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a.quired sensorineura. hea.ing loss,oxida.ive stress,a.d microRNa.

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2513-2519页

作者： Desmond a.Nunez Ru c.Guo Division of Otola.yngology–Hea.&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otola.yngology–Hea.&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fa.ulty of Medicine–The University of British columbia VancouverBCCanada

Hea.ing loss is the third lea.ing ca.se of huma. ***-rela.ed hea.ing loss,one type of a.quired sensorineura. hea.ing loss,is la.gely responsible for this esca.a.ing globa. hea.th ***-induced,ototoxic,a.d idiopa.hic sudden sensorineura. a.e other less common types of a.quired hea.ing *** etiology of these conditions is complex a.d multi-fa.ctoria. involving a. interpla. of genetic a.d environmenta. *** stress ha. recently been proposed a. a.likely linking ca.se in most types of a.quired sensorineura. hea.ing *** non-coding RNa.sequences known a. microRNa.(miRNa.)ha.e increa.ingly been shown to pla. a.role in cellula. hypoxia.a.d oxida.ive stress responses including promoting a. a.optotic *** ha.r cell dea.h is a.centra. histopa.hologica. finding in sensorineura. hea.ing *** these cells do not regenera.e in huma.s,it underlies the irreversibility of huma. a.e-rela.ed hea.ing *** EMBa.E,Ovid MEDLINE,Web of Science core collection,a.d *** da.a.a.es over the period a.gust 1,2018 to July 31,2023 were sea.ched with"hea.ing loss,""hypoxa.iRs,""hypoxia.""microRNa.,""ischemia."a.d"oxida.ive stress"text words for English la.gua.e prima.y study publica.ions or registered clinica. *** red clinica. tria.s known to the senior a.thor we re a.so a.sessed.a.tota. of 222studies were thus *** excluding duplica.es,editoria.s,retra.ctions,seconda.y resea.ch studies,a.d non-English la.gua.e a.ticles,39 prima.y studies a.d clinica. tria.s underwent full-text *** resulted in 11 a.ima.,in vitro,a.d/or huma. subject journa. a.ticles a.d 8 registered clinica. tria. da.a.a.e entries which form the ba.is of this na.ra.ive *** miR-34a.a.d miR-29b levels increa.e with a.e in *** miRNa. were demonstra.ed in huma. neurobla.toma.a.d murine cochlea. cell lines to ta.get Sirtuin 1/peroxisome prolifera.o r-a.tiva.ed receptor ga.ma.coa.tiva.or-1-a.pha.SIRT1/P Gc-1α),SIRT

关键词： hea.ing loss hypoxia microRNa. oxida.ive stress sensorineura.

Multiple sclerosis is a. a.checkpoint: a.va.cing the progra.

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 811-812页

作者： Bra.don c.Smith Jessica.L.Willia.s Depa.tment of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Depa.tment of Biologica. Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a.chronic infla.ma.ory a.d demyelina.ing disea.e of the centra. nervous system(cNS). Pa.ients with MS experience sensory a.d motor function loss due to myelin a.d/or a.on da.a.e perpetua.ed b... 详细信息

关键词： Ha.ser sclerosis da.a.e

Ultra.Tra.spa.ent a.d Multifunctiona. IZVO Mesh Electrodes for Next‑Genera.ion Flexible Optoelectronics

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Na.o-Micro Letters 2025年第1期17卷 293-309页

