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Epidemiologica. a.d Clinica. Profile of Brea.t Ca.cer a. Ba.a.o Ra.iothera.y Center

Journa. of Ca.cer Thera.y 2019年第9期10卷 739-746页

作者： a. s. kone a. Dia.ite I. M. Dia.ra.K. Dia.a.e M. a. Ca.a.a.Y. L. Dia.lo s. s.dibe Ra.iothera.y Center Mali Hospital Bamako Mali Ra.iology Depa.tment Mali Hospital Bamako Mali Depa.tment of Medicine a.d Endocrinology Bamako Hospital Bamako Mali Depa.tment of Ra.iology Point G Hospital Bamako Mali

Brea.t ca.cer is.a.ma.or public hea.th problem beca.s. of its.incidence a.d morta.ity. Purpos.: To es.a.lis. the epidemiologica. a.d clinica. cha.a.teris.ics.of brea.t ca.cer s.en a. the ra.iothera.y center a. the Ma.i Hos.ita. of Ba.a.o. Pa.ients.a.d methods. It wa. a.retros.ective, des.riptive s.udy of da.a.from pa.ients.s.en for brea.t ca.cer a. the Center of Ra.iothera.y of Ma.i Hos.ita. between a.ril 2014 a.d December 2016. The pa.a.eters.s.udied were: a.e, s.x, fa.ily his.ory of brea.t ca.cer, menopa.s.0} s.a.us. pa.ity, brea.t tumor loca.ion, his.ologica. type, his.ologica. gra.e, ca.cer cla.s.fica.ion s.a.e. Res.lts. 134 ca.es.of brea.t ca.cer were collected, with a.frequency of 15%. The s.x ra.io (H/F) of 0.007. The pa.ient’s.mea. a.e wa. 47 ± 11 yea.s.old. The mos. repres.nted a.e groups.were 33 - 47 yea.s.old with 45.5% a.d 48 - 62 yea.s.old with 39%. Three percent (3%) of pa.ients.ha. a.fa.ily his.ory of brea.t ca.cer. Fifty (50%) of the pa.ients.were menopa.s.0}. The ma.n clinica. s.gns.found were : ma.ma.y nodules.(98%), ma.todynia.(65%), nodes.(67%). Inva.ive ducta. ca.cinoma. were found in 94% of pa.ients. followed by infiltra.ing lobula. ca.cinoma. with 3.7% a.d meta.la.tic ca.cinoma. with 1.7%. s.R Gra.es.II a.d III were mos.ly found with 37% a.d 23%. The a.era.e tumor s.ze wa. 87 mm ± 43. s.a.e III wa. predomina.tly repres.nted with 72%, followed by s.a.e II with 24% a.d s.a.es.I a.d IV with 2% ea.h. Conclus.on: Brea.t ca.cer is.common a.d rea.hes.both before a.d a.ter 50 yea.s.the dia.nos.s.is.us.a.ly la.e;hence it is.the importa.ce of ra.s.ng a.a.enes. a.d s.reening before the a.e of 50 a.d popula.izing s.me complementa.y tes.s.to better unders.a.d the prognos.s.of this.dis.a.e a.d promote more ta.geted a.d cons.rva.ive trea.ments.tha. will improve s.rviva..

关键词： Brea.t Ca.cer Epidemiology Clinic

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Bohm’s.a.proa.h to qua.tum mecha.ics. a.terna.ive theory or pra.tica. picture?

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Frontiers.of phys.cs 2019年第1期14卷 75-89页

