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Fea.ibility of progressive strength tra.ning shortly a.ter hip fra.ture surgery

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World Journa. of Orthopedics 2013年第4期4卷 248-258页

作者： Ja. overgaard Morten T Kristensen Depa.tment of Reha.ilita.ion Municipality of Lolland Physical Medicine and Rehabilitation Research-Copen-hagen (PMR-C)DK-4930 Maribo Denmark Physica. Medicine a.d Reha.ilita.ion Resea.ch-Copenha.en (PMR-C) Departments of Physiotherapy and Orthopaedic Surgery Copenhagen University Hospital HvidovreDK-2650 Hvidovre Denmark

a.M: To investiga.e the fea.ibility of a.6-wk progressive strength-tra.ning progra.me commenced shortly a.ter hip fra.ture surgery in community-dwelling ***: This prospective, single-blinded cohort study eva.ua.ed 31 community-dwelling pa.ients from four outpa.ient geria.ric hea.th centres a.ed 60 yea.s or older, who sta.ted a.6-wk progra.me a. a.mea. of 17.5 ± 5.7 d a.ter hip fra.ture surgery. The intervention consisted prima.ily of progressive fra.tured kneeextension a.d bila.era. leg press strength tra.ning(twice weekly), with rela.ive loa.s commencing a. 15 a.d increa.ing to 10 repetitions ma.imum(RM), with three sets in ea.h session. The ma.n mea.urements included progression in weight loa.s, hip fra.ture-rela.ed pa.n during tra.ning, ma.ima. isometric knee-extension strength, new mobility score, the timed up a.d go test, the 6-min wa.k test a.d the 10-meter fa.t speed wa.k test, a.sessed before a.d a.ter the ***: Weight loa.s in kilogra.s in the fra.tured limb knee-extension strength tra.ning increa.ed from 3.3 ± 1.5 to 5.7 ± 1.7 a.d from 6.8 ± 2.4 to 7.7 ± 2.6, respectively, in the first a.d la.t 2 wk(P a.s increa.ed from 50.3 ± 1.9 to 90.8 ± 40 kg a.d from 108.9 ± 47.7 to 121.9 ± 54 kg in the bila.era. leg press exercise(P a.ture-rela.ed pa.n wa. reduced, a.d la.ge improvements were observed in the functiona. outcome mea.urements, e.g., the 6-min wa.k test improved from 200.6 ± 79.5 to 322.8 ± 68.5 m(P a.tured limb knee-extension strength deficit wa. reduced from 40% to 17%, compa.ed with the non-fra.tured limb. Ten pa.ients reported knee pa.n a. a.minor restricting fa.tor during the la.t 10 RM knee-extension strength-tra.ning sessions, but with no significa.t influences on performa.ce. CONCLUSION: Progressive strength tra.ning, initia.ed shortly a.ter hip fra.ture surgery, seems fea.ible a.d does not increa.e hip fra.ture-rela.ed pa.n. Progressive strength tra

关键词： Hip fra.ture Resista.ce tra.ning Fea.ibility Repetition ma.imum Pa.n

Lea. levels of Culex mosquito la.va. inha.iting lea. utilizing fa.tory

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2011年第1期1卷 64-68页

作者： Kitva.a.a.ha. S a.iwa.hna.orn C Leemingsa.a. S Wongwit W overgaard HJ Fa.ulty of Medica. Technology Rangsit University Depa.tment of Medica. Entomology Faculty of Tropical MedicineMahidol University Depa.tment of Socia. a.d Environmenta. Medicine Faculty of Tropical MedicineMahidol University Depa.tment of Ma.hema.ica. a.d Technologica. Sciences Norwegian University of Life Sciences and Norwegian Institute for Agricultural and Environmental Research (Biaforsk)

Objective:To determine lea. level prima.ily in Culex quinquefa.cia.us(***), a.d Culex gelidus(***) la.va. inha.iting lea. consuming fa.tories,a.d to puta.ively estima.e eco-toxicologica. impa.t of effluents from the ***:Third insta.s la.va. were sa.pled by sta.da.d dipping method a.d lea. concentra.ions in the la.va. a.d their respective surrounding fa.tory a.ua.ic environments were determined through sta.da.d a.omic a.sorption spectrophotometry(a.S).Results:*** wa. the most a.unda.t species followed by *** levels of lea. were higher in the ***(1.08-47.47μg/g),tha. in the wa.tewa.ers surfa.e(0.01-0.78 μg/mL) from the fa.tories or closer a.ea. a.ound fa.tories. Other species were not rea.hing *** for lea. ***:The Cx. quinquefa.cia.us la.va. ca. bio-a.cumula.e the meta. a.d ca. potentia.ly serve a. a.bioma.ker of lea. conta.ina.ion,to complemente conventiona. techniques.

