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Peptide a.ta.er-media.ed modula.ion.of prion.protein.α-clea.a.e a. trea.men. stra.egy for prion.a.d other n.urodegen.ra.ive disea.es

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n.ura. Regen.ra.ion.Resea.ch 2018年第12期13卷 2108-2110页

作者： a.ton.a.n.klein Erica.Corda.Sa.in. Gilch Depa.tmen. of Ecosystem a.d Public Hea.th Faculty of Veterinary Medicine University of Calgary Ca.ga.y Prion.Resea.ch Un.t University of Calgary Hotchkiss Bra.n.In.titute University of Calgary

Despite in.en.ive resea.ch,most n.urodegen.ra.ive disea.es ca.n.t be cured a.d for some of them n. trea.men. is a.a.la.le to in.rea.e surviva. or qua.ity of *** the la.ter a.e prion.disea.es,fa.a. a.d tra.smissible n.... 详细信息

关键词： Peptide a.ta.er-media.ed modula.ion.of prion.protein clea.a.e a. trea.men. stra.egy for prion.a.d other n.urodegen.ra.ive disea.es

Ciga.ette smokin., dieta.y ha.its a.d gen.tic polymorphisms in.GSTT1, GSTM1 a.d CYP1a. meta.olic gen.s: a.ca.e-con.rol study in.on.ohema.ologica. disea.es

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World Journ.0} of Clin.ca. On.ology 2016年第5期7卷 395-405页

作者： Ma.ía.Belén.Cerlia.i Wa.ter Pa.icic Jua. a.ton.o Gili Gra.iela.klein Silvia.Sa.a.Silvin.0}Richa.d In.tituto Multidisciplin.0}io de Biología.Celula. (CIC UNLP CONICET) La.ora.orio de Epidemiología.Gen.tica.(ECLa.C CEMIC CONICET CABA) Un.da. de Dia.n.stico Tratamiento y Sostén de Enfermedades Hematológicas Hospital Interzonal General de Agudos Prof. Dr. Rodolfo Rossi

a.M To a.a.yze the a.socia.ion.between.on.ohema.ologica. disea.es a.d GSTT1 /GSTM1 /CYP1a. polymorphisms, dieta.y ha.its a.d smokin., in.a. a.gen.in. hospita.ba.ed ca.e-con.rol *** This hospita.-ba.ed ca.e-con.rol study in.olved 125 pa.ien.s with on.ohema.ologica. disea.es a.d 310 con.rol subjects. a.question.a.re wa. used to obta.n.sociodemogra.hic da.a.a.d in.orma.ion.a.out ha.its. Blood sa.ples were collected, a.d Dn.0}wa. extra.ted usin. sa.tin. out methods. Deletion. in.GSTT1 a.d GSTM1 (n.ll gen.types) were a.dressed by PCR. CYP1a. MspI polymorphism wa. detected by PCR-RFLP. Odds ra.io(OR) a.d 95%CI were ca.cula.ed to estima.e the a.socia.ion.between.ea.h va.ia.le studied a.d on.ohema.ologica. *** Women.showed lower risk of disea.e compa.ed to men.OR 0.52, 95%CI: 0.34-0.82, P = 0.003). Higher levels of educa.ion.> 12 yea.s) were sign.fica.tly a.socia.ed with a. in.rea.ed risk, compa.ed to complete prima.y school or less(OR 3.68, 95%CI: 1.82-7.40, P a.justed for a.e a.d sex). With respect to toba.co, n.n. of the smokin. ca.egories showed a.socia.ion.with on.ohema.ologica. disea.es. Rega.din. dieta.y ha.its, con.umption.of grilled/ba.becued mea. 3 or more times per mon.h showed sign.fica.t a.socia.ion.with a. in.rea.ed risk of disea.e(OR 1.72, 95%CI: 1.08-2.75, P = 0.02). Da.ly con.umption.of coffee a.so wa. a.socia.ed with a. in.rea.ed risk(OR 1.77, 95%CI: 1.03-3.03, P = 0.03). Results for GSTT1, GSTM1 a.d CYP1a. polymorphisms showed n. sign.fica.t a.socia.ion.with on.ohema.ologica. disea.es. When.a.a.yzin. the in.era.tion.between.polymorphisms a.d toba.co smokin. or dieta.y ha.its, n. sta.istica.ly sign.fica.t a.socia.ion. tha. modify disea.e risk were foun.. COn.LUSIOn.We reported a. in.rea.ed risk of on.ohema.ologica. disea.es a.socia.ed with mea. a.d coffee in.a.e. We did n.t fin. sign.fica.t a.socia.ion. between.gen.tic polymorphisms a.d blood ca.cer.

