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Short lessons in ba.ic life support improve self-a.sura.ce in performing ca.diopulmona.y resuscita.ion

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World Journa. of Emergency Medicine 2016年第4期7卷 255-262页

作者： Ma.io Kobra. Sa.cha.La.gewa.d Christina.Murr Christia.e neu Jea.nette Schmid Depa.tment of a.a.sthesiology Intensive Care and Emergency Medicine Asklepios Western Clinical Centre 20 Suurheid City of Hamburg 22559 Federal Republic of Germany a.a.emy of the Rescue Service Coopera.ion in Schleswig-Holstein 50 Esmarch Street City of Heide 25746 Federal Republic of Germany Regio Clinica. Center GmbH Sana Group 71 75 Ramskamp Elmshorn 25337 County of Pinneberg Federal Republic of Germany Executive Committee of the Goethe University Fra.kfurt a.M. City of Frankfurt 60323 Federal Republic of Germany

Ba.KGROUND:There a.e severa. rea.ons why resuscita.ion mea.ures ma. lea. to inferior results:difficulties in tea. building,dela.ed rea.iza.ion of the emergency a.d interruption of chest *** study investiga.ed the outcome of a.new form of in-hospita. ca.diopulmona.y resuscita.ion(CPR) tra.ning with specia. focus on cha.ges in self-a.sura.ce of potentia. helpers when fa.ed with emergency ***:Following a.12-month period of CPR tra.ning,questionna.res were distributed to pa.ticipa.ts a.d *** non-pa.ticipa.ts who intended to undergo the tra.ning a. a.la.er da.e served a. control ***:The study showed tha. pa.ticipa.ts experienced a.significa.t improvement in selfa.sura.ce,compa.ed with their remembered self-a.sura.ce before the *** self-a.sura.ce a.so wa. significa.tly grea.er tha. tha. of the control group of ***:Short lessons in CPR ha.e a. impa.t on the self-a.sura.ce of medica. a.d non-medica. personnel.

关键词： Ba.ic life support Simula.ion tra.ning Non-technica. skills Ca.diopulmona.y resuscita.ion

Understa.ding Genetic Loa. in Pota.o for Hybrid Diploid Breeding

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Molecula. Pla.t 2019年第7期12卷 896-898页

作者： Christia. W.B.Ba.hem Herma. J.va. eck Michiel E.de Vries Pla.t Breeding Wageningen University and Research Wageningen the Netherlands Solynta Wageningen the Netherlands

Recently, Zha.g et a..(2019) ha.e ma.a.ed to provide a.unda.t evidence to support long-held theories rega.ding mecha.isms of inbreeding depression a.d potentia. effects of heterosis tha. a.e likely to ha.e a.considera.le impa.t on pota.o breeding in the future (Figure 1). Despite its la.ge genetic va.ia.ion rega.ding yield, ha.vest index, a.d wa.er use efficiency, pota.o breeding ha. a.ta.ned only negligible a.va.ces in the most importa.t breeding goa.s such a. yield, tuber qua.ity, a.d a.iotic stress tolera.ce, a.d only modest progress in pa.hogen resista.ce. This low level of improvement is clea.ly due to the complexity of breeding a.heterozygous tetra.loid outbreeder ra.her tha. to the la.k of genetic potentia. a.a.la.le in wild a.d cultiva.ed ma.eria.. In contra.t, breeding a. the diploid level, in pa.ticula. in combina.ion with self-compa.ibility, will a.low the fixa.ion of beneficia. a.leles to homozygosity.

关键词： Genetic Loa. Pota.o Hybrid Diploid Breeding

Investiga.ion of Li-ion tra.sport in Li7P3S11 a.d solid-sta.e lithium ba.teries

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Journa. of Energy Chemistry 2019年第11期28卷 1-7页

作者： Chua.g Yu Swa.na.Ga.a.a.hy Ernst R.H.va. eck La.bert va. Eijck Niek de Klerk Erik M.Kelder Ma.nix Wa.ema.er Depa.tment of Ra.ia.ion Science a.d Technology Delft University of TechnologyMekelweg 152629JB Delftthe Netherlands Institute for Molecules a.d Ma.eria.s Radboud University NijmegenHeyendaalseweg 1356525 AJ Nijmegenthe Netherlands

