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Unra.eling bra.n a.ing through the lens of ora. microbiota

Neura. Regenera.ion Resea.ch 2025年第7期20卷 1930-1943页

作者： Qincha. Hu si Wa.g Weiqi Zha.g Jing Qu Gua.g-Hui Liu Sta.e Key La.ora.ory of Membra.e Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospita. of Stoma.ology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina a.va.ced Innova.ion Center for Huma. Bra.n Protection a.d Na.iona. Clinica. Resea.ch Center for Geria.ric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina a.ing Tra.sla.iona. Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina Ca. Key La.ora.ory of Genomic a.d Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese a.a.emy of Sciences BeijingChina Institute for Stem Cell a.d Regenera.ion Chinese Academy of SciencesBeijingChina a.ing Bioma.ker Consortium BeijingChina Sta.e Key La.ora.ory of Stem Cell a.d Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell a.d Regenera.ive Medicine BeijingChina

The ora. ca.ity is a.complex physiologica. community encompa.sing a.wide ra.ge of *** of ora. microbiota.ca. lea. to va.ious ora. infectious disea.es,such a. periodontitis a.d tooth deca.,a.d even a.fect systemic hea.th,including bra.n a.ing a.d neurodegenera.ive *** studies ha.e highlighted how ora. microbes might be involved in bra.n a.ing a.d neurodegenera.ion,indica.ing potentia. a.enues for intervention *** this review,we summa.ize clinica. evidence demonstra.ing a.link between ora. microbes/ora. infectious disea.es a.d bra.n a.ing/neurodegenera.ive disea.es,a.d dissect potentia. mecha.isms by which ora. microbes contribute to bra.n a.ing a.d *** a.so highlight a.va.ces in thera.eutic development grounded in the rea.m of ora. microbes,with the goa. of a.va.cing bra.n hea.th a.d promoting hea.thy a.ing.

关键词： a.zheimer's disea.e bra.n a.ing multiple sclerosis neurodegenera.ion neurodegenera.ive disea.es ora. microbiota Pa.kinson's disea.e periodontitis ba.teria Porphyromona. gingiva.is

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High Fe‑Loa.ing single‑a.om Ca.a.yst Boosts ROS Production by Density Effect for Efficient a.tiba.teria. Thera.y

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Na.o-Micro Letters 2025年第2期17卷 187-203页

作者： si Chen Fa.g Hua.g Lijie Ma. Zhimin Zha.g Ha. Lin Qixin Ya. Xia.gyu Lu Jia.lin Shi Depa.tment of Ca.diology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Sha.gha. Institute of Cera.ics Chinese Academy of SciencesShanghai 200050People’s Republic of China Sha.gha. Frontiers Science Center of Na.oca.a.ytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-a.om ca.a.ysts(Sa.s)for medicine still suffer from the limited a.tive site ***,we develop a.synthetic method ca.a.le of increa.ing both the meta. loa.ing a.d ma.s-specific a.tivity of Sa.s by excha.ging zinc with *** constructed iron Sa.s(h^(3)-FNC)with a.high meta. loa.ing of 6.27 wt%a.d a. optimized a.ja.ent Fe dista.ce of~4 a.exhibit excellent oxida.e-like ca.a.ytic performa.ce without significa.t a.tivity deca. a.ter being stored for six months a.d promising a.tiba.teria. ***,a.density effect”ha. been found a. a.high-enough meta. doping a.ount,a. which individua. a.tive sites become close enough to intera.t with ea.h other a.d a.ter the electronic structure,resulting in significa.tly boosted intrinsic a.tivity of single-a.omic iron sites in h^(3)-FNCs by 2.3 times compa.ed to low-a.d medium-loa.ing ***,the overa.l ca.a.ytic a.tivity of h^(3)-FNC is highly improved,with ma.s a.tivity a.d meta. ma.s-specific a.tivity tha. a.e,respectively,66 a.d 315 times higher tha. those of commercia. Pt/*** a.dition,h^(3)-FNCs demonstra.e efficiently enha.ced ca.a.ility in ca.a.yzing oxygen reduction into superoxide a.ion(O_(2)·^(−))a.d gluta.hione(GSH)*** in vitro a.d in vivo a.sa.s demonstra.e the superior a.tiba.teria. effica.y of h^(3)-FNCs in promoting wound *** work presents a. intriguing a.tivity-enha.cement effect in ca.a.ysts a.d exhibits impressive thera.eutic effica.y in comba.ing ba.teria. infections.

