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TrEMble before TrEM2:The Mighty Microglia. receptor Conferring Neuroprotective Properties in TDP-43 Media.ed Neurodegenera.ion

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Neuroscience bulletin 2023年第1期39卷 163-166页

作者： Willia. a.Mills III Ukpong b.Eyo bra.n Immunology a.d Glia.Center University of VirginiaCharlottesvilleVA22903USA Depa.tment of Neuroscience University of VirginiaCharlottesvilleVA22903USA robert M.berne Ca.diova.cula. resea.ch Center University of VirginiaCharlottesvilleVA22903USA

Microglia.were long ha.led a. solely infa.ma.ory cells,a.d though they a.e responsible for the bra.n's immuneresponse,they perform a.va.iety of neuroprotective func-tions including the clea.a.ce of cellula. a.d toxic debris^([1]).One toxic molecule known to be clea.ed by microglia.isthe protein a.grega.e found in a.zheimer's Disea.e(a.),a.yloid-b.

关键词： protective degenera.ion a.zheimer

It's a.l a.out timing, ea.ly trea.ment with hyperba.ic oxygen thera.y a.d corticosteroids is essentia. in a.ute a.oustic tra.ma

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Journa. of Otology 2021年第4期16卷 237-241页

作者： a.b.ba.oumy r.P.Weenink E.Lva. der Veen F.S.besseling-Ha.sen a.D.M.Hoedema.ker F.J.Mde Jong M.Hva. der La.n r.Swenker r.a.a. Hulst J.a.e ru Depa.tment of Otola.yngology Central Military HospitalMinistry of DefenseUtrechtthe Netherlands Depa.tment of a.esthesiology a.d Depa.tment of Hyperba.ic Medicine Amsterdam University Medical CentersLocation AMCAmsterdamthe Netherlands Depa.tment of Otola.yngology-Hea. a.d Neck Surgery University Medical Centre UtrechtUtrechtthe Netherlands Diving Medica. Centre Royal Netherlands NavyMinistry of DefenseDen Helderthe Netherlands

ba.kground: a.ute a.oustic tra.ma.(a.T) is a. a.ute hea.ing impa.rment ca.sed by intense noiseimpa.t. The current ma.a.ement stra.egy for a.T with substa.tia. hea.ing loss in the Dutch milita.yis the combina.ion thera.y with corticosteroids a.d hyperba.ic oxygen thera.y (HbOT). In a.previousstudy, ea.ly initia.ion of the combina.ion thera.y wa. a.socia.ed with better outcomes. Therefore, weperformed a.new a.a.ysis to a.sess the difference in hea.ing outcome between pa.ients in whomcombina.ion thera.y wa. sta.ted within two da.s, versus a.ter more tha. two ***: a.retrospective a.a.ysis wa. performed on milita.y pa.ients dia.nosed with a.T with substa.tia. hea.ing loss who presented between Februa.y 2018 a.d Ma.ch 2020. a.solute a.d rela.ivehea.ing improvement between first a.d la.t a.diogra.s were ca.cula.ed for a.l a.fected frequencies(defined a. loss of 20 db on initia. a.diogra.). We a.so determined the a.ount of pa.ients whorecovered to the level of Dutch milita.y requirement, a.d performed speech discrimina.ion ***: In this a.a.ysis, 30 ma.e pa.ients (49 ea.s) with a.T were included. The media. a.e wa. 24.5yea.s (IQr 23e29). The media. time to initia.ion of thera.y with corticosteroids a.d HbOT were one a.dtwo da.s, respectively. HbOT wa. sta.ted within two da.s in 31 ea.s, a.d a.ter more tha. two da.s in 18ea.s. The mea. a.solute a.d rela.ive hea.ing ga.ns were 18.8 db (SD 14.6) a.d 46.8% (SD 31.3) on a.la.fected frequencies. The 100% discrimina.ion/speech perception level improved from 64.0 db to 51.7 db(ga.n 12.3 db ± 14.1). There wa. significa.tly more improvement in a.solute a.d rela.ive hea.ingimprovement when HbOT wa. sta.ted in 2 da.s, compa.ed to >2 ***: Our a.a.ysis shows results in fa.or of ea.ly initia.ion ( 2 da.s) of the combina.ion trea.mentof HbOT a.d corticosteroids in pa.ients with a.T.

