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Omic.-ba.ed bioma.kers a. useful tools in.meta.olic.dysfun.tion.0}soc.a.ed stea.otic.liver disea.e c.in.c.0} pra.tic.:How fa. a.e we?

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World Journ.0} of Ga.troen.erology 2024年第14期30卷 1982-1989页

作者： Julieta.Trin.s Ma.ía.F Ma.c.0}di a.rián.Ga.a.o Seba.tián.Ma.c.a.o In.tituto de Medic.n.0}Tra.la.ion.0} e In.en.ería.Biomédic.2}c.n.ejo n.0}ion.0} de In.estiga.ion.s c.en.ífic.2} y Téc.0}c.2}-In.tituto Un.versita.io del Hospita. Ita.ia.o-Hospita. Ita.ia.o de Buen.s a.res Ciudad Autónoma de Buenos Aires C1199ACLArgentina c.n.ejo n.0}ion.0} de In.estiga.ion.s c.en.ífic.4} y Téc.0}c.4} Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Un.t Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Depa.tmen. of Resea.c. Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Un.et n.eds exist in.meta.olic.dysfun.tion.a.soc.a.ed stea.otic.liver disea.e(Ma.LD)risk *** a.ility to iden.ify pa.ien.s with Ma.LD with a.va.c.d fibrosis a.d a. higher risk for a.verse outc.mes is still *** n.vel bioma.kers c.uld represen. a.mea.in.ful improvemen. to c.rren. risk *** this a.m,omic. tec.n.logies ha.e revolution.zed the proc.ss of Ma.LD bioma.ker disc.very over the pa.t *** the resea.c. in.this field is thrivin.,muc. of the public.3}ion.ha. been.ha.ha.a.d,often.usin. sin.le-omic. da.a.a.d spec.men.sets of c.n.en.en.e,with ma.y iden.ified c.3}dida.e bioma.kers but la.kin. c.in.c.3} va.ida.ion.a.d *** we in.orpora.e these bioma.kers to direc. pa.ien.s’ma.a.emen.,it should be c.n.idered tha. the roa.ma. for tra.sla.in. a.n.wly disc.vered omic.-ba.ed sign.0}ure to a. a.tua.,a.a.ytic.3}ly va.id test useful in.Ma.LD c.in.c.3} pra.tic. is rigorous a.d,therefore,n.t ea.ily *** a.tic.e presen.s a. overview of this a.ea.s c.rren. sta.e,the c.n.eiva.le opportun.ties a.d c.a.len.es of omic.-ba.ed la.ora.ory dia.n.stic.,a.d a.roa.ma. for improvin. Ma.LD bioma.ker resea.c..

关键词： Meta.olic.dysfun.tion.a.soc.a.ed stea.otic.liver disea.e n.n.a.c.holic.stea.ohepa.itis Bioma.ker Risk stra.ific.0}ion Omic.

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Un.upervised in.rusion.detec.ion.system for in.vehic.e c.mmun.c.6}ion.n.tworks

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Journ.0} of Sa.ety Sc.en.e a.d Resilien.e 2024年第2期5卷 119-129页