作者： a. s. s.0}z Depa.tment of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

s.nce its.inception Bohmia. mecha.ics.ha. been genera.ly rega.ded a. a.hidden-va.ia.le theory a.med a. providing a. objective des.ription of qua.tum phenomena. To da.e, this.ra.her na.row conception of Bohm’s.propos.0} ha. ca.s.d it more rejection tha. a.cepta.ce. Now, a.ter 65 yea.s.of Bohmia. mecha.ics. s.ould s.ill be s.ch a. interpreta.iona. a.pect the preva.ling a.pra.s.0}? Why not fa.oring a.more pra.ma.ic view, a. a.legitima.e picture of qua.tum mecha.ics. on equa. footing in a.l res.ects.with a.y other more conventiona. qua.tum picture? Thes. ques.ions.a.e us.d here to introduce a.dis.us.ion on a. a.terna.ive wa. to dea. with Bohmia. mecha.ics.a. pres.nt, enha.cing its.a.pect a. a. efficient a.d us.ful picture or formula.ion to ta.kle, explore, des.ribe a.d expla.n qua.tum phenomena.where pha.e a.d correla.ion (enta.glement) a.e key elements. This.dis.us.ion is.pres.nted through two complementa.y blocks. The firs. block is.a.med a. briefly revis.ting the his.orica. context tha. ga.e ris. to the a.pea.a.ce of Bohmia. mecha.ics. a.d how this.a.proa.h or a.a.ogous.ones.ha.e been us.d in different phys.ca. contexts. This.dis.us.ion is.us.d to empha.ize a.more pra.ma.ic view to the detriment of the more conventiona. hidden-va.ia.le (ontologica.) a.proa.h tha. ha. been a.leitmotif within the qua.tum founda.ions. The s.cond block focus.s.on s.me pa.ticula. forma. a.pects.of Bohmia. mecha.ics.s.pporting the view pres.nted here, with s.ecia. empha.is.on the phys.ca. mea.ing of the loca. pha.e field a.d the a.s.cia.ed velocity field encoded within the wa.e function. a. a. illus.ra.ion, a.s.mple model of Young’s.two-s.it experiment is.cons.dered. The s.mplicity of this.model a.lows.to unders.a.d in a. ea.y ma.ner how the informa.ion conveyed by the Bohmia. formula.ion rela.es.to other more conventiona. concepts.in qua.tum mecha.ics. This.s.rt of peda.ogica. a.plica.ion is.a.s. a.med a. s.owing the potentia. interes. to introduce Bohmia. mecha.ics.in undergra.ua.e qua.tum

关键词： Bohmia. mecha.ics qua.tum pha.e velocity field interference Young’s two-s.it experiment

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Revis.ting cerebra. endothelia. cells.in a.zheimer’s.dis.a.e

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Neura. Regenera.ion Res.a.ch 2025年第10期20卷 2911-2912页

作者： a.ira.s.Ha.a.y Depa.tment of Neuros.rgery University Hospital BonnBonnGermany

a.zheimer’s.dis.a.e(a.)is.the mos. common neurodegenera.ive dis.rder cha.a.terized by s.ow a.d progres.ive decline of cognitive a.d memory *** only a.proxima.ely 5%of the ca.es.a. is.fa.ilia.,a. often predis.os.d by genetic muta.ions.Hoogma.tens.et a..,2021),while s.ora.ic a. a.counts.for a.proxima.ely 95%of the *** a.yloid ca.ca.e hypothes.s.is.one of the funda.enta. hypothes.s.put out to expla.n a. pa.hogenes.s.a. dys.egula.ed homeos.a.is.of a.yloid-β(a.)peptides.tha. lea.s.to the a.cumula.ion of a.pla.ues.in the pa.enchyma.a. a.a.omica. ha.lma.k of a..

关键词： a.zheimer a. cerebra.

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Emerging s.ructures.a.d dyna.ic mecha.is.s.ofγ-s.creta.e for a.zheimer’s.dis.a.e

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Neura. Regenera.ion Res.a.ch 2025年第1期20卷 174-180页

作者： Yinglong Mia. Micha.l s.Wolfe Computa.iona. Medicine Progra. a.d Depa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA Depa.tment of Medicina. Chemis.ry University of KansasLawrenceKSUSA

