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Structure-tissue exposure/selectivity rela.ionship(STR) correla.es with clinica. effica.y/sa.ety

a.ta.Pha.ma.eutica.Sinica.B 2022年第5期12卷 2462-2478页

作者： Wei Ga. Hongxia.g Hu Lipeng Da. Mia. He Heba. Yua. Huixia.Zha.g Jinhui Lia. Bo Wen Ya. Li Ma.ia.Pa.misa.o Moha.ed Dit Ma.y traore Simon Zhou Duxin Sun Depa.tment of Pha.ma.eutica. Sciences College of PharmacyUniversity of MichiganAnn ArborMI 48109USA Tra.sla.iona. Development a.d Clinica. Pha.ma.ology Bristol Myers SquibbSummitNJ 07920USA

Drug optimiza.ion, which improves drug potency/specificity by structure-a.tivity rela.ionship(Sa.) a.d drug-like properties, is rigorously performed to select drug ca.dida.es for clinica. tria.s. However,the current drug optimiza.ion ma. overlook the structure-tissue exposure/selectivity-rela.ionship(STR) in disea.e-ta.geted tissues vs. norma. tissues, which ma. mislea. the drug ca.dida.e selection a.d impa.t the ba.a.ce of clinica. effica.y/toxicity. In this study, we investiga.ed the STR in correla.ion with observed clinica. effica.y/toxicity using seven selective estrogen receptor modula.ors(SERMs) tha. ha.e simila. structures, sa.e molecula. ta.get, a.d simila./different pha.ma.okinetics. The results showed tha. drug’s pla.ma.exposure wa. not correla.ed with drug’s exposures in the ta.get tissues(tumor, fa. pa., bone, uterus),while tissue exposure/selectivity of SERMs wa. correla.ed with clinica. effica.y/sa.ety. Slight structure modifica.ions of four SERMs did not cha.ge drug’s pla.ma.exposure but a.tered drug’s tissue exposure/*** SERMs with high protein binding showed higher a.cumula.ion in tumors compa.ed to surrounding norma. tissues, which is likely due to tumor EPR effect of protein-bound drugs. These suggest tha. STR a.ters drug’s tissue exposure/selectivity in disea.e-ta.geted tissues vs. norma. tissues impa.ting clinica. effica.y/toxicity. Drug optimiza.ion needs to ba.a.ce the Sa. a.d STR in selecting drug ca.dida.e for clinica. tria. to improve success of clinica. drug development.

关键词： Structure-a.tivity-rela.ionship(Sa.) Structure-tissue exposure/selectivity rela.ionship(STR) Drug optimiza.ion Clinica. effica.y/toxicity Drug development

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Liver a.scesses: Wha. Dia.nostics a.d Thera.eutics in the Ka.i Reference Hea.th Center (Ma.i)?

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Surgica. Science 2018年第9期9卷 344-350页

作者： a.doula.e Dia.ra.Koniba.Keita.a.a.ou traore a.sita. Koné Ma.ia.sa.Kona.e Idrissa.Tounka.a.Ma.a.ou a. Keita.Issa.traore Modibo Togola.Fa.ima.K. Ta.l Da.uda.Dia.lo Mousta.h Issa.Ma.a.e Debora. Sa.ra.Sa.ogo a.ouba.a. Koné Ibra.im Dia.ite a.ha.sa.e traore a.égné Togo Genera. Surgery Depa.tment Kati Mali a.esthesia.Service a.d Resuscita.ion Depa.tment Kati Mali Ga.troenterology Depa.tment Kati Mali

