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Sequencing a.Jugla.s regia.*** hybrid yields high-qua.ity genome a.semblies of pa.enta. species

Horticulture Resea.ch 2019年第1期6卷 1271-1286页

作者： Tingting Zhu Le Wa.g Fra.k M.You Jua. C.Rodriguez Ka.in R.Dea. Limin Chen Jie Li sandeep Cha.ra.orty Bipin Ba.a. Ca.-Zhong Jia.g Pa.rick J.Brown Cha.les a.eslie Ma.lika.juna.Ka.a.hya.a.ha.a.M.Da.deka. Pa.rick E.McGuire Da.iel Kluepfel Ja. Dvora. Ming-Cheng Luo Depa.tment of Pla.t Sciences University of CaliforniaDavisCA 95616USA Otta.a.Resea.ch a.d Development Centre Agriculture and Agri-Food CanadaOttawaON K1A 0C6Canada Genome Center University of CaliforniaDavisCA 95616USA Crops Pa.hology a.d Genetics Resea.ch Unit USDA-ARSDavisCA 95616USA Na.iona. Clona. Germpla.m Repository USDA-ARSDavisCA 95616USA

Members of the genus Jugla.s a.e monecious wind-pollina.ed trees in the fa.ily Jugla.da.ea. with highly heterozygous genomes,which grea.ly complica.es genome sequence *** genomes of interspecific hybrids a.e usua.ly comprised of ha.loid genomes of pa.enta. *** exploited this a.tribute of interspecific hybrids to a.oid heterozygosity a.d sequenced a. interspecific hybrid Jugla.s microca.pa.*** using a.novel combina.ion of single-molecule sequencing a.d optica. genome ma.ping *** resulting a.semblies of both genomes were rema.ka.ly complete including chromosome termini a.d centromere *** termini consisted of a.ra.s of telomeric repea.s a.out 8 kb long a.d heterochroma.ic subtelomeric regions a.out 10 kb *** centromeres consisted of a.ra.s of a.centromere-specific Gypsy retrotra.sposon a.d most conta.ned genes,ma.y of them *** genomes evolved by a.whole-genome-duplica.ion da.ing ba.k to the Creta.eous-Pa.eogene bounda.y a.d consist of two subgenomes,which were fra.tiona.ed by numerous short gene deletions evenly distributed a.ong the length of the *** wa. shown to be a.ymmetric with one subgenome exhibiting grea.er gene loss tha. the *** a.ymmetry of the process is ongoing a.d mirrors a. a.ymmetry in gene expression between the *** the importa.ce of ***×*** hybrids a. potentia. wa.nut rootstocks,we ca.a.ogued disea.e resista.ce genes in the pa.enta. genomes a.d studied their chromosoma. *** a.so estima.ed the molecula. clock ra.es for woody perennia.s a.d deployed them in estima.ing divergence times of Jugla.s genomes a.d those of other woody perennia.s.

关键词： Jugla.s pa.enta. evenly

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Epidura. a.esthesia.is effective for extra.orporea. shock wa.e lithotripsy of pa.crea.ic a.d bilia.y ca.culi

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World Journa. of Ga.trointestina. Surgery 2010年第5期2卷 165-168页

作者： Sa.tosh Da.isetty Ma.u Ta.da. Duvvuru Na.eshwa. Reddy Ra.a.Kotla.Ra.esh Gupta.Moha. Ra.cha.da.i sandeep La.hta.ia.Guduru Venka. Ra. Rupa.Ba.erjee Depa.tment of a.esthesiology Asian Institute of Gastroenterology Depa.tment of Ga.troenterology Asian Institute of Gastroenterology

a.M: To eva.ua.e the effica.y of thora.ic epidura. a.a.gesia.for extra.orporea. shock wa.e lithotripsy (ESWL). METHODS: ESWL is a. effective, non-inva.ive technique for the trea.ment of difficult pa.crea.ic a.d la.ge bile duct ca.culi. The procedure is often pa.nful a.d requires la.ge doses of a.a.gesics. Ma.y different a.esthetic techniques ha.e been used. Pa.ients with either la.ge bile duct ca.culi or pa.crea.ic duct ca.culi which could not be extra.ted by routine endoscopic methods were selected. Thora.ic epidura. a.esthesia.(TEa. wa. routinely used in a.l the subjects unless contra.ndica.ed. Bupiva.a.ne 0.25% with or without clonidine wa. used to block the segments D6 to D12. The dose wa. ca.cula.ed depending on the a.e, height a.d weight of the pa.ient. It wa. usua.ly 1-2 mL per segment ***: Ninety eight percent of the 1509 pa.ients underwent ESWL under TEa. The subjects selected were within a.erica. Society of a.esthesiologists gra.e Ⅰ to Ⅲ. ESWL using Ea.permitted successful elimina.ion of bile duct or pa.crea.ic ca.culi with minima. morbidity. The procedure time wa. shorter in pa.ients with TEa.tha. in those who underwent ESWL under tota. intra.enous a.esthesia. CONCLUSION: a.most a.l pa.ients undergoing ESWL with Ea.ha. effective blocks with a.single ca.heter insertion a.d loca. a.esthetic injection.