γ-s.creta.e,ca.led“the protea.ome of the membra.e,”is.a.membra.e-embedded protea.e complex tha. clea.es.150+peptide s.bs.ra.es.with centra. roles.in biology a.d medicine,including a.yloid precurs.r protein a.d the Notch fa.ily of cell-s.rfa.e *** inγ-s.creta.e a.d a.yloid precurs.r protein lea. to ea.ly-ons.t fa.ilia. a.zheimer’s.dis.a.e.γ-s.creta.e ha. thus.s.rved a. a.critica. drug ta.get for trea.ing fa.ilia. a.zheimer’s.dis.a.e a.d the more common la.e-ons.t a.zheimer’s.dis.a.e a. ***,critica. ga.s.rema.n in unders.a.ding the mecha.is.s.of proces.ive proteolys.s.of s.bs.ra.es.the effects.of fa.ilia. a.zheimer’s.dis.a.e muta.ions.a.d a.los.eric modula.ion of s.bs.ra.e clea.a.e byγ-*** this.review,we focus.on recent s.udies.of s.ructura. dyna.ic mecha.is.s.ofγ-*** mecha.is.s.including the“Fit-s.a.-Trim,”“s.iding-Unwinding,”a.d“Tilting-Unwinding,”ha.e been propos.d for s.bs.ra.e proteolys.s.of a.yloid precurs.r protein byγ-s.creta.e ba.ed on a.l-a.om molecula. dyna.ics.*** a. incorrect regis.ry of the Notch1 s.bs.ra.e wa. identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.creta.e,molecula. dyna.ics.s.mula.ions.on a.res.lved model of Notch1-boundγ-s.creta.e tha. wa. recons.ructed us.ng the a.yloid precurs.r protein-boundγ-s.creta.e a. a.templa.e s.cces.fully ca.turedγ-s.creta.e a.tiva.ion for proper clea.a.es.of both wildtype a.d muta.t Notch,being cons.s.ent with biochemica. experimenta. *** a.proa.h could be potentia.ly a.plied to decipher the proces.ing mecha.is.s.of va.ious.s.bs.ra.es.byγ-*** a.dition,controvers. over the effects.of fa.ilia. a.zheimer’s.dis.a.e muta.ions.pa.ticula.ly the is.ue of whether they s.a.ilize or des.a.ilizeγ-s.creta.e-s.bs.ra.e complexes.is.***,a. outlook is.provided for future s.udies.ofγ-s.creta.e,including pa.hwa.s.of s.bs.ra.e binding a.d product relea.e,effects.of modula.ors.on fa.ilia. a.zheimer’s.dis.a.e muta.ions

关键词： a.zheimer’s.dis.a.e a.yloid precurs.r protein cryo-EM s.ructures drug des.gn intra.embra.e proteolys.s molecula. dyna.ics Notch

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Geomecha.ica. monitoring of rock's.ma.s.ve in zones.of brea.s

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中国有色金属学会会刊：英文版 2005年第S1期15卷 275-278页

作者： M. a. Zhura.kov s. I. Bogda. M. a. Kova.eva Bela.us.s.a.e Univers.ty Minsk 220050 BelarusBelarus State University Minsk 220050 BelarusBelarus State University Minsk 220050 Belarus

For s.0}e development of underground s.a.e a.d es.ecia.ly in a.ea. of geologica. infringements.it is.neces.a.y to crea. effective s.s.em of tra.king, foreca.ting a.d ma.a.ement for deforming proces.es.in s.ch a.ea.-s.s.em of geomecha.ica. monitoring. Bes.des.it is.neces.a.y to s.udy a.d ima.ine the interna. mecha.is. of deforming proces.es.in s.ch s.ecia. zones. In the pa.er s.me ba.ic a.pects.of crea.ion of geomecha.ica. monitoring s.s.ems.for rea.iza.ion of s.pervis.on, s.udy a.d modelling of deforming proces.es. for modelling a.d s.udy of the s.res.-s.ra.n s.a.e of ma.s.f in a.ea. of la.ge-s.a.e underground mining works.in view of a.block-hiera.chica. s.ructure of rock’s.ma.s.ve (pres.nce of geologica. infringements. a.e cons.dered. In pa.ticula. s.ch importa.t ta.ks. a. res.a.ch of deforming proces.es.in a.ea. of geologica. infringements.with the help of GPs.technologies.a.d us. of the received res.lts.for the modeling; cons.ruction of models.a.equa.ely des.ribing a.condition of rock’s.ma.s.ve in a.ea.of geologica. infringement. s.me res.lts.of res.a.ches.on s.udy of ca.ities.influence on occurrence of a. a.ea.of limiting conditions.in region of geologica. infringement a.d pos.ible s.ift a.ong infringement a.e s.bmitted.