The objectives were to determine the frequency of hepa.ic a.scess, a.d to describe the clinica. a.d pa.a.clinica. a.pects a.d the thera.eutic moda.ities. Method a.d ma.eria.: This is a.prospective study covering 24 months (Ja.ua.y 2016-December 2017). Results: This wa. a.prospective study of 30 ca.es of liver a.scess, ra.ging from Ja.ua.y 2016 to December 2017, a.period of 12 months. Inclusion criteria. Wha. were included in this study were a.l pa.ients hospita.ized a.d trea.ed for liver a.scess. Criteria.for non-inclusion: a.scess ca.es ha.e not been trea.ed in the service. The sex ra.io wa. 2.3 a.d the a.era.e a.e wa. 35 yea.s old. The ma.n clinica. signs were: fever (56.7%), hepa.itis (73.3%) a.d hepa.omega.y (26.7%). Hepa.ic collections objected to a.domina. ultra.onogra.hy were loca.ized in the right lobe in 70%. Surgica. trea.ment wa. performed in 10% of ca.es. Medica. trea.ment a.one wa. performed in the ma.ority of ca.es (56.7%);ecloca.ed puncture wa. required in 10 ca.es (33.3%). The follow-up wa. simple in a.l our pa.ients a.d we did not register dea.hs;the a.era.e dura.ion of trea.ment wa. 5 da.s. Conclusion: Topica. pa.hology in surgica. pra.tice in our country, liver a.scess is common in our depa.tment;medica. trea.ment is cura.ive in the a.sence of complica.ions.

关键词： a.scess Liver Ma.i

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White Blood Cells Detection Using Spectra. Tresholding

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Journa. of Signa. a.d Informa.ion Processing 2023年第1期14卷 1-8页

作者： Ka.a.a.Ndèye La.a.Boye Mouha.a.ou Mousta.ha.traore a.i Biomedica. Engineering Depa.tment Polytechnical University of West Africa Dakar Senegal La.ora.ory of Funda.enta. a.d a.plied Microbiology University Cheikh Anta Diop Dakar Senegal

The study of the morphology of White Blood Cells (WBCs) further contributes to the clinica. dia.nosis of blood disea.es. In this resea.ch pa.er, we come up with a. ima.e segmenta.ion enha.cement by combining Fourier Fa.t Tra.sform on smea. blood ca.ture a.d cla.sica. thresholding. The Fa.t Fourier Tra.sform (FFT) is a.very powerful tool in ima.e processing a.d it wa. used to segment a.d extra.t the WBCs. Our ima.e processing method uses a.Fa.t Fourier Tra.sform combined with filtering a.d a. Inverse Fa.t Fourier Tra.sform for the extra.tion a.d visua.iza.ion of the high frequency region of the ima.e. In order to remove residua. Red Blood Cells a.ting a. noise in the expected result, a.fina. thresholding step is a.ded a. the end of the processing. The results presented in this a.ticle report the tests performed using our ma.hema.ica. implementa.ion. Moreover, we were a.le to detect a.d differentia.e the sub-fa.ilies of WBCs.

关键词： Segmenta.ion Fourier Tra.sform White Blood Cell

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Cholinestera.e a.tivity a. a. Indica.or of Hea.th Risks a.ong Kou Va.ley Fa.mers

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Journa. of Biosciences a.d Medicines 2024年第7期12卷 71-86页

作者： Thiombia.o Cherileila.Hien S. a.istide Koevi Na.ège Ba.ili Ba.oma.Oua.ta.a.a.doula.e traore Pa.rice traore T. Isidore Hien Herve Centre Mura. Institut National de Sant Publique (INSP) Bobo-Dioulasso Burkina Faso Institut Suprieur des Science de la.Sa.t (INSSa. University of Nazi Boni Bobo-Dioulasso Burkina Faso Institut de Recherche en Science de la.Sa.t (IRSS) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso

Introduction: Pesticides a.e currently a. essentia. component of a.ricultura. production techniques for controlling pests a.d weeds. In Burkina.Fa.o, non-complia.ce with good pra.tice in the use of pesticides poses a.rea. hea.th problem for the popula.ion. This study exa.ines the hea.th risks a.socia.ed with pesticide ma.a.ement in rice-growing a.ea.. Ma.eria. a.d Methods: a.field survey wa. conducted in Ba.a. involving fa.mers, focusing on their socio-demogra.hic cha.a.teristics, pesticide usa.e, a.d hea.th effects. Cholinestera.e levels were mea.ured in subsa.ple of fa.mers using a.porta.le device. Da.a.were a.a.ysed using Microsoft Excel, ca.cula.ing mea.s a.d percenta.es for va.ious pra.tices. Hea.th consulta.ions, protection methods, a.d pesticide ma.a.ement were studied. Erythrocyte a.etylcholinestera.e a.tivity wa. compa.ed before a.d a.ter trea.ment. Da.a.were ca.egorised into cla.ses ba.ed on inhibition levels, a.d correla.ion a.a.yses determined rela.ionships between va.ia.les such a. a.e, yea.s of experience, a.d cholinestera.e a.tivity. Results: The results indica.e tha. rice cultiva.ion is ma.nly ca.ried out by a.fa.rly young popula.ion, with nea.ly 63% being under the a.e of 50. Common poor pra.tices in pesticide use include improper stora.e a.d reuse of leftover pesticides. Seven types of pesticides were identified, including orga.ophospha.es such a. glyphosa.e, which wa. used in 26.7% of ca.es. This orga.ophospha.e ha. resulted in cla.s B poisoning, ca.sing a.30% - 50% reduction in erythrocyte cholinestera.e a.tivity. The hea.th effects of pesticide use a.e felt by a.ricultura. fa.mers through va.ious symptoms of poisoning. Conclusion: To reduce the occurrence of pesticide poisoning, it is essentia. to la.nch informa.ion a.d a.a.eness ca.pa.gns a.ong the popula.ion a.d fa.mers to promote sa.e pra.tices in pesticide use in Ba.a. Burkina.Fa.o.

关键词： Pesticides Environmenta. Sa.ita.y Risk a.etylcholinestera.e Fa.mers Ba.a Burkina.Fa.o

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Ultra.Violet (UV): a.Good Ba.teria. Sterilizer?

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Journa. of Biosciences a.d Medicines 2023年第2期11卷 80-85页

作者： Sira.Sidibe Mouha.a.ou Mousta.ha.Boye Ma.ya. Mouha.a.ou a.i traore Biomedica. Engineering Depa.tment Polytechnical University of West Africa Dakar Senegal La.ora.ory of Funda.enta. a.d a.plied Microbiology University Cheikh Anta Diop Dakar Senegal

Introduction: The a.m of this study wa. to improve the DISTER-UV a.d to perform microbiologica. qua.ity control a. the biomedica. la.ora.ory of the West a.rica. Polytechnic University from Ja.ua.y 2022 to November 2022. Methodology: During this eleven-month prospective study, we set up a.qua.ity control device (QCD). For microbiologica. qua.ity control, we performed different cultures of ba.teria.with different ba.teriologica. a.d morphologica. cha.a.teristics a. T0 (no steriliza.ion) a.d a. T30 (a.ter 30 minutes of steriliza.ion under DISTER-UV). Results: a.ter the rea.iza.ion, the DCQ a.ta.hed to the DISTER-UV1 a.lows to displa. of the UV wa.elength present in the light box. This device a.so displa.s a.d a.erts when the UV intensity emitted by the la.ps is below 250 nm. During microbiologica. qua.ity control, the cultures ca.ried out a. T30 a.d incuba.ed for 24 hours did not revea. a.y ba.teria. colonies. This shows the ba.tericida. cha.a.ter of DISTER-UV-2. Conclusion: The improvement a.d the microbiologica. qua.ity control a.lowed us to switch from DISTER-UV1 (without sensor) to DISTER-UV-2 (with sensor or DCQ). The biologica. control a.lowed us to a.firm tha. the DISTER-UV-2 is ba.tericida..

关键词： Steriliza.ion Ultra.iolet Ra.ia.ion Ba.tericide Qua.ity Control Ba.teria

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Progressive Cha.a.teristics of HIV Infection in the Elderly in the Cohort of the Interna. Medicine Depa.tment of the Points G University Hospita., Ba.a.o. Ma.i

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a.va.ces in Infectious Disea.es 2023年第1期13卷 109-116页

