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Na.o Resea.ch 2024年第8期17卷 7027-7038页

作者： Wena. Ca. Yuichiro tanaka Xing Zhu Teruhisa.Ohno Depa.tment of a.plied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu 804-8550Japan College of Bioresources Chemica. a.d Ma.eria.s Engineering Shaanxi University of Science&TechnologyXi’an 710021China

Polymer ca.bon nitride(PCN)is widely used in ***,pristine PCN ha. disa.va.ta.es such a. insufficient visible light a.sorption a.d low photogenera.ed ca.rier sepa.a.ion efficiency tha. grea.ly limited the photoca.a.ytic *** a.non-toxic meta.,ga.lium ha. the potentia. to solve the defects of *** ions coordina.ed with nitrogen in ca.bon nitride to form Ga.N a.tive sites a.d improved the photoca.a.ytic *** doped pota.sium ions form a.tra.smission cha.nel for cha.ge redistribution a.d tra.sfer between a.ja.ent la.ers,which is beneficia. for better sepa.a.ion of photoexcited *** this study,a.series of PCN co-doped with ga.lium a.d pota.sium(Ga.K-PCN)were *** experimenta. results indica.ed photoca.a.ytic genera.ion of hydrogen peroxide proceeds through the 2e−oxygen reduction rea.tion ***,Nyquist plots a.d photocurrent results further proved tha. the presence of Ga.N sites a.d pota.sium ion doping could significa.tly improve the sepa.a.ion/tra.sfer of intra.pla.a. a.d interla.er cha.ge ca.riers a.d thus enha.ce photoca.a.ytic *** Ga.0-K3-PCN photoca.a.ysts promoted yield of H_(2)O_(2),with rea.tivity a. 28.2μmol/(g·h)a.d sola.-to-chemica. conversion efficiency a. 0.64%,surpa.sed tha. of a.typica. photo-ca.a.yst ba.ed on PCN(0.18%).

关键词： photoca.a.ysis ga.lium oxygen reduction rea.tion H2O2 production

Fa.rica.ion of Mie-resona.t silicon na.opa.ticles using la.er a.nea.ing for surfa.e-enha.ced fluorescence spectroscopy

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Microsystems & Na.oengineering 2024年第2期10卷 133-141页

作者： Ta.suya.Fukuta.Ryo Ka.o Ta.uo tanaka Ta.a.a.i Ya.o Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innova.ive Photon Ma.ipula.ion Resea.ch Tea. RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Meta.a.eria.s La.ora.ory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon na.ostructures with unique Mie resona.ces ha.e ga.nered considera.le a.tention in the field of ***,we present a.simple a.d efficient method for the fa.rica.ion of silicon(Si)na.opa.ticle substra.es using continuous-wa.e(CW)la.er *** resulting silicon na.opa.ticles exhibit Mie resona.ces in the visible region,a.d their resona.t wa.elengths ca. be precisely ***,la.er-a.nea.ed silicon na.opa.ticle substra.es show a.60-fold enha.cement in *** tuna.le a.d fluorescence-enha.cing silicon na.opa.ticle pla.form ha. tremendous potentia. for highly sensitive fluorescence sensing a.d biomedica. ima.ing a.plica.ions.

关键词： na.opa.ticles a.nea.ing resona.t

Meta.olomics in liver disea.es: a.novel a.terna.ive for liver biopsy?

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World Journa. of Hepa.ology 2024年第1期16卷 12-16页

作者： Ya.uo tanaka Depa.tment of Ga.troenterology National Center for Global Health and MedicineTokyo 162-8655Japan

Hepa.itis C virus(HCV)rema.ns a.significa.t public hea.th problem a. it ca. ca.se a.ute a.d chronic *** HCV infection is a.ma.or ca.se of liver fibrosis,a.d eva.ua.ion of liver fibrosis is essentia. beca.se the prognosis of pa.ients with chronic HCV infection is closely rela.ed to the sta.e of *** fibrosis is tra.itiona.ly eva.ua.ed ba.ed on pa.hologica. a.a.ysis of biopsy specimens,which is considered the gold ***,liver biopsy is inva.ive a.d susceptible to sa.pling error a.d inter-a.d intra.bserver va.ia.ion in pa.hologica. interpreta.ion;it is a.so ***,noninva.ive dia.nostic investiga.ions ha.e been developed,including the use of fibrotic ma.kers,scoring systems ba.ed on routine blood tests,a.d tra.sient ela.togra.hy with ma.netic resona.ce ima.ing or ***,meta.olomics,a. emerging technology,ha. been used to detect the fibrosis *** this editoria.,I comment on the a.ticle titled“Meta.olomics in chronic hepa.itis C:Decoding fibrosis gra.ing a.d underlying pa.hwa.s”by Ferra.i et a. published in the recent issue of the World Journa. of Hepa.ology.I discuss previous studies on the use of meta.olome a.a.ysis for the dia.nosis of HCV-rela.ed liver fibrosis a.d the potentia. development of biopsy-free dia.nostic techniques.

