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Present a.d future of new systemic thera.ies for ea.ly a.d intermedia.e sta.es of hepa.ocellula. ca.cinoma

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World Journa. of Ga.troenterology 2024年第19期30卷 2512-2522页

作者： Jua. Jose Urquijo-ponce Ca.los a.ventosa.Ma.eu Mercedes La.orre-Sánchez Inma.ula.a.Ca.telló-Mira.les Moisés Dia.o Hepa.ology Unit Depa.tment of Digestive Disea.es Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepa.ocellula. ca.cinoma.HCC)is a.high morta.ity neopla.m which usua.ly a.pea.s on a.cirrhotic *** thera.eutic a.sena. a.d subsequent prognostic outlook a.e intrinsica.ly linked to the HCC sta.e a. *** the current deployment of trea.ments with cura.ive intent(liver resection/loca. a.la.ion a.d liver tra.spla.ta.ion)in ea.ly a.d intermedia.e sta.es,a.high ra.e of HCC recurrence persists,underscoring a.pivota. clinica. *** systemic thera.ies(ST),pa.ticula.ly immunothera.y,ha.e demonstra.e promising outcomes in terms of increa.e overa.l surviva.,but they a.e currently bound to the a.va.ced sta.e of *** review provides a.comprehensive a.a.ysis of the litera.ure,encompa.sing studies up to Ma.ch 10,2024,eva.ua.ing the impa.t of novel ST in the ea.ly a.d intermedia.e HCC sta.es,specia.ly focusing on the findings of neoa.juva.t a.d a.juva.t regimens,a.med a. increa.ing significa.tly overa.l surviva. a.d recurrence-free surviva. a.ter a.trea.ment with cura.ive *** a.so investiga.e the potentia. role of ST in enha.cing the downsta.ing ra.e for the intermedia.e-sta.e HCC initia.ly deemed ineligible for trea.ment with cura.ive ***,we critica.ly discuss a.out the current releva.ce of the results of these studies a.d the encoura.ing future implica.ions of ST in the trea.ment schedules of ea.ly a.d intermedia.e HCC sta.es.

关键词： Hepa.ocellula. ca.cinoma Ea.ly sta.e Intermedia.e sta.e Neoa.juva.t a.juva.t Systemic thera.y

Post-fire recovery of Puya.ra.mondii, vegeta.ion a.d birds in the puna.of Hua.ca.án Na.iona. Pa.k, Perú

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Journa. of Mounta.n Science 2024年第1期21卷 20-32页

作者： Mery L.SUNI Giova.a.P.Va.ILLO Césa. a.a.a.Enoc Ja.a.PENa.Letty Sa.INa. M.Estela.ponce Pa.l M.Ra.Sa. Pla.t Physiology La.ora.ory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Na.ura. History Museum Universidad Nacional Mayor de San MarcosLima 15072Peru a.plied Phytology La.ora.ory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Depa.tment of Sta.istics Faculty of Mathematical SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Depa.tment of Chemica. a.d Biologica. Sciences Universidad de las Américas PueblaSan Andrés Cholula CP Cholula CP 72810Mexico

a.la.ge fire of 233 ha.in Hua.ca.án Na.iona. Pa.k in Peru provided a. opportunity to compa.e pla.t a.d bird responses in burned a.d nea.by unburned zones of the puna. Heights a.d live dia.eters of fla.ship Puya.ra.mondii rosettes(a.signed to four broa. developmenta. pha.es), pla.t communities(66 species in 24 fa.ilies a.d nine growth forms) a.d bird communities(77 species in six trophic guilds) were monitored a.ter the fire. a.though no morta.ity wa. observed, Puya.ra.mondii pla.ts were a.fected by the fire, losing a.proxima.ely 60% of their photosynthetic a.ea.a.ross a.l developmenta. pha.es, but recovered quickly during the first two yea.s a.ter fire. The compa.ison of Puya.rosette recovery a.ter fire wa. complica.ed by the cha.ges in live rosette dia.eter for unburned pla.ts, which showed pla.ticity of photosynthetic a.ea.linked to sea.ona. a.d a.nua. fluctua.ions in precipita.ion in this rela.ively dry environment(decrea.ed by 26% for ma.ure a.ult pla.ts over the study period). Fire ca.sed a. immedia.e cha.ge in the density, bioma.s a.d composition of vegeta.ion. a.though the species present rema.ned simila., their a.unda.ces cha.ged significa.tly immedia.ely a.ter the fire, with nota.le reductions in domina.t tussock gra.ses. This provided opportunities for other pla.ts, resulting in higher postfire diversity of pla.t species, genera. fa.ilies a.d growth forms. In turn, the cha.ges in vegeta.ion a.ter fire a.fected the composition of birds a.cording to their trophic guild. Gra.ivores la.gely disa.pea.ed,genera.ists were mostly una.fected, a.d other guilds showed a.more complex response. a. the vegeta.ion recovered, most displa.ed birds returned within a.proxima.ely one yea..

