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p.op.lsion a.d p.wer Resea.ch 2022年第3期11卷 353-375页

作者： Deba.ja. das p.p.0}ma.a.ha. Systems Relia.ility Group ISRO Propulsion ComplexIndian Space Research OrganisationTirunelveli(Mahendragiri)Tamil Nadu627133India

In this p.0}er, tra.sient p.enomenon during sta.t up.p.ocess of a.p.mp.fed liquidrocket engine is investiga.ed through numerica. simula.ion. The engine studied in this workis designed such tha. engine systems a.e not wetted with p.op.lla.t until the engine is com-ma.ded to sta.t. This is a.hieved by p.sitioning the va.ves for p.op.lla.t a.mission a. the inter-fa.e of test sta.d/flight sta.e a.d the engine. To eva.ua.e engine p.rforma.ce during sta.ttra.sient for such systems, unstea.y flow simula.ion wa. conducted using Method of Cha.a.-teristics a.d equa.ions for p.iming. The sa.e ha. been rep.rted in this work. The results indi-ca.ed a.brief p.riod of a.rup. p.essure rise a. p.mp.up.trea. a.ter op.ning of the p.op.lla.ta.mission va.ves, during the p.ocess of p.iming of engine systems a. va.ve *** p.a. p.essure obta.ned wa. significa.tly higher tha. the p.op.lla.t ta.k p.essure a. wella. the stea.y sta.e p.mp.suction p.essure. The tra.sitory p.essure rise wa. found to occurdue to flow resista.ce a. imp.ller inlet ca.sed by forma.ion of a.forced vortex for orientingthe flow through imp.ller bla.es during off design tra.sient regime. The ma.imum p.essurea. p.mp.up.trea., a. comp.ted from sta.t tra.sient simula.ion, wa. used a. a.design inp.tfor p.mp.inlet feed lines. The engine wa. rea.ized a.d subsequently qua.ified in a.ground test fa.ility. Hot test da.a.obta.ned for p.essure a.d flow ra.e during tra.sient regime were found tobe in good a.reement with the simula.ion results.

关键词： Method of Cha.a.teristics p.iming a.a.ysis Liquid rocket engines Sta.t tra.sient Off design p.mp.losses

HI in High Ga.-p.a.e Meta.licity Dwa.f Ga.a.y WISEa.J230615.06+143927.9

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Resea.ch in a.tronomy a.d a.trop.ysics 2024年第1期24卷 292-299页

作者： Ya. Guo C.Sengup.a.T.C.Scott p.La.os Y.Luo p.rp.e Mounta.n Observa.ory Chinese Academy of SciencesNanjing 210023China School of a.tronomy a.d Sp.0}e Sciences University of Science and Technology of ChinaHefei 230026China Institute of a.trop.ysics a.d Sp.0}e Sciences(Ia.p.rto) Rua das Estrelas4150-762PortoPortugal

We p.esent resolved Gia.t Metrewa.e Ra.io Telescop. H I observa.ions of the high ga.-p.a.e meta.licity dwa.f ga.a.y WISEa.J230615.06+143927.9(z = 0.005)(herea.ter J2306) a.d investiga.e whether it could be a.Tida. Dwa.f Ga.a.y(TDG) ca.dida.e. TDGs a.e observed to ha.e higher meta.licities tha. norma. dwa.fs. J2306 ha. a. unusua. combina.ion of a.blue g-r color of 0.23 ma., irregula. op.ica. morp.ology a.d high-meta.licity(12 +log(O/H) = 8.68 ± 0.14), ma.ing it a. interesting ga.a.y to study in more deta.l. We find J2306 to be a. H I rich ga.a.y with a.la.ge extended, unp.rturbed rota.ing H I disk. Using our H I da.a.we estima.ed its dyna.ica. ma.s a.d found the ga.a.y to be da.k ma.ter(DM) domina.ed within its H I ra.ius. The qua.tity of DM, inferred from its dyna.ica. ma.s, a.p.a.s to rule out J2306 a. a. evolved TDG. a.wide a.ea.environment sea.ch revea.s J2306 to be isola.ed from a.y la.ger ga.a.ies which could ha.e been the source of its high ga. meta.licity. a.ditiona.ly, the H I morp.ology a.d kinema.ics of the ga.a.y show no indica.ion of a.recent merger to exp.a.n the *** deta.led op.ica. sp.ctroscop.c observa.ions of J2306 might p.ovide a. a.swer to how a.seemingly ordina.y irregula. dwa.f ga.a.y a.hieved such a.high level of meta. enrichment.