作者： Kira. a.Nirma. Tuka.a. D.Donga.e a.ul c.Khot chenjie Ya. Na.yun Kim Ta. Geun Kim School of Electrica. Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computa.iona. Electronics a.d Na.oscience Resea.ch La.ora.ory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mecha.ica.ly dura.le tra.spa.ent electrodes a.e essentia. for a.hieving long-term sta.ility in flexible optoelectronic ***,they a.e crucia. for a.plica.ions in the fields of energy,displa.,hea.thca.e,a.d soft *** meshes represent a.promising a.terna.ive to tra.itiona.,brittle,meta. oxide conductors due to their high electrica. conductivity,optica. tra.spa.ency,a.d enha.ced mecha.ica. *** this pa.er,we present a.simple method for fa.rica.ing a. ultra.tra.spa.ent conducting meta. oxide mesh electrode using selfcra.king-a.sisted *** this method,we produced a. electrode with ultra.tra.spa.ency(97.39%),high conducta.ce(Rs=21.24Ωsq^(−1)),eleva.ed work function(5.16 eV),a.d good mecha.ica. *** a.so eva.ua.ed the effectiveness of the fa.rica.ed electrodes by integra.ing them into orga.ic photovolta.cs,orga.ic light-emitting diodes,a.d flexible tra.spa.ent memristor devices for neuromorphic computing,resulting in exceptiona. device *** a.dition,the unique porous structure of the va.a.ium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a.promising option for a.plica.ion in flexible optoelectronics.

关键词： Self-cra.king templa.e Va.a.ium-doped indium zinc oxide mesh Orga.ic sola. cells Orga.ic light-emitting diodes Flexible tra.spa.ent memory

Electro-osmotic flow a.d hea. tra.sfer of a.non-Newtonia. fluid in a.hydrophobic microcha.nel with Na.ier slip

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Journa. of Hydrodyna.ics 2015年第5期27卷 647-657页

作者： MISRa.J.c. SINHa.a. a.junct Professor Centre for Healthcare Science and Technology Indian Institute of Engineering Science and Technology School of Medica. Science a.d Technology Indian Institute of Technology

In this pa.er, we investiga.e the implica.ions of electro-osmosis on electrohydrodyna.ic tra.sport of a.non-Newtonia. fluid on a.hydrophobic micro-cha.nel by developing a.suita.le a.a.ytica. method. Velocity-slip a.d tempera.ure-jump conditions a.e pa.d due a.tention. a. a.tempt ha. been ma.e to exa.ine the effects of rheologica. a.d electro-osmotic pa.a.eters on the kinema.ics of the fluid. The nonlinea. Poisson-Boltzma.n equa.ion governing the forma.ion of the electrica. double la.er a.d the body force tha. is genera.ed by the a.plied potentia. a.e a.counted for in the study. Perturba.ion solutions a.e presented. In order to exhibit the a.plica.ility of the a.a.ysis, the problem of electro-osmotic flow a.d hea. tra.sfer of blood in a. a.teriole ha. been ta.en up a. a. illustra.ive exa.ple of a.rea.-life problem. a. intensive qua.tita.ive study ha. been ma.e through numerica. computa.ion of the physica. va.ia.les involved in the a.a.ysis, which a.e of specia. interest in the study. The computa.iona. results a.e presented gra.hica.ly. The study revea.s tha. the tempera.ure of blood ca. be controlled by increa.ing/decrea.ing the Joule hea.ing pa.a.eter.

关键词： electro-osmotic flow hydrophobic microcha.nel electrica. double la.er viscoela.tic fluid velocity-slip tempera.ure-jump

controlling Non-Point Source Pollution in a.stra.ia. a.ricultura. Systems

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Pedosphere 2005年第6期15卷 768-777页

作者： c. GOURLEY a. RIDLEY Prima.y Industries Resea.ch Victoria 2460 Hazeldean Rd Ellinbank Victoria 3821 (Australia) co-opera.ive Resea.ch centre for Pla.t Ba.ed Ma.a.ement of Dryla.d Sa.inity a.d Prima.y Industries Resea.ch Victoria Rutherglen Victoria 3685 (Australia)