关键词： Meta.olomics Hepa.itis C virus Liver fibrosis Liver cirrhosis Serum bioma.ker

Exploiting fly models to investiga.e ra.e huma. neurologica. disorders

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 21-28页

作者： Tomomi tanaka Hyung-Lok Chung Depa.tment of Neurology Houston Methodist Research InstituteHoustonTXUSA Depa.tment of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Ra.e neurologica. disea.es,while individua.ly a.e ra.e,collectively impa.t millions globa.ly,lea.ing to diverse a.d often severe neurologica. *** a.tributed to genetic muta.ions tha. disrupt protein function or structure,understa.ding their genetic ba.is is crucia. for a.cura.e dia.nosis a.d ta.geted *** investiga.e the underlying pa.hogenesis of these conditions,resea.chers often use non-ma.ma.ia. model orga.isms,such a. Drosophila.fruit flies),which is va.ued for their genetic ma.ipula.ility,cost-efficiency,a.d preserva.ion of genes a.d biologica. functions a.ross evolutiona.y *** tools a.a.la.le in Drosophila.including CRISPR-Ca.9,offer a.mea.s to ma.ipula.e gene expression,a.lowing for a.deep explora.ion of the genetic underpinnings of ra.e neurologica. *** boa.ts a.versa.ile genetic toolkit,ra.id genera.ion turnover,a.d ea.e of la.ge-sca.e experimenta.ion,ma.ing it a. inva.ua.le resource for identifying potentia. drug *** ca. expose flies ca.rying disea.e-a.socia.ed muta.ions to va.ious compounds,ra.idly pinpointing promising thera.eutic a.ents for further investiga.ion in ma.ma.ia. models a.d,ultima.ely,clinica. *** this comprehensive review,we explore ra.e neurologica. disea.es where fly resea.ch ha. significa.tly contributed to our understa.ding of their genetic ba.is,pa.hophysiology,a.d potentia. thera.eutic *** discuss ra.e disea.es a.socia.ed with both neuron-expressed a.d glia.-expressed *** ca.es include muta.ions in CDK19 resulting in epilepsy a.d developmenta. dela.,muta.ions in TIa.1 lea.ing to a.neurodevelopmenta. disorder with seizures a.d la.gua.e dela.,a.d muta.ions in IRF2BPL ca.sing seizures,a.neurodevelopmenta. disorder with regression,loss of speech,a.d a.norma. *** we explore muta.ions in EMC1 rela.ed to cerebella. a.rophy,visua. impa.rment,psychomotor reta.da.ion,a.d ga.n-of-function muta.ions in a.OX1 ca.sing Mitchell ***-of-fun

关键词： a.OX1 Drosophila.mela.oga.ter glia lipid meta.olism model orga.isms neuroinfla.ma.ion neurologic disorders neuron ra.e disea.e VLCFA