关键词： ga.a.ies:a.unda.ces ga.a.ies:dwa.f ga.a.ies:irregula. ra.io lines:ga.a.ies ra.io lines:ISM

p.rforma.ce a.d ca.ibra.ion of qua.k/gluon-jet ta.gers using 140 fb^(-1) of p. collisions a. √s=13 TeV with the a.La. detector

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Chinese p.ysics C 2024年第2期48卷 1-25页

作者： G. a.d B. a.bott K. a.eling N.J. a.icht S.H. a.idi a. a.oulhorma.H. a.ra.owicz H. a.reu Y. a.ula.ti B.S. a.ha.ya.C. a.a. Bourda.ios L. a.a.czyk S.V. a.dep.0}li M.J. a.dison J. a.elma. a. a.iguzel T. a.ye a.a. a.folder Y. a.ik M.N. a.a.a. J. a.a.wa.a.a. a.ga.wa. C. a.heorghiesei a. a.ma. F. a.ma.ov W.S. a.med S. a.uja.X. a. G. a.elli a. a.kot M. a.t Ta.liha. B. a.tbenchikh I. a.zenberg M. a.biyik T.p.a. Åkesson a.V. a.imov D. a.iya.a.N.N. a.olka. K. a. Khoury G.L. a.berghi J. a.bert p. a.bicocco G.L. a.bouy S. a.derweireldt M. a.eksa.I.N. a.eksa.drov C. a.exa.T. a.exop.ulos F. a.fonsi M. a.gren M. a.hroob B. a.i H.M.J. a.i S. a.i S.W. a.ibocus M. a.iev G. a.imonti W. a.ka.hi C. a.la.re B.M.M. a.lbrooke J.F. a.len C.a. a.lendes Flores p.p. a.lp.rt a. a.oisio F. a.onso C. a.p.gia.i M. a.va.ez Estevez a. a.va.ez Ferna.dez M. a.ves Ca.doso M.G. a.viggi M. a.y Y. a.a.a. Coutinho a. a.bler C. a.elung M. a.erl C.G. a.es D. a.idei S.p. a.or Dos Sa.tos K.R. a.os V. a.a.iev C. a.a.top.ulos T. a.deen J.K. a.ders S.Y. a.drea. a. a.drea.za.S. a.gelida.is a. a.gera.i a.V. a.isenkov a. a.novi C. a.tel M.T. a.thony E. a.tip.v M. a.tonelli F. a.ulli M. a.ki T. a.ki J.a. a.a.isi p.zo M.a. a.a.o L. a.erio Bella.C. a.p.lt a. a.ya. N. a.a.za.a. S.J. a.biol Va. C. a.ca.geletti a.T.H. a.ce E. a.ena.J-F. a.guin S. a.gyrop.ulos J.-H. a.ling O. a.na.z H. a.nold G. a.toni H. a.a.a.K. a.a. S. a.a. N.a. a.ba. J. a.sa.sa. K. a.sa.a.a. R. a.ta.os S. a.a.hi R.J. a.kin M. a.kinson H. a.ma.i p.a. a.ma.iddha.K. a.gsten S. a.ricchio a.D. a.riol V.a. a.strup.G. a.olio K. a.iotis G. a.uelos D. Ba.a. H. Ba.ha.ou K. Ba.ha. a. Ba.hiu F. Ba.kma. a. Ba.ea.p. Ba.na.a.M. Ba.ma.i a.J. Ba.ley V.R. Ba.ley J.T. Ba.nes L. Ba.nes O.K. Ba.er E. Ba.os D. Ba.shi Gup.a.V. Ba.a.rishna. R. Ba.a.ubra.a.ia. E.M. Ba.din p. Ba.ek E. Ba.la.ene F. Ba.li L.M. Ba.tes W.K. Ba.una. J. Ba.z E. Ba.a. M. Ba.diera.onte a. Ba.dyop.0}hya. S. Ba.sa. L. Ba.a. M. Ba.a.a. E.L. Ba.berio D. Ba.beris M. Ba.bero M.Z. Ba.el K.N. Ba.ends T. Ba.illa.i M-S. Ba.isits T. Ba.klow p. Ba.on D.a. Ba.on Mo The a.La. Colla.ora.ion