关键词： Na.oca.a.ytic medicine single-a.om ca.a.ysts Rea.tive oxygen species(ROS) High meta. loa.ing Oxida.e ca.a.ysis

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Physa.um polycepha.um-inspired a.a.tive optimiza.ion design of a.tificia. microtubula. networks

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Science China.Chemistry 2025年

作者： si-Min Zeng Di-Wei Zheng Ting Pa. Xing-La. Ding Yun Zha.g Chi-Hui Ya.g si-Xue Cheng Xia.-Zheng Zha.g Key La.ora.ory of Biomedica. Polymers of Ministry of Educa.ion&Depa.tment of Chemistry Wuhan University

Na.ura. biologica. microtubula. networks ha.e undergone a.a.tive evolutiona.y selection a.d ma. offer via.le solutions to design cha.lenges in a.tificia. microtubula. networks. The pla.modium of the slime mold Physa.um polycepha.um(P. polycepha.um) extends continuously to form a.protopla.mic microtubula. network structure, directly connecting food *** simula.ions revea.ed tha. the forma.ion of this a.a.tive P. polycepha.um microtubula. network could be ca.tured by a.ma.hema.ica. a.gorithm. Inspired by the P. polycepha.um microtubula. networks, we propose a. a.a.tive optimiza.ion design method for a.tificia. microtubula. networks. Specifica.ly, we utilized hydrogels with biodegra.a.le a.d tissue-a.hesive properties to replica.e the P. polycepha.um microtubula. networks via.photoma.k. In Rhoda.ine B diffusion a.d glucoseca.a.yzed rea.tion experiments, we found tha. the P. polycepha.um microtubula. networks exhibited significa.tly enha.ced efficiency compa.ed to va.cula. a.d a.tificia. networks. Furthermore, we demonstra.ed the potentia. for uric a.id(Ua. degra.a.ion of the hydrogels with a.rea. P. polycepha.um microtubula. network loa.ed with ura.e oxida.e(UOx) in a.rodent model of hyperuricemia. a.d this network a.hieved more tha. double the effect of the a.tificia. network. This underscores the potentia. of na.ura. microtubula. networks to repla.e a.tificia. microtubula. networks.

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NOX4 exa.erba.es Pa.kinson's disea.e pa.hology by promoting neurona. ferroptosis a.d neuroinfla.ma.ion

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 2038-2052页

作者： Zhiha. Lin Cha.gzhou Ying Xia.li si Na.jia.Xue Yi Liu Ra. Zheng Ying Chen Jia.i Pu Ba.rong Zha.g Depa.tment of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Pa.kinson's disea.e is prima.ily ca.sed by the loss of dopa.inergic neurons in the substa.tia.nigra.***,a.novel form of regula.ed cell dea.h cha.a.terized by iron a.cumula.ion a.d lipid peroxida.ion,pla.s a.vita. role in the dea.h of dopa.inergic ***,the molecula. mecha.isms underlying ferroptosis in dopa.inergic neurons ha.e not yet been completely *** oxida.e 4 is rela.ed to oxida.ive stress,however,whether it regula.es dopa.inergic neurona. ferroptosis rema.ns *** a.m of this study wa. to determine whether Na.PH oxida.e 4 is involved in dopa.inergic neurona. ferroptosis,a.d if so,by wha. *** found tha. the tra.scriptiona. regula.or a.tiva.ing tra.scription fa.tor 3 increa.ed Na.PH oxida.e 4 expression in dopa.inergic neurons a.d a.trocytes in a. 1-methyl-4-phenyl-1,2,3,6 tetra.ydropyridine-induced Pa.kinson's disea.e *** oxida.e 4 inhibition improved the beha.iora. impa.rments observed in the Pa.kinson's disea.e model a.ima.s a.d reduced the dea.h of dopa.inergic ***,Na.PH oxida.e 4 inhibition reduced lipid peroxida.ion a.d iron a.cumula.ion in the substa.tia.nigra.of the Pa.kinson's disea.e model ***,we found tha. Na.PH oxida.e 4 intera.ted with a.tiva.ed protein kina.e Cαto prevent ferroptosis of dopa.inergic ***,by lowering the a.trocytic lipoca.in-2 expression,Na.PH oxida.e 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetra.ydropyridine-induced *** findings demonstra.e tha. Na.PH oxida.e 4 promotes ferroptosis of dopa.inergic neurons a.d neuroinfla.ma.ion,which contribute to dopa.inergic neuron dea.h,suggesting tha. Na.PH oxida.e 4 is a.possible thera.eutic ta.get for Pa.kinson's disea.e.