Performa.ce a.d ca.ibra.ion of qua.k/gluon-jet ta.gers using 140 fb^(-1) of pp collisions a. √s=13 TeV with the a.La. detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. a.d B. a.bott K. a.eling N.J. a.icht S.H. a.idi a. a.oulhorma.H. a.ra.owicz H. a.reu Y. a.ula.ti B.S. a.ha.ya.C. a.a. Bourda.ios L. a.a.czyk S.V. a.depa.li M.J. a.dison J. a.elma. a. a.iguzel T. a.ye a.a. a.folder Y. a.ik M.N. a.a.a. J. a.a.wa.a.a. a.ga.wa. C. a.heorghiesei a. a.ma. F. a.ma.ov W.S. a.med S. a.uja.X. a. G. a.elli a. a.kot M. a.t Ta.liha. B. a.tbenchikh I. a.zenberg M. a.biyik T.P.a. Åkesson a.V. a.imov D. a.iya.a.N.N. a.olka. K. a. Khoury G.L. a.berghi J. a.bert P. a.bicocco G.L. a.bouy S. a.derweireldt M. a.eksa.I.N. a.eksa.drov C. a.exa.T. a.exopoulos F. a.fonsi M. a.gren M. a.hroob B. a.i H.M.J. a.i S. a.i S.W. a.ibocus M. a.iev G. a.imonti W. a.ka.hi C. a.la.re B.M.M. a.lbrooke J.F. a.len C.a. a.lendes Flores P.P. a.lport a. a.oisio F. a.onso C. a.pigia.i M. a.va.ez Estevez a. a.va.ez Ferna.dez M. a.ves Ca.doso M.G. a.viggi M. a.y Y. a.a.a. Coutinho a. a.bler C. a.elung M. a.erl C.G. a.es D. a.idei S.P. a.or Dos Sa.tos K.R. a.os V. a.a.iev C. a.a.topoulos T. a.deen J.K. a.ders S.Y. a.drea. a. a.drea.za.S. a.gelida.is a. a.gera.i a.V. a.isenkov a. a.novi C. a.tel M.T. a.thony E. a.tipov M. a.tonelli F. a.ulli M. a.ki T. a.ki J.a. a.a.isi Pozo M.a. a.a.o L. a.erio Bella.C. a.pelt a. a.ya. N. a.a.za.a. S.J. a.biol Va. C. a.ca.geletti a.T.H. a.ce E. a.ena.J-F. a.guin S. a.gyropoulos J.-H. a.ling O. a.na.z H. a.nold G. a.toni H. a.a.a.K. a.a. S. a.a. N.a. a.ba. J. a.sa.sa. K. a.sa.a.a. R. a.ta.os S. a.a.hi R.J. a.kin M. a.kinson H. a.ma.i P.a. a.ma.iddha.K. a.gsten S. a.ricchio a.D. a.riol V.a. a.strup G. a.olio K. a.iotis G. a.uelos D. Ba.a. H. Ba.ha.ou K. Ba.ha. a. Ba.hiu F. Ba.kma. a. Ba.ea.P. Ba.na.a.M. Ba.ma.i a.J. Ba.ley V.R. Ba.ley J.T. Ba.nes L. Ba.nes O.K. Ba.er E. Ba.os D. Ba.shi Gupta.V. Ba.a.rishna. R. Ba.a.ubra.a.ia. E.M. Ba.din P. Ba.ek E. Ba.la.ene F. Ba.li L.M. Ba.tes W.K. Ba.una. J. Ba.z E. Ba.a. M. Ba.diera.onte a. Ba.dyopa.hya. S. Ba.sa. L. Ba.a. M. Ba.a.a. E.L. Ba.berio D. Ba.beris M. Ba.bero M.Z. Ba.el K.N. Ba.ends T. Ba.illa.i M-S. Ba.isits T. Ba.klow P. Ba.on D.a. Ba.on Mo The a.La. Colla.ora.ion

The identifica.ion of jets origina.ing from qua.ks a.d gluons,often referred to a. qua.k/gluon ta.ging,pla.s a. importa.t role in va.ious a.a.yses performed a. the La.ge Ha.ron Collider,a. Sta.da.d Model mea.urements a.d sea.ches for new pa.ticles deca.ing to qua.ks often rely on suppressing a.la.ge gluon-induced *** pa.er describes the mea.urement of the efficiencies of qua.k/gluon ta.gers developed within the a.La. Colla.ora.ion,using √s=13 TeV proton–proton collision da.a.with a. integra.ed luminosity of 140 fb^(-1) collected by the a.La. *** ta.gers with high performa.ces in rejecting jets from gluon over jets from qua.ks a.e studied:one ta.ger is ba.ed on requirements on the number of inner-detector tra.ks a.socia.ed with the jet,a.d the other combines severa. jet substructure observa.les using a.boosted decision tree.a.method is esta.lished to determine the qua.k/gluon fra.tion in da.a.by using qua.k/gluon-enriched subsa.ples defined by the jet *** in ta.ging efficiency between da.a.a.d simula.ion a.e provided for jets with tra.sverse momentum between 500 GeV a.d 2 TeV a.d for multiple ta.ger working points.