作者： a.doula.e Ma.a.ou traore Ga.a. Da.o Ma.a.ou Cissoko Cha.les Da.a.Djenebou Tra.ré Ibra.im Dollo Djibril Sy a.sétou Soukho Ma.a.ou Dembélé Da.uda.Ka.soum Minta.a.del Ka.er traore Ha.a. a.a.sa.e traore Depa.tment of Infectious Disea.es CHU du Point G Bamako Mali Depa.tment of Medecine CHU “Hôpital du Mali” Bamako Mali Depa.tment of Interna. Medicine CHU du Point G Bamako Mali

Few da.a.a.e a.a.la.le on HIV infection in the elderly a.d they a.e a. importa.t popula.ion in our different cohorts in view of the improvement in the qua.ity of ca.e over the la.t ten yea.s. Objective: to determine the clinica. a.d immunovirologica. cha.a.teristics a. well a. the a.cepta.ce of a.tiretrovira. drugs in this pa.ient popula.ion. This is a.cohort study of the files of PLHIV (People living with HIV) a.ed 50 yea.s or more, followed in the Interna. Medicine Depa.tment of the Point G University Hospita. between Ja.ua.y 2007 a.d December 2012. Results: Out of 161 HIV-infected pa.ients in the cohort, 38 were a.ed 50 yea.s or older, of whom 11 met the criteria.a.d were included. The media. a.e wa. 55 yea.s, 90.9% of whom were in the [50 - 59 yea.s] a.e group, with 63.6% being women (sex ra.io = 0.57). a. a.mission, 3 pa.ients (27.3%) ha. prurigo a.d 2 (18.2%) ha. ora.-pha.yngea. ca.didia.is. a. inclusion, 45.5% of pa.ients were cla.sified a. WHO sta.e 2 a.d one a. WHO sta.e 4. a.l were on a.Vs, including 10 on 1st line HIV-1 a.d 1 on HIV-2. On triple thera.y, the a.era.e weight ga.n wa. 5.1 kg a. D15 a.d 6.84 kg a. M6. However, a. M12 there wa. a.weight loss of 1.04 kg. The mea. CD4 T cell ga.n wa. +102/mm3 a. M6 a.d +188/mm3 a. 12 months. a. D0, mea. vira. loa. = 565024.75 copies/mm3 [99 - 1100000] in 4/11. a. M12, two pa.ients ha. undetecta.le vira. loa.s. Conclusion: The preva.ence of HIV in elderly subjects is certa.nly underestima.ed. Tha.ks to triple a.tiretrovira. thera.y, PLHIV a.e a.ing with HIV but screening is not systema.ica.ly proposed during consulta.ions in elderly subjects. It is necessa.y to reinforce communica.ion a.out HIV a. a.l a.es.

关键词： HIV Elderly Clinica. Immunovirology

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Fa.mers Perceptions a.out Clima.e Cha.ge, Ma.a.ement Pra.tice a.d Their On-Fa.m a.option Stra.egies a. Rice Fields in Sa.u a.d Kunta.r of the Ga.bia. West a.rica

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a.erica. Journa. of Clima.e Cha.ge 2020年第1期9卷 1-10页

作者： Fa.ou Boja.g Seydou traore a.a.a.Togola.Ya.ouba.Dia.lo Institut Polytechnique Rura. de Forma.ion et de Recherches a.pliquées Katibougou Mali Centre Regiona. de Forma.ion et d’a.plica.ion en a.rométéorologie et Hydrologie Opéra.ionnelle (a.RHYMET) Niger

Lowla.d rice production is highly vulnera.le to extreme tempera.ure a. a.result of clima.e cha.ge. The study a.a.yses fa.mer’s perception a.out clima.e cha.ge, ma.a.ement pra.tice a.d their on-fa.m a.option stra.egies a. the rice fields of Sa.u a.d Kunta.r study loca.ion. The selected villa.es were the ma.n rice production a.ea. where rice is a.monoculture crop. Focus group discussion wa. held with twenty rice growing fa.mers a. Sa.ua.d Kunta.r, a.d these were divided into five groups. Persona. interview a.d key informa.t involves the two villa.e hea., two youth development cha.rpersons (VDC) a.d the extension worker overseeing both villa.es. This wa. done to ga.n in-depth knowledge on the subject ma.ter. The a.a.ysis results indica.ed tha. more tha. 50% of the rice growing fa.mers were fema.e a.d do not undergo forma. educa.ion. More tha. 70% of them ha.ing perceived knowledge on the ca.ses of clima.e cha.ge, inorga.ic fertilizer use, tra.spla.ting of rice seedlings, use of improved rice va.ieties, a.d on-fa.m coping stra.egies such a. cha.ging of cropping ca.enda. a.d the use of pesticides to cope with current a.d future clima.e situa.ion.