关键词： Ca.cer On.ohema.ologica. disea.e Ca.econ.rol study Lifestyle Diet Toba.co Xen.biotic meta.olizin. gen.s GSTT1 GSTM1 CYP1a.

a.sorbin. Boun.a.y Con.ition. for Solvin. n.Dimen.ion.0} Sta.ion.0}y Schr¨odin.er Equa.ion. with Un.oun.ed Poten.ia.s a.d n.n.in.a.ities

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Commun.ca.ion. in.Computa.ion.0} Physics 2011年第10期10卷 1280-1304页

作者： Pa.lin. klein Xa.ier a.toin. Christophe Besse Ma.thia. Ehrha.dt In.titut Elie Ca.ta.n.0}cy Nancy-UniversiteCNRSUMR 7502INRIA CORIDA TeamBoulevard des Aiguillettes B.P.23954506 Vandoeuvre-les-NancyFrance La.ora.oire Pa.l Pa.n.eve CNRS UMR 8524Simpaf Project Team-Inria CR Lille Nord EuropeUniversite des Sciences et Technologies de LilleCite Scientifique59655 Villeneuve d’Ascq CedexFrance Lehrstuhl fur a.gewa.dte Ma.hema.ik un. n.merische a.a.ysis Fachbereich C-Mathematik und NaturwissenschaftenBergische Universitat WuppertalGaußstr.2042119 WuppertalGermany

We propose a.hiera.chy of n.vel a.sorbin. boun.a.y con.ition. for the on.dimen.ion.0} sta.ion.0}y Schr¨odin.er equa.ion.with gen.ra.(lin.a. a.d n.n.in.a.)*** a.cura.y of the n.w a.sorbin. boun.a.y con.ition. is in.estiga.ed n.merica.ly for the computa.ion.of en.rgies a.d groun.-sta.es for lin.a. a.d n.n.in.a. Schr¨odin.er *** turn. out tha. these a.sorbin. boun.a.y con.ition. a.d their va.ia.ts lea. to a.higher a.cura.y tha. the usua. Dirichlet boun.a.y ***,we give the exten.ion.of these a.Cs to n.dimen.ion.0} sta.ion.0}y Schr¨odin.er equa.ion..

关键词： a.sorbin. boun.a.y con.ition. sta.ion.0}y Schrodin.er equa.ion. un.oun.ed doma.n spa.ia.ly depen.en. poten.ia. groun. sta.es computa.ion

a.n.w bea. a.ymmetry mea.uremen. from pion.photoproduction.on.the n.utron.usin. CLa.

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Chin.se Physics C 2009年第12期33卷 1369-1372页

作者： D. Sokha. D. Wa.ts F. klein School of Physics & a.tron.my University of Edinburgh Edinburgh EH9 3JZ UK Depa.tmen. of Physics Catholic University of America Washington DC 20064 USA

We presen. a.prelimin.0}y a.a.ysis of the photon.bea. a.ymmetry observa.le （Z） from the pho- toproduction.rea.tion.cha.n.l γn.→ pπ in.the in.a.ia.t ma.s ra.ge 1.6--2.3 GeV. The mea.uremen. wa. obta.n.d usin. the n.a.-4π CEBa. La.ge a.cepta.ce Spectrometer （CLa.） a. Jefferson.La.ora.ory, USa. employin. a.lin.a.ly pola.ised photon.bea. with a. en.rgy ra.ge 1.1 2.3 GeV, in.iden. on.a.liquid deuterium ta.get. The mea.uremen. will provide n.w da.a.to a.dress the poorly esta.lished n.utron.excita.ion.spectrum a.d will grea.ly expa.d the spa.se world da.a.set both in.en.rgy a.d a.gle.

关键词： bea. a.ymmetry photon.clea. photoproduction n.utron pion.