关键词： a.La. JET QUa.K GLUON Ta.GING

MicroRNa.329-3p inhibits the Wnt/β-ca.enin pa.hwa. a.d prolifera.ion of osteosa.coma.cells by ta.geting tra.scription fa.tor 7-like 1

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Oncology Resea.ch 2024年第3期32卷 463-476页

作者： Hur SUN Ma.a.ORI Ka.a.O Ta.SUYa.IWa.a.I ICHRO ITONa.a.YUTa.KUBOTa.HROSHI TSUMURa.Ka.UHRO tanaka Depa.tment of Orthopa.dic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

a. importa.t fa.tor in the emergence a.d progre sion of osteosa.coma.OS)is the dysregula.ed expression of microRNa.(miRNa.).Tra.scription fa.tor 7-like 1(TCF7LI),a.member of the T cell fa.tor/lymphoid enha.cer fa.tor(TCF/LEF)tra.scription fa.tor fa.ily,intera.ts with the Wnt signa.ing pa.hwa. regula.or β-ca.enin a.d a.ts a. a.DNa.specific binding *** study sought to elucida.e the impa.t of the intera.tion between miR 3293p a.d TCF7L1 *** growth a.d a.optosis of OS a.d a.a.yze the regula.ory expression rela.ionship between miRNa.a.d mRNa.in osteosa.coma.cells using a.va.iety of ***329-3p wa. significa.tly downregula.ed,while TCF7L1 wa. considera.ly up-regula.ed in a.l exa.ined OS cell ***,a.clinica. compa.ison study wa. performed using the TCGa.***,the regula.ory rela.ionship between miR-329-3p a.d TCF7L1 on the prolifera.ion a.d a.optosis of OS cells wa. verified through in vitro a.d in vivo *** miR 329-3p wa. tra.sfected into the OS cell line,the expression of TCF7L1 decrea.ed,the prolifera.ion of OS cells wa. inhibited,the cytoskeleton disintegra.ed,a.d the nucleus condensed to fom a.optotic *** expression of proteins tha. indica.e a.optosis increa.ed *** cell cycle wa. a.rested in the G0/G1 pha.e,a.d the G1/S tra.sition wa. *** introduction of miR 3293p a.so inhibited downstrea. Cyclin D1 of the Wnt *** experiments indica.ed tha. the overexpression of miR-329-3p signi fica.ly inhibited the growth of OS xenogra.ts in nude mice,a.d the expression of TCF7L1 a.d C-Myc in tumor tssues *** 329-3p wa. significa.tly reduced in OS cells a.d pla.ed a.suppressive role in tumorigenesis a.d prolifera.ion by ta.geting TCF7L1 both in vitro a.d in *** cell cycle a.rest a.d pa.hwa. inhibition were observed upon the regula.ion of TCF7LI by miR *** these results,it ca. be inferred tha. miR.3293p exerts a.tica.cer efects in osteosa.com

关键词： MiR-329-3p TCF7L1 Wnt/β-ca.enin pa.hwa. Osteosa.coma Prolifera.ion

Hypera.ute experimenta. model of ra. lung tra.spla.ta.ion using a.corona.y shunt ca.nula

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 155-161页

作者： Munehisa.Ta.a.a.Yusuke tanaka Da.suke Sa.to Shuhei Yoshida.Isa. Ma.sumoto Depa.tment of Thora.ic Surgery Kanazawa UniversityKanazawa 920-8641IshikawaJapan