关键词： Burning Pla.t bioma.s Trophic guilds a.des Gia.t rosette pla.ts

Towa.ds globa. covera.e of gridded pa.a.eteriza.ion for CLIma.e GENera.or(CLIGEN)

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Big Ea.th Da.a 2024年第1期8卷 142-165页

作者： a.drew T.Fullha.t Guillermo E.ponce-Ca.pos Menberu B.Meles Rya. P.McGehee Ha.ya. Wei Gera.do a.menda.iz Shea.Burns Da.id C.Goodrich Southwest Wa.ershed resea.ch Center USDa.a.S TucsonAZUSA School of Na.ura. resources a.d the Environment University of ArizonaTucsonAZUSA Susta.na.le a.ricultura. Wa.er Systems Unit USDa.a.S DavisCAUSA a.ricultura. a.d Biosystems Engineering Iowa State UniversityAmesIAUSA

Stocha.tic wea.her genera.ors crea.e time series tha. reproduce key wea.her dyna.ics present in long-term *** da.a.et deta.led herein is a.la.ge-sca.e gridded pa.a.eteriza.ion for CLIma.e GENera.or(CLIGEN)tha. fills spa.ia. ga.s in the covera.e of existing regiona. CLIGEN pa.a.eteriza.ions,thereby obta.ning nea.-globa. a.a.la.ility of combined *** da.a.et prima.ily covers countries north of 40°la.itude with 0.25°spa.ia. *** CLIGEN pa.a.eters were estima.ed ba.ed on 20-yea. records from four popula. globa. clima.e *** pa.a.eters were sta.istica.ly downsca.ed to estima.e point-sca.e va.ues,while point-sca.e tempera.ure a.d sola. ra.ia.ion pa.a.eters were a.proxima.ed by direct ca.cula.ion from high-resolution *** pa.a.eter va.ues were used in some ca.es,such a. with wind ***-va.ida.ion wa. done to a.sess the downsca.ing a.proa.h for six precipita.ion pa.a.eters using known point-sca.e va.ues from ground-ba.ed CLIGEN *** pa.a.eter va.ues were derived from da.ly a.cumula.ion records a. 7,281 sta.ions a.d high tempora. resolution records a. 609 *** sensitive pa.a.eters,monthly a.era.e storm a.cumula.ion a.d ma.imum 30-minute intensity,were shown ha.e RMSE va.ues of 1.48 mm a.d 4.67 mm hr^(−1),*** precipita.ion a.d the a.nua. number of da.s with precipita.ion occurrence were both within 5%of ground-ba.ed pa.a.eteriza.ions,effectively improving clima.e da.a.a.a.la.ility.

关键词： a.riculture clima.e hydrology soil erosion stocha.tic wea.her genera.or

Geochemica. Cha.a.teriza.ion of Soils in the Pla.a.La.e Environment of La.una.de Encinilla., Chihua.ua. Mexico

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Open Journa. of Geology 2024年第9期14卷 900-918页

作者： Ma.ía.Ferna.da.ponce-González a.eja.dro Villa.obos-a.a.ón Va.essa.Verónica.Espejel-Ga.cía.Da.hne Espejel-Ga.cía Fa.ulta. de Ingeniería Universidad Autónoma de Chihuahua Chihuahua México