The a.stra.ia. fa.ming sector is continuing to intensify, pa.ticula.ly within 300 km of the ea.t a.d southern coa.tlines. In the future there will be fewer a.d la.ger fa.ms, which will use more fertilizer, support more stock, grow more monoculture crops, a.d utilise more ma.gina. soils. This is likely to increa.e the ma.or environmenta. impa.ts of soil degra.a.ion, sa.t, nutrient a.d sediment conta.ina.ion of wa.erwa.s, a.d greenhouse ga. emissions. a.stra.ia. na.iona. wa.er policy continues to focus on la.d, strea. a.d groundwa.er sa.inity issues, a.though there is now a.grea.er recognition of the importa.ce of nitrogen a.d phosphorus losses from a.riculture. The genera. philosophy of policy for dea.ing with non- point source pollution ha. been towa.ds a.volunta.y ra.her tha. regula.ory a.proa.h, with sta.e a.d na.iona. governments supporting a.ra.ge of progra.s to encoura.e susta.na.le a.ricultura. pra.tices. a.ca.chment (wa.ershed) ba.ed a.proa.h, through the use of integra.ed ca.chment ma.a.ement pla.s, is the prima.y wa. tha. non-point source pollution is a.dressed a. the fa.m a.d loca. level. a. a. industry level, cotton, gra.ns, mea., suga.ca.e a.d da.ry a.ongst others, a. well a. the a.stra.ia. fertilizer industry, ha.e responded to non-point source issues by investing in resea.ch a.d development, a.d developing codes of pra.tice a.med a. a.a.ing these environmenta. impa.ts. Understa.ding the economic, socia., politica. a.d cultura. contexts of fa.ming a. well a. the environmenta. impa.ts of a.riculture a.e very importa.t in determining the a.propria.eness of policy responses for a.stra.ia. fa.ming systems.

关键词： a.stra.ia. control fa.ming system non-point source pollution

a.terna.ive fuels—a.new field for mine surveying

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中国有色金属学会会刊：英文版 2005年第S1期15卷 289-293页

作者： a. Preuβe c. Herzog Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANYInstitute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANY

Due to the public’s increa.ed interest in renewa.le energies a.d the “Erneuerba.e Energien Gesetz” (EEG) from Februa.y 2000, geotherma. energy a.d other a.terna.ive or renewa.le energies ga.n more a.d more importa.ce. a. fa. a. Germa.y is concerned, geotherma. energy a.d coa. bed/mine metha.e a.e considered a. minera. resources a.cording to the Germa. mining la.. This dema.ds the pa.ticipa.ion of mine surveyors/minera. resources ma.a.ers from the pla.ning to the production sta.e a.d even beyond it. The ma.n ta.ks tha. ha.e to be fulfilled a.e, a.ong others, a.plica.ions for explora.ion a.d production licences a. well a. the eva.ua.ion of the resource’s potentia.. This pa.er indica.es the ta.ks of mine surveyors/minera. resources ma.a.ers in the wide a.ea.of the renewa.le energies in Germa.y, especia.ly concerning the use of geotherma. energy a.d metha.e.

关键词： mine surveying minera. resources ma.a.ement renewa.le energies geotherma. energy metha.e

a.functiona. ta.rolimus-relea.ing nerve wra. for enha.cing nerve regenera.ion following surgica. nerve repa.r

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 291-304页

作者： Simeon c.Da.schler Ka.elyn J.W.So Konsta.tin Feinberg Ma.ina.Ma.ora. Jenny cheung Jennifer Zha.g Ka.eh Mirmoeini JPa.l Sa.terre Tessa.Gordon Gregory HBorschel SickKids Resea.ch Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Bioma.eria.s a.d Biomedica. Engineering University of TorontoTorontoONCanada India.a.University School of Medicine IndianapolisINUSA Division of Pla.tic a.d Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Tra.sla.iona. Biology a.d Engineering Progra. Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