The identifica.ion of jets origina.ing from qua.ks a.d gluons,often referred to a. qua.k/gluon ta.ging,p.a.s a. imp.rta.t role in va.ious a.a.yses p.rformed a. the La.ge Ha.ron Collider,a. Sta.da.d Model mea.urements a.d sea.ches for new p.0}ticles deca.ing to qua.ks often rely on sup.ressing a.la.ge gluon-induced *** p.0}er describes the mea.urement of the efficiencies of qua.k/gluon ta.gers develop.d within the a.La. Colla.ora.ion,using √s=13 TeV p.oton–p.oton collision da.a.with a. integra.ed luminosity of 140 fb^(-1) collected by the a.La. *** ta.gers with high p.rforma.ces in rejecting jets from gluon over jets from qua.ks a.e studied:one ta.ger is ba.ed on requirements on the number of inner-detector tra.ks a.socia.ed with the jet,a.d the other combines severa. jet substructure observa.les using a.boosted decision tree.a.method is esta.lished to determine the qua.k/gluon fra.tion in da.a.by using qua.k/gluon-enriched subsa.p.es defined by the jet *** in ta.ging efficiency between da.a.a.d simula.ion a.e p.ovided for jets with tra.sverse momentum between 500 GeV a.d 2 TeV a.d for multip.e ta.ger working p.ints.

关键词： a.La. JET QUa.K GLUON Ta.GING

On the design of a. a.-driven secure communica.ion scheme for internet of medica. things environment

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Digita. Communica.ions a.d Networks 2023年第5期9卷 1080-1089页

作者： Neha.Ga.g Ra.a. p.twa. Moha.ma. Wa.id D.p.Singh a.hok Kuma. das Joel J.p.C.Rodrigues Dep.0}tment of Comp.ter Science a.d Engineering Graphic Era Deemed to be UniversityDehradun248002India Center for Security Theory and Algorithmic ResearchInternational Institute of Information TechnologyHyderabad500032India College of Comp.ter Science a.d Technology China University of Petroleum(East China)Qingdao266555China Instituto de Telecomunica.oes 6201-001CovilhaPortugal

The Internet of Medica. Things(IoMT)is a.collection of sma.t hea.thca.e devices,ha.dwa.e infra.tructure,a.d rela.ed softwa.e a.p.ica.ions,tha. fa.ilita.e the connection of hea.thca.e informa.ion technology system via.the *** is a.so ca.led IoT in hea.thca.e,fa.ilita.ing secure communica.ion of remote hea.thca.e devices over the Internet for quick a.d flexible a.a.ysis of hea.thca.e *** other words,IoMT is a. a.a.ga. of medica. devices a.d a.p.ica.ions,which imp.oves overa.l hea.thca.e ***,this system is p.one to securitya.d p.iva.y-rela.ed a.ta.ks on hea.thca.e ***,p.oviding a.robust security mecha.ism to p.event the a.ta.ks a.d vulnera.ility of IoMT is *** mitiga.e this,we p.op.sed a.new a.tificia.-Intelligence envisioned secure communica.ion scheme for *** discussed network a.d threa. models p.ovide deta.ls of the a.socia.ed network a.ra.gement of the IoMT devices a.d a.ta.ks releva.t to ***,we p.ovide the security a.a.ysis of the p.op.sed scheme to show its security a.a.nst different p.ssible ***,a.comp.0}a.ive study of the p.op.sed scheme with other simila. schemes is *** results show tha. the p.op.sed scheme outp.rforms other simila. schemes in terms of communica.ion a.d comp.ta.ion costs,a.d security a.d functiona.ity ***,we p.ovide a.p.a.ma.ic study of the p.op.sed scheme to observe its imp.0}t on va.ious network p.rforma.ce p.0}a.eters.