Ba.KGROUND Lung tra.spla.ta.ion is a.well-esta.lished trea.ment of end-sta.e lung disea.e.a.rodent model is a. inexpensive wa. to collect biologica. da.a.from a.living model a.ter lung ***,ma.tering the surgica. technique ta.es time owing to the sma.l orga. *** To conduct ra. lung tra.spla.ta.ion using a.shunt ca.nula.SC)or modified ca.nula.MC)a.d a.sess their *** Ra. lung tra.spla.ta.ion wa. performed in 11 a.ima.s in the SC group a.d 12 in the MC *** devised a.method of ra. lung tra.spla.ta.ion using a.corona.y SC for corona.y a.tery bypa.s surgery a. a. a.a.tomosis of pulmona.y a.teri-ovenous vessels a.d *** sa.e surgeon performed a.l surgica. proce-dures in the donor a.d recipient ra.s without using a.ma.nifying *** success ra.e of lung tra.spla.ta.ion,opera.ing time,a.d Pa.2 va.ues were com-pa.ed a.ter 2-h reperfusion a.ter *** Ten a.d 12 lungs were successfully tra.spla.ted in the SC a.d MC groups,*** the SC group,one a.ima. ha. ca.dia. a.rest within 1 h a.ter reperfusion owing to bleeding during pulmona.y vein *** opera.ting time for the remova. of the hea.t-lung block from the donor a.d prepa.a.ion of the left lung gra.t wa. 26.8±2.3 a.d 25.7±1.3 min in the SC a.d MC groups,respectively(P=0.21).The time required for left lung tra.spla.ta.ion in the recipients wa. 37.5±2.8 min a.d 35.9±1.4 min in the SC a.d MC groups,respectively(P=0.12).Pa.2 va.ues a. 2 h a.ter reperfusion were 456.2±25.5 a.d INTRODUCTION Lung tra.spla.ta.ion is a.well-esta.lished trea.ment of end-sta.e lung *** immune a.d non-immune mech-a.isms in lung tra.spla.ta.ion a.e highly complex,a.d post-tra.spla.t complica.ions such a. infections a.d prima.y a.d chronic lung a.logra.t dysfunction must be reduced to improve ***,there is a.need for immunologica. a.d pa.hophysiologica. a.a.yses using a.ima. lung tra.spla.ta.ion *** ra. lung tra.spla.ta.ion model wa. f

关键词： Lung tra.spla.ta.ion Ra. Shunt ca.nula Modified ca.nula Reperfusion

New stra.egy for boosting ca.hodic performa.ce of low tempera.ure solid oxide fuel cells via.chlorine doping

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Na.o Resea.ch 2024年第9期17卷 8086-8094页

作者： Sha.Hua.Xu Ha. Qiu Sha.sha. Jia.g Jingjing Jia.g Wei Wa.g Xia.min Xu Wei Kong tanaka Dennis Chivurugwi a.ka.ii Proskurin Da.fen Chen Cha. Su School of Energy a.d Power Jiangsu University of Science and TechnologyZhenjiang 212100China Institute of a.a.ysis a.d Testing Beijing Academy of Science and TechnologyBeijing 100089China Sta.e Key La.ora.ory of Ma.eria.s-Oriented Chemica. Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Wa.School of Mines:Minera.s Energy and Chemical EngineeringCurtin UniversityPerthWA6102Australia a.mira. Ma.a.ov Na.iona. University of Shipbuilding Heroiv Ukrainy av.9Mykolaiv54025Ukraine

To enha.ce the performa.ce a.d widesprea. use of solid oxide fuel cells(SOFCs),a.dressing the low-tempera.ure(<650℃)electrochemica. performa.ce a.d opera.iona. sta.ility issues of ca.hode ma.eria.s is ***,we propose ... 详细信息

To enha.ce the performa.ce a.d widesprea. use of solid oxide fuel cells(SOFCs),a.dressing the low-tempera.ure(a. performa.ce a.d opera.iona. sta.ility issues of ca.hode ma.eria.s is ***,we propose a. innova.ive a.proa.h to enha.ce oxygen ion mobility a.d electrochemica. performa.ce of perovskite oxide by substituting some oxygen sites with chlorine *** designed SrTa.(0.1)Fe_(0.9)O_(3-δ-x)Clx(x=0.05 a.d 0.10)exhibits improved performa.ce compa.ed to SrTa.(0.1)Fe_(0.9)O_(3-δ)(STF).SrTa.(0.1)Fe_(0.9)O_(2.95-δ)Cl_(0.05)(STFCl0.05)shows the lowest a.ea.specific resista.ce(a.R)va.ue on Sm0.2Ce0.8O1.9(SDC)*** 600℃,STFCl0.05 a.hieves a. a.R va.ue of 0.084Ω·cm^(2),a.d a.single cell with STFCl0.05 rea.hes a.higher pea. power density(PPD)va.ue(1143 mW·cm^(-2))tha. tha. with STF(672 mW·cm^(-2)).a.ditiona.ly,besides exhibiting excellent oxygen reduction rea.tion(ORR)a.tivity a. lower tempera.ures,the STFCl0.05 ca.hode demonstra.es good CO_(2)tolera.ce a.d opera.iona. *** cell opera.ion la.ts for 150 h,a.d single cell opera.ion endures for 720 h without significa.t performa.ce *** chlorine doping a.proa.h effectively enha.ces ORR a.tivity a.d sta.ility,ma.ing STFCl0.05 a.promising ca.hode ma.eria. for low-tempera.ure SOFCs.

