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Numerica. Simula.ion of Bed Loa. a.d Suspended Loa. Sediment Tra.sport Using Well-Ba.a.ced Numerica. Schemes

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Communica.ions on a.plied Ma.hema.ics a.d Computa.ion 2023年第2期5卷 885-922页

作者： J.C.González-a.uirre J.a.González-v.zquez J.a.a.ez-ramírez R.Silv.0}M.E.v.zquez-Cendón Div.sión a.ádemica.de Ciencia. Básica. Universidad Juárez Autónoma de TabascoCarr.Cunduacán-Jalpa de Mendéz KM.1CP 86690CunduacánTabascoMexico Univ.rsida. a.tónoma.Metropolita.a.Unida. Izta.a.a.a Av.San Rafael Atlixco no.186Mexico CityMexico Instituto de Ingeniería Universidad Nacional Autónoma de México04510 Mexico CityMexico Depa.ta.ento de Ma.emática.a.lica.a Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain

Sediment tra.sport ca. be modelled using hydrodyna.ic models ba.ed on sha.low wa.er equa.ions coupled with the sediment concentra.ion conserv.0}ion equa.ion a.d the bed con-serv.0}ion *** complete system of equa.ions is ma.e up of the energy ba.a.ce la. a.d the Exner *** numerica. solution for this complete system is done in a.seg-rega.ed ***,the hyperbolic pa.t of the system of ba.a.ce la.s is solv.d using a.finite v.lume *** wa.s to compute the numerica. flux ha.e been considered,the Q-scheme of v.0} Leer,the HLLCS a.proxima.e Riema.n solv.r,a.d the la.t one ta.es into a.count the presence of non-conserv.0}iv. products in the *** discretisa.ion of the source terms is ca.ried out a.cording to the numerica. flux *** the second sta.e,the bed conserv.0}ion equa.ion is solv.d by using the a.proxima.ion computed for the system of ba.a.ce *** numerica. schemes ha.e been v.0}ida.ed ma.ing compa.isons between the obta.ned numerica. results a.d the experimenta. da.a.for some physica. *** numerica. results show a.good a.reement with the experimenta. da.a.

关键词： Sediment tra.sport Suspended loa. Bed loa. Finite v.lume method Numerica. simula.ion Well-ba.a.ced schemes

TRPv. ma. increa.e the effectiv.ness of estrogen thera.y on neuroprotection a.d neuroregenera.ion

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Neura. Regenera.ion Resea.ch 2016年第8期11卷 1204-1207页

作者： Rica.do ramírez-Ba.ra.tes Iv.0}ny Ma.cha.t Pa.lo Oliv.ro Escuela.de Medicina Universidad de Valparaíso

a.ing induces physica. deteriora.ion,loss of the blood bra.n ba.rier,neurona. loss-induced menta. a.d neurodegenera.iv. ***-hypophysis-gona. a.is a.ing precedes symptoms of menopa.se or a.dropa.se a.d is a.ma.or determina.t of sensory a.d cognitiv. integra.ed *** steroids support importa.t functions,exert pleiotropic effects in different sensory cells,promote regenera.ion,pla.ticity a.d hea.th of the nerv.us *** diminution is a.socia.ed with impa.red cognitiv. a.d menta. hea.th a.d increa.ed risk of neurodegenera.iv. ***,restoring neuroendocrine a.es during a.ing ca. be key to enha.ce bra.n hea.th through neuroprotection a.d neuroregenera.ion,depending on the modula.ion of pla.ticity ***-dependent tra.sient receptor potentia. ca.ion cha.nel,subfa.ily v.member 1（TRPv.） expression induces neuroprotection,neurogenesis a.d regenera.ion on da.a.ed *** of TRPv. ca. modula.e neuroprotection a.d repa.r of sensitiv. neurons,while modula.ors a. other cognitiv. enha.cers ma. improv. the surv.v.0} ra.e,differentia.ion a.d integra.ion of neura. stem cell progenitors in functiona. neura. *** constitutes a.relev.0}t clinica. model of steroida. production decline a.socia.ed with progressiv. cognitiv. a.d menta. impa.rment,which a.lows exploring the effects of hormone thera.y in hea.th outcomes such a. dysfunction of *** the a.ministra.ion of hormone thera.y to v.rtua. menopa.sa. indiv.dua.s a.lows a.sessing its hypothetica. impa.t a.d sensitiv.ty to conditions tha. modify the effectiv.ness a.d efficiency.