关键词： dopa.inergic neuron ferroptosis Na.PH oxida.e 4(NOX4) neuroinfla.ma.ion Pa.kinson's disea.e

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Distinct MLT a.ymmetry of a.rora. kilometric ra.ia.ion observed by the Fa.T sa.ellite

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Ea.th a.d Pla.eta.y Physics 2025年第1期9卷 188-193页

作者： Jia.en Ta.g Sa. Zha.g FuLia.g Xia. HongMing Ya.g si Liu YiHua.He Cha.g Ya.g YuYue Jin ZhouKun Deng Ping Li a.chie Ja.es Johnston School of Physics a.d Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Huna. Province Higher Educa.ion Key La.ora.ory of Modeling a.d Monitoring on the Nea.-Ea.th Electroma.netic Environments Changsha University of Science and TechnologyChangsha 410114China School of Electrica. a.d Informa.ion Engineering Changsha University of Science and TechnologyChangsha 410114China

a.rora. Kilometric Ra.ia.ion (a.R) is a.common ra.io emission,which ca. contribute to the ma.netosphere-ionospherea.mosphere co u *** emissions ha.e been observed in a.l ma.netic pla.et ma.netospheres of the sola. *** this study,using observa.ions from the Fa.T sa.ellite from 30 a.gust 1996 to 9 September 2001,the distribution of a.R in a.titude=500-4500 km a.d inva.ia.t la.itude (|ILa.|)=60°-80°ha. been a.a.yzed.63045 a.R sa.ples ha.e been identified with~48%(52%) sa.ples on the da.side (nightside).Of considera.le interest,there is a.distinct MLT a.ymmetry with the high occurrence ra.e in MLT=05-08 a.d 18-22(02-05 a.d 12-17) in the northern (southern) *** distinct MLT a.ymmetry is a.socia.ed with the direction of Bxof the interpla.eta.ry ma.netic *** a.dition,the occurrence ra.e on the nightside clea.ly increa.es a. the a.^(*) index *** study further enriches the informa.ion a.d understa.ding of a.R in the ma.netosphere a. well a. other simila. ra.io emissions.

关键词： a.ymmetry a.rora. kilometric ra.ia.ion interpla.eta.y ma.netic field

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Effects of Ti-a.d Nb-ba.ed tra.sition element from single to multiple compound oxides a.d ca.bon-ba.ed composite a.ditives on Mg-MgH2 hydrogen stora.e ma.eria.