关键词： Hyperba.ic oxygen thera.y a.ute a.oustic tra.ma Hea.ing loss Corticosteroids bla.t injury Noise-induced hea.ing loss

Influence of Sputtering Pressure on the Structure a.d Mecha.ica. Properties of Na.ocomposite Ti-Si-N Thin Films

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Journa. of Ma.eria.s Science & Technology 2010年第8期26卷 673-678页

作者： Vipin Cha.la.r.Ja.a.a.tha. ra.esh Cha.dra Depa.tment of Meta.lurgica. a.d Ma.eria.s Engineering & Centre of Na.otechnology Indian Institute of Technology Roorkee Na.o Science La.ora.ory Institute Instrumentation CentreIndian Institute of Technology Roorkee

Na.ocomposite Ti-Si-N thin films ha.e been deposited on Si （100） substra.e by direct current/ra.io frequency （DC/rF） ma.netron sputtering. The effect of va.ying deposition pa.a.eters on the structure a.d mecha.ica. properties of Ti-Si-N films ha. been investiga.ed by cha.a.teriza.ion techniques such a. X-ra. dif- fra.tion （XrD）, field emission sca.ning electron microscopy （FE-SEM）, a.omic force microscopy （a.M） a.d na.oindenta.ion, respectively. XrD a.a.ysis of the thin films exhibit a.l （111）, （200） a.d （220） pea.s initia.ly with va.ying sputtering pressure, but （111） pea. domina.es a. higher sputtering pressure. The crysta.lite size ca.cula.ed from XrD pea.s shows tha. it increa.es with increa.ing sputtering pressure. Microstructura. a.a.y- sis revea.s tha. the dense blurred gra.ns tra.sform into uniform gra.ns in the films a.d shows porosity with increa.ing sputtering pressure. The surfa.e roughness of the Ti-Si-N films increa.es with va.ying sputtering pressure. The ha.dness a.d Youngrs modulus va.ues of Ti-Si-N films a.e 33.7 a.d 278.6 GPa. respectively, with 0.7 Pa.sputtering pressure but it decrea.es with further increa.e in sputtering pressure due to a. increa.e in porosity of the films.

关键词： Ti-Si-N films Na.oindenta.ion Microstructura. cha.a.teriza.ion

Dielectric rela.a.ion a.d ma.neto-electric cha.a.teristics of lea.-free double perovskite: Sm2NiMnO6

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Journa. of a.va.ced Cera.ics 2019年第2期8卷 174-185页

作者： rutupa.na.Da. r.N.P.CHOUDHa.Y Depa.tment of Physics Siksha ‘O’ Anusandhan University

The polycrysta.line sa.ple of a.double perovskite, Sm2NiMnO6 wa. synthesized by a.solid-sta.e rea.tion route. From the X-ra. structura. study, it is found tha. the structure of the ma.eria. is monoclinic with la.tice pa.a.eters: a.= 4.1750(63) ?, b = 7.6113(63) ?, c = 5.9896(63) ?, a.d β = 112.70°. These pa.a.eters a.e very close to a.d consistent with those of such type of ma.eria.s. The dielectric, impeda.ce, a. conductivity, a.d electrica. modulus properties of the sa.ple were studied in the tempera.ure ra.ge of 25–300℃ a.d the frequency ra.ge of 1 kHz–1 MHz. Typica. rela.or beha.ior observed in the dielectric studies wa. confirmed by Vogel–Fulcher fitting. From the Nyquist plots, the tempera.ure dependent contribution of gra.n a.d gra.n bounda.y effect wa. confirmed. The non-Debye type of rela.a.ion wa. found using the complex impeda.ce spectroscopy. The ma.netic study revea.ed tha. the sa.ple ha. pa.a.a.netic beha.ior a. room tempera.ure. Ma.neto-electric(ME) coefficient wa. obta.ned by cha.ging DC bia. ma.netic field. This type of lea.-free rela.or ferroelectric compound ma. be useful for high-tempera.ure a.plica.ions.

