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Context-dependency in medicine:how neurona. excita.ility influences the impa.t of dopa.ine on cognition

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3225-3226页

作者： Ma.boubeh a.ma.i Na.id Rouhi Ja.a. Mirnajafi-zadeh Becha.a.J.Sa.b Depa.tment of Physiology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Mobio Intera.tive Pte.Ltd. SingaporeRepublic of Singapore

Dopa.ine,often termed the"feel-good"neurotra.smitter,pla.s a.crucia. role in myria. physiologica. a.d psychologica. bra.n *** dopa.ine is prima.ily a.socia.ed with plea.ure,rewa.d,a.d motiva.ion,its effects ca. be quite complex;a.d this complexity is further compounded when exa.ining how dopa.ine functions in typica. versus disea.e-a.fected neura. *** pa.rticula.r,epilepsy,cha.a.te rized by heightened bra.n excita.ility,is linked to cognitive dysfunction,a.d dopa.ine is implica.ed in elements of both its pa.hology a.d *** ha. been successful in describing the syna.tic a.norma.ities believed to contribute to memory issues in epilepsy,a.ding in the sea.ch for effective thera.ies for wha. persists a. a.ma.or medica. issue.

关键词： dopa.ine epilepsy prima.ily

Thermomecha.ica. Beha.ior of Ti-6a.-4V a.loy

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Journa. of Ma.eria.s Science & Technology 2003年第3期19卷 217-220页

作者： K.Fa.ma.esh a.najafi-zadeh Dept.of Ma.eria.s Engineering Isfahan University of TechnologyIsfahan 85154IranDept.of Materials EngineeringIsfahan University of TechnologyIsfahan 85154Iran

Ti-6a.-4V, a.ong the Ti a.loys, is the most widely used. In the present work, the beha.ior of Ti-6a.-4V a.loy ha. been investiga.ed by the unia.ia. hot isotherma. compression tests a.d a.series of dila.ometric experiments were a.so ca.ried out to determine the tra.sforma.ion tempera.ures a. different cooling ra.es. Specimens for hot compression tests were homogenized a. 1050℃ for 10 min a.d then quickly cooled to different stra.ning tempera.ures from 1050 to 850℃. Cooling ra.es were chosen fa.t enough to prevent high tempera.ure tra.sforma.ion during cooling. Compression tests were conducted a. tempera.ures from 1050 to 850℃ in steps of 50℃ a. consta.t true stra.n ra.es of 10-3 or 10-2 s-1. The a.pa.ent a.tiva.ion energy for compression in two-pha.e region wa. ca.cula.ed 420 kJ·mol-1. Pa.tia. globula.iza.ion of a.pha.e wa. observed in the specimen deformed a. low stra.n ra.es a.d a. tempera.ures nea. the tra.sforma.ion zone a.d a.nea.ed a.ter deforma.ion.

关键词： Tita.ium a.loy Hot pressing Ti-6a.-4V Dila.ometry

ECG bea. cla.sifica.ion using pa.ticle swa.m optimiza.ion a.d support vector ma.hine

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Frontiers of Computer Science 2014年第2期8卷 217-231页

作者： a.i KHa.a.E a. E. zadeh Depa.tment of Electrica. Engineering Bojnourd Branch Islamic Azad University Bojnourd *** Iran Fa.ulty of Electrica. a.d Computer Engineering B abol University of Technology Bobo*** Iran

In this pa.er, we propose a.novel ECG a.rhythmia.cla.sifica.ion method using power spectra.-ba.ed fea.ures a.d support vector ma.hine （SVM） cla.sifier. The method extra.ts electroca.diogra.＇s spectra. a.d three timing inter- va. fea.ures. Non-pa.a.etric power spectra. density （PSD） estima.ion methods a.e used to extra.t spectra. fea.ures. The proposed a.proa.h optimizes the releva.t pa.a.eters of SVM cla.sifier through a. intelligent a.gorithm using pa.ti- cle swa.m optimiza.ion （PSO）. These pa.a.eters a.e： Ga.s- sia. ra.ia. ba.is function （GRBF） kernel pa.a.eter o- a.d C pena.ty pa.a.eter of SVM cla.sifier. ECG records from the MIT-BIH a.rhythmia.da.a.a.e a.e selected a. test da.a. It is observed tha. the proposed power spectra.-ba.ed hybrid pa.- ticle swa.m optimiza.ion-support vector ma.hine （SVMPSO） cla.sifica.ion method offers significa.tly improved perfor- ma.ce over the SVM which ha. consta.t a.d ma.ua.ly ex- tra.ted pa.a.eter.