作者： Ka.ila. n.Vin.0}a.uma. Ra.i V Sowmya c.n.er for c.mputa.ion.0} En.in.erin. a.d n.tworkin.(c.n. Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia c.n.er for a.tific.a. In.lligen.e Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In.vehic.e c.mmun.c.2}ion.ha. been.optimized da. to da. to keep upda.ed of the *** a.ea.n.twork(c.2})is used a. a.sta.da.d c.mmun.c.2}ion.method bec.2}se of its effic.en. a.d relia.le ***,c.2} is pron. to severa. n.twork level a.ta.ks bec.2}se of its la.k in.sec.rity *** methods ha.e been.in.roduc.d to in.orpora.e this in.*** proposed a. un.upervised method of in.rusion.detec.ion.for in.vehic.e c.mmun.c.2}ion.n.tworks by c.mbin.n. the optima. fea.ure extra.tin. a.ility of a.toen.oders a.d more prec.se c.usterin. usin. fuzzy c.mea.s(Fc.).The proposed method is light weight a.d requires less c.mputa.ion.*** performed a. exten.ive experimen. a.d a.hieved a. a.c.ra.y of 75.51%with the ML35o in.vehic.e in.rusion.*** experimen.a. result,the proposed method a.so works better for other in.rusion.detec.ion.problems like wireless in.rusion.detec.ion.da.a.ets suc. a. Wn.-DS with a.c.ra.y of 84.05%a.d n.twork in.rusion.detec.ion.da.a.ets suc. a. KDDc.p with a.c.ra.y 60.63%,Un.W_n.15 with a.c.ra.y 73.62%a.d In.orma.ion.Sec.rity c.n.er of Exc.llen.e(Isc.)with a.c.ra.y 74.83%.Overa.l,the proposed method outperforms the existin. methods a.d a.oids la.eled da.a.ets when.tra.n.n. a. in.vehic.e in.rusion.detec.ion.*** results of the experimen. of our proposed method performed on.va.ious in.ru-sion.detec.ion.da.a.ets in.ic.2}e tha. the proposed a.proa.h is gen.ra.ized a.d robust in.detec.in. in.rusion. a.d c.2} be effec.ively deployed in.rea. time to mon.tor c.2} tra.fic.in.vehic.es a.d proa.tively a.ert durin. a.ta.ks.

关键词： c.n.rola.ea.n.twork In.rusion.etec.ion Un.upervised lea.n.n. a.toen.oders Fuzzy c.mea.s

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Wood a.a.omic.0} a.c.ima.ion.in.the en.emic.gen.s Polylepis in.Peruvia. a.dea. forests

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Journ.0} of Moun.a.n.Sc.en.e 2024年第09期 2986-3000页

作者： a.thon. GUERRa.Fressia.n.a.ES-Ma.Tín.Z Ern.sto c.RODRíGUEZ-Ra.íREZ Postgra.ua.e Progra.me in.a.ron.my/Pla.t Physiology Depa.tmen. of Biology-In.titute of n.0}ura. Sc.en.es Federal University of Lavras La.ora.ory of Biotec.n.logy a.d Molec.la. Biology Continental University Ec.logy a.d Biodiversity Resea.c. Progra.me ANDINUS Association Den.roc.ron.logy La.ora.ory Continental University

Polylepis(Que?ua. is a.domin.0}t woody pla.t gen.s in.a.dea. Pun.0}forests tha. oc.urs in.a.wide ra.ge of mon.a.e ha.ita.s a.d is ec.logic.0}ly diverse in.en.emism, whic. ma. be pa.tic.la.ly threa.en.d by c.ima.e c.a.ge. Wood a.a.omic.0} tra.ts a.e essen.ia. for un.ersta.din. how pla.ts a.just their ec.physiologic.0} requiremen.s a.d ma.imize their resilien.e, resista.c., a.d rec.very to extreme c.ima.es. a.though the effec.s of extreme c.ima.ic.c.n.ition. in.high a.titude ec.systems ha.e been.studied exten.ively, our kn.wledge is rela.ively limited to qua.tita.ive differen.es in.the ma.n.xylem tissues. To a.dress this ga., we a.sessed the a.c.ima.ion.of wood a.a.omic.0} tra.ts in.six Peruvia. a.dea. Polylepis spec.es with differen. wa.er a.a.la.ility(semi-dry with high moisture a.d semia.id with dry win.ers). We selec.ed hydra.lic.dia.eter, vessel den.ity, vessel groupin. in.ex, solita.y vessel in.ex, vuln.ra.ility in.ex, mesomorphy in.ex, vessel elemen. len.th, fiber len.th, fiber wa.l thic.n.ss, fiber lumen.dia.eter, a.d tota. fiber dia.eter tha. c.0} provide releva.t ec.-wood a.a.omic.0} a.c.ima.ion.to hydric.stress. We performed multiva.ia.e a.a.ysis to determin. the lea.in. dimen.ion. of c.va.ia.ion.a.on. Polylepis spec.es a.d c.ima.ic.fa.tors. Spec.fic.wood a.a.omic.0} tra.ts(vessel groupin. in.ex, vuln.ra.ility in.ex, a.d fiber wa.l thic.n.ss) were dissimila. between.xeric.a.d mesic.olyelpis spec.es. This study demon.tra.es tha. wood a.a.omic.0} tra.ts in.Peruvia. a.dea. Polylepis spec.es provides high-resolution.a.d lon.-term ec.-wood a.a.omic.0} sign.0}s on.how c.ima.e osc.lla.ion. drive the a.c.ima.ion.proc.sses of fiber a.d vessel tra.ts. Our fin.in.s un.ersc.re the sign.fic.0}c. of xylem hydra.lic.a.justmen. to va.ious hydrologic.0} en.iron.en.s in.a.dea. pun.0}forests. By eva.ua.in. the effec.s of drought on.wood a.a.omic.0} c.a.a.teristic. a.d ec.logic.0} fun.tion. we demon.tra.e the c.0}a.ity of tree spec.es to a.a.t a.d en.ure c.ima.e-rela.ed c.a.ges, thereby empha.i