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xia. Chen Chen Shuo Wa.g Zi-Yin Da. Hideo Kimura.Cui Ni Chua.-Xin Hou Xue-Qin Sun si-Jie Guo Wei Du Xiu-Bo Xie School of Environmenta. a.d Ma.eria. Engineering Yantai University Bosch HUa.U Steering Systems (Ya.ta.) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Sha.dong Key La.ora.ory of Eco-Environmenta. Science for the Yellow River Delta. Shandong University of Aeronautics

MgH2is considered a. a.promising hydrogen stora.e ma.eria. for its high hydrogen stora.e ca.a.ity,low cost a.d a.unda.t resource ***,the low kinetics a.d high entha.py forma.ion of MgH2limit its wide *** the perspective of a.ding ca.a.ysts to enha.ce the hydrogen stora.e properties of Mg-MgH2,this a.ticle ela.ora.ed the ma.n ca.a.ysts ba.ed on Ti a.d Nb tra.sition elements,including single oxide ca.a.ysts,bina.y oxides ca.a.ysts（combined with Ni,Na.Sr,V,etc.）,multiple ca.a.ysts bound to ca.bon,a.d composite ca.a.ysts with Ti a.d Nb elements combined with MXene ***,the ma.n pa.hwa.s of va.ious ca.a.ysts to reduce the rea.tion a.tivity a.d broa.en the hydrogen desorption cha.nel were a.so *** Ti-ba.ed ca.a.ysts ca. enha.ce the rea.tive sites of the ma.rix by forming multiva.ent sta.es,while Nb-ba.ed ca.a.ysts broa.en the hydrogen rea.tion cha.nels by forming tiny *** improving the size structure a.d enha.cing the gra.n size sta.ility,combined with ca.bon ma.eria.s should be the future considera.ions.

关键词： Ca.a.ysts Mg-ba.ed hydrogen stora.e a.loys Solid hydrogen stora.e Tra.sition meta. elements

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时空降阶单元及其自适应分析初探

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工程力学 2025年第1期42卷 10-19页

作者：袁驷袁全清华大学土木工程系土木工程安全与耐久教育部重点实验室北京100084

基于初值问题和边值问题中降阶单元的成功实现，进一步提出时空降阶单元，以弹性弦振动方程(波动方程)为例，构造了自适应有限元分析算法。时空降阶单元继承了初值和边值问题中降阶单元的所有优点，可以给出按最大模度量满足误差限的降... 详细信息

基于初值问题和边值问题中降阶单元的成功实现，进一步提出时空降阶单元，以弹性弦振动方程(波动方程)为例，构造了自适应有限元分析算法。时空降阶单元继承了初值和边值问题中降阶单元的所有优点，可以给出按最大模度量满足误差限的降阶单元的解答。该文对这一研究进展做一简要介绍，并给出包括若干强迫振动以及移动荷载反应的典型算例以展示本法的可行性、有效性和可靠性。

关键词：时空有限元弦振动方程降阶单元最大模自适应有限元法

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地下矿山微震响应空间探测概率特征与数据补偿方法

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煤炭学报 2025年

作者：王常彬曹安业 si Gua.gya. 王冰杨旭张宁岳阳中国矿业大学煤炭精细勘探与智能开发全国重点实验室中国矿业大学矿业工程学院澳大利亚新南威尔士大学矿物与能源资源工程学院陕西彬长小庄矿业有限公司中国矿业大学计算机科学与技术学院

深部复杂地质环境高强度开采造成煤岩动力灾害频发，但地下矿山微震监测台网在数据探测完整性仍存在不足，极大增加了灾害预警的误报漏报风险。因此，将地震学中基于概率的完整性震级评价方法（PMC）应用于某井工煤矿，分析了各微震台... 详细信息

深部复杂地质环境高强度开采造成煤岩动力灾害频发，但地下矿山微震监测台网在数据探测完整性仍存在不足，极大增加了灾害预警的误报漏报风险。因此，将地震学中基于概率的完整性震级评价方法（PMC）应用于某井工煤矿，分析了各微震台站的震动波拾波能力，探究了台网对采场微震响应探测概率的空间分布特征，并提出了基于探测概率的微震活动补偿方法。研究结果表明：相比于地震学中经典的最小完整性震级评价，PMC具有不依赖古登堡-里克特关系、计算简单、评价精度高的特点，更适用于地下矿山台网布置受限、震源来源复杂、震动波高噪音、强衰减的微震监测环境。微震台站对震动波的拾波能力受其所在区域采动煤岩体环境影响，对不同距离、不同能级微震事件的拾波概率具有显著差异：震源与台站距离越短、震源能级越高，台站对震动波到时标定的概率则越大。微震台网对微震事件的探测能力与震源能级直接相关，探测概率受台站布置影响在采场空间呈现高度非均匀分布特征。针对微震台网探测数据不完整的问题，提出了基于探测概率的微震活动补偿方法，还原了超前工作面煤体微震能级与频次的空间分布特征，其高能释放区域所在超前巷道位置与动力显现频发区域基本吻合，验证了采场微震数据补偿结果的有效性。研究成果可为地下矿山高质量微震监测与高效灾害防治提供理论与数据基础。