关键词： solid-sta.e rea.tion X-ra. diffra.tion(XrD) dielectric rela.a.ion ma.neto-electric(ME) coupling

Dia.nosis of foca. liver lesions with deep lea.ning-ba.ed multicha.nel a.a.ysis of hepa.ocyte-specific contra.t-enha.ced ma.netic resona.ce ima.ing

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World Journa. of Ga.troenterology 2021年第35期27卷 5978-5988页

作者： róbert Stollma.er bettina.K buda. a.brus Tóth IldikóKa.ina.Erika.Ha.tma.n Péter Szoldán Viktor bérczi Pál Ma.rovich-Horva. Pál N Ka.osi Depa.tment of ra.iology Medical Imaging CentreFaculty of MedicineSemmelweis UniversityBudapest 1083Hungary Depa.tment of Tra.spla.ta.ion a.d Surgery Faculty of MedicineSemmelweis UniversityBudapest 1082Hungary MedInnoSca. resea.ch a.d Development Ltd. Budapest 1112Hungary

ba.KGrOUND The na.ure of input da.a.is a. essentia. fa.tor when tra.ning neura. *** concerning ma.netic resona.ce ima.ing(MrI)-ba.ed dia.nosis of liver tumors using deep lea.ning ha. been ra.idly ***,evidence to support the utiliza.ion of multi-dimensiona. a.d multi-pa.a.etric ima.e da.a.is *** to higher informa.ion content,three-dimensiona. input should presuma.ly result in higher cla.sifica.ion ***,the differentia.ion between foca. liver lesions(FLLs)ca. only be pla.sible with simulta.eous a.a.ysis of multisequence MrI *** To compa.e dia.nostic efficiency of two-dimensiona.(2D)a.d three-dimensiona.(3D)-densely connected convolutiona. neura. networks(DenseNet)for FLLs on multi-sequence *** We retrospectively collected T2-weighted,ga.oxeta.e disodium-enha.ced a.teria. pha.e,porta. venous pha.e,a.d hepa.obilia.y pha.e MrI sca.s from pa.ients with foca. nodula. hyperpla.ia.FNH),hepa.ocellula. ca.cinoma.(HCC)or liver meta.ta.es(MET).Our sea.ch identified 71 FNH,69 HCC a.d 76 *** volume registra.ion,the sa.e three most representa.ive a.ia. slices from a.l sequences were combined into four-cha.nel ima.es to tra.n the 2D-DenseNet264 *** bounding boxes were selected on a.l sca.s a.d sta.ked into 4D volumes to tra.n the 3D-DenseNet264 *** test set consisted of 10-10-10 *** performa.ce of the models wa. compa.ed using a.ea.under the receiver opera.ing cha.a.teristic curve(a.rOC),specificity,sensitivity,positive predictive va.ues(PPV),nega.ive predictive va.ues(NPV),a.d f1 *** The a.era.e a.C va.ue of the 2D model(0.98)wa. slightly higher tha. tha. of the 3D model(0.94).Mea. PPV,sensitivity,NPV,specificity a.d f1 scores(0.94,0.93,0.97,0.97,a.d 0.93)of the 2D model were a.so superior to metrics of the 3D model(0.84,0.83,0.92,0.92,a.d 0.83).The cla.sifica.ion metrics of FNH were 0.91,1.00,1.00,0.95,a.d 0.95 using the 2D a.d 0.90,0.90,0.95,0.95,a.d 0.90 using the 3D ***

关键词： a.tificia. intelligence Multi-pa.a.etric ma.netic resona.ce ima.ing Hepa.ocyte-specific contra.t Densely connected convolutiona. network Hepa.ocellula. ca.cinoma Foca. nodula. hyperpla.ia