The high Li-ion conductivity of the Li7P3S11 sulfide-ba.ed solid electrolyte ma.es it a.promising ca.dida.e for a.l-solid-sta.e lithium ba.teries. The Li-ion tra.sport over electrode-electrolyte a.d electrolyteelectrolyte interfa.es, vita. for the performa.ce of solid-sta.e ba.teries, is investiga.ed by impeda.ce spectroscopy a.d solid-sta.e NMR experiments. a. a.l-solid-sta.e Li-ion ba.tery is a.sembled with the Li7P3S11 electrolyte, na.o-Li2S ca.hode a.d Li-In foil a.ode, showing a.rela.ively la.ge initia. discha.ge ca.a.ity of 1139.5 m a./g a. a.current density of 0.064 m a.cm^ 2 reta.ning 850.0 m a./g a.ter 30 cycles. Electrochemica. impeda.ce spectroscopy suggests tha. the decrea.e in ca.a.ity over cycling is due to the increa.ed interfa.ia. resista.ce between the electrode a.d the electrolyte. 1D excha.ge ^7Li NMR qua.tifies the interfa.ia. Li-ion tra.sport between the uncycled electrode a.d the electrolyte, resulting in a.diffusion coefficient of 1.70(3) ×10^-14cm^2/s a. 333 K a.d a. energy ba.rier of 0.132 e V for the Li-ion tra.sport between Li2S ca.hode a.d Li7P3S11 electrolyte. This indica.es tha. the ba.rier for Li-ion tra.sport over the electrode-electrolyte interfa.e is sma.l. However, the sma.l diffusion coefficient for Li-ion diffusion between the Li2S a.d the Li7P3S11 suggests tha. these conta.t interfa.es between electrode a.d electrolyte a.e rela.ively sca.ce, cha.lenging the performa.ce of these solid-sta.e ba.teries.

关键词： Li7P3S11 Li-ion tra.sport Spin-la.tice NMR Excha.ge NMR Solid-sta.e ba.tery

Toma.o fruit a. a.model for tissue-specific gene silencing in crop pla.ts

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Horticulture Resea.ch 2020年第1期7卷 839-845页

作者： a.i Feder Sa.a. Jensen a.qua. Wa.g La.ce Courtney Lesley Middleton Joyce Va. eck Yongsheng Liu Ja.es J.Giova.noni Boyce Thompson Institute for Pla.t Resea.ch Cornell UniversityIthacaNYUSA Section of Pla.t Breeding a.d Genetics Cornell UniversityIthacaNYUSA School of Biotechnology a.d Food Engineering Hefei University of Technology230009 HefeiChina Section of Pla.t Biology Cornell UniversityIthacaNYUSA US Depa.tment of a.riculture–a.ricultura. Resea.ch Service Robert W.Holley Center for Agriculture and HealthIthacaNYUSA

Use of CRISPR-Ca.9(Clustered Regula.ly Interspa.ed Short Pa.indromic Repea.s(CRISPR)-CRISPR-a.socia.ed 9)-media.ed genome editing ha. prolifera.ed for use in numerous pla.t species to modify gene function a.d expression,usua.ly in the context of either tra.sient or sta.ly inherited genetic *** extremely useful in ma.y a.plica.ions,modifica.ion of some loci yields outcomes detrimenta. to further experimenta. eva.ua.ion or via.ility of the ta.get *** of Ca.9 under a.promoter conferring gene knockouts in a.tissue-specific subset of genomes ha. been demonstra.ed in insect a.d a.ima. models,a.d recently in *** developed a. in pla.ta.GFP(green fluorescent protein)a.sa. system to demonstra.e fruit-specific gene editing in toma.o using a.phosphoenolpyruva.e ca.boxyla.e 2 gene *** then ta.geted a.SET-doma.n conta.ning polycomb protein,SlEZ2,previously shown to yield pleiotropic phenotypes when ta.geted via.^(35)S-driven RNa.interference a.d we were a.le to cha.a.terize fruit phenotypes a.sent a.ditiona. developmenta. ***-specific gene editing will ha.e a.plica.ions in a.sessing function of essentia. genes otherwise difficult to study via.germline modifica.ions a.d will provide routes to edited genomes in tissues tha. could not otherwise be recovered when their germline modifica.ion perturbs their norma. development.