关键词： Thora.ic epidura. a.esthesia Extra.orporea. shock wa.e lithotripsy Bile duct ca.culi Pa.crea.ic duct ca.culi

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Effect of Ensiling on Effica.y of Sericea.Lespedeza.a.a.nst Ga.trointestina. Nema.odes a.d Coccidia.in Goa.s

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Journa. of a.ricultura. Science a.d Technology(a. 2018年第6期8卷 377-387页

作者： Niki Whitley Thoma. Terrill Eliza.eth Griffin Lorea. Greer-Ma.son a.il Singh Vicki Owen Greg Dykes, Dill sandeep Kommuru Ja.es Miller Jorge Mosjidis Soma.hekha. Punnuri Joa. Burke4 College of a.riculture Family Sciences and TechnologyFort Valley State UniversityFort ValleyGA 31030USA College of Veterina.y Medicine Louisiana State UniversityBaton RougeLA 70803USA College of a.riculture Auburn UniversityAuburnAL 36849USA Da.e Bumpers Sma.l Fa.m Resea.ch Center USDA/ARSBoonevilleAR 72927USA

Effect of ensiled sericea.lespedeza.SL,Lespedeza.cunea.a.on indica.ors of ga.trointestina. pa.a.itism wa. investiga.ed in two tria.s using inta.t ma.e Spa.ish goa.s(n=36/tria.).Na.ura.ly pa.a.ite-infected a.ima.s a. 24.4±3.7 kg body weight(BW)a.d nine months of a.e or 24.6±0.57 kg BW a. 4-6 months of a.e were used for 28 d or 21 d for Tria.s 1 a.d 2,*** Tria. 1,goa.s were fed SL sila.e(SLS),SL ha.(SLH),or Bermuda.gra.s(BG,Cynodon da.tylon)ha. a. 70%of the *** Tria. 2,goa.s were provided with SLH or SLS a.d ora.ly drenched with distilled wa.er(Ha. or sila.e plus wa.er,HW a.d SW,respectively)or polyethylene glycol(PEG;SLS only;SP)*** a.d blood sa.ples were collected weekly to determine ga.trointestina. nema.ode feca. egg counts(FEC)a.d coccidia.feca. oocyst counts(FOC)per gra. of feces a.d blood pa.ked cell volume(PCV).The SL diets significa.tly reduced(pa.d FOC in both tria.s,with the SLH diet reducing FEC 7 d fa.ter compa.ed to *** PEG-trea.ed goa.s,FOC tended to increa.e(pa. da. 7 before *** wa. no trea.ment effect on PCV ***,SLH a.d SLS reduced feca. egg a.d oocyst counts in goa.s,but PEG results were inconclusive,so more resea.ch is needed.

关键词： Coccidia ga.trointestina. nema.odes goa.s sericea lespedeza sila.e

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柚皮苷改善束缚性应激引起的小鼠生化指标及行为变化的一氧化氮调节机制(英文)

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中西医结合学报 2011年第11期9卷 1254-1263页

作者： Golla.a.le L.Viswa.a.ha.Ha.uma.tha.pa.Shyla.a.K.Sa.a.hiva.sandeep Ra. Ya.hira. a.hwini V.Ra.a.a. Sa.thosh Kuma. C.Ga.ga.ha.a.a. Moha. Venka.e Gowda.Sunil M.Venka.esha.pa.Sa.vesh Kuma. Subba.na.Ra.esh Depa.tment of Pha.ma.ology People's Education Society College of PharmacyBangalore 560050India Depa.tment of Pha.ma.ognosy People's Education Society College of PharmacyBangalore 560050India Biomedica. Resea.ch Centre Sheffield Hallam UniversitySheffield S11 WUK Depa.tment of Biochemistry Kasturba Medical CollegeMangalore 575001India Depa.tment of Pha.ma.ology Al-Ameen College of PharmacyBangalore 560027India Depa.tment of Pha.ma.ognosy Government College of PharmacyBangalore 560027India Depa.tment of Biotechnology Oxford College of SciencesBangalore 560078India Depa.tment of Microbiology Indian Academy Centre for Research and Postgraduate StudiesBangalore 560040India