关键词： geologica. infringement s.ift dis.la.ement s.res.-s.ra.n s.a.e

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Complementa.y roles.of glia. cells.in genera.ing region-s.ecific neuroinfla.ma.ory res.ons.s.a.d pha.ocytos.s.in Pa.kins.n’s.dis.a.e

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Neura. Regenera.ion Res.a.ch 2025年第10期20卷 2917-2918页

作者： Leyre a.erra.Ma.ia.s.a.merich Univers.da. de Na.a.ra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMa.Univers.da. de Na.a.ra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinfla.ma.ion is.a.s.cia.ed with Pa.kins.n’s.dis.a.e:Rea.tive glios.s.a.d neuroinfla.ma.ion a.e ha.lma.ks.of Pa.kins.n’s.dis.a.e(PD),a.multis.s.em neurodegenera.ive dis.rder cha.a.terized by a.progres.ive los. of dopa.inergic *** ha. long been cons.dered a.mere cons.quence of neurona. los.,but whether it promotes.PD or is.a.key pla.er in dis.a.e progres.ion rema.ns.to be *** leukocyte a.tigen.

关键词： infla.ma.ion leukocyte genera.ing

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Propa.a.ion of P-a.d s.wa.es.in initia.ly s.res.ed gra.ita.ing ha.f s.a.e

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a.plied Ma.hema.ics.a.d Mecha.ics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTa.s. K. VIs.Wa.a.MA Depa.tment of a.plied Ma.hema.ics Indian School of Mines

The pres.nt pa.er contributes.in s.udying the pha.e velocities.of P- a.d s.wa.es.in a.ha.f s.a.e s.bjected to a.compres.ive initia. s.res. a.d gra.ity field. The dens.ty a.d a.celera.ion due to gra.ity va.y qua.ra.ica.ly a.ong the depth. The dis.ers.on equa.ion is.derived in a.clos.d form. It is.s.own tha. the pha.e velocities.depend not only on the initia. s.res., gra.ity, a.d direction of propa.a.ion but a.s. on the inhomogeneity pa.a.eter a.s.cia.ed with the dens.ty a.d a.celera.ion due to gra.ity. Va.ious.pa.ticula. ca.es.a.e obta.ned, a.d the res.lts.ma.ch with the cla.s.ca. res.lts. Numerica. inves.iga.ions.on the pha.e velocities.of P- a.d s.wa.es.a.a.ns. the wa.e number a.e ma.e for va.ious.s.ts.of va.ues.of the ma.eria. pa.a.eters. a.d the res.lts.a.e illus.ra.ed gra.hica.ly. The gra.hica. us.r interfa.e model is.developed to genera.ize the effect.

关键词： P-wa.e s.wa.e initia. s.res. gra.ity ha.f s.a.e gra.hica. us.r interfa.e

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a.modified neura. lea.ning a.gorithm for online res.s.a.ce es.ima.ion in vector controlled induction drives. rotor motor

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Frontiers.in Energy 2015年第1期9卷 22-30页

作者： a. CHITRa.s. HIMa.a.HI s.hool of Electrica. Engineering Vellore Institute of TechnologyUniversity Katpadi Vellore 632014 India Depa.tment of Electrica. a.d Electronics.Engineering PondicherryEngineering College Pudhucherry 605014 India

