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对钙调磷酸酶抑制剂致肾功能障碍的肝移植患者采用西罗莫司转换治疗的作用和局限性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 17-18页

作者： La. P. yoshida a. Brown K. 杨瑗

This study eva.ua.es sirolimus in preserving rena. function in 28 pa.ients who developed rena. insufficiency a.ter liver *** with a.crea.inine level higher tha. 1.8 mg/ml were eligible for conversion. Of the 28 pa.ients, 7 (25% ) did not tolera.e sirolimus, 6 (21% ) progressed to end-sta.e rena. disea.e (ESRD), a.d 14 (50% ) ha.e been ma.nta.ned on sirolimus with sta.le rena. function. The 28 pa.ients overa.l ha. a.decline in crea.inine of 0.38 mg/dl (P=0.029) a. week 4, with a.sma.l increa.e by week 24. However, the subset of 14 pa.ients who did not develop ESRD ha. a.decline in crea.inine tha. persisted to week 48. While the differences between those who developed ESRD a.d those with sta.le rena. function were not sta.istica.ly significa.t, the pa.ients who developed ESRD ha. a.higher crea.inine a. conversion (2.8 vs 2.3) a.d a.lower crea.inine clea.a.ce (36 vs 53 ml/min). Pa.ients receiving sirolimus ha. a.persistent rise in cholesterol (Pa. function wa. limited by pa.ients una.le to tolera.e drug (25% ) a.d pa.ients who developed ESRD (21% ).a.subgroup of pa.ients (50% ) ha. a. improvement in crea.inine tha. persisted for 48 weeks.

关键词：肝移植患者肾功能西罗莫司终末期肾病肌酐水平

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15C的中子晕结构研究

15C的中子晕结构研究

单眼玻璃体后脱离发生后对侧眼发生玻璃体后脱离的进程

第十次全国核结构研讨会暨第六次全国核结构专题讨论会

作者：方德清 Ya.a.uchi T. 郑涛 Oza.a.a. Chiba.M. Ka.ungo R. Ka.o T. Morimoto K. Ohnishi T. Suda.T. Ya.a.uchi Y. yoshida a. yoshida K. Ta.iha.a.I. 中国科学院上海应用物理研究所 The Institute of Physica. a.d Chemica. Resea.ch(RIKEN) WakoSaitama 351-0198Japan The Institute of Physica. a.d Chemica. Resea.ch(RIKEN) WakoSaitama 351-0198Japan 北京大学物理学院技术物理系北京 100871

实验测量了83 a.MeV 14,15C的核反应总截面(σR)及15C产生14,15C和14C产生13C的动量分布(P//).分析得到了15C产生14C和13C的动量分布半高宽(FWHM)分别为71±9MeV/c和223±28MeV/c,而14C产生13C的FWHM为195±21MeV/c.从15C和14C产生13C的FWHM与Gold-ha.er模型的预言基本一致.而15C产生14C的FWHM却要比该模型计算小得多.同时观测到15C的σR比相邻核有反常增加.在Gla.ber模型框架中,对实验测得的P//和σR进行了探讨.P//和σR的分析结果同时显示15C的最后一个中主要处于s1/2态,具有中子晕结构.

关键词：动量分布核反应总截面 Gla.ber模型

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 52-52页

作者： Hikichi T. yoshida a. 张磊 Depa.tment of Ophtha.mology Asahikawa Medical College Asahika- wa Japan Dr.

Purpose To determine when posterior vitreous deta.hment (PVD) develops in the fellow eye a.ter development in the first eye. Design Prospective, observa.iona. ca.e series. Pa.ticipa.ts Fifty-one pa.ients with a.ute unila.era. PVD pa.tici pa.ed in the study. Methods a.l pa.ients underwent a.comprehensive ocula. exa.in a.ion, including a.dyna.ic vitreous exa.ina.ion using biomicroscopy with a.d wit hout a.preset lens a.d retina. exa.ina.ion with sclera. depression, every 3 mont hs a. lea.t until PVD developed in the fellow eye. Results Posterior vitreous de ta.hment developed in 4 eyes (8%) within 6 months, 12 eyes (24%) within 1 yea. , 24 eyes (47%) within 18 months, 33 eyes (65%) within 2 yea.s, 41 eyes (80%) within 30 months, a.d 46 eyes (90%) within 3 yea.s. In 5 eyes (10%), PVD did not develop during the follow-up period of more tha. 3 yea.s. Conclusions Poste rior vitreous deta.hment develops frequently in the felloweye from 6 months to 2 yea.s a.ter development in the first. These findings a.e useful for the ma.a.em ent of pa.ients with unila.era. PVD.

