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Surgica. cystoga.trostomy: Is it still worthwhile?

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World Journa. of Ga.troenterology 2024年第17期30卷 2298-2301页

作者： Kin Pa. a. Kenneth siu Ho Chok Depa.tment of Surgery Queen Mary HospitalThe University of Hong KongHong Kong 999077China Depa.tment of Surgery The Chinese University of Hong KongHong Kong 999077China

The a.ticle by Ker et a. explores the trea.ment of peripa.crea.ic fluid collection(PFC).The use of percuta.eous dra.na.e,endoscopy,a.d surgery for ma.a.ing PFC a.e *** dra.na.e is noted for its low risk profile,while endoscopic cystoga.trostomy is more effective due to the wider orifice of the meta.lic *** cystoga.trostomy is a.definitive trea.ment with a.reduced need for reintervention,especia.ly for ca.es with extensive collections a.d significa.t *** choice of trea.ment moda.ity should be ta.lored to individua. pa.ient cha.a.teristics a.d disea.e fa.tors,considering the expertise a.a.la.le.

关键词： Endoscopic cystga.trostomy Surgica. cystga.trostomy Pa.crea.itis Pa.crea.ic necrosis Peripa.crea.ic collection

Fa.lt Dia.nosis Scheme for Ra.lwa. Switch Ma.hine Using Multi-Sensor Fusion Tensor Ma.hine

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Computers, Ma.eria.s & Continua 2024年第6期79卷 4533-4549页

作者： Chen Chen Zhongwei Xu Meng Mei Ka. Hua.g siu Ming Lo School of Electronic a.d Informa.ion Engineering Tongji UniversityShanghai201804China Depa.tment of a.chitecture a.d Civil Engineering City University of Hong KongHong KongChina School of Computer Engineering Jimei UniversityXiamen361021China

Ra.lwa. switch ma.hine is essentia. for ma.nta.ning the sa.ety a.d punctua.ity of tra.n opera.ions.a.da.a.driven fa.lt dia.nosis scheme for ra.lwa. switch ma.hine using tensor ma.hine a.d multi-representa.ion monitoring da.a.is developed *** existing methods,this a.proa.h ta.es into a.count the spa.ia. informa.ion of the time series monitoring da.a.a.igning with the doma.n expertise of on-site ma.ua. ***,a.multi-sensor fusion tensor ma.hine is designed to improve single signa. da.a.s limita.ions in insufficient ***,one-dimensiona. signa. da.a.is preprocessed a.d tra.sformed into two-dimensiona. ***,the fusion fea.ure tensor is crea.ed by utilizing the ima.es of the three-pha.e current a.d employing the Ca.DE-COMP/Pa.a.a.(CP)decomposition ***,the tensor lea.ning-ba.ed model is built using the extra.ted fusion fea.ure *** developed fa.lt dia.nosis scheme is va.id with the field three-pha.e current *** experiment indica.es a. enha.ced performa.ce of the developed fa.lt dia.nosis scheme over the current a.proa.h,pa.ticula.ly in terms of reca.l,precision,a.d F1-score.

关键词： Ra.lwa. switch ma.hine tensor ma.hine fa.lt dia.nosis

Exploring trea.ment options in ca.cer: Tumor trea.ment stra.egies

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第8期9卷 3337-3380页

作者： Beilei Liu Hongyu Zhou Licheng Ta. Kin To Hugo siu Xin-Yua. Gua. Depa.tment of Clinica. Oncology The University of Hong Kong-Shenzhen HospitalShenzhenChina Depa.tment of Clinica. Oncology The University of Hong KongHong KongChina sta.e Key La.ora.ory for Liver Resea.ch The University of Hong KongHong KongChina a.va.ced Energy Science a.d Technology Gua.gdong La.ora.ory HuizhouChina MOE Key La.ora.ory of Tumor Molecula. Biology Jinan UniversityGuangzhouChina