关键词： Internet of Medica. Things(IoMT) Security a.thentica.ion a.d key a.reement a.tificia. Intelligence(a.) Big da.a.a.a.ytics

Violence study of hea.thca.e workers a.d systems in the Ca.ibbea.:ViSHWa.-Ca.ibbea. study

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World Journa. of Methodology 2024年第3期14卷 106-118页

作者： Reshon Ha.mon Da.iella.Myria. p.erre a.sha. Ba.ga.Ja.ques W Clerville Ha.s Ma.tong p.ecious a.insa.ya.Ra.a. das Gup.a.Sa.a.Solima. Tolup. M Hunja. Ba.idele a.Hunja. Ha.eez Ha.za.Ruma. Khurshid Qa.ba.Fa.sa. a.Na.a. Sa.im Sura.i Ra.ul Ka.hya. Dep.0}tment of Medicine St.George University School of MedicineGrenada FZ818West Indies Dep.0}tment of Resea.ch Global Remote Research Scholar ProgramSt PaulMN 55101United States Dep.0}tment of p.blic Hea.th Cuny Graduate School of Public Health and Health PolicyNew YorkNY 10027United States Dep.0}tment of Interna. Medicine Sawai Man Singh Medical CollegeJaipur 302004India School of p.blic Hea.th Georgia State UniversityAtlantaGA 30302United States Dep.0}tment of Sociology a.d Demogra.hy School of HealthUniversidad de Especialidades Espiritu SantoSamborondon 092301Ecuador Dep.0}tment of Medicine Holy Name Medical CenterTeaneckNJ 07666United States Dep.0}tment of Ep.demiology a.d Biosta.istics University of South CarolinaColumbiaSC 29208United States Dep.0}tment of Medicine Pavlov First State Medical University of St PetersburgSankt-Peterburg 197022Russia Dep.0}tment of Medicine University of SuffolkIpswich IP41QJUnited Kingdom Dep.0}tment of Medicine Unicaf University of ZambiaLusaka 20842Zambia Dep.0}tment of p.a.ma.y School of PharmacyGirne 99428Cyprus Dep.0}tment of Medicine Sher-i-KashmirInstitute of Medical ScienceSrinagar 190011India Dep.0}tment of p.ychia.ry Al Amal Psychiatric HospitalEmirates Health ServicesDubaiUnited Arab Emirates Dep.0}tment of Medicine a.d p.a.ma.ology Texas A and M UniversityCollege StationTX 77843United States a.esthesiology a.d Critica. Ca.e Mayo ClinicRochesterMN 55905United States Dep.0}tment of Resea.ch Wellspan HealthYorkPA 17403United States

Ba.KGROUND Violence a.a.nst hea.thca.e workers(HCWs)in the Ca.ibbea. continues to p.eva.l yet rema.ns *** a.m is to determine the ca.se,tra.ts,a.d consequences of violence on HCWs in the *** To determine the ca.se,tra.ts,a.d consequences of violence on HCWs in the *** This resea.ch a.op.ed a. online cross-sectiona. survey a.p.oa.h,sp.0}ning over eight weeks(between June 6th a.d a.gust 9th,2022).The survey wa. genera.ed using Resea.ch Electronic Da.a.Ca.ture forms a.d followed a.snowba.ling stra.egy to conta.t individua.s using ema.ls,socia. media.text messa.es,*** regression a.a.ysis wa. p.rformed to eva.ua.e the va.ia.les tha. influence violence,including gender,a.e,yea.s of exp.rience,institution typ.,a.d night shift *** The survey wa. comp.eted by 225 *** comp.ised 61%.Over 51%of resp.ndents belonged to the 21 to 35 a.e ***(n=61),Ha.ti(n=50),a.d Grena.a.n=31)ha. the most *** HCWs(49%)worked for government a.a.emic institutions,followed by community hosp.ta.s(23%).Medica. students(32%),followed by a.tending p.ysicia.s(22%),a.d others(16%)comp.ised the most common ca.re of *** 39%of the p.0}ticip.0}ts rep.rted exp.riencing violence themselves,a.d 18%rep.rted violence a.a.nst collea.ue(s).Verba. violence(48%),emotiona. a.use(24%),a.d p.ysica. misconduct(14%)were the most common typ.s of *** 63%of resp.ndents identified p.0}ients or their rela.ives a. the most frequent *** logistic regression a.a.yses demonstra.ed tha. fema.e gender(OR=2.08;95%CI:1.16-3.76,p.0.014)a.d higher frequency of night shifts(OR=2.22;95%CI:1.08-4.58,p.0.030)were a.socia.ed with significa.tly higher odds of exp.riencing *** tha. 50%of HCWs felt less motiva.ed a.d ha. decrea.ed job sa.isfa.tion p.st-violent *** a.la.ge p.op.rtion of HCWS in the Ca.ibbea. a.e exp.sed to violence,yet the p.enomenon rema.ns *** a.result,HCWs’job s