关键词：玻璃体后脱离对侧眼巩膜压迫器眼科检查视网膜检查生物显微镜前置镜前瞻性观察序列研究

Evolutiona.y Origin of Ja. Proteins a.d Ja.m ona.e Signa.ing

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Molecula. Pla.t 2019年第2期12卷 153-155页

作者： Gregg a. Howe Yuki yoshida DOE Pla.t Resea.ch La.ora.ory Michigan State University East Lansing Ml 48824 USA Depa.tment of Biochemistry a.d Molecula. Biology Michigan State University East Lansing Ml 48824 USA Pla.t Resilience Institute Michigan State University East Lansing Ml 48824 USA Gra.ua.e School of Science a.d Technology Kumamoto University Kumamoto 860-8555 Japan

The ma.y roles of ja.mona.e in pla.t growth, reproduction, a.d defense ra.se interesting questions a.out how this lipid-derived hormone emerged during evolution. Recent studies indica.e tha. a.uhigher pla.t*5 pa.hwa. involving ja.monoyl-L-isoleucine (Ja.lle) a. the receptor-a.tive liga.d is conserved in va.cula. pla.ts (Bowma. et a.., 2017;Howe et a.., 2018). Within this core sign a.ing pa.hwa., J a. protei ns link Ja.lle perception to cha.ges in the a.tivity of MYC tra.scription fa.tors (TFs)(Figure 1) a.d ha.e emerged a. a.conserved hub for crossta.k in hormone response pa.hwa.s.

关键词： Evolutiona.y Origin Ja. Proteins Ja.m ona.e Signa.ing

New insights into the roles for DYRK fa.ily in ma.ma.ia. development a.d congenita. disea.es

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Genes & Disea.es 2023年第3期10卷 758-770页

作者： Sa.shu yoshida Kiyotsugu yoshida Depa.tment of Biochemistry The Jikei University School of MedicineMinato-kuTokyo 1058461Japan

The dua.-specificity tyrosine-regula.ed kina.e (DYRK) fa.ily is evolutiona.ily conserved from invertebra.e to ma.ma.s. DYRKs regula.e cell prolifera.ion, a.optosis, surviva., a.d differentia.ion by modifying the protein a.tiva.ion sta.e, cellula. loca.iza.ion, a.d turnover. In contra.t to severa. studies in cellula. models, the a.a.la.le evidence rega.ding the in vivo roles of DYRKs in ma.ma.ia. development is limited. This review summa.izes the in vivo studies on Dyrks which provide insight into their roles in ma.ma.ia. tissue development a.d congenita. disea.es. In vivo evidence obta.ned using knockout a.d genetica.ly modified a.ima.s helps to understa.d a.d develop novel clinica. thera.ies a.d drug for huma. congenita. disea.es, such a. Down syndrome a.d neurona. disorders (a.socia.ed with DYRK1a. a.d skeleta. ciliopa.hies (a.socia.ed with DYRK2).

关键词： Ciliopa.hies Development Down syndr ome DYRKS Embryogenesis

1例费城染色体阳性的急性成淋巴细胞性白血病的老年患者出现浆液性视网膜脱离

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 15-15页

作者： yoshida a. Ka.a.o Y.- I. Eto T. 司冰心 Depa.tment of Ophtha.mology Kyushu University Graduate School of Medical Science 3- 1- 1MaidashiHigashi- ku Fukuoka 812- 8582 Japan

Purpose: To describe a. elderly woma. who presented with a.serous retina. deta.hment (SRD) a. the first sign of Phila.elphia. chromosome- positive a.ute lymphobla.tic leukemia.(Ph+ a.L). Design: Observa.iona. ca.e report. Methods: a.complete ophtha.mic a.d systemic eva.ua.ion wa. performed on a.62- yea.- old woma. beca.se of decrea.ed vision of 20/60 OD a.d 20/25 OS. Results: Fundus exa.ina.ion revea.ed a.SRD involving the fovea. Fluorescein a.giogra.hy disclosed multifoca. spots of hyperfluorescence in the ea.ly pha.e, a.d diffuse subretina. a.cumula.ion of fluorescein in the la.e pha.e. She wa. dia.nosedwith Ph+ a.L beca.se of systemic findings. She underwent systemic chemothera.y a.d went into complete remission. Visua. a.uity improved to 20/20 in both eyes with resolution of the bila.era. SRD. Conclusions: Our observa.ions indica.e tha. a.sudden a.pea.a.ce of SRD, even in a. elderly pa.ient, wa.ra.ts a.thorough systemic screening for underlying leukemia. This is especia.ly importa.t, beca.se prompt systemic chemothera.y ca. improve the visua. a.uity a.d the prognosis.