Tra.itiona. thera.eutic a.proa.hes such a. chemothera.y a.d ra.ia.ion thera.y ha.e burdened ca.cer pa.ients with onerous physica. a.d psychologica. ***,the la.dsca.e of tumor trea.ment ha. undergone a.comprehensive a.d rema.ka.le *** a. fervently pursued moda.ities a.e sma.l molecule ta.geted a.ents,a.tibody-drug conjuga.es(a.Cs),cell-ba.ed thera.ies,a.d gene *** cutting-edge trea.ment moda.ities not only a.ford persona.ized a.d precise tumor ta.geting,but a.so provide pa.ients with enha.ced thera.eutic comfort a.d the potentia. to impede disea.e ***,it is a.knowledged tha. these thera.eutic stra.egies still ha.bour unta.ped potentia. for further *** a.comprehensive understa.ding of the merits a.d limita.ions of these trea.ment moda.ities holds the promise of offering novel perspectives for clinica. pra.tice a.d founda.iona. resea.ch *** this review,we discussed the different trea.ment moda.ities,including sma.l molecule ta.geted drugs,peptide drugs,a.tibody drugs,cell thera.y,a.d gene *** will provide a.deta.led expla.a.ion of ea.h method,a.dressing their sta.us of development,clinica. cha.lenges,a.d potentia. *** a.m is to a.sist clinicia.s a.d resea.chers in ga.ning a.deeper understa.ding of these diverse trea.ment options,ena.ling them to ca.ry out effective trea.ment a.d a.va.ce their resea.ch more effciently.

关键词： drugs trea.ment holds

a. Overview of Chemica. Constituents, Medicina. Properties, Clinica. Tria.s, a.d Pa.ents of Twigs of Morus a.ba.Ra.ulus Mori)

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World Journa. of Tra.itiona. Chinese Medicine 2024年第2期10卷 149-158页

作者： Eric Wei Chia.g Cha. Hung Tuck Cha. siu Kuin Wong Depa.tment of Food Science a.d Nutrition Faculty of Applied SciencesUCSI UniversityCherasKuala LumpurMalaysia Secreta.ia. of Interna.iona. Society for Ma.grove Ecosystems Faculty of AgricultureUniversity of the RyukyusOkinawaJapan School of Founda.ion Studies Xiamen University MalaysiaSepangSelangorMalaysia

The rich chemica. constituents a.d diverse pha.ma.ologica. properties of Ra.ulus Mori(RM) or the twig of Morus a.ba.with evidence supported by clinica. tria.s a.d pa.ents a.e reviewed. Known a. Sa.gzhi in Chinese, RM is widely used in tra.itiona. Chinese medicine to trea. gout, a.thritis, a.d rheuma.ism. Chemica. constituents include fla.onoids, benzofura.s, a.ka.oids, stilbenes, cha.cones, phenolic a.ids, a.d couma.ins. Bioa.tivities of RM include a.tidia.etic, a.ti-obesity, a.ti-infla.ma.ory, a.tityrosina.e, neuroprotective, a.tioxida.t, hepa.oprotective, cytoprotective, renoprotective, a.tihyperuricemic, a.a.gesic, a.tifunga., DNa.protective, a.tica.cer, ga.troprotective, ca.dioprotective, a.ti-ha.r a.ing, a.ti-a.thritic, a.d a.tipla.elet a.grega.ion properties. The most a.tive compounds from RM a.e mulberrin, oxyresvera.rol, a.d mulberroside a. a.l four clinica. tria.s on RM a.e focused on the trea.ment of dia.etes. The pa.ents enta.l using RM extra.ts a. cosmetics for skin whitening a.d a. a.ents for hypoglycemia. Topics for further resea.ch on RM a.e suggested.

关键词： Clinica. tria.s mulberrin mulberroside A oxyresvera.rol pa.ents Sa.gzhi

Hormone-ba.ed pha.ma.othera.y for meta.olic dysfunction-a.socia.ed fa.ty liver disea.e

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Medica. Review 2024年第2期4卷 158-168页

作者： Za.a.siu Wa.Chui Ya.ia. Xue a.min Xu Sta.e Key La.ora.ory of Pha.ma.eutica. Biotechnology The University of Hong KongHong Kong SARChina Depa.tment of Medicine The University of Hong KongHong Kong SARChina School of Biomedica. Sciences The University of Hong KongHong Kong SARChina Sta.e Key La.ora.ory of Pha.ma.eutica. Biotechnology The University of Hong Kong999077Hong Kong SARChina Depa.tment of Medicine The University of Hong Kong999077Hong Kong SARChina Depa.tment of Pha.ma.ology a.d Pha.ma.y The University of Hong Kong999077Hong Kong SARChina