关键词： Perception Clima.e Cha.ge Ma.a.ement Stra.egies a.option Stra.egies

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The Complica.ions of Cesa.ea. Section a. Tea.hing Hospita. Ga.riel TOURE, Ba.a.o Ma.i

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Open Journa. of Obstetrics a.d Gynecology 2020年第4期10卷 546-557页

作者： a.doula.e Sissoko a.a.sa.e traore Ibra.im Ka.te a.a.ou Bocoum Souma.a.Ouma. traore Seydou Fa.e Da.iel Dembele a.ina.a.Kouma.Ma.a.ou Sima.Fa.ouma.a.K. Tounka.a.a.a.ou Fomba.Ibra.ima.Teguete Youssouf traore Souma.la.Keita.Nia.i Moukoro Tea.hing Hospita. Ga.riel TOURE Bamako Mali Tea.hing Hospita. Bamako Mali Tea.hing Hospita. Point G Bamako Mali District Hospita. Commune V Bamako Mali Tea.hing Hospita. Ka.i Bamako Mali Resea.ch Center CHU of Quebec University of Laval Quebec Canada

Cesa.ea. opera.ion permits to sa.e the mother a.d fetus. However, in developing countries a. ours, complica.ions rela.ed to this cesa.ea. a.e not to be neglected. It constitutes a. importa.t ca.se of ma.erna. a.d feta. morbidity a.d morta.ity. Here we ra.port the experience of our structure a.out the complica.ions of cesa.ea.. Objectives: The objectives of this study were to study the complica.ions the complica.ions of cesa.ea. section a. tea.hing hospita. Ga.riel TOURE, Ba.a.o Ma.i. Ma.eria.s a.d methods: We ha.e ca.ried out a.cross sectiona. a.a.ytic study from Ja.ua.y 1st?2003 to December 31st?2013. a.l the pa.ients who ga.e birth by cesa.ea. opera.ion in gynecology-obstetric service of tea.hing hospita. Ga.riel TOURE were included during this period of study. Descriptive sta.istics were used, Chi-squa.e test Pea.son, a.d?Cochra. a.mita.e test ha.e?been used to ca.cula.e the P-va.ue of trend. We performed multiva.ia.e a.a.yses with a.high a.pha.threshold of 10%, a.d then logistic regression multiva.ia.e. Results: We ha.e registered 28,376 deliveries with 9509 ca.es of cesa.ea. (33.5%) a.d a.complica.ion cesa.ea. ra.e of 32% (3049/9509). The ma.n risk fa.tors for cesa.ea. opera.ion completions were a.olescence primipa.ity, obesity, the non-rea.iza.ion of a.tena.a. ca.e, eva.ua.ions a.d co-morbidities. Intra.pera.ive complica.ions were domina.ed by hemorrha.e 8.3% a.d bla.der lesion 1.1%, wherea. a.emia.(58.8%) a.d pa.ieta. infection (21.1%) domina.ed the postopera.ive complica.ions ta.le. The eva.ua.ion (Odds Ra.io a.justed (ORa. = 1.96) a. well pre-ecla.psia.ecla.psia.(ORa.= 2.34) a.d the sicle cell disea.e (ORa.= 9.99) were the ma.n influencing fa.tors of ma.eria. dea.h. Pra.via.pla.enta.(ORa.= 1.75) a.ruption pla.enta.(ORa.= 11.08) a.d feta. ma.forma.ion (ORa.= 2.21) domina.ed the influencing fa.tors of perina.a. dea.h. Conclusion:?The cesa.ea. complica.ions ra.es were high in our improvement of the qua.ity of a.tena.a. ca.e.?The reorga.iza.ion a.d revita.iza.i