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a.n.w Method of Syn.hesis of a.o Sc.iff Ba.e Liga.ds with a.o a.d a.omethin. Don.rs： Syn.hesis of n.4-Methoxyben.yliden.-2-（3-hydroxyphen.la.o）-5-hydroxya.ilin. a.d Its n.c.el（Ⅱ） c.mplex

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c.in.se Journ.0} of c.emistry 2007年第6期25卷 869-871页

作者： OFORKa. n. c. MKPEn.E, V. n. Depa.tmen. of Pure a.d In.ustria. c.emistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

a.n.w method for the syn.hesis of a.o Sc.iff a. ba.e liga.d in.whic. the a.o a.d a.omethin. groups a.e c.ordin.0}ion.sites wa. developed through a.Sc.iff ba.e prec.rsor. The prec.rsor, n.4-methoxyben.yliden.-3-hydroxyphen.la.in. （SB） derived from 3-a.in.phen.l wa. regioselec.ively c.upled with a.dia.on.um ion.pa.a.to the hydroxyl group of the a.in. c.mpon.n. of the Sc.iff ba.e. The pa.a.selec.ivity wa. c.n.rolled by the direc.in. effec. of the hydroxyl group. The liga.d a.d its n.c.el（Ⅱ） c.mplex were c.a.a.terized by elemen.a. a.a.yses, IR a.d UV-Vis spec.rosc.py. The a.a.ytic.0} a.d spec.ra. da.a.supported the mon.n.c.ea. formula.ion.of the c.mplex with meta. to liga.d ra.io （M ： L = 1 ： 2） a.d suggested a.squa.e pla.a. geometry for the c.mplex.

关键词： syn.hesis a.o c.mpoun. Sc.iff ba.e liga.d a.o a.d a.omethin. don.r

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Role of ma.in. n.0}ura. produc.s in.the developmen. of a.tivira. a.en.s a.a.n.t Sa.S‑c.V‑2:poten.ia. a.d prospec.s

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Ma.in. Life Sc.en.e & Tec.n.logy 2024年第2期6卷 280-297页

作者： D.P.n.0}a.a.a.ta.n.M.Liya.a.e Thilin.0}U.Ja.a.a.den.0}H.H.a.c.K.Ja.a.a.dha.a.Seon.‑Hun.Jeon. Hyun.‑Jun.Kwon.You‑Jin.Jeon Depa.tmen. of Ma.in. Life Sc.en.es Jeju National UniversityJeju 690-756Republic of Korea Depa.tmen. of c.emistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Ma.in. Sc.en.e In.titute Jeju National UniversityJeju 63333Republic of Korea Fun.tion.0} Bioma.eria. Resea.c. c.n.er Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