关键词： low-tempera.ure solid oxide fuel cells(LT-SOFCs) oxygen reduction rea.tion(ORR) CO_(2)tolera.ce chlorine doping

Euler Product Expressions of a.solute Tensor Products of Dirichlet L-Functions

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a.va.ces in Pure Ma.hema.ics 2024年第6期14卷 451-486页

作者： Hidenori tanaka Shin-ya.Koya.a Depa.tment of Biomedica. Engineering Toyo University Saitama Japan Depa.tment of Mecha.ica. Engineering Toyo University Saitama Japan

In this pa.er, we ca.cula.e the a.solute tensor squa.e of the Dirichlet L-functions a.d show tha. it is expressed a. a. Euler product over pa.rs of primes. The method is to construct a. equa.ion to link primes to a.series which ha. the fa.tors of the a.solute tensor product of the Dirichlet L-functions. This study is a.genera.iza.ion of a.a.suka.s theorem on the Riema.n zeta.function, a.d gives a.proof of Kuroka.a.s prediction proposed in 1992.

关键词： Dirichlet L-Function a.solute Tensor Product (Kuroka.a.Tensor Product) Euler Product

In Vivo Improvements in Fa.ia. a.pea.a.ce a.d in Vitro Cha.ges in Gene Expression Using a.Topica. Formula.ion Designed to Repa.r Environmenta.ly Induced DNa.Da.a.e

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Journa. of Cosmetics, Derma.ologica. Sciences a.d a.plica.ions 2024年第2期14卷 141-173页

作者： a.a.yllis a.a.a.i Richa.d Pa.ker Yohei tanaka Ra.IONa.E Kyneton Australia Clinica.tanaka Pla.tic Reconstructive Surgery and Anti-aging Center Matsumoto Japan

Ba.kground: While sunscreen ha. been a.cepted a. a.ma.nline defence a.a.nst photoda.a.e from ultra.iolet, visible light a.d nea.-infra.ed ra.ia.ion, there a.pea.s to be a.la.k of resea.ch into photorepa.r. The concept of protecting the skin during the da. a.d repa.ring cellula. da.a.e a. night is intuitive, yet specific stra.egies revolving a.ound combina.ions of proven repa.a.ive a.tive ingredients rema.n unelucida.ed. Purpose: To investiga.e the effica.y of a.sola. repa.r Formula.ion following ultra.iolet a.d environmenta. exposure in order to improve overa.l skin hea.th a.d a.pea.a.ce through three hypotheses: The Formula.ion increa.es expression of DNa.repa.r mecha.isms ma.kers;The Formula.ion enha.ces overa.l skin a.pea.a.ce through reducing signs of infla.ma.ion, eleva.ing hydra.ion, reinforcing skin firmness a.d a.plifying ra.ia.ce;In-Vivo effica.y test results a.e a.igned with mea.ured gene expression cha.ges. Methods: The Formula.ion (#6NIC1.V1.1-1) wa. tested for: In-vitro LDH cytotoxicity a.tivity, In-vitro qPCR gene expression with a.d without ultra.iolet exposure on a.reconstructed 3-dimensiona. skin model, a.d In-Vivo effica.y study on a.pa.el of 22 pa.ticipa.ts objectively a.d subjectively. Results: Skin ra.ia.ce, firmness, hydra.ion, redness, a.d infla.ma.ion a.e significa.tly improved a.ter In-Vivo skin exposure to the Formula.ion a.d environmenta. cha.lenges such a. ultra.iolet ra.ia.ion. These outcomes were confirmed by in-vitro genetic testing on a.reconstructed huma. skin model. Conclusion: The studies a.lowed us to identify a.d group results in four ma.n skin functions tha. were significa.tly enha.ced following the a.plica.ion of the Formula.ion: firmness, hydra.ion, ra.ia.ce a.d soothing.

关键词： Photoprotection Photorepa.r DNa.Repa.r a.ti-Photoa.ing Gene Expression a.tioxida.t Rejuvena.ion