关键词：费城染色体右眼视力荧光造影眼底检查化学治疗报道提示左眼视力多灶性观察性强荧光

a.model for a.a.yzing phenomena.in multicellula. orga.isms with multiva.ia.le polynomia.s： Polynomia. life

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Interna.iona. Journa. of Bioma.hema.ics 2018年第1期11卷 175-184页

作者： Hiroshi yoshida Depa.tment of Ma.hema.ics Kyushu UniversityMotooka 744 Nishi-ku Fukuoka 819-0395 Japan

Most of life ma.nta.ns itself through turnover, na.ely cell prolifera.ion, movement a.d elimina.ion. Hydra.s cells, for exa.ple, disa.pea. continuously from the ends of tenta. cles, but these cells a.e replenished by cell prolifera.ion within the body. Inspired by such a.biologica. fa.t, a.d together with va.ious opera.ions of polynomia.s, I here propose polynomia.-life model towa.d a.a.ysis of some phenomena.in multicellula. orga.isms. Polynomia. life consists of multicells tha. a.e expressed a. multiva.ia.le polynomia.s. a.cell is expressed a. a.term of polynomia., in which point （m, n） is described a. a.term zmy~ a.d the condition is described a. its coefficient. Sta.ting with a.single term a.d following reductions by set of polynomia.s, I simula.e the development from a.cell to a.multicell. In order to confirm uniqueness of the eventua. multicell-pa.tern, GrSbner ba.e ca. be used, which ha. been conventiona.ly used to ensure uniqueness of norma. form in the ma.hema.ica. context. In this fra.ework, I present va.ious pa.terns through the polynomia.-life model a.d discuss pa.terns ma.nta.ned through turnover. Cell elimina. tion seems to pla. a. importa.t role in turnover, which ma. shed some light on ca.cer or regenera.ive medicine.

关键词： Regenera.ion turnover multiva.ia.le polynomia.s polynomia. life.

a.predua. of a.predua. of B_σ a.d its a.plica.ions to commuta.ors

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Science China.Ma.hema.ics 2018年第8期61卷 1437-1472页

作者： Yoshihiro Sa.a.o Hiroko yoshida Depa.tment of Ma.hema.ics a.d Informa.ion Science Tokyo Metropolitan University

a.predua. of B_σ-spa.es is investiga.ed. a.predua. of a.predua. of B_σ-spa.es is a.so investiga.ed,which ca. be used to investiga.e the boundedness property of the commuta.ors. The rela.ion between Herz spa.es a.d loca. Morrey spa.es is discussed. a. a. a.plica.ion of the dua.ity results, one obta.ns the boundedness of the singula. integra. opera.ors, the Ha.dy-Littlewood ma.ima. opera.ors a.d the fra.tiona. integra. opera.ors, a. well a. the commuta.ors genera.ed by the bounded mea. oscilla.ion(BMO) a.d the singula. integra. *** is new in this pa.er is tha. we do not ha.e to depend on the specific structure of the opera.ors. The results on the boundedness of opera.ors a.e formula.ed in terms of B_σ-spa.es a.d B_σ-spa.es together with the deta.led compa.ison of the ones in Herz spa.es a.d loca. Morrey spa.es. a.other a.plica.ion is the nonsmooth a.omic decomposition a.a.ted to B_σ-spa.es.

关键词： B_σ-spa.es dua.ity decomposition Herz spa.es loca. Morrey spa.es

Pla.e a.d plume tectonics:Numerica. simula.ion a.d seismic tomogra.hy

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Geoscience Frontiers 2015年第1期6卷 1-2页

作者： Ma.a.i yoshida Depa.tment of Deep Ea.th Structure a.d Dyna.ics Resea.ch Jaan Agency for Marine-Earth Science and Technology(JAMSTEC)

a.out three deca.es a.ter the esta.lishment of the pla.e tec- tonics theory in the la.e 1960s, Ma.uya.a.（1994） proposed the ＂plume tectonics＂ theory ba.ed on whole-ma.tle seismic tomogra. phy ima.e （Fuka., 1992; Fuka. et a.., 1994）. a.cording to this the- ory, the ea.th＇s interior is divided into three regimes： the ea.th＇s surfa.e region governed by la.era. motions of tectonic pla.es, the ma.tle governed by vertica. motions of ＂superplumes＂（i.e., la.ge- sca.e ma.tle upwelling/downwelling plumes）, a.d the core, whose convection style is proba.ly controlled by superplumes in the ma.tle. With the ra.id progress in ea.th science a.ter the birth of the plume tectonics theory, it is now widely a.cepted tha. va.ious geologica. phenomena.observed in the ea.th＇s surfa.e a.e closely linked to the fluid motion in the deep ma.tle （e.g., Da.ies, 2011）.

关键词： Pla.e a.d plume tectonics UHT deep LVL