La.una.de Encinilla., loca.ed in Chihua.ua. Mexico, is a. ephemera. la.e situa.ed within a.pla.a.la.e sedimenta.y depositiona. environment. This region pla.s a.significa.t role in the a.uifer supplying wa.er to Chihua.ua.City. a.surficia. soil sa.pling ca.pa.gn wa. conducted in 2017, 2018, a.d 2021 to a.sess the potentia. impa.t of surfa.e soil composition on groundwa.er qua.ity. The collected soil sa.ples were a.a.yzed using inductively coupled pla.ma.ma.s spectrometry (ICP-MS) following microwa.e-a.sisted digestion. The a.a.ytica. results were employed to genera.e spa.ia. distribution ma.s of elementa. concentra.ions using QGIS, a.plying interpola.ion methods such a. inverse dista.ce weighting (IDW) a.d Kriging. The a.a.ysis revea.ed eleva.ed concentra.ions of beryllium (Be), ca.cium (Ca., ca.mium (Cd), chromium (Cr), ma.nesium (Mg), a.d strontium (Sr) in the ea.tern pa.t of the study a.ea. In contra.t, a.senic (a.) a.d iron (Fe) were more preva.ent in the western sector. Nota.ly, high levels of ba.ium (Ba., silver (a.), coba.t (Co), pota.sium (K), a.d sca.dium (Sc) were identified in the northea.tern region. a. the sa.e time, nickel (Ni), tita.ium (Ti), a.d va.a.ium (V) were concentra.ed in the northern portion. Ma.ga.ese (Mn) wa. pa.ticula.ly prominent in the southern a.ea. The geogenic source of these elements is likely linked to the volca.ic rocks from the surrounding mounta.n ra.ges.

关键词： Groundwa.er Qua.ity Soils El Sa.z-Encinilla. a.uifer Chihua.ua GIS

Pha.ocytosis: a.Pra.tica. a.proa.h for Eva.ua.ing Neutrophil Function in Hea.th a.d Disea.e

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Modern resea.ch in Infla.ma.ion 2024年第2期13卷 9-28页

作者： Osca. Roja.-Espinosa.Pa.ricia.a.ce-Pa.edes Sergio Isla.-Trujillo Luis Enrique Becerril-Villa.ueva.Ma.ía.Dolores ponce-Rega.a.o Depa.ta.ento de Inmunologa Escuela Nacional de Ciencias Biolgicas Instituto Politcnico Nacional Ciudad de Mxico Mxico La.ora.orio de Psicoinmunologa Instituto Nacional de Psiquiatra Ramn de la Fuente Ciudad de Mxico Mxico Depa.ta.ento de Ciencia. de la.Sa.ud Centro Universitario de los Altos Universidad de Guadalajara Jalisco Mxico

Neutrophils, crucia. pla.ers in the effector pha.e of the immune response, a.e recognized a. importa.t media.ors of both inna.e a.d a.a.tive immune responses. Through the production of pro- a.d a.ti-infla.ma.ory cytokines, they modula.e the function of T a.d other lymphoid cells. Countless reports ha.e highlighted the importa.ce of these cells a. efficient a.timicrobia. a.ents a.d a.nota.ed their involvement in the pa.hology of infectious a.d noninfectious disea.es. The development of modern, sophistica.ed technologies ha. a.lowed the study of the functions of these cells in clinica. settings. These a.va.ced technologies include fluorescence-a.tiva.ed cell sorters, confoca. microscopy, a.toma.ed cell ima.e a.a.yzers, a.d live cell a.a.ysis instruments. Unfortuna.ely, the cost of these modern instruments, ma.ntena.ce, rea.ents, a.d the need for qua.ified technicia.s prohibit their use in low-income la.ora.ories a.d universities in developing countries. With this in mind, we propose a.series of ba.ic tests tha. ca. be used in low-input clinica. la.ora.ories a.d universities to eva.ua.e the function of neutrophils in hea.th a.d disea.e. Our methodology a.lows us to a.sess in a.pra.tica. a.d low-cost ma.ner the functions of neutrophils in the pha.ocytic process, including opsoniza.ion, ingestion, ROI production (NBT reduction), myeloperoxida.e content, pha.osome-lysosome fusion, microbicida. a.tivity, a.d NET production. Thus, under a.disa.va.ta.eous a.bia.ce, this ma. guide physicia.s in deciding whether a.pa.ient’s illness involves pha.ocytic defects without imposing a.hea.y fina.cia. *** a.stra.t[-rId13-]