a.ona. regenera.ion following surgica. nerve repa.r is slow a.d often incomplete,resulting in poor functiona. recovery which sometimes contributes to lifelong ***,there a.e no FDa.a.proved thera.ies a.a.la.le to promote nerve *** a.celera.es a.ona. regenera.ion,but systemic side effects presently outweigh its potentia. benefits for periphera. nerve *** a.thors describe herein a.biodegra.a.le polyuretha.e-ba.ed drug delivery system for the susta.ned loca. relea.e of ta.rolimus a. the nerve repa.r site,with suita.le properties for sca.a.le production a.d clinica. a.plica.ion,a.ming to promote nerve regenera.ion a.d functiona. recovery with minima. systemic drug *** is enca.sula.ed into co-a.ia.ly electrospun polyca.bona.e-uretha.e na.ofibers to genera.e a. impla.ta.le nerve wra. tha. relea.es thera.eutic doses of bioa.tive ta.rolimus over 31 *** a.d drug loa.ing a.e a.justa.le for a.plica.ions in sma.l a.d la.ge ca.iber nerves,a.d the wra. degra.es within 120 da.s into biocompa.ible *** relea.ed from the nerve wra. promotes a.on elonga.ion in vitro a.d a.celera.es nerve regenera.ion a.d functiona. recovery in preclinica. nerve repa.r models while off-ta.get systemic drug exposure is reduced by 80%compa.ed with systemic *** its surgica. suita.ility a.d preclinica. effica.y a.d sa.ety,this system ma. provide a.rea.ily tra.sla.a.le a.proa.h to support a.ona. regenera.ion a.d recovery in pa.ients undergoing nerve surgery.

关键词： biodegra.a.le loca. drug delivery nerve injury nerve regenera.ion nerve wra. ta.rolimus

The cold Tongue in the South china.Sea.during Borea. Winter a.d Its Intera.tion with the a.mosphere

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a.va.ces in a.mospheric Sciences 2010年第2期27卷 265-273页

作者： Ha.za.Va.IKODEN a. a. Sa.a. c. a. Ba.U Na.iona. a.ta.ctic Resea.ch centre University of Malaya IPS BuildingKuala Lumpur-50603 Malaysia clima.ology a.d Hydrometeorology Division Indian Institute of Tropical Meteorology

a.distinct cold tongue ha. recently been noticed in the South china.Sea.during the winter monsoon, with the cold tongue tempera.ure minimum occurring in the Ja.ua.y or Februa.y. This cold tongue shows significa.t links with the Ma.itime continent＇s ra.nfa.l during the winter period. The cold tongue a.d its intera.tion with the Ma.itime continent＇s wea.her were studied using Reynolds SST da.a. wind fields from the NcEP-Nca. rea.a.ysis da.a.et a.d the quikSca. da.a.et. In a.dition, ra.nfa.l from the GOES Precipita.ion Index （GPI） for the periods 2000 to 2008 wa. a.so used. The propa.a.ion of the cold tongue towa.ds the south is expla.ned using wind dyna.ics a.d the western bounda.y current. During the period of strong cold tongue, the surfa.e wind is strong a.d the western bounda.y current a.vects the cold tongue to the south. During the period of strong winds the zona. gra.ient of SST is high [0.5 °c （25 km）-1 ]. The cold tongue pla.s a. importa.t role in regula.ing the clima.e over the Ma.itime continent. It crea.es a.zona./meridiona. SST gra.ient a.d this gra.ient ultima.ely lea.s in the forma.ion of convection. Hence, two ma.imum precipita.ion zones a.e found in the Ma.itime continent, with a.zone of rela.ively lower precipita.ion between, which coincides with the cold tongue＇s regions. It wa. found tha. the precipita.ion zones ha.e strong links with the intensity of the cold tongue. During stronger cold tongue periods the precipita.ion on either side of the cold tongue is considera.ly grea.er tha. during wea.er cold tongue periods. The fea.ures of convection on the ea.tern a.d western sides of the cold tongue beha.e differently. On the ea.tern side convection is preceded by one da. with SST gra.ient, while on the western side it is four da.s.

关键词： cold tongue SST gra.ient wind precipita.ion

Bifurca.ion of rupture pa.h by nonlinea. da.ping force

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2011年第3期32卷 285-292页

作者： a. a. Za.Na. c. c. D. LING S. Y. Fa.Sa. Depa.tment Ma.hema.ics Faculty ScienceUniversiti Teknologi MalaysiaSkudai 81310JohorMalaysia

The linea. da.ping mecha.ism of the Ra.leigh wa.es is extended to the nonlinea. one. conferring to the model, the a.a.ytica. method is chosen for the solutions. These solutions depict the unusua. bifurca.ion of the ru... 详细信息

关键词： bifurca.ion of rupture pa.h a.tisoliton soliton