关键词： otherwise specific editing

Ma.a.ement of occluded self-expa.ding bilia.y meta. stents in ma.igna.t bilia.y disea.e

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2018年第1期17卷 49-54页

作者： Simon Nennstiel Isolde Tschurtschentha.er Bruno neu Ha.a.a.gül Monther Ba.bouj Rola.d M. Schmid Stefa. von Delius a.drea. Weber Klinik und Poliklinik fur Innere Medizin Ⅱ Klinikum rechts der Isar der Technischen Universitar Manchen Ismaninger Straβe 22 Munich 81675 Germany Medizinische Klinik II Krankenhaus Landshut-Achdorf Academic Teaching Hospital Technische Universitar Munchen Achdorferweg 3 Landshut 84036Germany

Ba.kground: Occlusion of self-expa.ding meta. stents(SEMS) in ma.igna.t bilia.y obstruction occurs in up to 40% of pa.ients. This study a.med to compa.e the different techniques to resolve stent occlusion in our collective of ***: Pa.ients with ma.igna.t bilia.y obstruction a.d occlusion of bilia.y meta. stent a. a.tertia.y referra. endoscopic center were retrospectively identified between a.ril 1, 1994 a.d Ma. 31, 2014. The clinica. records were further a.a.yzed rega.ding the cha.a.teristics of pa.ients, ma.igna.t strictures, SEMS,ma.a.ement stra.egies, stent pa.ency, subsequent interventions, surviva. time a.d ca.e ***: a.tota. of 108 pa.ients with bilia.y meta. stent occlusion were identified. Seventy-nine of these pa.ients were eligible for further a.a.ysis. Fa.ored ma.a.ement wa. pla.tic stent insertion in 73.4% pa.ients. Second SEMS were inserted in 12.7% pa.ients. Percuta.eous tra.shepa.ic bilia.y dra.na.e a.d mecha.ica. clea.sing were conducted in a.minority of pa.ients. Further a.a.ysis showed no sta.istica.ly significa.t difference in media. overa.l seconda.y stent pa.ency(88 vs. 143 da.s, P = 0.069), media. surviva. time(95 vs. 192 da.s, P = 0.116), media. subsequent intervention ra.e(53.4% vs. 40.0%, P = 0.501)a.d media. ca.e cha.ge(€5145 vs. €3473, P = 0.803) for the trea.ment with a.second meta. stent insertion compa.ed to pla.tic stent insertion. In pa.ients with surviva. time of more tha. three months,significa.tly more pa.ients trea.ed with pla.tic stents needed re-interventions tha. pa.ients trea.ed with second SEMS(93.3% vs. 57.1%, P = 0.037).Conclusions: In ma.igna.t bilia.y strictures, both pla.tic a.d meta. stent insertions a.e fea.ible stra.egies for the trea.ment of occluded SEMS. Our da.a.suggest tha. in pa.lia.ive bilia.y stenting, pa.ients especia.ly those with longer expected surviva. might benefit from second SEMS insertion. Ca.eful pa.ient selection is importa.t to ensure a.proper decision for either ma.a.ement

关键词： Self-expa.ding meta. stents Bilia.y tra.t neopla.ms Endoscopic retrogra.e chola.giopa.crea.ogra.hy Bilia.y tra.t disea.es Complica.ions

Sca.enger receptor BI: a.multi-purpose pla.er in cholesterol a.d steroid meta.olism

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World Journa. of Ga.troenterology 2010年第47期16卷 591-5924页

作者： Menno Hoekstra.Theo JC Va. Berkel Mira.da.Va. eck Division of Biopha.ma.eutics Leiden/Amsterdam Center for Drug Research Gorlaeus Laboratories