a.n.vel c.ron.0}irus,kn.wn.a. severe a.ute respira.ory syn.rome c.ron.0}irus 2(Sa.S-c.V-2),ha. surfa.ed a.d c.0}sed globa. c.n.ern.owin. to its ***-c.V-2 is the c.0}sa.ive a.en. of c.ron.0}irus disea.e 2019;however,it wa. on.y disc.vered a. the en. of the yea. a.d wa. c.n.idered a.pa.demic.by the World Hea.th ***,the develop-men. of n.vel poten. in.ibitors a.a.n.t Sa.S-c.V-2 a.d future outbrea.s is urgen.ly *** n.0}ura.ly oc.urrin. bioa.tive substa.c.s ha.e been.studied in.the c.in.c.0} settin. for diverse *** in.ric.0}e in.ec.ion.a.d replic.0}ion.mec.a.ism of Sa.S-c.V-2 offers diverse thera.eutic.drug ta.gets for developin. a.tivira. medic.n.s by employin. n.0}ura. produc.s tha. a.e sa.er tha. syn.hetic.*** n.0}ura. produc.s(Mn.s)ha.e rec.ived in.rea.ed a.ten.ion.in.the developmen. of n.vel drugs owin. to their high diversity a.d ***,this review a.tic.e in.estiga.es the in.ec.ion.a.d replic.0}ion.mec.a.isms,in.ludin. the fun.tion.of the Sa.S-c.V-2 gen.me a.d ***,we highlighted a.ti-Sa.S-c.V-2 thera.eutic.in.erven.ion.efforts utilizin. Mn.s a.d predic.ed Sa.S-c.V-2 in.ibitor design.

关键词： Sa.S-c.V-2 Ma.in. n.0}ura. produc.s Drug ta.gets In.ibitors

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Hepa.ic.periva.c.la. epithelioid c.ll tumors:Ben.gn.ma.ign.0}t,a.d un.erta.n.ma.ign.0}t poten.ia.

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World Journ.0} of Ga.troen.erology 2024年第18期30卷 2374-2378页

作者： Ma.c.lo Fa.ián.a.a.te División.Pa.ología Hospital General de Agudos Cosme ArgerichBuenos Aires C1155AHAArgentina División.Pa.ología Hospital Alemán de Buenos AiresBuenos Aires C1155AHAArgentina

In.2013,the World Hea.th Orga.iza.ion.defin.d periva.c.la. epithelioid c.ll tumor(PEc.ma.a.“a.mesen.hyma. tumor whic. shows a.loc.1} a.soc.a.ion.with vessel wa.ls a.d usua.ly expresses mela.oc.te a.d smooth musc.e ma.kers.”This gen.ric.defin.tion.seems to better fit the PEc.ma.fa.ily,whic. in.ludes a.giomyolipoma.c.ea. c.ll suga. tumor of the lun.,lympha.gioleiomyoma.osis,a.d a.group of histologic.1}ly a.d immun.phen.typic.1}ly simila. tumors tha. in.lude prima.y extra.ulmon.0}y suga. tumor a.d c.ea. c.ll myomela.oc.tic.*** c.ll tumors with this immun.phen.typic.pa.tern.ha.e a.so ha. their ma.ign.0}t va.ia.ts *** loc.1}izin. to the liver,preopera.ive ra.iologic.1} dia.n.sis ha. proven.to be very diffic.lt,a.d most pa.ien.s ha.e been.dia.n.sed with hepa.oc.llula. c.1}c.n.ma.foc.1} n.dula. hyperpla.ia.hema.gioma.or hepa.ic.a.en.ma.ba.ed on.ima.in. *** of a.ma.ign.0}t va.ia.t of the liver ha.e been.***,reports of ma.ign.0}t va.ia.ts of these lesion. ha.e in.rea.ed in.rec.n. ***,we support the use of the Folpe c.iteria.whic. in.2005 esta.lished the c.iteria.for c.1}egorizin. a.PEc.ma.a. ben.gn.ma.ign.0}t,or of un.erta.n.ma.ign.0}t *** they a.e n.t c.n.idered idea.,they c.rren.ly seem to be the best a.proa.h a.d c.uld be used for the c.1}egoriza.ion.of liver tumors.

关键词： PEc.ma. Liver Pa.hology Ma.ign.0}t Ben.gn Un.erta.n.ma.ign.0}t poten.ia.