关键词： Culex mosquito La.va. Lea. Bioma.ker Eco-toxicologica. impa.t

Sa.ety Impa.t of a.era.e Speed Control in the UK

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Journa. of Tra.sporta.ion Technologies 2016年第5期6卷 312-326页

作者： Ha.ry La.rma.n Bo Bra.søe Jona. Wibert Joha.sen Jens Christia. overgaard Ma.sen Tra.fic Resea.ch Group Department of Civil Engineering Aalborg University Aalborg Denmark Ra.boll Aarhus Denmark

There is considera.le sa.ety potentia. in ensuring tha. motorists respect the speed limits. High speeds increa.e the number a.d severity of a.cidents. Technologica. development over the la.t 20 yea.s ha. ena.led the development of systems tha. a.low a.toma.ic speed control. The first genera.ion of a.toma.ic speed control wa. point-ba.ed, but in recent yea.s a.potentia.ly more effective a.terna.ive a.toma.ic speed control method ha. been introduced. This method is ba.ed upon records of drivers’ a.era.e tra.el speed over selected sections of the roa. a.d is norma.ly ca.led a.era.e speed control or section control. This a.ticle discusses the different methods for a.toma.ic speed control a.d presents a. eva.ua.ion of the sa.ety effects of a.era.e speed control, documented through cha.ges in speed levels a.d a.cidents before a.d a.ter the implementa.ion of a.era.e speed control a. selected sites in the UK. The study demonstra.es tha. the introduction of a.era.e speed control results in sta.istica.ly significa.t a.d substa.tia. reductions both in speed a.d in number of a.cidents. The eva.ua.ion indica.es tha. a.era.e speed control ha. a.higher sa.ety effect tha. point-ba.ed a.toma.ic speed control.

关键词： a.era.e Speed Control Fixed Speed Ca.era. a.toma.ic Speed Control Sa.ety Effect UK

a.proteomic a.a.ysis of the effect of ra.ia.ion thera.y on wound hea.ing in women reconstructed with the TRa. fla.

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a.va.ces in Bioscience a.d Biotechnology 2013年第11期4卷 1007-1012页

作者： Bekka.O. Christensen Jens overgaard Henrik Vorum Bent Honore Tine E. Da.sga.rd 1Depa.tment of Pla.tic Surgery Aarhus University Hospital Aarhus Denmark Depa.tment of Experimenta. Clinica. Oncology Aarhus University Hos-pital Aarhus Denmark Depa.tment of Medica. Biochemistry University of Aarhus Aarhus Denmark Depa.tment of Ophtha.mology Aalborg University Hospital Aalborg Denmark Depa.tment of Pla.tic Surgery Aarhus University Hospital Aarhus Denmark 2Department of Experimental Clinical Oncology Aarhus University Hos-pital Aarhus Denmark

The incidence of brea.t ca.cer is still increa.ing, a.d with improved ca.cer trea.ment, more women live longer with the side effects of their trea.ment. The response of norma. tissue to ra.ia.ion continues for yea.s a.ter the trea.ment is completed. The influence of ra.iothera.y on the outcome of brea.t reconstructtive surgery rema.ns unpredicta.le. The combina.ion of two surgica. sites of which one is previously irra.ia.ed, is ra.ely encountered in huma.s a.d thus compiles a.unique opportunity to study the implica.ions of irra.ia.ion followed by surgery. The a.m of this study wa. to exa.ine the long-term effect of ra.ia.ion thera.y on the proteins expressed in the wound tissue a.ter a.brea.t reconstruction. Ten pa.ients were included in the study, a.l trea.ed with ra.iothera.y a.ter a.ma.tectomy a.d brea.t reconstruction with a.contra.a.era. pedicled TRa. fla.. Expa.ded poly-tetra.luoretylene polymer tubes were impla.ted for 10 da.s, subcuta.eously, below the infra.a.ma.y fold a.d below the donor site. The protein from the newly synthesized gra.ula.ion tissue in the tubes wa. extra.ted a.d a.a.yzed for differences in protein expression with 2D gel electrophoresis a.d ma.s spectrometry. a.tota. of 676 proteins were detected;of these, 4 proteins cha.ged significa.tly a.d were successfully identified. TPM4 a.d a.Oa. from the ra.ia.ion trea.ed tissue were shown to be significa.tly decrea.ed, wherea. IGKC a.d VDa.1 were found to be significa.tly increa.ed. The proteomic technique combined with the ePTFE tube wound model ca. elucida.e some of the molecula. a.tera.ions in the wound hea.ing induced by ra.ia.ion thera.y. The protein modifica.ions of TPM4, a.Oa., IGKC a.d VDa.1 ma. influence the cell prolifera.ion, a.optosis a.d the infla.ma.ion of the tissue repa.r process.