Sca.enger receptor cla.s B type Ⅰ (SR-BI) is a. importa.t member of the sca.enger receptor fa.ily of integra. membra.e glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol a.d steroid meta.olism. SR-BI in hepa.ocytes is the sole molecule involved in selective upta.e of cholesteryl esters from high-density lipoprotein (HDL). SR-BI pla.s a.physiologica. role in binding a.d upta.e of na.ive a.olipoprotein B (a.oB)-conta.ning lipoproteins by hepa.ocytes, which identif ies SR-BI a. a.multipurpose pla.er in lipid upta.e from the blood circula.ion into hepa.ocytes in mice. In a.renocortica. cells, SR-BI media.es the selective upta.e of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from a.rena. glucocorticoid insuff iciency, which suggests tha. functiona. SR-BI protein is necessa.y for optima. a.rena. steroidogenesis in mice. SR-BI in ma.ropha.es pla.s a.dua. role in cholesterol meta.olism a. it is a.le to ta.e up cholesterol a.socia.ed with HDL a.d a.oBconta.ning lipoproteins a.d ca. possibly fa.ilita.e cholesterol efflux to HDL. a.sence of SR-BI is a.socia.ed with thrombocytopenia.a.d a.tered thrombosis susceptibility, which suggests a.novel role for SR-BI in regula.ing pla.elet number a.d function in mice. Tra.sgenic expression of cholesteryl ester tra.sfer protein in huma.ized SR-BI knockout mice norma.izes hepa.ic delivery of HDL-cholesteryl esters. However, other pa.hologies a.socia.ed with SR-BI def iciency, i.e. increa.ed a.herosclerosis susceptibility, a.rena. glucocorticoid insuffi ciency, a.d impa.red pla.elet function a.e not norma.ized, which suggests a. importa.t role for SR-BI in cholesterol a.d steroid meta.olism in ma.. In conclusion, genera.ion of SR-BI knockout mice ha. signif ica.tly contributed to our knowledge of the physiologica. role of SR-BI. Studies using these mice ha.e identif ied SR-BI a. a

关键词： Sca.enger receptor cla.s B type Ⅰ Highdensity lipoprotein Cholesterol Lipoprotein meta.olism Liver Ma.ropha.es a.rena. gla.d Pla.elets Steroido- genesis

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三氟哌酸与利福平联合的抗菌作用

中国抗生素杂志 1991年第3期16卷 187-192,208页

作者：张永信 H.C.neu 上海医科大学抗生素研究所上海200040 美国纽约哥伦比亚大学医学院

三氟哌酸对需氧的革兰氏阴性杆菌和葡萄球菌有优异的抗菌活性,但对链球菌和厌氧菌活性低,而这些菌对利福平敏感。利福平固定为2μg/ml或8μg/ml与三氟哌酸作联合药敏试验。结果表明两药联合后不产生协同、相加和无关各占14.6％和83.6％,... 详细信息

三氟哌酸对需氧的革兰氏阴性杆菌和葡萄球菌有优异的抗菌活性,但对链球菌和厌氧菌活性低,而这些菌对利福平敏感。利福平固定为2μg/ml或8μg/ml与三氟哌酸作联合药敏试验。结果表明两药联合后不产生协同、相加和无关各占14.6％和83.6％,仅1株菌呈现拮抗(1.8％)。5株试验菌的药物联合杀菌曲线也未见协同。提示两药联合,虽然相互无关,但却能抑制一些三氟哌酸单药不足以抑制的细菌,值得进一步作临床应用研究。

关键词：三氟哌酸利福平联合抗菌作用

Fea.ibility study for genetic testing a.d SNP a.a.ysis in infa.ts

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Open Journa. of Nursing 2014年第2期4卷 67-73页

作者： Ma.a.ynn neu Ma.isa.Ehringer Ca.sa.dra.Ma.cheggia.i-Howa.d College of Nursing University of Colorado Aurora Colorado USA Institute of Beha.iora. Genetics University of Colorado Boulder Colorado USA

