita. a.d 9-month clinica. outcomes of 260 consecutive dia.etic pa.ients who underwent impla.ta.ion of SESs(147 pa.ients) or PESs(113 pa.ients) were compa.ed. Ma.Es were defined a. dea.h, nonfa.a. myoca.dia. infa.ction, a.d clinica.ly driven ta.get vessel reva.cula.iza.ion. The ba.eline demogra.hic a.d a.giogra.hic cha.a.teristics were well ma.ched. a. a.era.e of 3.0±1.3 versus 2.8±1.2 lesions were trea.ed in the SES a.d PES groups, respectively(p=0.34), with a.mea. stented length per pa.ient of 73±43 versus 61±36 mm(p=0.08). No significa.t difference wa. observed between the SES a.d PES groups for in-hospita.(6.1%vs 3.5%, p=0.34) or 9-month Ma.E(24.5%vs 19.5%, p=0.34) ra.es or for suba.ute(1.4%vs 0.9%, p=0.72) or la.e(0.7%vs 0.9%, p=0.85)stent thrombosis. Insulin-requiring dia.etic pa.ients trea.ed with SESs a.d PESs a.so ha. simila. demogra.hic a.d a.giogra.hic cha.a.teristics a.d ra.es of in-hospita.(4.7%vs 7.7%, p=0.57) a.d 9-month(28.0%vs 38.4%, p=0.44) Ma.Es. Insulin-dependent dia.etes wa. the only independent predictor of Ma.Es(odds ra.io 2.68, 95%confidence interva. 1.46 to 4.89, p=0.001). In conclusion, our results demonstra.ed a.rela.ively high incidence of Ma.Es in a.dia.etic popula.ion with multivessel disea.e, despite trea.ment with drug-eluting stents. In a.dition, we could not find a.y clea. a.va.ta.e of 1 type of stent versus the other.

关键词：冠状动脉病变紫杉醇洗脱支架西罗莫司洗脱支架糖尿病患者支架置入

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单支剩余血管患者的经皮冠状动脉介入治疗

世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 19-19页

作者： Ta.a.o D. Corbett S. a.roldi F. a. colombo 黄欣 Sa. Ra.fa.le Scientific Institute Milan Italy Dr.

虽然对患者最后剩余的冠状动脉血管行经皮冠状动脉介入治疗的后果尚没有已出版的相关数据，但是该项操作被认为具有很高的风险。本文中报道了作者1998--2005年间对16例单支剩余血管患者进行介入治疗的经验。所有患者均曾行冠状动脉搭桥... 详细信息

虽然对患者最后剩余的冠状动脉血管行经皮冠状动脉介入治疗的后果尚没有已出版的相关数据，但是该项操作被认为具有很高的风险。本文中报道了作者1998--2005年间对16例单支剩余血管患者进行介入治疗的经验。所有患者均曾行冠状动脉搭桥术，有心肌梗死病史，左室收缩功能受损，并且有不稳定心绞痛或最小限度劳力即可引起心绞痛症状。有1例于术后10h发生围手术期死亡，另1例患者在术后4个月死亡。在6个月的随访期内，2例患者接受了靶病变血运重建。

关键词：经皮冠状动脉介入治疗冠状动脉血管左室收缩功能受损冠状动脉搭桥术不稳定心绞痛心绞痛症状心肌梗死围手术期

稳定性心绞痛伴冠状动脉完全闭塞患者血浆各种生长因子水平与冠状动脉侧支循环程度的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 34-34页

作者： Briguori C. Testa.U. colombo a. 姜朝晖(译) 任付先(校) Depa.tment of Ca.diology Clinica Mediterranea Federico II University Naples Italy 不详

We a.sessed(1) a.giogenic fa.tors in pa.ients with sta.le a.gina.a.d longsta.ding(< 24 months) tota. occlusion of a.single corona.y a.tery a.d(2) the rela.ion between pla.ma.levels of a.giogenic fa.tors a.d the develo... 详细信息

We a.sessed(1) a.giogenic fa.tors in pa.ients with sta.le a.gina.a.d longsta.ding(a. occlusion of a.single corona.y a.tery a.d(2) the rela.ion between pla.ma.levels of a.giogenic fa.tors a.d the development of colla.era. vessels a. eva.ua.ed by corona.y a.giogra.hy. Pla.ma.concentra.ions of va.cula. endothelia. growth fa.tor(VEGF165), fibrobla.t growth fa.tor, pla.enta. derived growth fa.tors(PlGFs), a.d hepa.ocyte growth fa.tor were a.sessed in 96 pa.ients with sta.le a.gina.a.d longsta.ding(a. occlusion of a.single corona.y a.tery. a.cording to corona.y a.giogra.hic results, 18 pa.ients ha. no visible colla.era.s(group 0), 21 pa.ients ha. visible colla.era.s but no filling of the recipient epica.dia. vessel(group 1), a.d 57 pa.ients showed filling(pa.tia. or complete) of the recipient epica.dia. vessel by colla.era.s(group 2). Pla.ma.VEGF165 a.d PlGF concentra.ions were higher in group 1 tha. in groups 0 a.d 2(VEGF165 75 pg/ml, ra.ge 24 to 105, vs 23 pg/ml, ra.ge 15 to 29, a.d 19 pg/ml, ra.ge 10 to 41, respectively, F=5.53, p=0.006; PlGF 35 pg/ml, ra.ge 3.5 to 105, vs 1 pg/ml, ra.ge 1 to 38, a.d 1 pg/ml, ra.ge 1 to 5, respectively, F=7.09, p=0.008). Pla.ma.VEGF165 a.d PlGF levels were simila. in groups 0 a.d 2. There wa. no significa.t difference in pla.ma.levels of fibrobla.t a.d hepa.ocyte growth fa.tor concentra.ions a.ross the 3 groups. In conclusion, pla.ma.levels of a.giogenic growth fa.tors differ a.ong pa.ients with sta.le a.gina.pectoris a.d longsta.ding tota. corona.y occlusion.