关键词： Pha.ocytosis Neutrophils Microbicida. a.tivity Netosis

Usa.ility perceptions a.d beliefs a.out sma.t thermosta.s by chi-squa.e test, signa. detection theory, a.d fuzzy detection theory in regions of Mexico

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Frontiers in Energy 2019年第3期13卷 522-538页

作者： Pedro ponce Therese PEFFER a.turo MOLINA Tecnologico de Monterrey calle del puente 222 MexicoMexico CityNon-US/Non-Canadian 64849Mexico Ca.ifornia.Institute for Energy a.d Environment University of California BerkeleyBerkeleyCA 94720USA

It is well known tha. sma.t thermosta.s (STs) ha.e become key devices in the implementa.ion of sma.t homes;thus, they a.e considered a. prima.y elements for the control of electrica. energy consumption in households. Moreover, energy consumption is dra.tica.ly a.fected when the end users select unsuita.le STs or when they do not use the STs correctly. Furthermore, in future, Mexico will fa.e serious electrica. energy cha.lenges tha. ca. be considera.ly resolved if the end users opera.e the STs in a.correct ma.ner. Hence, it is importa.t to ca.ry out a. in-depth study a.d a.a.ysis on thermosta.s, by focusing on socia. a.pects tha. influence the technologica. use a.d performa.ce of the thermosta.s. This pa.er proposes the use of a.signa. detection theory (SDT), fuzzy detection theory (FDT), a.d chi-squa.e (CS) test in order to understa.d the perceptions a.d beliefs of end users a.out the use of STs in Mexico. This pa.er extensively shows the perceptions a.d beliefs a.out the selected thermosta.s in Mexico. Besides, it presents a. in-depth discussion on the cognitive perceptions a.d beliefs of end users. Moreover, it shows why the expecta.ions of the end users a.out STs a.e not met. It a.so promotes the technologica. a.d socia. development of STs such tha. they a.e rela.ively more a.cepted in complex electrica. grids such a. sma.t grids.

关键词： thermosta.s perceptions beliefs signa. detection theory (SDT) fuzzy signa. detection theory (FSDT) chi-squa.e (CS) test

Newly Described Components a.d Regula.ory Mecha.isms of Circa.ia. Clock Function in a.a.idopsis tha.ia.a

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Molecula. Pla.t 2012年第3期5卷 545-553页

作者： Ma.uel a.ria. Troncoso-ponce a.d Pa.oma.Ma. Center for resea.ch in a.ricultura. Genomics （CRa.） Parc de Recerca UAB Edifici CRAG Barcelona 08193 Spain

The circa.ia. clock tempora.ly coordina.es pla.t growth a.d meta.olism in close synchroniza.ion with the diurna. a.d sea.ona. environmenta. cha.ges. resea.ch over the la.t deca.e ha. identified a.number of clock components a.d a.va.iety of regula.ory mecha.isms responsible for the rhythmic oscilla.ions in meta.olic a.d physiologica. a.tivities. a. the core of the clock, tra.scriptiona./tra.sla.iona. feedba.k loops modula.e the expression of a.significa.t proportion of the genome. In this a.ticle, we briefly describe some of the very recent a.va.ces tha. ha.e improved our understa.ding of clock orga.iza.ion a.d function in a.a.idopsis tha.ia.a. The new studies illustra.e the role of clock protein complex for- ma.ion on circa.ia. ga.ing of pla.t growth a.d identify a.terna.ive splicing a. a.new regula.ory mecha.ism for clock function. Exa.ina.ion of key clock properties such a. tempera.ure compensa.ion ha. a.so opened new a.enues for func- tiona. resea.ch within the pla.t clockwork. The emerging connections between the circa.ia. clock a.d meta.olism, hor- mone signa.ing a.d response to biotic a.d a.iotic stress a.so a.d new la.ers of complexity to the clock network a.d underscore the significa.ce of the circa.ia. clock regula.ing the da.ly life of pla.ts.

关键词： circa.ia. clock circa.ia. rhythms a.a.idopsis tha.ia.a feedba.k loops.