Purpose: Determine whether pa.ents would consent to genotyping for tempera.ent cha.a.teristics for their infa.ts;esta.lish tha. qua.ity DNa.is obta.ned from infa.ts using a.cheek swa.. Design a.d Methods: Seventeen mother-fa.her dya.s a.d infa.ts, 11 to 35 weeks of a.e, who ha. pa.ticipa.ed in a.GERD (ga.troesopha.ea. reflux disea.e) ma.sa.e study pa.ticipa.ed in this fea.ibility study. Results: Seventy-one percent of pa.ents a.reed to genotyping. Most pa.ents who pa.ticipa.ed were concurrently enrolled in the GERD ma.sa.e study. Rea.ons provided for pa.ticipa.ing were support of resea.ch a.d the desire to help other fa.ilies who ha. infa.ts with GERD. Pa.ents who pa.ticipa.ed a.so ha. higher educa.iona. a.ta.nment tha. those who declined. Rea.ons for declining were dislike of genetic resea.ch. a.l sa.ples could be a.a.yzed. Pra.tice Implica.ions. Ma.y pa.-ents a.lowed genotyping, especia.ly if currently enga.ed with resea.ch sta.f. Cheek swa.s a.e a.noninva.ive a.d sa.isfa.tory method of DNa.collection.

关键词： DNA Infa.ts Tempera.ent Pa.ent Consent

Endoscopic stent thera.y in pa.ients with chronic pa.crea.itis:a.5-yea. follow-up study

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World Journa. of Ga.troenterology 2013年第5期19卷 715-720页

作者： a.drea. Weber Jochen Schneider Bruno neu a.exa.der Meining Peter Born Stefa. von Delius Monther Ba.bouj Rola.d M Schmid Ha.a.a.gül Christia. Prinz II Medizinische Klinik und Poliklinik Klinikum Rechts der IsarTechnische Universitt München81675 MünchenGermany II Medizinische Klinik Gastroenterologie und HepatologieHelios Klinikum WuppertalUniversitt Witten/Herdecke42283 WuppertalGermany

a.M:This study a.a.yzed clinica. long-term outcomes a.ter endoscopic thera.y,including the incidence a.d trea.ment of rela.se. METHODS:This study included 19 consecutive pa.ients(12 ma.e,7 fema.e,media. a.e 54 yea.s)with obstructive chronic pa.crea.itis who were a.mitted to the 2nd Medica. Depa.tment of the Technica. University of *** pa.ients presented severe chronic pa.crea.itis(sta.eⅢ°)a.cording to the Ca.bridge *** ma.ority of the pa.ients suffered intermittent pa.n a.ta.ks.6 of 19 pa.ients ha. strictures of the pa.crea.ic duct;13 of 19 pa.ients ha. strictures a.d *** first endoscopic retrogra.e pa.crea.ogra.hy(ERP)included a. endoscopic sphincterotomy, dila.a.ion of the pa.crea.ic duct,a.d stent *** first control ERP wa. performed 4 wk a.ter the initia. intervention,a.d the subsequent control ERP wa. performed a.ter 3 mo to re-eva.ua.e the clinica. a.d morphologica. *** follow-up wa. performed a.nua.ly to document the course of pa.n a.d the ma.a.ement of *** course of pa.n wa. a.sessed by a.pa.n sca.e from 0 to *** da.e a.d choice of the thera.eutic procedure were documented in ca.e of rela.se. RESULTS:Initia. endoscopic intervention wa. successfully completed in 17 of 19 *** 17 pa.ients reported pa.tia. or complete pa.n relief a.ter endoscopic *** thera.y fa.led in 2 pa.ients. Both pa.ients were excluded from further *** fa.led pa.ient underwent surgery,a.d the other pa.ient wa. trea.ed conserva.ively with pa.n *** of 19 pa.ients were followed a.ter the successful completion of endoscopic stent *** of 17 pa.ients were lost to *** pa.ient wa. not a.a.l-a.le for interviews a.ter the 1st yea. of *** pa.ients died during the 3rd yea. of *** both pa.ients chronic pa.crea.itis wa. excluded a. the ca.se of *** pa.ient died of myoca.dia. infa.ction, a.d one pa.ient succumbed to *** three pa.ient

关键词： Chronic pa.crea.itis Pa.n Stent thera.y Endoscopic retrogra.e chola.giopa.crea.ogra.hy Pa.crea.icolithia.is