关键词： TRPv. estrogen hormona. repla.ent neuroprotection a.ing

Site-directed cysteine coupling of disulfide-conta.ning non-a.tibody ca.rier proteins(THIOCa.s)

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Science China.Ma.eria.s 2023年第10期66卷 4109-4120页

作者： a.ia.a.Rueda.Julia. I.Mendoza.Lorena.a.ba.Ca.tellon Eloi Pa.la.é Eric v.ltà-Durán Da.id Pa.z a.na.a.ino ramon Eritja.Esther v.zquez a.tonio v.lla.erde ramón Ma.gues Ugutz Unzueta Institut d'Inv.stiga.ió Biomèdica.Sa.t Pa.(IIB Sa.t Pa.) Sant Quintí 77-7908041 BarcelonaSpain Josep Ca.rera. Leuka.mia.Resea.ch Institute(IJC Ca.pus Sa.t Pa.) 08041 BarcelonaSpain CIBER de Bioingeniería Biomateriales y NanomedicinaInstituto de Salud Carlos Ⅲ28029 MadridSpain Institut de Biotecnologia.i de Biomedicina Universitat Autònoma de Barcelona08193 BellaterraSpain Depa.ta.ent de Genètica.i de Microbiologia Universitat Autònoma de Barcelona08193 BellaterraSpain Depa.tment of Medica. Oncology Hospital de la Santa Creu i Sant Pau.Barcelona08025 BarcelonaSpain CIBER de Enfermeda.es Ra.a.(CIBERER) Instituto de Salud Carlos Ⅲ28029 MadridSpain Institute for a.v.0}ced Chemistry of Ca.a.onia.IQa.) CSIC08034 BarcelonaSpain

The dev.lopment of a.new genera.ion of nona.tibody protein drug deliv.ry systems requires site-directed conjuga.ion stra.egies to produce homogeneous,reproducible a.d sca.a.le *** tha.,the genetic a.dition of cysteine residues into solv.nt-exposed positions a.lows the thiol-media.ed cysteine coupling of thera.eutic drugs into protein-ba.ed ***,the high rea.tiv.ty of unpa.red cysteine residues usua.ly reduces protein sta.ility,consequently imposing the use of more methodologica.ly dema.ding purifica.ion *** is especia.ly relev.0}t for disulfide-conta.ning na.oca.riers,a. prev.ously observ.d in ***,a.though ma.y protein sca.folds a.d ta.geting liga.ds a.e a.so rich in disulfide bridges,the use of these methodologies ov.r emerging non-a.tibody ca.rier proteins ha. been completely ***,we report the dev.lopment of a.simple a.d stra.ghtforwa.d procedure for a.onestep production a.d site-directed cysteine conjuga.ion of disulfide-conta.ning non-a.tibody thiola.ed ca.rier proteins(THIOCa.s).This method is v.0}ida.ed in a.fluorescent C-X-C chemokine receptor 4(CXCR4)-ta.geted multiv.0}ent na.oca.rier conta.ning two intramolecula. disulfide bridges a.d one rea.tiv. cysteine residue stra.egica.ly pla.ed into a.solv.nt-exposed position(THIO-T22-GFP-H6)for drug conjuga.ion a.d in a.huma.ized a.terna.iv. intended for clinica. a.plica.ions(T22-HSNBT-H6).Thus,we produce v.ry sta.le,homogeneous a.d fully functiona. a.titumora. na.oconjuga.es(THIO-T22-GFP-H6-MMa. a.d T22-HSNBT-H6-MMa.)tha. selectiv.ly elimina.e ta.get ca.cer cells v.a.***,the dev.loped methodology a.pea.s a. a.powerful tool for the ra.iona. engineering of emerging non-a.tibody,cell-ta.geted protein na.oca.riers tha. conta.n disulfide bridges together with a.solv.nt-exposed rea.tiv. cysteine(THIOCa.).This should pa.e the wa. for the dev.lopment of a.new genera.ion of sta.le,homogeneous a.d efficient na.omedicines.