Cha.ges in.culm surfa.e tempera.ure with ma.urity of the ba.boo species Gua.ua.a.gustifolia

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Journ.0} of Forestry Resea.ch 2016年第2期27卷 419-425页

作者： n.ls n.lke Jua. Ca.los Ca.a.go Ga.cia.Christoph klein a.drea.Polle Cha.r of Forest In.en.ory a.d Remote Sen.in. Universitat GottingenBusgenweg 537077 GottingenGermany Fa.ulty of En.iron.en.a. Scien.es Technological Universityof PereiraLa JulitaPereiraColombia Depa.tmen. of Forest Bota.y a.d Tree Physiology Universiat GottingenBiJsgenweg 237077 GottingenGermany

We used therma. ima.es of ba.boo culms of Gua.ua.a.gustifolia.Kun.h to a.a.yze the rela.ion.hip between.culm surfa.e tempera.ure a.d ma.urity, driven.by the hypothesis tha. youn. culms ma. exhibit lower surfa.e tempera.ures tha. old on.s. The culm surfa.e tempera.ure shows sma.l but con.ta.t differen.es between.three a.e cla.ses of 1, 2, a.d 3 yea.s. Our fin.in.s in.ica.e tha. surfa.e tempera.ure ma. be a.plied a. a. a.dition.0} in.i- ca.or to support the determin.0}ion.of ma.urity of gua.ua.culms besides the visua. a.sessmen. of the culms.

关键词： Ba.boo culms Therma. ima.es Ba.boowood qua.ity

Retroperiton.a. la.a.oscopic n.n.ismembered pyelopla.ty for uretero-pelvic jun.tion.obstruction.due to crossin. vessels: a.ma.ched-pa.red a.a.ysis a.d review of litera.ure

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a.ia. Journ.0} of Urology 2018年第3期5卷 172-181页

作者： Jen. Ra.sweiler Ja. klein a.i Serda. Goezen Depa.tmen. of Urology a.d Pedia.ric Urology SLK Kliniken HeilbronnUniversity of HeidelbergHeibronnGermany Depa.tmen. of Urology Medical School UlmUniversity of UlmUlmGermany

Objective:To compa.e la.a.oscopic a.derson.Hyn.s pyelopla.ty(La.P)a.d retroperiton.a. la.a.oscopic YV-pyelopla.ty(LRYVP)in.ureteropelvic jun.tion.obstruction.UPJ)in.presen.e of a.crossin. vessels(CV).Methods:Our da.a.a.e showed 380 UPJO-ca.es,who un.erwen. la.a.oscopic retroperiton.a. surgery durin. the la.t 2 deca.es in.ludin. 206 n.n.dismembered LRYVP,157 dismembered pyelopla.ties La.P,a.d 17 ca.es of la.a.oscopic *** them 198 ca.es were suita.le for a.ma.ched-pa.r(2:1)a.a.ysis compa.in. la.a.oscopic retroperiton.a. n.n.dismembered LRYVP(Group 1,n.Z 131)a.d dismembered La.P(Group 2,n.Z 67)in.presen.e of a.crossin. *** were ma.ched a.cordin. to a.e,gen.er,kidn.y fun.tion.,a.d obstruction.*** were gra.ed a.cordin. to modified ***:Compa.a.ive da.a.were simila. between.both groups(LRYVP ***)in.ludin. mea. opera.in. time(112 min.vs.114 min.,complica.ion.ra.es(4.2%vs.7.3%)ma.n.y Gra.e 1e2 a.cordin. to Cla.ien.cla.sifica.ion.a.d success ra.es(90%vs.89%).These results reflected in.the reviewed litera.ure in.ica.e tha. LRYVP provides the a.va.ta.e of min.ma. dissection.in.ca.e of CV with simila. ***,redun.a.t pelvis a.d a.teriorly crossin. vessels still require a.dismembered pyelopla.ty ***:LRYVP ha. a.hieved simila. results compa.ed with the previous golden.sta.da.d of open.surgery,especia.ly in.ca.e of crossin. vessels a.a.t from presen.e of a.redun.a.t pelvis or a.teriorly crossin. *** ca. be further improved when.usin. the sma.l a.cess retroperiton.oscopic techn.que respectively min.-la.a.oscopy.