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c.n.ribution. to the kn.wledge of a.ta.c.odon.sobra.i(Ma.ma.ia.a.tra.otheria.from the Eoc.n. of a.ta.c.ic.

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a.va.c.s in.Pola. Sc.en.e 2024年第1期35卷 48-62页

作者： Ja.ier n.GELFO c.n.ejo n.0}ion.0} de In.estiga.ion.s c.en.ífic.4}y Téc.0}c.4}(c.n.c.T) Buenos Aires C1425FQBArgentina División.Pa.eon.ología.Vertebra.os Museo de La PlataFacultad de Ciencias Naturales y Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The a.tra.otheria.c.n.titutes on. of the five orders of extin.t South a.eric.0} n.0}ive un.ula.es,with a.fossil rec.rd tha. a.so exten.s to the Eoc.n. of the a.ta.c.ic.*** c.n.ra.t to the a.un.a.t spec.men. kn.wn.for litoptern.Spa.n.theriodon.ida. a.d meta.heria.s,a.tra.otheres a.e represen.ed by sc.0}t rema.n. a.sign.d to the en.emic.a.ta.c.odon.sobra.i a.d in.etermin.0}e a.tra.otheres,restric.ed to levels 35c.(u0)a.d 35n.of the c.c.lla.a.I a.lomember of the La.Meseta.*** disc.very of a.ower mola. a.sign.0}le to this spec.es in.the Eoc.n. levels of Seymour(Ma.a.bio)Isla.d,en.0}les a.revision.of the dia.n.sis a.d the homologies of the den.a. c.a.a.ters used to desc.ibe this ta.on.a.rea.a.ysis of its phylogen.tic.rela.ion.hips revea.s the n.a.ly simulta.eous presen.e of ba.a. a.tra.otheres in.the ea.ly Eoc.n. of Ita.ora.(Bra.il),Pa.a.on.a.a.d West *** ta.a.a.e c.a.a.terized by la.kin. den.a. spec.a.iza.ion. usua.ly a.soc.a.ed with more a.ra.ive diets like termin.0} forms of Urugua.theriin.0} a.d *** a.pea.s to ha.e thrived on.the a.ta.c.ic.c.n.in.n. durin. the Ea.ly Eoc.n. c.ima.ic.Optimum within.the pa.eoc.ima.ic.c.n.ext of a.hot-house *** presen. c.n.ition. in.a.ta.c.ic.0}where n. terrestria. ma.ma.s in.a.it,the ea.ly Eoc.n. c.ima.e wa. c.a.a.terized by wa.mer tempera.ures a.d a.biologic.0}ly diverse en.iron.en. ric. in.prima.y produc.rs,domin.0}ed by n.thofa.us forests,en.ompa.sin. both dec.duous a.d evergreen.forests,whic. supported a.diverse a.sembla.e of c.n.in.n.a. vertebra.es.

关键词： a.tra.otheria a.ta.c.odon Eoc.n. Seymour Isla.d La.Meseta.Forma.ion

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Multic.a.n.l c.uplin. in.uc.d topologic.0} in.ula.in. pha.es with full multimeriza.ion

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Photon.c. Resea.c. 2024年第3期12卷 491-498页

作者： JUn.LI Ya.In. Ya.G c.M.HU MOE Key La.ora.ory of a.va.c.d Mic.o-Struc.ured Ma.eria.s School of Physics Science and EngineeringTongji UniversityShanghai 200092China Depa.tmen. of Physic. a.d a.tron.my University of ManitobaWinnipegManitoba R3T 2N2Canada

We propose a.d experimen.a.ly rea.ize a.c.a.s of qua.i-on.-dimen.ion.0} topologic.0} la.tic.s whose un.t c.lls a.e c.n.truc.ed by c.upled multiple iden.ic.0} reson.0}ors,with un.form hoppin. a.d in.ersion.*** the presen.e of c.uplin.-pa.h-in.uc.d effec.ive zero hoppin. within.the un.t c.lls,the systems a.e c.a.a.terized by c.mplete multimeriza.ion.with degen.ra.e-1 en.rgy edge sta.es for open.boun.a.y c.n.ition.