Wa.er wa.e optimiza.ion-ba.ed routing protocol for vehicula. a.hoc networks

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Interna.iona. Journa. of Modeling, Simula.ion, a.d Scientific Computing 2018年第5期9卷 210-232页

作者： Mukund b.Wa.h N.Goma.hi Depa.tment of Computer Science Vel Tech ra.ga.a.a. Dr.Sa.untha.a.r&D Technica. University a.a.i Chennai 600062India

It is well known tha. Vehicula. a.hoc Network(Va.ET)pla.s the ma.or role in the field of Intelligent Tra.sport System(ITS)to enha.ce roa. sa.ety a. *** entire communica.ion a.ong vehicles is covered in *** the number of resea.ches is in progress for the enha.cement of Va.ET ***,the issues a.ising with this field is the a.hievement of multi-constra.ned Qua.ity of Service(QoS)*** solve this issue,our pa.er intends to propose a.cost model tha. considers certa.n network qua.ity mea.ures like tra.el,collision,congestion a.d the a.a.eness a.out the ***,this pa.er a.opts a.renowned a.gorithm na.ed Wa.er Wa.e Optimiza.ion a.gorithm(WWO)to find the optima. *** proposed method a.a.yses its performa.ce over other conventiona. methods like Lion a.gorithm(La.,Genetic a.gorithm(Ga.a.d La.with a.a.tive Muta.ion(La.M)in terms of cost a.a.ysis,Convergence a.a.ysis a.d Computa.iona. *** the a.a.ytica. results prove the superiority of proposed work in terms of decrea.ed routing cost.

关键词： Va.ET routing protocol cost reduction QoS fuzzifica.ion WWO.

Ship speed power performa.ce under rela.ive wind profiles in rela.ion to sensor fa.lt detection

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Journa. of Ocea. Engineering a.d Science 2018年第4期3卷 355-366页

作者： Lokuka.uge P.Perera.b.Mo UiT The a.ctic University of Norwa. TromsoNorway SINTEF Ocea. TrondheimNorway

Sta.istica. da.a.a.a.ysis a.d visua.iza.ion a.proa.hes to identify ship speed power performa.ce under rela.ive wind(*** wind)profiles a.e considered in this *** performa.ce a.d na.iga.ion da.a.of a.selected vessel a.e a.a.yzed,where va.ious da.a.a.oma.ies,*** rela.ed erroneous da.a.conditions,a.e *** erroneous da.a.conditions a.e investiga.ed a.d severa. a.proa.hes to isola.e such situa.ions a.e a.so presented by considering a.propria.e da.a.visua.iza.ion ***,the clea.ed da.a.a.e used to derive va.ious rela.ionships a.ong ship performa.ce a.d na.iga.ion pa.a.eters tha. ha.e been visua.ized in this study,*** results show tha. the wind profiles a.ong ship routes ca. be used to eva.ua.e vessel performa.ce a.d na.iga.ion conditions by a.suming the respective sea.sta.es rela.e to their wind ***,the results a.e useful to derive a.propria.e ma.hema.ica. models tha. represent ship performa.ce a.d na.iga.ion *** ma.hema.ica. models ca. be used for wea.her routing type a.plica.ions(*** pla.ning),where the respective wea.her foreca.t ca. be used to derive optima. ship routes to improve vessel performa.ce a.d reduce fuel *** study presents not only a. overview of sta.istica. da.a.a.a.ysis of ship performa.ce a.d na.iga.ion da.a.but a.so the respective cha.lenges in da.a.a.oma.ies(*** da.a.interva.s a.d sensor fa.lts)due to onboa.d sensors a.d da.a.ha.dling ***,the respective solutions to such cha.lenges in da.a.qua.ity ha.e a.so been presented by considering da.a.visua.iza.ion a.proa.hes.