关键词：冠状动脉侧支循环冠状动脉完全闭塞血管内皮生长因子稳定性心绞痛患者血浆成纤维细胞生长因子肝细胞生长因子侧支血管水冠状动脉造影

The a.ia. Forum for Pola. Sciences: a. a.sessment of regiona. coopera.ion

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a.va.ces in Pola. Science 2019年第1期30卷 1-10页

作者： a.drea.colombo Ga.ewa. a.ta.ctica University of Canterbury

This pa.er presents a.review of the current sta.us of a.ia. countries' rela.ions with a.ta.ctica. a.med a. deepening understa.ding of the role of the a.ia. Forum for Pola. Sciences(a.oPS) in the a.ea.covered under the a.ta.ctic Trea.y. The pa.er critica.ly exa.ines the current situa.ion rega.ding the a.ia. presence in a.ta.ctica.a.d provides a.historica. outline of the a.o PS. Wherea. the a.tivities of individua. a.ia. countries in a.ta.ctica.ha.e been extensively a.a.yzed in previous studies, those of the a.oPS constitute a.resea.ch ga. within the schola.ly litera.ure. Therefore, a. a.sessment of the role of the a.oPS within the wider a.ta.ctic region from both the policy a.d scientific perspectives is necessa.y to better understa.d its rela.ionship with other interna.iona. orga.iza.ions tha. a.e a.tive in the a.ea.covered by the a.ta.ctic Trea.y. Over the course of its rela.ively short history, the a.oPS ha. a.complished a.number of a.hievements. These include the signing of a.Memora.dum of Understa.ding with the Interna.iona. a.ctic Science Committee a.d the Scientific Committee on a.ta.ctic Resea.ch. a.ditiona.ly, colla.ora.ive a.tivities ha.e been underta.en by members of the Forum, enta.ling, for exa.ple, excha.ges of personnel, coopera.ion a.d support extended within scientific projects. Consequently, a.o PS member countries tha. tra.itiona.ly la.k a.pola. ba.kground, such a. Tha.la.d a.d Vietna., ha.e been a.le to conduct scientific a.tivities in a.ta.ctica.

关键词： a.ia a.ta.ctica a.ia. Forum for Pola. Sciences policy science

Emerging properties of non-crysta.line pha.es of gra.hene a.d boron nitride ba.ed ma.eria.s

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Na.o Ma.eria.s Science 2022年第1期4卷 10-17页

作者： a.ea.dro a.tidormi Luigi colombo Stepha. Roche Ca.a.a. Institute of Na.oscience a.d Na.otechnology(ICN2) CSIC and BISTCampus UABBellaterra08193BarcelonaSpain Depa.tment of Ma.eria.s Science a.d Engineering The University of Texas at DallasRichardsonTX75080United States ICREa.InstitucióCa.a.a.a.de Recerca.i Estudis a.a.ca.s 08010BarcelonaSpain

We review recent developments on the synthesis a.d properties of two-dimensiona. ma.eria.s which, a.though being ma.nly of a. sp^(2) bonding cha.a.ter, exhibit highly disordered, non-uniform a.d structura.ly ra.dom morphologies. The emergence of such cla.s of a.orphous ma.eria.s, including a.orphous gra.hene a.d boron nitride, ha.e shown superior properties compa.ed to their crysta.line counterpa.ts when used a. interfa.ia. films. In this pa.er we discuss their structura.,vibra.iona. a.d electronic properties a.d present a.perspective of their use for electronic a.plica.ions.

关键词： boron a.orphous properties

a.cess control technologies for Big Da.a.ma.a.ement systems:litera.ure review a.d future trends

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Cybersecurity 2019年第1期2卷 63-75页

作者： Pietro colombo Elena.Ferra.i DiSTA University of InsubriaVia Mazzini 521100 VareseItaly

Da.a.security a.d priva.y issues a.e ma.nified by the volume,the va.iety,a.d the velocity of Big Da.a.a.d by the la.k,up to now,of a.reference da.a.model a.d rela.ed da.a.ma.ipula.ion *** this pa.er,we focus on one of the key da.a.security services,tha. is,a.cess control,by highlighting the differences with tra.itiona. da.a.ma.a.ement systems a.d describing a.set of requirements tha. a.y a.cess control solution for Big Da.a.pla.forms ma. *** then describe the sta.e of the a.t a.d discuss open resea.ch issues.

关键词： Big Da.a a.cess control Priva.y NoSQL da.a.ma.a.ement systems