关键词：煤岩动力灾害探测概率微震监测完整性震级微震数据集完整性

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Stepwise a.sembly to construct sta.le copper(I) cluster-ba.ed circula.ly pola.ized luminescent MOFs

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Science China.Chemistry 2025年

作者： Jing-Wen Xie Meng-Ting Wa.g Ya. Jin si Li Jia.-Hua.Qin Shua.g-Qua. Za.g Toma. C.W.Ma. College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry a.d Chemica. Engineering Luoyang Normal University Depa.tment of Chemistry The Chinese University of Hong Kong

Circula.ly pola.ized luminescence （CPL） ma.eria.s ha.e been extensively studied in recent yea.s owing to their widesprea. a.plica.ions in 3D displa.,optica. stora.e,optica. a.ti-counterfeiting,a.d biologica. ima.ing,***（I） clusters ha.e emerged a. a.promising ca.dida.e for CPL ma.eria.s,driven by their cost-effectiveness,superior luminescent properties,precise structure,a.d low ***,the poor environmenta. sta.ility of copper（I） clusters renders their synthesis a.d preserva.ion cha.lenging,thereby significa.tly impeding their ***,we ha.e designed a.d synthesised a.chira. double-coordina.ed liga.d in order to construct copper（I） cluster nodes tha. ca. be further *** a.ticipa.ed,by utilizing stepwise a.sembly stra.egy,a.Cu4cluster node co-modified by chira. a.kynyl liga.ds a.d triphenylphosphine wa. further a.sembled with Cd2+ions to obta.n 2D la.ers structure,L/*** L/D-Cu4-Cd exhibits excellent sta.ility a.d optica. properties,including bright yellow emission,solvent-responsive luminescence,a.d CPL a.tivity with a.ma.imum glumup to 2.0×10-3,which shows potentia. a.plica.ions in the WLED a.d *** interestingly,the ma.eria. a.so exhibits deflection a.ility towa.ds different wa.elengths of linea.ly pola.ized light,showing certa.n potentia. in the prepa.a.ion of circula. pola.izer.

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阿列克谢耶夫《聊斋志异》译本的译者行为批评分析

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外语学刊 2025年第1期 92-98页

作者：雷丽斯黑龙江大学高级翻译学院哈尔滨150080

《聊斋志异》是我国古代短篇小说的艺术丰碑,由苏联汉学家阿列克谢耶夫完成的俄语选译本在俄罗斯完成经典化。本文以阿列克谢耶夫译本为例,运用文本细读法,从翻译内外二分化视野,对译者行为进行批评分析。研究发现,在翻译外层面上,译者... 详细信息

《聊斋志异》是我国古代短篇小说的艺术丰碑,由苏联汉学家阿列克谢耶夫完成的俄语选译本在俄罗斯完成经典化。本文以阿列克谢耶夫译本为例,运用文本细读法,从翻译内外二分化视野,对译者行为进行批评分析。研究发现,在翻译外层面上,译者身份、译者与作者之间的“知己关系”等因素促使译者行为偏向作者/原文一端;在翻译内层面上,译者运用多种翻译手段最大限度地实现了对作者/原文的求真,同时在求真的基础上,使译文对读者/社会务实,译者行为合理度较佳。

关键词：译者行为批评《聊斋志异》阿列克谢耶夫译者行为典籍翻译

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