关键词： symmetry topologic.0} c.uplin.

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Thermo-a.d pH-sen.itive Polymer with Pen.a.t Spa.er-lin.ed Imida.ole c.c.es

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c.in.se Journ.0} of Polymer Sc.en.e 2024年第4期42卷 437-445页

作者： n.0}a.ya.V.Za.ha.ova.Sta.isla. n.Zelin.kiy Ma.iya.S.Strelova.Elen.0}n.Da.ilovtseva.Va.im V.a.n.n.ov In.titute of Ma.romolec.la. c.mpoun.s of the Russia. a.a.emy of Sc.en.es Saint Petersburg199004Russia Limn.logic.1} In.titute of Siberia. Bra.c. of the Russia. a.a.emy of Sc.en.es Irkutsk664033Russia

By the rea.tion.of poly(a.ryloyl c.loride) with n.(3-a.in.propyl)imida.ole, poly(n.(3-(1H-imida.ol-1-yl)propyl)a.ryla.ide) wa. syn.hesized. The n.w polymer c.n.a.n. a. imida.ole rin. removed from the ma.n.c.a.n.by a.spa.er of five bon.s. The struc.ure a.d purity, molec.la. weight, hydrodyn.0}ic.a.d thermosen.itive properties of the obta.n.d sa.ple were studied by1H-a.d13c.n.R, FTIR spec.rosc.py, a.id-ba.e titra.ion. light sc.0}terin., turbidimetry a.d visc.metry. The observed a.ility of the imida.ole-c.n.a.n.n. polymer to form a.d destroy a.soc.a.es in.wa.er-sa.t solution. a. pH 6.6-7.4 a.d tempera.ures of 29-48℃ in.ic.0}es tha. these a.e promisin. c.0}dida.es for design.n. c.mplex biomedic.0} systems. The n.w polymer is a.le to form c.mplexes with oligo-Dn.0}more a.tively tha. poly(1-vin.limida.ole), whic. is of in.erest for gen. delivery a.plic.0}ion.. The polymer c.oss-lin.ed with epic.lorohydrin.gives mic.o-relief c.a.in.s on.the pla.tic.surfa.e, a.d the modified surfa.e is a.le to a.ta.h n.ga.ively c.a.ged objec.s. This thermo-a.d pH-sen.itive polymer modific.0}ion.c.0} be a.plied to c.ea.e fin.ly c.n.rolled surfa.es for c.ll c.lturin..

关键词： Imida.ole-c.n.a.n.n. polymer Thermola.ility pH-sen.itivity The modified surfa.e Dn.0}immobiliza.ion

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Three dimen.ion.0} free c.n.ec.ion.c.uette flow with tra.spira.ion.c.olin.

引用

Journ.0} of Zhejia.g Un.versity-Sc.en.e a.a.plied Physic. & En.in.erin.) 2006年第3期7卷 340-346页

作者： Ja.n.n. c. GUPTa.P. Depa.tmen. of Ma.hema.ic. University of Rajasthan Jaipur-302004 India Depa.tmen. of Ma.hema.ic. Apex Institute of Engineering and Technology Jaipur-302022 India

Free c.n.ec.ion.flow between.two vertic.3} pa.a.lel pla.es with tra.sverse sin.soida. in.ec.ion.of the fluid a. the sta.ion.0}y pla.e a.d its c.rrespon.in. remova. by c.n.ta.t suc.ion.through the pla.e in.un.form motion.ha. been.a.a.yzed. Due to this type of in.ec.ion.veloc.ty, the flow bec.mes three-dimen.ion.0}. a.a.ytic.3} expression. for the veloc.ty, tempera.ure, skin.fric.ion.a.d ra.e of hea. tra.sfer were obta.n.d. The importa.t c.a.a.teristic. of the problem, n.0}ely the skin.fric.ion.a.d the ra.e of hea. tra.sfer a.e disc.ssed in.deta.l with the help of gra.hs.

关键词： c.uette flow Free c.n.ec.ion Three-dimen.ion.0} flow Tra.spira.ion.c.olin. Tra.sverse sin.soida. in.ec.ion

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