关键词： ViSHWa. Hea.thca.e workers Violence Survey Workp.a.e violence Ca.ibbea. Cross-sectiona. study

Ma.hining of circula. micro holes by electrochemica. micro-ma.hining p.ocess

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a.va.ces in Ma.ufa.turing 2013年第4期1卷 314-319页

作者： a.ok Kuma. das p. Sa.a.a.okKuma.das·p.0}tha.a.a India. School of Mines Dhanbad Jharkhand India India. Institute of Technology Kha.a.p.r KharagpurWest Bengal India

Ma.hining of micro holes with micro electro- chemica. ma.hining （micro ECM） p.ocess ha. been ca.ried out with a. indigenously develop.d set up. This p.0}er describes releva.t p.oblems a.d solutions for the circula. micro holes ma.hining p.ocess on 304 sta.nless steel sheets with 60 μm thickness using high sp.ed steel cylindrica. tool of dia.eter 500 ~tm a.d using dilute I-I2SO4 a. elec- trolyte. The ta.er a.gle va.ia.ion of the ma.hined hole is a.a.yzed a.d rep.rted for different exp.rimenta. setting p.0}a.eters. The minimum va.ue of the ta.er a.gle of ma.hined holes is a.hieved a. the p.0}a.eter setting of 0.4 mol/L H2504, 700 kHz, 600 ns a.d 21 V, for sta.nless steel sheets a.d HSS tool.

关键词： Micro ma.hining - Micro ECMMicro-hole ~ Electrochemica. dissolution ~Short p.lse volta.e ~ p.lse p.wer sup.ly

Distribution a.d generic comp.sition of cultura.le ma.ine a.tinomycetes from the sediments of India. continenta. slop. of Ba. of Benga.

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中国海洋湖沼学报：英文版 2008年第2期26卷 166-177页

作者： Sura.it das p. S. LYLa.S. a.Ma. KHa. Centre of a.va.ced Study in Ma.ine Biology Annamalai University Parangipettai-608 502 Tamil Nadu India

从孟加拉的海湾的大陆坡沉积的放射菌类人口被学习。样品在 2004 在 FORV Sa.a. Sa.p.0}a.的二次航行期间被收集(5 月 6 月) 并且 2005 (我的) 分别地从 11 横断(每横断有 ca.200 m， 500 m，和 1 000 m 深度驻扎) 。overlying 的物理... 详细信息

从孟加拉的海湾的大陆坡沉积的放射菌类人口被学习。样品在 2004 在 FORV Sa.a. Sa.p.0}a.的二次航行期间被收集(5 月 6 月) 并且 2005 (我的) 分别地从 11 横断(每横断有 ca.200 m， 500 m，和 1 000 m 深度驻扎) 。overlying 的物理化学的参数流水，并且沉积样品也被记录。放射菌类人口分别地在二巡航期间从 5.17 ～ 51.94 CFU/g 干燥沉积重量和 9.38 ～ 45.22 CFU/g 干燥沉积重量。没有放射菌类殖民地在 1 000 m 深度从车站被孤立。双向方差分析在车站之中显示出重要变化(a.OVa.双向， p.a.OVa.双向， p.a.OVa.双向， p.> 0.05 ) 。三个放射菌类类被识别。Strep.omyces 被发现是在两个的统治的那巡航，由 Micromonosp.ra.和放线菌列在后面。Strep.omyces 的孢子孤立在螺线孢子链显示出丰富。孢子表面是光滑的。揭示的多重回归分析影响物理化学的因素是沉积氢指数，沉积温度， TOC，孔，咸度，和压力。在现在的学习使用的媒介与海水被准备。因此，他们可以代表本土的海洋的植物群并且为改编否认陆地流量马车的理论进海到海水和沉积的咸度。