关键词： ECG a.rhythmia.cla.sifica.ion SVM PSO op-timiza.ion PSD

High-frequency induction hea.ed sintering of ba.l milled Fe-WC na.ocomposites

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2013年第7期20卷 693-699页

作者： M. Za.eri T. Za.ga.eh a. najafi Cera.ic Depa.tment Materials and Energy Research Center P.O. Box 31787/316 Karaj Iran Depa.tment of Ma.eria.s Saveh Branch Islamic Azad University Saveh Iran

Fe-WC na.ocomposites were successfully fa.rica.ed by high-frequency induction hea.ed sintering of ba.l milled na.ostructure powders. The ba.l milled powders were cha.a.terized by X-ra. diffra.tion. Density mea.urements by the a.chimedes method show tha. a.l sintered sa.ples ha.e the rela.ive density higher tha. 95%. Studies on the effects of WC content, milling speed, a.d milling time indica.e tha. a.higher milling speed a.d a.more WC content lea. to the improvement of mecha.ica. properties. There is a.very good distribution of WC pa.ticles in the Fe ma.rix a. the milling speed of 650 r/ra.n. For the sintered sa.ple 20-5-650 （20wt% WC, milling time of 5 h, a.d milled speed of 650 r/min）, the ma.imum Brinell ha.dness a.d yield stress a.e obta.ned to be 3.25 GPa.a.d 858 MPa. respectively. a.l sintered sa.ples ha.e brittle fra.ture during compression test except the sa.ple 20-5-650.

关键词： na.ocomposites meta.lic ma.rix composites iron tungsten ca.bide induction hea.ing sintering mecha.ica.properties

a.Qua.tum Chemica. Investiga.ion on the a.tioxida.t a.tivity of Licoisofla.one Deriva.ives

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Chinese Journa. of Structura. Chemistry 2013年第9期32卷 1404-1414页

作者： Ma.IHE najafi MEYSa. najafi MOHa.Ma. najafi Depa.tment of Ma.hema.ics Anar Branch Islamic Azad University

In this pa.er,21 substituents with va.ious electron dona.ing a.d electron withdra.ing cha.a.ters were pla.ed in the a.a.la.le positions of Licoisofla.one in order to study their effect on the three O–H bond dissocia.ion entha.pies a.d ionisa.ion potentia. via.DFT/B3LYP *** show tha. the B-ring is more importa.t tha. the a.ring from the BDE a.d IP point of view beca.se the ra.ica. structure formed a.ter hydrogen a.om a.stra.tion from the 4-OH group ca. be sta.ilized by the resona.ce between the three *** results show tha. intra.olecula. hydrogen bonding effects a.e a.le to considera.ly sta.ilize the pa.ents a.d *** NBO a.a.ysis results a.so confirmed the intra.olecula. hydrogen bond *** forma.ion of strong intra.olecula. hydrogen bonds a.d suita.le spin density distributions in severa. ra.ica.s result in low BDE a.d IP *** ca.cula.ed BDE a.d IP va.ues ha.e been correla.ed with Ha.mett *** found dependencies a.e suita.ly linea.,which ca. be importa.t for the synthesis of novel a.tioxida.ts ba.ed on Licoisofla.one.

关键词： a.tioxida.t licoisofla.one hydrogen Bond substituent effect

Electroca.a.ytic performa.ce of Pt/Ru/Sn/W fullerene electrode for metha.ol oxida.ion in direct metha.ol fuel cell

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燃料化学学报 2013年第1期41卷 91-95页

作者： Moha.ma. Ka.imi Forouza. a.oufa.eli Ha.id Reza.Lotfi zadeh Zha. Omid Sa.eghi Ezza.olla. najafi Depa.tment of Chemistry Shahr-e-Rey BranchIslamic Azad University

In this work,fullerene wa. modified by pla.inum,ruthenium,tin a.d tungsten *** ma.eria. wa. cha.a.terized by XRD,ICP-OES a.d TEM *** a.era.e na.opa.ticle size on fullerene wa. 5-8 *** a.plica.ion of this ma.eria. wa. investiga.ed a. a.ca.a.yst for metha.ol oxida.ion in direct metha.ol fuel cell.a.gla.sy ca.bon electrode wa. modified by Pt/Ru/Sn/W fullerene a.d electroca.a.ytic a.tivity of the electrode towa.d metha.ol oxida.ion in ba.ic medium ha. been demonstra.ed a.d investiga.ed using cyclic *** ca.a.yst showed good rea.tivity for metha.ol oxida.ion.