Meta.olic dysfunction-a.socia.ed fa.ty liver disea.e(Ma.LD)ha. rea.hed epidemic proportions globa.ly in pa.a.lel to the rising preva.ence of *** its significa.t burden,there is no a.proved pha.ma.othera.y specifica.ly ta.lored for this *** potentia. drug ca.dida.es for Ma.LD ha.e encountered setba.ks in clinica. tria.s,due to sa.ety concerns or/a.d insufficient thera.eutic ***,severa. investiga.iona. drugs tha. mimic the a.tions of endogenous meta.olic hormones,including thyroid hormone receptorβ(THRβ)a.onists,fibrobla.t growth fa.tor 21(FGF21)a.a.ogues,a.d gluca.on-like peptide-1 receptor a.onists(GLP-1Ra.),showed promising thera.eutic effica.y a.d excellent sa.ety *** them,resmetirom,a.liver-ta.geted THRβ-selective a.onist,ha. met the prima.y outcomes in a.levia.ion of meta.olic dysfunction-a.socia.ed stea.ohepa.itis(Ma.H),the a.va.ced form of Ma.LD,a.d liver fibrosis in pha.e-3 clinica. *** hormone-ba.ed pha.ma.othera.ies not only exhibit va.ied degrees of thera.peutic effica.y in mitiga.ing hepa.ic stea.osis,infla.ma.ion a.d fibrosis,but a.so improve meta.olic ***more,these three hormona. a.onists/a.a.ogues a.t in a.complementa.y ma.ner to exert their pha.ma.ologica. effects,suggesting their combined thera.ies ma. yield synergistic thera.eutic *** in-depth studies on the intrica.e interpla. a.ong these meta.olic hormones a.e impera.ive for the development of more effica.ious combina.ion thera.ies,ena.ling precision ma.a.ement of Ma.LD a.d its a.socia.ed comorbidities.

关键词： meta.olic hormones meta.olic dysfunctiona.socia.ed stea.ohepa.itis(Ma.H) liver fibrosis biopha.ma.eutica. development clinica. tria.s

Synthesis, Structure a.d Non-linea. Optica. Properties of Ma.ga.ese Mercury Tetra.hiocya.a.e

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Chinese Chemica. Letters 1999年第3期10卷 257-260页

作者： Yun Xing Ya. Qi Fa.G Duo Rong YUa. Yu Peng TIa. Zhi LIU Xia. MeiWa.G Min Hua.JIa.G D. WILLIa.S a. siu Zhi Ga.g Ca. (Institute of Crysta. Ma.eria.s a.d Sta.e Key La.ora.ory of Crysta. Ma.eria.s,Sha.dong University. Jina. 250100)(Depa.tment of Chem Institute of Crysta. Ma.eria.s State Key Lab. of Crystal Materials Shandong University Jinan 250100 China Depa.tment of Chemistry Hong Kong Univ. of Sci. and Technol. Hong Kong Hong Kong Institute of La.er Spectroscopy Stake Key Lab. Ultrafast Laser S. Zhongshan University Guangzhou 510275 China

The title copound Ma.ga.ese Mercury Tetra.hiocya.a.e (MnHg (SCN)(4)) ha. been synthesized a.d its structure ha. been determined. It belongs to tetra.ona. system, I (4) over ba. spa.e group. The cell dimensions a.e: a.= 1.1324 (3) nm, c = 0.4270 (2) nm, V = 0.5475 (3) nm(3), Z = 2, D-c = 2.959 g/cm(3), R = 0.028, R-w = 0.037. The structure fea.ure of the crysta. is the Hg-S-C=N-Mn bridge which lea.s to the forma.ion of a. infinite three dimensiona. network. Irra.ia.ed by a.1064 nm Nd:Ya. la.er bea., MnHg (SCN), shows a.532 nm second ha.monic intensity which is 18 times a. tha. of orga.ic nonlinea. optica. crysta. urea. a.d therefore shows a.quite promising a.plica.ion va.ue a. a.useful nonliea. optica. ma.eria..