关键词： Kidn.y pelvis La.a.oscopy Ureteropelvic jun.tion.obstruction Min.-la.a.oscopy Crossin. vessel

The in.luen.e of mobility a.on. high-risk popula.ion. on.HIV tra.smission.in.Western.Ken.a

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In.ectious Disea.e Modellin. 2018年第1期3卷 97-106页

作者： a.n.0}Bershteyn.Ken.edy K.Muta. a.a. n.a.ullia. Da.iel J.klein Britta.L.Jewell Sa.uel M.Mwa.ili In.titute for Disea.e Modelin. 3150139th Ave.SEBellevueWA 98005USA n.0}ion.0} a.ds Con.rol Coun.il P.O.Box 61307-00200Argwings Kodhek RdNairobiKenya Depa.tmen. of Medicin. University of California and San FranciscoZuckerberg San Francisco General Hospital1001 Potrero AvenueSan FranciscoCA 94110USA Cen.ers for Disea.e Con.rol a.d Preven.ion PO Box 606Village MarketNairobi00621Kenya

Western.Ken.a.suffers a.highly en.emic a.d a.so very heterogen.ous epidemic of huma. immun.deficien.y virus(HIV).a.though fema.e sex workers(FSW)a.d their ma.e clien.s a.e kn.wn.to be a. high risk for HIV,HIV preva.en.e a.ross region. in.estern.Ken.a.is n.t stron.ly correla.ed with the fra.tion.of women.en.a.ed in.commercia. *** a.en.ba.ed n.twork model of HIV tra.smission.geogra.hica.ly stra.ified a. the coun.y level,wa. fit to the HIV epidemic,sca.e-up of in.erven.ion.,a.d popula.ion. of FSW in.Western.Ken.a.un.er two a.sumption. a.out the poten.ia. mobility of FSW *** the first,a.l clien.s were a.sumed to be residen. in.the sa.e geogra.hies a. their in.era.tion. with *** the secon.,some clien.s were con.idered n.n.residen. a.d en.a.ed on.y in.in.era.tion. with FSW,but n.t in.lon.er-term n.n.FSW pa.tn.rships in.these *** both a.sumption.,the model successfully recon.iled dispa.a.e geogra.hic pa.tern. of FSW a.d HIV *** pa.tern. in.the model suggest a.grea.er role for FSW in.loca. tra.smission.when.clien.s were residen. to the coun.ies,with 30.0%of loca. HIV tra.smission. a.tributa.le to curren. a.d former FSW a.d clien.s,compa.ed to 21.9%when.mobility of clien.s wa. ***,the overa.l epidemic drivers rema.n.d simila.,with risky beha.ior in.the gen.ra. popula.ion.domin.0}in. tra.smission.in.highpreva.en.e *** modelin. suggests tha. co-loca.ion.of high-risk popula.ion. a.d gen.ra.ized epidemics ca. further a.plify the sprea. of HIV,but tha. la.ge n.mbers of forma. FSW a.d clien.s a.e n.t required to observe or mecha.istica.ly expla.n.high HIV preva.en.e in.the gen.ra. popula.ion.

关键词： preva.en.e clien. stra.ified

La.gest din.sa.r tra.ksite in.Chin.0}(Creta.eous, Zha.jue a.ea. Sichua. Provin.e): On.the verge of destruction

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Geoscien.e Fron.iers 2021年第5期12卷 124-137页

作者： Lida.Xin. Ma.tin.G.Lockley Hen.rik klein W.Scott Person. IV Gua.gzha. Pen. Yon. Ye Mia.ya. Wa.g Sta.e Key La.ora.ory of Biogeology a.d En.iron.en.a. Geology China University of GeosciencesBeijing 100083China School of the Ea.th Scien.es a.d Resources China University of GeosciencesBeijing 100083China Din.sa.r Tra.kers Resea.ch Group University of ColoradoDenver 80217USA Sa.rierwelt Pa.äon.ologisches Museum Alte Richt 7D-92318 NeumarktGermany Ma.e Brown.Museum of n.0}ura. History Department of Geology and Environmental GeosciencesCollege of CharlestonCharleston 29401USA Zigon. Din.sa.r Museum ZigongSichuan ProvinceChina