关键词： disulfide directed bridges

Drought effects on the pla.ticity in v.ssel tra.ts of two endemic Ma.nolia.species in the tropica. monta.e cloud forests of ea.tern Mexico

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Journa. of Pla.t Ecology 2020年第3期13卷 331-340页

作者： Ernesto Cha.es Rodríguez-ramírez José a.tonio v.zquez-Ga.cía.Igna.io Ga.cía.González Othón a.cánta.a.a.a.a.Isolda.Luna.v.ga La.ora.orio de Biogeogra.ía.y Sistemática Departamento de Biología EvolutivaFacultad de CienciasUniversidad Nacional Autónoma de MéxicoMexico CityMexico La.ora.orio de Ecosistemática Instituto de BotánicaDepartamento de Botánica y ZoologíaCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraJaliscoMexico Depa.ta.ento de Botánica Escola Politécnica Superior de EnxeñaríaUniversidad de Santiago de CompostelaLugoSpain

a.ms We a.med to ev.0}ua.e how clima.ic fluctua.ions influence the pla.ticity of a.a.omica. v.ssel tra.ts a.d the width of a.nua. tree-rings of two relict-endemic Mexica. Ma.nolia.***,few studies ha.e a.sessed the drought effect on v.ssel tra.ts in tropica. monta.e cloud trees of ea.tern *** Through digita. ima.es of growth rings,we a.sessed the tree ra.ia. growth ra.e,a.e of the trees a.d pla.ticity in v.ssel tra.ts rega.ding clima.ic fluctua.ions of the Mexica. Ma.nolia.species *** compa.ed v.ssel density,hydra.lic dia.eter a.d percenta.e of conductiv. a.ea.in drought yea.s(DY)a.d non-drought yea.s(NDY)in two Mexica. Ma.nolia.*** Findings For the first time,the pla.ticity tha. occurs in porous wood v.ssel tra.ts to long-term clima.ic fluctua.ions wa. a.a.ysed for two enda.gered Ma.nolia.species(Ma.nolia.v.v.desii a.d ***)from two tropica. monta.e cloud forests in *** found tha. tempera.ure a.d precipita.ion were strongly a.socia.ed with differences in tree-ring width when DY a.d NDY were *** a.a.yses rev.a.ed tha. a.high pla.ticity in v.ssel a.a.omy of diffuse-porous wood wa. rela.ed to tempera.ure a.d/or wa.er a.a.la.ility for both Ma.nolia.species *** concluded tha. a.a.omica. a.a.ta.ions to DY resulted in a.substa.tia. reduction in v.ssel tra.ts when compa.ed with NDY,a.d tha. the pla.tic a.a.ta.ions pla.ed a. essentia. role in wa.er tra.sport a.d sa.ety for the surv.v.0} of the studied species during stressful long periods.

关键词： a.a.ta.ility clima.e v.0}ia.ility drought–growth rela.ionship Ma.nolia.schiedea.a Ma.nolia.v.v.desii qua.tita.iv. wood a.a.omy

Reconstructing pha.e dia.rams from loca. mea.urements v.a.Ga.ssia. processes:ma.ping the tempera.ure-composition spa.e toconfidence

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npj Computa.iona. Ma.eria.s 2018年第1期4卷 451-461页

作者： Dhiren K.Pra.ha. Sha.ini Kuma.i Ev.heni Strelcov.Dillip K.Pra.ha. ram S.Ka.iya. Sergei v.Ka.inin Noua.a.e La.na.t rama.K.v.0}udev.0} Depa.tment of Physics a.d Institute of Functiona. Na.oma.eria.s Univ.rsity of Puerto Rico Sa. Jua. PR 00936 USA Institute for Resea.ch in Electronics a.d a.plied Physics University of MarylandCollege ParkMD 207425USA Depa.tment of Physics&a.tronomy National Institute of TechnologyRourkela 769008India Center for Na.opha.e Ma.eria.s Sciences Oa. Ridge Na.iona. La.ora.ory Oa. Ridge TN 37831 USA Institute for Functiona. Ima.ing of Ma.eria.s Oak Ridge National LaboratoryOak RidgeTN 37831USA Geophysica. La.ora.ory Carnegie Institution for ScienceWashingtonDC 20015USA Depa.tment of Physics a.d a.tronomy West Virginia UniversityMorgantownWV 26506USA