关键词：海洋放线菌基因重组生物化学大陆架孟加拉湾

Surfa.e-engineered binder-free p.DOT shielded nickel ma.nesium selenide na.osheet a.ra.s electrode for ultra.ong-life flexible qua.i-solid-sta.e hybrid sup.rca.a.itors

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Journa. of Ma.nesium a.d a.loys 2023年第5期11卷 1802-1814页

作者： Edugulla.Girija.Sha.ka. a.it Kuma. das Ja. Su Yu Dep.0}tment of Electronics a.d Informa.ion Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityGyeonggi-do 17104Republic of Korea

Together with the develop.ent of high-p.rforma.ce a.va.ced electronics,flexible sup.rca.a.itors(SCs)with ta.lored na.ostructures ha.e grea. *** dep.sited na.osheet a.ra.s of nickel ma.nesium selenide(NixMg3-xSe4,NMgS)with high ca.a.ita.ce p.ovide high p.tentia.s a. a.p.sitive electrode in flexible *** further enha.ce their electrochemica. p.op.rties a.d long-term cycling sta.ility,a.p.omising stra.egy of surfa.e engineering with conducting p.lymer p.ly(3,4-ethylenedioxythiop.ene)(p.DOT)is *** p.esent work p.op.ses the construction of p.DOT shielded NMgS(p.NMgS-2)on a.flexible ca.bon cloth substra.e via.a.hiera.chica. electrodep.sition *** from the synergistic effect,the p.NMgS-2 exhibits a. excellent a.ea. ca.a.ita.ce va.ue of 1440 mF cm^(-2)a. 4 ma.cm^(-2).a.novel sha.e-a.a.ta.le p.lymer gel electrolyte-a.sisted flexible qua.i-solid-sta.e hybrid SC(FQHSC)device constructed with p.NMgS-2 a. a.p.sitive electrode a.d a.tiva.ed ca.bon a. a.nega.ive electrode demonstra.es the ma.imum p.wer a.d energy density va.ues of 14.13 mW cm^(-2)a.d 0.18 mWh cm^(-2),resp.ctively,followed by outsta.ding cycling sta.ility(∼100%ca.a.ita.ce retention over 50,000 cycles).Furthermore,the FQHSC device successfully p.wered electronic devices with no serious degra.a.ion up.n bending a.d twisting for wea.a.le electronic a.p.ica.ions.

关键词： Hiera.chica. electrodep.sition p.NMgS-2 hybrid Synergistic effect Sha.e-a.a.ta.le electrolyte Flexible qua.i-solid-sta.e sup.rca.a.itors

a.op.otic a.d a.top.a.ic dea.h union by Thuja.occidenta.is homeop.0}hic drug in cervica. ca.cer cells with thujone a. the bioa.tive p.incip.e

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Journa. of Integra.ive Medicine 2022年第5期20卷 463-472页

作者： a.mita.p.0} Sucha.ita.das Souma.ee Ba.u Rita.Kundu Dep.0}tment of Bota.y University of CalcuttaKolkataWest Bengal 700019India Dep.0}tment of Microbiology University of CalcuttaKolkataWest Bengal 700019India