关键词： MnHg (SCN)(4) synthesis structure nonlinea. optica. property

Low-Cost High-Performa.ce 10 G Tra.smitter a.d Receiver Optica. Suba.sembly

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光学学报 2003年第S1期23卷 607-608页

作者： K.S. Cheng E. Cheung R. Cheung S. Cheung a. Chow C.W. Fa. H.W. Ho a. Hui M.W.K. Ma. S.K. La. S.L. La. K.S. Lee a. siu S.K. Ya. F. Tong Hong Kong a.plied Science a.d Technology Resea.ch Institute 18F Gateway Tower 6 Tsim Sha Tsui Hong KongChina a.so a. the Informa.ion Engineering Depa.tment The Chinese University of Hong Kong Shatin Hong Kong China

We describe briefly here the recent R&D a.tivities in the optica. suba.sembly pa.ka.ing technologies a. the Hong Kong a.plied Science a.d Technology Resea.ch Institute (a.TRI). We ha.e designed, developed a.d prototyped multiple of low-cost high performa.ce pa.ka.es for seria. a.d pa.a.lel tra.smitters a.d receivers, in pa.ticula., the novel chip-in-pla.tic (CiP) pa.ka.e designed for 10G seria. tra.smission for da.a.communica.ions.

关键词： Science a.d Technology seria. tra.smission da.a.communica.ions high performa.ce Hong Kong

Solita.y extra.va.ia. prima.y peritonea. ca.cinoma.with direct inva.ion into the liver,dia.hra.m a.d lung without peritonea. dissemina.ion or dista.t meta.ta.is

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2024年第3期23卷 322-325页

作者： Billy Ho Hung Cheung Wong Hoi She siu Lun Ho a.bert Chi Ya. Cha. Chung Ma. Lo Ta. To Cheung Depa.tment of Surgery The University of Hong KongHong KongChina Depa.tment of Pa.hology The University of Hong KongHong KongChina

To the Editor:Extra.va.ia. prima.y peritonea. ca.cinoma.EOPPC)is a. uncommon ma.igna.cy with ma.y simila.ities to epithelia. ova.ia. ca.cinoma.in histologica.,clinica.,a.d etiologica. a.pects[1].This phenomenon is expla.ned by their common embryona. origin,in which both develop from the coelomic epithelium in the ea.ly embryologica. *** their simila.ities,the incidence of EOPPC is significa.tly lower tha. tha. of epithelia. ova.ia. ca.cinoma.6.78 ca.es per million vs.120.5 ca.es per million)[1].

关键词： peritonea. inva.ion meta.ta.is

Broa.-spectrum ginsentides a.e principa. bioa.tives in unra.eling the cure-a.l effects of ginseng

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a.ta.Pha.ma.eutica.Sinica.B 2024年第2期14卷 653-666页

作者： Shining Loo a.tony Ka. Ba.a.ra.a. Dutta.Xia.hong Zha.g Na. Feng siu Kwa. Sze Chua.-Fa.Liu Xia.lia.g Wa.g Ja.es P.Ta. School of Biologica. Sciences Nanyang Technological UniversitySingapore 637551Singapore a.a.emy of Pha.ma.y Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Depa.tment of Biologica. Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Ma.eria.Medica Chinese Academy of Medical SciencesBeijing 100050China Depa.tment of Hea.th Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress a.d illness connection is complex a.d involves multiple physiologica. *** ginsengs,reputed for their broa.-spectrum“cure-a.l”effect,a.e widely prescribed to trea. stress a.d rela.ed ***,the identity of ginseng’s“cure-a.l”medicina. compounds tha. relieve stress rema.ns ***,we identify ginsentides a. the principa. bioa.tives tha. coordina.e multiple systems to restore homeosta.is in response to *** a.e disulfide-rich,cell-penetra.ing a.d proteolytic-sta.le *** a.finity-enrichment ma.s spectrometry ta.get identifica.ion together with in vitro,ex vivo a.d in vivo va.ida.ions,we show tha. highly purified or synthetic ginsentides promote va.orela.a.ion by producing nitric oxide through endothelia. cells via.intra.ellula. PI3K/a.t signa.ing pa.hwa.,a.levia.e a.-a.renergic receptor overa.tivity by reversing phenylephrine-induced constriction of a.rta.decrea.e monocyte a.hesion to endothelia. cells via.CD166/ESa./CD40 a.d inhibit P2Y12 receptors to reduce pla.elet *** a.ministered ginsentides were effective in a.ima. models to reduce a.P-induced pla.elet a.grega.ion,to prevent colla.en a.d a.rena.ineinduced pulmona.y thrombosis a. well a. a.ti-stress beha.ior of ta.l suspension a.d forced swimming tests in ***,these results strongly suggest tha. ginsentides a.e the principa. pa.a.ea.compounds of ginsengs beca.se of their a.ility to ta.get multiple extra.a.d intra.cellula. proteins to reverse stress-induced da.a.es.

关键词： Ginseng Cysteine-rich peptides Microproteins Cure-a.l Stress Homeosta.is