Clinica. usefulness of a.herence to ga.tro-esopha.ea. reflux disea.e guideline by Spa.ish ga.troenterologists

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World Journa. of Ga.troenterology 2012年第35期18卷 4885-4891页

作者： Fermín Mea.in Julio ponce Ma.ta.ponce a.ustín Ba.boa.Miguel a.González Ja.ier Za.a.diel Service of Ga.troenterology Centro Medico Teknon Digestive Disea.e Unit Hospital Quiron Centro de Investiga.ion Biomedica.en Red:Enfermeda.es Hepa.ica.y Digestiva. Service of Ga.troenterology Hospital Universitario La Fe Biosta.istics Innovex-Grupo Quintiles Espana Medica. Depa.tment a.tra.eneca.Fa.ma.eutica

a.M:To investiga.e usefulness of a.herence to ga.troesopha.ea. reflux disea.e(GERD) guideline esta.lished by the Spa.ish a.socia.ion of ***:Prospective,observa.iona. a.d multicentre study of 301 pa.ients with typica. symptoms of GERD who should be ma.a.ed in a.corda.ce with guidelines a.d were a.tended by ga.troenterologists in da.ly ***(a.ed > 18 yea.s) were eligible for inclusion if they ha. typica. symptoms of GERD(hea.tburn a.d/or a.id regurgita.ion) a. the ma.or compla.nt in the presence or a.sence of a.compa.ying a.ypica. symptoms,such a. dyspeptic symptoms a.d/or supra.sopha.ea. *** a.d thera.eutic decisions should be ma.e ba.ed on specific recommenda.ions of the Spa.ish clinica. pra.tice guideline for GERD which is a.widely dissemina.ed a.d well known instrument a.ong Spa.ish in digestive disea.e ***:Endoscopy wa. indica.ed in 123(41%) pa.ients:50 with a.a.m symptoms,32 with a.e > 50 yea.s without a.a.m ***-two pa.ients(58.5%) ha. esopha.itis(gra.e a.23,gra.e B,28,gra.e C,18,gra.e D,3).In the presence of a.a.m symptoms,endoscopy wa. indica.ed consistently with recommenda.ions in 98% of ***,in the a.sence of a.a.m symptoms,endoscopy wa. indica.ed in 33% of pa.ients > 50 yea.s(not recommended by the guideline).a.herence for proton pump inhibitors(PPIs) thera.y wa. 80%,but doses prescribed were lower(ha.f) in 5% of ca.es a.d higher(double) in 15%.a.herence rega.ding dura.ion of PPI thera.y wa. 69%;dura.ion wa. shorter tha. recommended in 1%(4 wk in esopha.itis gra.es C-D) or longer in 30%(8 wk in esopha.itis gra.es a.B or in pa.ients without endoscopy).Trea.ment response wa. higher when PPI doses were consistent with guidelines,a.though differences were not significa.t(95% vs 85%).CONCLUSION:GERD guideline complia.ce wa. quite good a.though endoscopy wa. over indica.ed in pa.ients > 50 yea.s without a.a.m symptoms;PPIs were prescribed a. higher doses a.d longer dura.ion.

关键词： Ga.tro-esopha.ea. reflux disea.e Clinica.pra.tice guidelines a.herence to guidelines Trea.mentof ga.tro-esopha.ea. reflux disea.e

On a.Cla.s of Solutions to the Genera.ized Deriva.ive Schrodinger Equa.ions

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a.ta.Ma.hema.ica.Sinica.English Series 2019年第6期35卷 1057-1073页

作者： Felipe LINa.0} Gusta.o ponce Gleison N.Sa.TOS IMPA Estrada Dona Castorina 110 Rio de Janeiro 22460-320 RJ Brazil University of Ca.ifornia Santa Barbara CA 93106 USA Universida.e Federa. do Pia.i-UFPI.Ca.pus Ministro Petronio Portella Teresina 64049-550 PI Brazil

In this work we sha.l consider the initia. va.ue problem a.socia.ed to the genera.ized deriva.ive Schr?dinger(gDNLS) equa.ions ■ a.d ■ Following the a.gument introduced by Ca.ena.e a.d Na.mkin we sha.l esta.lish the loca. well-posedness for a.cla.s of sma.l da.a.in a. a.propria.e weighted Sobolev spa.e. The other ma.n tools in the proof include the homogeneous a.d inhomogeneous versions of the Ka.o smoothing effect for the linea. Schr?dinger equa.ion esta.lished by Kenig–ponce–Vega.

关键词： Deriva.ive nonlinea. Schrodinger loca. well-posedness