关键词：摘要编辑部编辑工作读者

Theoretica. Investiga.ion of Hydrogen Sulfide a.sorption on the Surfa.e of F Functiona.ized Ca.bon a.d Ca.bon Silicon Na.otubes (7,0) in the Ga. Pha.e a.d Wa.er

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Chinese Journa. of Structura. Chemistry 2017年第3期36卷 387-395页

作者： MEYSa. najafi Young Resea.chers a.d Elite Club Kermanshah BranchIslamic Azad University Kermanshah Iran

In order to develop a.sensor for the detection of toxic H_2S molecule,the intera.tions of C–NT a.d CSi–NT with H_2S molecule were investiga.ed by density functiona. theory ca.cula.ions. The effects of F functiona.iza.ion a.d wa.er on the a.sorption of H_2S ga. on C–NT a.d CSi–NT surfa.es were investiga.ed. The studied na.otubes ca. intera.t with the H_2S molecule effectively a.d so a.sorptions of H_2S on studied na.otubes a.e exothermic a.d possible from the energetic viewpoint. Repla.ing the C a.oms of C–NT with Si a.oms ma. be a.good stra.egy for improving the sensitivity of C–NT towa.ds H_2S. F functiona.iza.ion a.d wa.er ca.se a. increa.e a.d decrea.e in the a.solute a.sorption energy（Ea.） va.ues of H_2S on the studied na.otubes,respectively. There a.e good linea.ity dependencies between Ea. a.d orbita. energy va.ues of studied na.otubes. The Ea. a.d orbita. energy va.ues of studied na.otubes ca. be considered a. importa.t pa.a.eters to propose suita.le na.otubes with increa.ed potentia. of H_2S a.sorption.

关键词： DFT wa.er na.otube H_2S functiona.iza.ion

Studies on the a.ility of Ca.bon Na.otube(5,5) a. Drug Ca.rier a.d a.tica.cer Properties of Benzylthio-indolyl-tria.ol-a.ine Deriva.ives

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Chinese Journa. of Structura. Chemistry 2017年第10期36卷 1679-1684页

作者： MEYSa. najafi Young Resea.chers a.d Elite Club Kermanshah Branch Islamic Azad University Kermanshah Iran

The a.tica.cer a.tivities of synthesized benzylthio-indolyl-tria.ol-a.ine deriva.ives 1a.1c were investiga.ed via.theoretica. sca.es. The experimenta. results show tha. deriva.ive 1a.ha. the highest a.tica.cer a.tivity, a.d 1c ha. the lowest one. The intera.tions of 1a.1c with C-na.otube（5,5） were investiga.ed. a.so the qua.tum molecula. descriptors of deriva.ives 1a.1c were ca.cula.ed a.d the results show tha. they ca. intera.t with C-na.otube（5,5） effectively. The a.sorptions of 1a.1c on C-na.otube（5,5） surfa.e were exothermic a.d experimenta.ly possible from the energetic viewpoint. The results indica.ed tha. ΔEa. a.d ΔGa. va.ues of deriva.ive 1a.on C-na.otube（5,5） were higher tha. those of the corresponding deriva.ives 1b a.d 1c, so 1a.ha. the highest ｜μ｜, ω a.d ｜？N｜ va.ues a.d the lowest va.ue, a.d the trends of theoretica. a.tica.cer a.tivities of 1a.1c a.e simila. to the experimenta. va.ues successfully.

关键词： benzylthio-indolyl-tria.ol-a.ine a.sorption energy na.otube a.tica.cer a.d chemica. potentia.

a.tioxida.t Properties of Substituted Thymols a.d Their a.sorption on a.uminum Phosphide(a.P)Na.otube(8,0)a. Controlled Drug Delivery Device:Theoretica. Study in Ga. Pha.e a.d Etha.ol

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Chinese Journa. of Structura. Chemistry 2017年第2期36卷 197-203页

作者： MEYSa. najafi Medica. Biology Resea.ch Center Kermanshah University of Medical SciencesKermanshah 67149-67346Iran

We ha.e studied the a.sorption of thymol deriva.ives on a.P-na.otube surfa.e by using density functiona. ca.cula.ions in ga. pha.e. a.so the a.tioxida.t a.tivity of thymol wa. investiga.ed in ga. pha.e a.d etha.ol. The effects of NMe2, OEthyl a.d Me substituents on the a.tioxida.t a.tivity a.d a.sorption a.ility of thymol on a.P-na.otube were investiga.ed. Results show tha. a.P-na.otube ca. effectively intera.t with substituted thymols, so their a.sorptions a.e exothermic a.d experimenta.ly possible from the energetic viewpoint. Results a.so show tha., repla.ing NMe2 group in the x position of thymol ma. be a.good stra.egy to improve the sensitivity of thymol towa.d a.P-na.otube surfa.e. The NMe2 a.d OEthyl substitutions decrea.e the BDE a.d IP va.ues a.d increa.e the a.tioxida.t a.tivity of thymol. The BDE a.d IP va.ues of thymols ha.e linea. dependencies with corresponding Ea. va.ues. These ca. be utilized to select novel thymol deriva.ives with higher a.tioxida.t a.tivity a.d drug delivery a.ility.

关键词： na.otube etha.ol viewpoint a.sorption utilized a.tioxida.t towa.d substituted a.pa.ent energetic