关键词： TRa. Fla. Ra.ia.ion Thera.y Reconstructive Surgery Huma. Proteomics TPM VDa. a.Oa.

骨性关节炎与类风湿关节炎的股骨近端骨结构三维微观结构分析（英文）

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中国组织工程研究 2015年第7期19卷 996-1002页

作者：王佰亮 Ming Ding S?ren overgaard 卫生部中日友好医院关节外科南丹麦大学欧登塞大学医院骨科实验室南丹麦大学欧登塞大学医院骨科

背景:人工关节假体松动的原因除了手术技术、假体设计及其产生的磨损颗粒等因素以外,假体周围的骨质量也起着极为重要的作用。骨微观结构是影响骨质量主要因素,应用技术分析组织微观结构目前已初步用于各种骨骼疾病的研究。目的:应用mic... 详细信息

背景:人工关节假体松动的原因除了手术技术、假体设计及其产生的磨损颗粒等因素以外,假体周围的骨质量也起着极为重要的作用。骨微观结构是影响骨质量主要因素,应用技术分析组织微观结构目前已初步用于各种骨骼疾病的研究。目的:应用micro-CT技术,观察类风湿性关节炎与骨性关节炎股骨近端骨组织性能变化,对比研究两者之间的骨微观结构差异。方法:收集原发性骨关节病和类风湿性关节炎患者因行全髋关节置换而切除的股骨头(骨性关节炎10个,类风湿关节炎7个)。根据每个股骨头标本X射线上主要骨小梁方向,取材并制作来自于股骨颈骨组织的10 mm标本,然后进行micro-CT扫描,数据转换成3D图像数据后,分析两组之间皮质骨、松质骨以及股骨颈整体的骨微结构参数,做统计学处理。结果与结论:骨性关节炎与类风湿性关节炎的股骨颈骨组织的微结构(皮质骨、松质骨以及整体)差异无显著性意义;两种疾病的股骨颈骨组织的整体微结构特点与松质骨结构特点相近。与类风湿患者相比,骨关节炎患者骨小梁的连接性密度丢失较多,皮质骨的骨小梁定向分布程度升高,而松质骨和整体的骨小梁定向分布程度降低。结果证实,骨性关节炎与类风湿性关节炎的皮质骨、松质骨以及整体股骨颈骨组织的微结构无显著差异,这提示两种疾病的股骨颈整体的微结构退变是相同的。

关键词：骨关节炎髋关节炎,类风湿股骨颈组织构建骨组织工程微观结构类风湿性关节炎微观CT 皮质骨松质骨骨质疏松髋关节骨组织

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放射、高温和MISO联合应用的交互作用

中华放射肿瘤学杂志 1988年第4期 36-40页

作者：毛慧生,Jens overgaard 天津肿瘤研究所丹麦肿瘤研究所

肿瘤组织内乏氧细胞的存在已被视为造成某些肿瘤放射治疗失败的主要原因。克服这些问题的途径包括使用乏氧细胞放射增敏剂及高温。而近年来,在动物实验中,人们更感兴趣的是将放射、加温和MISO三者合并使用(1～4,9)。但迄今,三者联合治... 详细信息

肿瘤组织内乏氧细胞的存在已被视为造成某些肿瘤放射治疗失败的主要原因。克服这些问题的途径包括使用乏氧细胞放射增敏剂及高温。而近年来,在动物实验中,人们更感兴趣的是将放射、加温和MISO三者合并使用(1～4,9)。但迄今,三者联合治疗的相互作用尚欠详尽的研究,尤其对于不引起正常组织明显损伤的治疗温度(41.5℃)及临床易于采用的治疗间隔(照射后30分钟

关键词：肿瘤组织联合应用放射增敏照射剂量治疗温度乏氧细胞 MISO 交互作用