关键词： Cesa.ea. Complica.ion Risk Fa.tors Morbidity Morta.ity

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Ultra.ound of the Siren Syndrome (Sirenomelia. in the District of Ba.a.o a.ropos of a.Ca.e

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Open Journa. of Medica. Ima.ing 2022年第3期12卷 165-170页

作者： Ouncoumba.Dia.ra.Ousma.e traore Ilia. Guindo Ma.a.ou Dembele Souleyma.e traore a.a.sa.e Kouma.Issa.Cisse Ma.a.a.ou Dia.lo Sia.a.Sidibe a.a.a.Dia.a.Keita Ra.iology Depa.tment of the Reference Hea.th Center of the CIII Commune of Ba.a.o Bamako Mali Ra.iology Depa.tment of the Medica. Clinic “Ma.ie Curie” Bamako Mali Ra.iology Depa.tment of the Ka.I Hospita. Center Bamako Mali Ra.iology Depa.tment of the Medica. Clinic “FERTILIa.DIa.OUNOU” Bamako Mali Ra.iology Depa.tment of the “Luxembourg” Mother-Child Hospita. Center Bamako Mali Ra.iology Depa.tment of the “Ga.riel TOURE” Hospita. Center Bamako Mali Ra.iology Depa.tment CHU Point G Bamako Mali

Sirenomelia.is a.ra.e feta. ma.forma.ion with more or less complete fusion of both lower limbs consistently a.socia.ed with bila.era. rena. a.norma.ities. The positive dia.nosis ca. be ma.e a.tena.a.ly by ultra.ound during the first trimester of pregna.cy but often before the 22 weeks of a.enorrhea. The objective wa. to think a.out the possible dia.nosis by ultra.ound in front of the urina.y a.oma.ies a.d the ologia.nios during the morphologica. study of the second trimester of pregna.cy. We report a.ca.e of sirenomelia.in a.25-yea.-old la.y a. pa.t of the routine prena.a. a.sessment suspected a.d confirmed during the morphologica. ultra.ound of the second trimester of pregna.cy a.d confirmed a.ter the termina.ion of pregna.cy in Ma.i in the Hea.th Center of Reference of commune III of the district of Ba.a.o. The morphologica. ultra.ound ma.e it possible to dia.nose the ma.forma.ion of the urina.y tra.t, the a.niotic fluid a.d to ma.e the thera.eutic decision of medica. termina.ion of pregna.cy a. the end of confirming the siren syndrome.

关键词： Sirenoma.ia Ultra.ound Feta. Ma.forma.ion Ma.i

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Development of a.Virtua. Environment for Simula.ion of a.3D Roa. Profile Using OpenCRG a.d Ma.La. GUI

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Engineering（科研） 2021年第12期13卷 677-689页

作者： Théophile Roch Ori N’Golo Ma.a.ou Kone Sibiri traore Université Felix Houphouë t Boigny de Cocody La.ora.oire de Technologie UFR SSMT Cote d’Ivoire Institut Péda.ogique Na.iona. de l’Enseignement Technique et Professionnel (IPNETP) Dépa.tement de Génie Méca.ique Cote d’Ivoire

In vehicle dyna.ics, there a.e wide a.plica.ions concerning the simula.ion of vehicles on roa.s. These simula.ion a.plica.ions rela.e to vehicle driving, ride comfort a.d dura.ility. a. a.cura.e prediction of simula.ion results requires relia.ility a.d efficiency of roa. representa.ions. The Ma.La. gra.hica. user interfa.e module, ca.led Ma.La. GUI, is used to develop virtua. simula.ion la.ora.ories tha. a.low the user to intera.t with a.computer progra. using gra.hica. objects. In this context, the a.m of this a.ticle is to use the Ma.La. OpenCRG suite of tools a.d the Ma.La. GUI to develop a.virtua. environment for simula.ing a.3D roa. profile. a.three-dimensiona. model of a.pothole with va.ia.le pa.a.eters is developed a.d integra.ed into the 3D roa. profile.

关键词： 3D Roa. Profile Pothole OpenCRG Ma.La. GUI

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