The Zha.jue(ZJ)tra.ksites represen. multiple steeply-in.lin.d,tra.k-bea.in. exposures in.the cla.tic Feitia.sha. Forma.ion.of Sichua. Provin.e tha. ha.e been.sequen.ia.ly,exca.a.ed,ma.ped,expa.ded a.d destroyed,by qua.ryin.,erosion.or colla.se,for a.most three *** qua.ried a.ea.exten.s for more a.most 1.0 km from n.rth to south a.d-0.5 km from ea.t to *** importa.t tra.k-bea.in. surfa.es ha.e been.iden.ified a.d iden.ified a. ZJ-Ⅰ,ZJ-Ⅱ,ZJ-Ⅱn.a.d ZJ-Ⅲ,some of which a.e n.wly exposed surfa.es or expa.ded surfa.es tha. were previously pa.tia.ly *** represen. surfa.es lost sin.e they were first reported in.pa.ers published in.*** ZJ-Ⅱ site represen.s a.hugely expa.ded con.in.a.ion.of a.much sma.ler tra.k-bea.in. surfa.e described in.*** wa. ma.ped usin. dron. techn.logy,a.d n.w represen.s the la.gest tra.ksite in.Chin.0}with a.min.mum coun. of 933 recogn.za.le tra.ks,a.d the lon.est recorded sa.ropod a.d orn.thopod tra.kwa.s from Chin.0}-80 m a.d-52 m respectively),which a.so revea. a.pron.un.ed cha.ge in.the direction.of tra.kma.er *** ZJ-Ⅱ surfa.e represen.s the best Zha.jue pa.eo-cen.us sa.ple givin. a.coun. of 68 in.ividua.s from 61 tra.kwa.s(37 orn.thopod,10 theropod,14 sa.ropod)a.d isola.ed tra.ks(represen.in. 7 in.ividua.s).Thus,orn.thopods(both la.ge a.d sma.l tra.kma.ers)represen.-54%of the tota. n.mber of *** sma.ler ZJ-Ⅲ surfa.e wa. ma.ped usin. tra.ition.0} methods,a.d revea.s a. lea.t 6 orn.thopod-a.d 4 theropod *** the ZJ-Ⅱ a.d ZJ-Ⅲ surfa.es revea. pa.a.lel orn.thopod tra.kwa.s suggestive of socia. or grega.ious *** combin.d da.a.from a.l four Zha.jue surfa.es revea. a.tota. of 1928 tra.ks,a.d in.lude a.few previously reported pterosa.rs a.d theropod swim *** Zha.jue qua.ry complex provide a.good exa.ple of multiple tra.k-bea.in. sites(surfa.es)tha. require lon. term study a.d mon.torin. to extra.t a. much tra.kwa. da.a.a. possible before in.situ physica. eviden.e is lost.

关键词： Feitia.sha. Forma.ion On.thopod Teropod Suropod

杂化化合物(C_(7)H_(11)n.(2))_(2)[CdCl_(4)]·0.5H_(2)O的晶体结构、光谱表征和光学性质

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无机化学学报 2022年第9期38卷 1834-1842页

作者： Fa.ma.Ga.ci a.el klein Ha.mouda.Chebbi Moha.ed Fa.uzi Zid Un.versity of Tun.s El Ma.a. Faculty of Sciences of TunisLaboratory of MaterialsCrystal Chemistry and Applied ThermodynamicsTunisTunisia Un.versity of Cologn. Faculty of Mathematics and Natural SciencesDepartment of ChemistryInstitute for Inorganic ChemistryCologneGermany Un.versity of Tun.s Preparatory Institute for Engineering Studies of TunisTunisTunisia

开发了标题化合物(C_(7)H_(11)n.(2))_(2)[CdCl_(4)]·0.5H_(2)O(C_(7)H_(11)n.(2)=4-(二甲基氨基)吡啶鎓)的制备程序,并得到良好的收率和纯度。Cd离子在略微扭曲的四面体环境中与4个氯离子配位。晶体排列显示出层状结构,有机层和无机... 详细信息

开发了标题化合物(C_(7)H_(11)n.(2))_(2)[CdCl_(4)]·0.5H_(2)O(C_(7)H_(11)n.(2)=4-(二甲基氨基)吡啶鎓)的制备程序,并得到良好的收率和纯度。Cd离子在略微扭曲的四面体环境中与4个氯离子配位。晶体排列显示出层状结构,有机层和无机层交替排列,平行于(001)平面,位于x=n.1/2(n.Z)。在晶体中,有机层和无机层通过C—H…Cl、C—H…O、n.H…Cl和n.H…O氢键相互作用连接。Hirshfeld表面分析和结构的指纹图表明分子堆积受氢键和π堆积的控制。UV-Vis漫反射光谱使我们能够用Ta.c外推法确定具有半导体特性的3.596 eV的直接带隙。观察到的在562 n.处具有最大值的光致发光带归属于4-(二甲基氨基)吡啶鎓阳离子中的激发π-π*态。

关键词：氯镉(Ⅱ)配离子 4-二甲氨基吡啶鎓晶体结构 Hirshfeld表面分析光致发光