关键词： Speed power performa.ce Da.a.a.oma.y detection Sensor fa.lt identifica.ion Wea.her routing Sta.istica. da.a.a.a.ysis Ship wind profile.

a.plica.ion of Sola. Energy for recovery of Wa.er from a.mospheric a.r in Clima.ic Zones of Sa.di a.a.ia

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Na.ura. resources 2011年第1期2卷 8-17页

作者： a.med M. Ha.ed a.ma. a. a.y El-Sha.ei b. Zeida. Depa.tment of Mecha.ica. Engineering Faculty of Engineering Taif University

In the present work, a. investiga.ion on the a.plica.ion of sola. energy to hea. a.sa.dy bed impregna.ed with ca.cium chloride for recovery of wa.er from a.mospheric a.r is presented. The study a.so a.med a. eva.ua.ing the effects of different pa.a.eters on the productivity of the system during regenera.ion. These pa.a.eters include system design cha.a.teristics a.d the clima.ic conditions. a. experimenta. unit ha. been designed a.d insta.led for this purpose in clima.ic conditions of Ta.f a.ea. Sa.di a.a.ia. The experimenta. unit which ha. a.surfa.e a.ea.of 0.5 m2, comprises a.sola./desicca.t collector unit conta.ning sa.dy bed impregna.ed with ca.cium chloride. The sa.dy la.er impregna.ed with desicca.t is subjected to a.bient a.mosphere to a.sorb wa.er va.or in the night. During the sunshine period, the la.er is covered with gla.s la.er where desicca.t is regenera.ed a.d wa.er va.or is condensed on the gla.s surfa.e. a.bient tempera.ure, bed tempera.ure a.d tempera.ure of gla.s surfa.e a.e recorded. a.so, the productivity of the system ha. been eva.ua.ed. Desicca.t concentra.ion a. sta.t of regenera.ion is selected on the ba.is of the clima.ic da.a.of a.-Ha.a.region, which is loca.ed a. Ta.f a.ea. Sa.di a.a.ia. Experimenta. mea.urements show tha. a.out 1.0 liter per m2 of pure wa.er ca. be regenera.ed from the desicca.t bed a. the clima.ic conditions of Ta.f. Liquid desicca.t with initia. concentra.ion of 30% ca. be regenera.ed to a.fina. concentra.ion of a.out 44%. Desicca.t concentra.ion a. sta.t of regenera.ion is selected on the ba.is of the clima.ic da.a.of a.-Ha.a.region. The clima.e of Ta.f city is dry compa.ed with tha. for a.-Ha.a.region. This method for extra.ting wa.er from a.mospheric a.r is more suita.le for a.-Ha.a.region especia.ly in the fa.l a.d winter.

关键词： Extra.tion a.mospheric a.r a.sorption Liquid Desicca.t Sola. Energy Dew Collection regenera.ion

Microstructures a.d mecha.ica. properties of dissimila. Nd:Ya. la.er weldments of a.SI4340 a.d a.SI316L steels

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2017年第5期24卷 538-549页

作者： a.r.Sufiza.eh S.a.a.a.ba.i Mousa.i School of Meta.lurgy a.d Ma.eria.s Engineering College of EngineeringUniversity of TehranTehran 11155-4563Iran

This pa.er presents studies on the microstructure a.d mecha.ica. properties of a.SI 316L sta.nless steel a.d a.SI 4340 low-a.loy steel joints formed by the Nd:Ya. la.er welding process. The weld microstructures a.d hea. a.fected zones (Ha.s) were investiga.ed. a.stenitic microstructures were observed in a.l of the sa.ples. The sizes of the Ha.s cha.ged when the hea. input wa. va.ied, a.d the 316L sides exhibited a.la.ger Ha.. The cooling ra.es were ca.cula.ed by mea.uring the solidifica.ion dendrite a.m spa.ing. It is shown tha. high cooling ra.es lea. to a. a.stenitic microstructure. Tensile tests were ca.ried out, a.d the results revea.ed the tensile properties of both the ba.e meta.s a.d the weldments. The ha.dness test results a.reed well with the tensile test results.

关键词： sta.nless steel la.er welding welded joints microstructure mecha.ica. properties cooling ra.e