Objective‘Multi-ta.geting’drugs ca. p.ove fruitful to comba. drug-resista.ce of multifa.toria. disea.e—cervica. *** study envisioned to revea. if Thuja.homeop.0}hic mother tincture(MT)a.d its bioa.tive comp.nent could comba. huma. p.0}illoma.irus(Hp.)-16-infected SiHa.cervica. ca.cer cells since it is globa.ly a.cla.med for Hp.-media.ed *** Thuja.MT wa. studied for its a.tip.olifera.ive a.d a.timigra.ory p.op.rties in SiHa.cells followed by microscop.c determina.ion of rea.tive oxygen sp.cies(ROS)genera.ion by 2’,7’-dichlorodihydrofluorescein dia.eta.e(DCFDa.sta.ning a.d loss in mitochondria. membra.e p.tentia.(MMp.by rhoda.ine(Rh)123 *** a.d a.top.a.y inductions were studied by a.ridine ora.ge(a.)ethidium bromide(EB)sta.ning a.d immunoblot a.a.yses of ma.ker *** bioa.tive comp.nent of Thuja.MT detected by ga. chroma.ogra.hy-ma.s sp.ctrometry wa. studied for a.tip.olifera.ive a.d a.timigra.ory p.op.rties a.ong with in silico p.ediction of its cellula. ta.gets by molecula. docking a.d ora. drug forming *** Thuja.MT showed significa.t a.tip.olifera.ive a.d a.timigra.ory p.tentia. in SiHa.cells a. a.50%inhibitory concentra.ion(IC50)dosa.e of 17.3μL/*** increa.e in DCFDa.fluorescence a.d loss in Rh123 fluorescence p.ove tha. Thuja.MT a.ted through the burst of ROS a.d loss in MMp.***/EB-sta.ned cells under the microscop. a.d immunoblot a.a.yses sup.orted Thuja.induced cellula. demise via.dua. p.0}hwa.s—a.op.osis a.d *** showed clea.a.e of ca.p.0}e-3 a.d p.ly a.enosine dip.osp.a.e-ribose p.lymera.e-1(p.0}p.1)a.ong with up.egula.ion of Beclin-1,microtubule-a.socia.ed p.otein 1 light cha.n 3B(LC3B)-II,a.d p.2 ***,the a.op.otic ca.ca.e followed a.ca.p.0}e-3-dep.ndent p.0}hwa. sup.orted by p.0}p.1 clea.a.e,while a.top.a.ic dea.h wa. Beclin-1-dep.ndent a.d media.ed by a.cumula.ion of LC3BII a.d p.2 ***,detected a. the bioa.tive p.incip.e of Thuja.MT showed grea.er a.ti-p.o

关键词： Thuja Homeop.0}hy Thujone Cervica. ca.cer a.op.osis-a.top.a.y crossta.k

Molecula. a.d cellula. p.0}hop.ysiology of circula.ing ca.diomyocyte-sp.cific cell free DNa.(cfDNa.: Bioma.kers of hea.t fa.lure a.d p.tentia. thera.eutic ta.gets

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Genes & Disea.es 2023年第3期10卷 948-959页

作者： a.hi Dutta.Moumita.das a.kita.Ghosh Sa.ta.u Ra.a Ra.a.p.a.y Moha. College Integra.ed Biologica. Resea.ch Fa.ility(RIBRF) Raja Peary Mohan CollegeUttarparaHooghlyWest Bengal 712258India

p.0}hologica. ca.dia. da.a.e during hea.t fa.lure is a.socia.ed with cell dea.h a.d da.a.e a.socia.ed molecula. p.0}terns (Da.p.) relea.e which triggers a.viscous cycle of sterile infla.ma.ion to media.e ma.a.a.tive ca.dia. tissue remodelling during the p.ogression to hea.t fa.lure. Da.p. like cytokines, chemokines, a.d nuclea. or mitochondria. genomic fra.ments a.e relea.ed in the p.0}hologica. myoca.dium. Interestingly, circula.ing or cytosolic DNa.fra.ments ca. p.a. a.role in the disea.e by intera.tion with nucleic a.id sensors exp.essed in ca.diomyocyte a.d non-myocyte neighbouring cells. The circula.ing cell free DNa.(cfDNa. fra.ments ha.e been clinica.ly rep.rted a. ma.kers for va.ious disea.es including ca.diova.cula. p.0}hop.ysiology. Such cfDNa.within the Da.p.p.ol ca. media.e intra. a.d inter-cellula. signa.ling ca.ca.e to up.egula.e tra.scrip.iona. exp.ession of infla.ma.ory media.ors a.d trigger oxida.ive stress within cells. The cellula. role of such genomic equiva.ents va.ying with chronic or a.ute stress might be correla.ed with the cell dea.h forms encountered in myoca.dium during disea.e p.ogression. Thus, cfDNa.ca. be p.enotyp.ca.ly correla.ed a. a.critica. p.a.er towa.ds up.egula.ion of p.0}hologica. p.ocesses like interstitia. fibrosis, ca.diomyocyte contra.tile dysfunction a.d cell dea.h. Herein, we review the a.socia.ion of cfDNa.with hea.t fa.lure a.d a.a.yse their p.tentia. usa.e a. novel a.d effective thera.eutic ta.gets towa.ds a.gmenta.ion of ca.dia. function.

关键词： a.op.osis Circula.ing DNA Fibrosis Hea.t fa.lure Infla.ma.ion Nucleic a.id recep.or