Online es.ima.ion of rotor res.s.a.ce is.es.en- tia. for high performa.ce vector controlled drives. In this.pa.er, a.novel modified neura. a.gorithm ha. been identified for the online es.ima.ion of rotor res.s.a.ce. Neura. ba.ed es.ima.ors.a.e now receiving a.tive con- s.dera.ion a. they ha.e a.number of a.va.ta.es.over conventiona. techniques. The tra.ning a.gorithm of the neura. network determines.its.lea.ning s.eed, s.a.ility, weight convergence, a.cura.y of es.ima.ion, s.eed of tra.king a.d ea.e of implementa.ion. In this.pa.er, the neura. es.ima.or ha. been s.udied with conventiona. a.d propos.d lea.ning a.gorithms. The s.ns.tivity of the rotor res.s.a.ce cha.ge ha. been tes.ed for a.wide ra.ge of va.ia.ion from -50% to ＋50% on the s.a.ility of the drive s.s.em with a.d without es.ima.or. It is.quiet a.pea.ing to s.ttle with optima. es.ima.ion time a.d error for the via.le rea.iza.ion. The s.udy is.conducted extens.vely for es.ima.ion a.d tra.king. The propos.d lea.ning a.gorithm is.found to exhibit good es.ima.ion a.d tra.king ca.a.ilities. Bes.des. it reduces.computa.iona. complexity a.d, hence, more fea.ible for pra.tica. digita. implementa. tion.

关键词： neura. networks ba.k propa.a.ion (BP) rotorres.s.a.ce es.ima.ors vector control induction motor

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EVa.Ua.ION OF s.a.E-DIs.Ha.GE RELa.IONs.IP IN COMPOUND CHa.NELs

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Journa. of Hydrodyna.ics 2008年第1期20卷 81-87页

作者： MOHa.HEGH a. KOUCHa.Za.EH s. College of Wa.er Cons.rva.cy a.d Hydropower Engineering Hohai University Nanjing 210098 China Centra. Hydra.lic Res.a.ch La.ora.ory Water Engineering Department Tehran University KarajIran

Experimenta. res.lts.were compa.ed with the computed res.lts.obta.ned from the nine mos. well-known methods.for computa.ion of dis.ha.ge in a.compound cha.nel. The res.lts.demons.ra.e a.high a.cura.y of the divided cha.nel method with the horizonta. divis.on lines. while the length of divis.on line is.included within the ca.cula.ion of the wetted perimeter. In a.dition, a. rela.ive depth increa.es. the res.lts.of the a.l methods.converge to ea.h other a.d a.s. in ca.e of s.eeper s.opes.in lower rela.ive depths. more a.reements.between different ca.cula.ed methods.a.d experimenta. res.lts.were obs.rved. Furthermore, the res.lts.s.ow the effects.of the ma.imum momentum tra.s.er on the horizonta. interfa.e between the ma.n cha.nel a.d flood pla.ns. while further a.gula. dis.a.ce from the horizonta. interfa.e towa.d the vertica. interfa.e between ma.n cha.nel a.d flood pla.ns.ca.s.s.gra.ua. decrea.e of momentum tra.s.er effects.

关键词： compound cha.nel momentum tra.s.er divis.on line flood pla.n

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Neuma.n＇s.method for bounda.y problems.of thin ela.tic s.ells

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a.plied Ma.hema.ics.a.d Mecha.ics.Englis. Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUs.a.T Depa.tment of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The pos.ibility of us.ng Neuma.n＇s.method to s.lve the bounda.y problems.for thin ela.tic s.ells.is.s.udied. The va.ia.iona. s.a.ement of the s.a.ic problems.for the s.ells.a.lows.for a.problem exa.ina.ion within the dis.ribution s.a.e. The convergence of Neuma.n＇s.method is.proven for the s.ells.with holes.when the bounda.y of the doma.n is.not completely fixed. The numerica. implementa.ion of Neuma.n＇s.method norma.ly requires.s.gnifica.t time before a.y relia.le res.lts.ca. be a.hieved. This.pa.er s.gges.s.a.wa. to improve the convergence of the proces., a.d a.lows.for pa.a.lel computing a.d eva.ua.ion during the ca.cula.ions.

关键词： bounda.y problem thin ela.tic s.ell theory Neuma.n's.method va.ia.iona. principle Korn's.inequa.ity dis.ribution embedding theorem Green tens.r

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