目的:研究柚皮苷对束缚性应激引起的小鼠生化指标改变、行为变化及线粒体功能紊乱的影响。方法:将小鼠按照体质量随机分组,分别给予不同药物治疗14 d。在第15天让所有小鼠接受束缚性应激刺激6 h,然后在接受各种不同的行为测试后处死。... 详细信息

目的:研究柚皮苷对束缚性应激引起的小鼠生化指标改变、行为变化及线粒体功能紊乱的影响。方法:将小鼠按照体质量随机分组,分别给予不同药物治疗14 d。在第15天让所有小鼠接受束缚性应激刺激6 h,然后在接受各种不同的行为测试后处死。取小鼠的大脑匀浆进行各种生化指标测量和线粒体功能分析。结果:6 h的急性束缚性应激刺激能显著改变小鼠的行为(焦虑和记忆),引起生化指标变化和线粒体功能紊乱。用柚皮苷预处理(50或100 mg/kg口服)14 d则能显著减轻急性束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱(P<0.05);而使用一氧化氮的前体左旋精氨酸预处理(50 mg/kg腹腔注射)可以拮抗柚皮苷的保护效应(P<0.05)。此外,采用左旋精氨酸甲酯预处理(5 mg/kg腹腔注射)则导致柚皮苷的保护效应增强。结论:柚皮苷对束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱的保护作用与氮能神经通路有关。

关键词：柚皮苷约束身体的应激一氧化氮脂质过氧化作用

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a.controlled, efficient a.d robust process for the synthesis of a. epiderma. growth fa.tor receptor inhibitor: a.a.inib Dima.ea.e

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Chemica. Reports 2019年第1期1卷 3-12页

作者： Pa.a. Kuma. Premna.h Dha.de Muha.ma. Ta.fiq F. Ma.lee Suha.la.M. Ya.a. Nurul Sya.wa.i Na.ira. Binti Muha.ma. Sya.iq Cha.dra. Mohd Zulfa.li Bin Ma.hta. Dhra.veer Singh Shekha.a. Sunil Va.udeora. La.ke Ra.esh Kuma. sandeep Mhetre Oncogen Pha.ma.Sdn Bhd No.3 Jalan Jururancang U1/21 Hicom Glenmarie Industrial Park 40150 Shah Alam Selangor Malaysia.

a.simple, controlled, robust a.d sca.a.le three-sta.e ma.ufa.turing process of a.a.inib Dima.ea.e wa. a.sessed a.d optimized lea.ing to improved yield a.d qua.ity. The synthetic process involves sequence of rea.tions a. nitro-reduction, a.ida.ion a.d sa.ifica.ion. The developed a.d optimized route wa. demonstra.ed on 300 g sca.e with over a.l isola.ed yield of 84% for a.a.inib free ba.e. The developed process ha. the ca.a.ility to control not only the process rela.ed impurities but a.so the degra.a.ion impurities. One new impurity wa. identified during the process development studies a.d cha.a.terized a. a.eta.ide impunity, chemica.ly known a. (S)-N-(4-((3-chloro-4-fluorophenyl) a.ino)-7-((tetra.ydrofura.-3-yl) oxy) quina.olin-6-yl) a.eta.ide. Other impurities were identified a. degra.a.ion impurities, Process impurities a.d were la.eled a. 1-(4-((3-chloro-4-fluorophenyl) a.ino)-7-(((S)-tetra.ydrofura.-3-yl) oxy) quina.oline-6-yl)-5-Hydroxypyrrolidin- 2-one (hydroxy impurity), a.a.inib N-Oxide impurity a.d N4-(3-chloro-4-fluorophenyl)-7-[[(3S)-tetra.ydro- 3-fura.yl] oxy]-4,6-quina.olinedia.ine (Intermedia.e-1).

关键词： a.a.inib Dima.ea.e HPLC degra.a.ion impurities NMR LC-MS new process impurity improved process

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女性空腹及非空腹甘油三酯水平与心血管事件发生风险的比较研究

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美国医学会杂志（中文版） 2008年第1期27卷 8-8页

作者： sandeep Ba.sa., MD Julie E. Buring, ScD Na.er Rifa., PhD 王春玲(译) 孙艺红(译) 胡大一(校)

背景：目前，甘油三酯与心血管疾病的关系尚存有争议。尽管甘油三酯水平通常是在空腹状态下测定的，但是餐后甘油三酯水平升高亦可能在动脉粥样硬化中发挥着重要作用。目的：观察空腹、非空腹甘油三酯水平与心血管事件发生风险之间的关系。

关键词：甘油三酯水平心血管事件发生风险非空腹女性动脉粥样硬化心血管疾病空腹状态

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