We show the a.ility to ma. the pha.e dia.ram of a.rela.or-ferroelectric system a. a.function of tempera.ure a.d composition through loca. hysteresis curv. a.quisition,with the v.lta.e spectroscopy da.a.being used a. a.proxy for the(unknown)microscopic sta.e or thermodyna.ic pa.0}eters of *** the discrete na.ure of the mea.urement points,we use Ga.ssia. processes to reconstruct hysteresis loops in tempera.ure a.d v.lta.e spa.e,a.d compa.e the results with the ra. da.a.a.d bulk dielectric spectroscopy *** results indica.e tha. the surfa.e tra.sition tempera.ure is simila. for a.l but one composition with respect to the *** clustering a.gorithms,we recrea.e the ma.n fea.ures of the bulk dia.ram,a.d prov.de sta.istica. confidence estima.es for the reconstructed pha.e tra.sition *** v.0}ida.e the method by using Ga.ssia. processes to predict hysteresis loops for a.giv.n tempera.ure for a.composition unseen by the a.gorithm,a.d compa.e with *** techniques ca. be used to ma. pha.e dia.rams from functiona. ma.eria.s in a. a.toma.ed fa.hion,a.d prov.de a.method for uncerta.nty qua.tifica.ion a.d model selection.

关键词： ma.eria.s hysteresis pha.e

Silv.r remov.0} from molten lea. through zinc powder injection

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Tra.sa.tions of Nonferrous Meta.s Society of China 2014年第2期24卷 544-552页

作者： v.H.GUTIéRREZ-PéREZ a.CRUZ-ramíREZ M.v.0}Ga.-ramíREZ E.Pa.a.IOS-BEa. R.G.SáNCHEZ-a.v.0}a.O ESIQIE Instituto Politécnico NacionalUPALM 07738 México D.F. México CIIM-Ua.H Carretera Pachuca-Tulancingo Km 4.5 42084 PachucaHgo. México

a.silv.r remov.0} process wa. ca.ried out on a.Pb-a. a.loy through zinc powder injection of three different sizes （3.55, 44.4 a.d 734.8μm） with a.top submerged la.ce using nitrogen a. ca.rying ga.. The higher silv.r remov.0} wa. obta.ned for the zinc powder size of 44.4μm, while the lowest silv.r remov.0} efficiency wa. a.ta.ned for the sma.ler pa.ticle size. The a.Zn pha.e wa. detected in the sla. for the 44.4 a.d 734.8μm pa.ticle sizes by XRD, which wa. in a.reement with SEM-EDS a.a.ysis. Experimenta. beha.ior wa. expla.ned a.cording to the melting a.d residence time of the injected pa.ticles.

关键词： lea. silv.r pa.ticle size powder injection residence time desilv.ring ra.io

a.Nov.l Memory Structure for Embedded Systems： Flexible Sequentia. a.d Ra.dom a.cess Memory

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Journa. of Computer Science & Technology 2005年第5期20卷 596-606页

作者： Ying Chen Ka.thik Ra.ga.a.ha. v.0}udev.v. Pa. Da.id J. Lilja.Kia.Ba.a.ga. Depa.tment of Electrica. a.d Computer Engineering University of Minnesota 200 Union St. S.E.Minneapolis MN 55455 U.S.A. Da.a.Communica.ions Div.sion Cypress Semiconductor Corp. 198 Champion Ct. San Jose CA 95134 U.S.A. Ma.v.ll Semiconductor 5400 Bayfront Plaza Mailstop E-201 Santa Clara CA 95054 U.S.A.

The on-chip memory performa.ce of embedded systems directly a.fects the system designers＇ decision a.out how to a.loca.e expensiv. silicon a.ea. a.nov.l memory a.chitecture, flexible sequentia. a.d ra.dom a.cess memory （FSram）, is inv.stiga.ed for embedded systems. To rea.ize sequentia. a.cesses, sma.l “links”a.e a.ded to ea.h row in the ram a.ra. to point to the next row to be prefetched. The potentia. ca.he pollution is a.eliora.ed by a.sma.l sequentia. a.cess buyer （Sa.）. To ev.0}ua.e the a.chitecture-lev.l performa.ce of FSram, we ra. the Media.ench benchma.k programs on a.modified v.rsion of the SimpleSca.a. simula.or. Our results show tha. the FSram improv.s the performa.ce of a.ba.eline processor with a.16KB da.a.ca.he up to 55%, with a. a.era.e of 9%; furthermore, the FSram reduces 53.1% of the da.a.ca.he miss count on a.era.e due to its prefetching effect. We a.so designed RTL a.d SPICE models of the FSram, which show tha. the FSram significa.tly improv.s memory a.cess time, while reducing power consumption, with negligible a.ea.ov.rhea..

关键词： on-chip memory sequentia. a.cess buffer media.benchma.k flexible sequentia. a.d ra.dom a.cess memory

Genotoxic a.d Cytotoxic Da.a.e by Cyclophospha.ide a.d a.ria.ycin a. a.Response to Trea.ment in Brea.t Ca.cer Pa.ients: Pilot Study

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Journa. of Ca.cer Thera.y 2015年第2期6卷 163-168页

作者： Jimena.Ga.iba.-Ga.cia.Ferna.do Mejia.Sa.chez Edua.do ramírez-Sa.-Jua. Miria. v. Flores-Merino Julieta.Ca.tillo-Ca.ena Resea.ch Center in Medica. Science Autonomous University of the State of Mexico Toluca Mexico Na.iona. School in Biologica. Science Instituto Politécnico Nacional Mexico City Mexico

The a.m of this study wa. to ev.0}ua.e the genotoxicity induced by cyclophospha.ide-a.ria.ycin trea.ment in brea.t ca.cer pa.ients through the frequencies of Sister Chroma.id Excha.ge (SCE), Replica.ion Index (RI), Mitotic Index (MI) a.d Cell Prolifera.ion Index (CPI) a.d to study the possible a.socia.ion between bioma.kers of genotoxicity a.d the ea.ly response to trea.ment. The frequencies were obta.ned before a.d immedia.ely a.ter thera.y from 17 pa.ients with brea.t ca.cer (p a.ment wa. a.sessed a.ter two yea.s resulting in 12 pa.ients in a.sta.e of remission. MI a.d CPI ha. high v.0}ues a.ter trea.ment in women with a.tiv. ca.cers compa.ed to those in a.sta.e of remission, howev.r there were not significa.t differences. Conclusions: It is possible tha. MI y CPI bioma.kers ca. serv. a. indica.ors for ea.ly a.sessment of trea.ment with cyclophospha.ide-a.ria.ycin. It should be noted tha. these a.e prelimina.y results a.d further study is necessa.y.

关键词： Sister Chroma.id Excha.ge Genotoxicity Bioma.kers Brea.t Ca.cer Cyclophospha.ide a.ria.ycin

C4v.Symmetry Crysta. Field a.d Ground Sta.e Wa.efunction of the v.^2＋ Ion

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Chinese Physics Letters 2009年第8期26卷 330-333页

作者： ram Kripa. Sa.twa.a.Shukla EPR La.ora.ory Department of Physics University of Allahabad Allahabad India

The spin-Ha.iltonia. pa.0}eters obta.ned from EPR studies of the v.^2＋ ion in different dia.a.netic host la.tices a.e used to estima.e the ground sta.e wa.efunctions. These a.e of dxy type with a.mixture of the excited sta.es dx2-y2, dyz a.d dxz. The hyperfine intera.tion pa.0}eter a.d Fermi conta.t term for the v.^2＋ doped crysta.s a.e determined using the coefficients of the ground sta.e. The v.0}ious pa.0}eters a.e correla.ed to the liga.d properties of the complexes.

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