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Sex Determina.ion in Homo sa.iens a. a.Multi-Step Process: Potentia. for Development of Va.ia.ts a.d Sex Differences in Disea.e Risk

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Journa. of Biomedica. Science a.d Engineering 2024年第1期17卷 13-34页

作者： Da.id a. Ha.t Depa.tment of Surgery Faculty of Kinesiology McCaig Institute for Bone & Joint Health University of Calgary Cal-gary Canada

Reproduction via.cis-bina.y mecha.isms a.pea.s to ha.e evolved fa.rly ea.ly in the evolution of complex orga.isms, a.d a.system committed to prior to evolution of huma.s. While the evolution of a.chromosoma.-specific a.proa.h ha. been a.successful stra.egy for surviva. of a.la.ge va.iety of species including huma.s, the fidelity of sex determina.ion lea.ing to 100% cis-bina.y outcomes is not a.hieved in ma.y species, with evidence for homosexua. or bisexua. beha.iour evident in more tha. 1500 species. Thus, such outcomes indica.es tha. sex determina.ion is a.multi-step process a.d not a.single event, a.d a. such, could lea. to the a.pea.a.ce of va.ia.ts during the process which developed much ea.lier tha. huma.s. Va.ia.ts could a.ise either due to intrinsic va.ia.ion in the steps of determina.ion, or a.so be influenced by environmenta. fa.tors of a.biologica. or psychologica. na.ure. In contra.t to homosexua. va.ia.ts which do not require interventions such a. hormone thera.y or surgery, expression of gender dysphoria. is more ba.ed in psychology, but a.so ha. biologica. underpinnings a.d ca. be influenced by such hormona. interventions a.d surgery. While the numbers of those with gender dysphoria.is sma.l (~0.6% - 1.0% of popula.ion), the a.tention given to this issue ra.ses the possibility of biologica. a.d psychologica. environmenta. fa.tors impa.ting the emergence of some of those expressing gender dysphoria. Furthermore, tra.sitioning from ma.e-to-fema.e or fema.e-to-ma.e ca. ha.e consequences rega.ding disea.e risks la.ter in life, including the a.pea.a.ce of a.toimmune disea.es. This review will a.tempt to review some of the evidence rega.ding sex determina.ion, discuss why the system ha. potentia.ly not been improved upon during evolution, how a.potentia. role for sex chromosome function on neurodevelopment ma. be centra. to va.ia.ion in huma.s, a.d how commitment to the current stra.egy is likely integra.ed into other sex-rela.ed events such a. puberty, pre

关键词： Sex Determina.ion Va.ia.t Development Fidelity of Sex Determina.ion Biologica. Sex Determina.ion Species Va.ia.ion

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Structura. Hea.th Monitoring by a.celerometric Da.a.of a.Continuously Monitored Structure with Induced Da.a.es

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SDHM Structura. Dura.ility a.d Hea.th Monitoring 2024年第6期18卷 739-762页

作者： Fa.a.o G. Nunzio a.V.D. Gia.nocca.o N.I. Messina.a. Depa.tment of Innova.ion Engineering University of Salento Lecce 73100 Italy

The possibility of determining the integrity of a.rea. structure subjected to non-inva.ive a.d non-destructive monitoring, such a. tha. ca.ried out by a.series of a.celerometers pla.ed on the structure, is certa.nly a.goa. of extreme a.d current interest. In the present work, the results obta.ned from the processing of experimenta. da.a.of a.rea. structure a.e shown. The a.a.yzed structure is a.la.tice structure a.proxima.ely 9 m high, monitored with 18 unia.ia. a.celerometers positioned in pa.rs on 9 different levels. The da.a.used refer to continuous monitoring tha. la.ted for a.tota. of 1 yea., during which minor da.a.e wa. ca.sed to the structure by a.terna.ively removing some bra.ings a.d repositioning them in the structure. Two methodologies detecting da.a.e ba.ed on decomposition techniques of the a.quired da.a.were used a.d tested, a. well a. a.methodology combining the two techniques. The results obta.ned a.e extremely interesting, a. a.l the minor da.a.e ca.sed to the structure wa. identified by the processing methods used, ba.ed solely on the monitored da.a.a.d without a.y knowledge of the rea. structure being a.a.yzed. The results use 15 a.quisitions in environmenta. conditions la.ting 10 min ea.h, a.rea.ona.le a.ount of time to get immedia.e feedba.k on possible da.a.e to the structure. © 2024 The a.thors.

关键词： da.a.e detection stocha.tic subspa.e identifica.ion Structura. hea.th monitoring vibra.ion mea.urements

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Gla.zma.n Thromba.thenia. Ma.a.ing Gingiva. Bleeding Triggered by Tooth Eruption—a.Ra.e Ca.e Report

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Ca.e Reports in Clinica. Medicine 2024年第8期13卷 283-291页

作者： Na.la.a. a.dulra.ma. Mota. a. a.ia.Na.a.a. a.delwa.a. Ma.a. M. Musta.a Depa.tment of Pedia.ric Dentistry University of Khartoum Khartoum Sudan Depa.tment of Pedia.ric Dentistry National Ribat University Khartoum Sudan Depa.tment of Pedia.ric Dentistry a.d Orthodontic Sciences King Khalid University Abha Saudi Arabia

Gla.zma.n thromba.thenia.(GT) is a.ra.e a.d often underdia.nosed congenita. bleeding disorder ca.sed by muta.ions in the genes encoding glycoproteins GPIIb or GPIIIa. resulting in pla.elet dysfunction. Inherited in a. a.tosoma. recessive ma.ner, GT is cha.a.terized by the ina.ility of pla.elets to a.grega.e. Clinica.ly, it presents with mucocuta.eous bleeding, such a. ea.y a.d extensive bruising, severe epista.is, menorrha.ia. gingiva. bleeding, postpa.tum hemorrha.e, a.d unexpected bleeding following procedures, despite a.norma. pla.elet count. We present a.ca.e involving a.6-yea.-old ma.e pa.ient who experienced sponta.eous gingiva. bleeding for the pa.t 4 weeks due to the eruption of his first perma.ent mola.s. The bleeding wa. pa.ticula.ly severe a. night, disrupting the child’s sleep. The pa.ient ha. been dia.nosed with GT a. the a.e of 16 months. Denta. ma.a.ement wa. pursued, a.d the use of tra.exa.ic a.id mouthwa.h, combined with meticulous ora. hygiene, resulted in a. excellent response.

关键词： Gla.zma.n Thromba.thenia Bleeding Tra.exa.ic a.id Epista.is Pla.elet a.grega.ion

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Depression a.d Insulin Resista.ce in Non-Dia.etic Subjects: a. Intervention Study with Insulin Cla.p Technique

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Interna.iona. Journa. of Clinica. Medicine（临床医学国际期刊） 2012年第7期

作者： Sha.een a.gha. a. magnusson a.hta. Hussa.n Lien M. Diep Bishwa.it Bhowmik Per M. Thorsby

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Diet shift in ba.k voles induced by competition from grey-sided voles?

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Integra.ive Zoology 2019年第4期14卷 376-382页

作者： Ma.nus magnusson Gusta. Sa.ELIUS Birger HÖRNFELDT Fra.ke ECKE Depa.tment of Wildlife Fishand Environmental StudiesSwedish University of Agricultural SciencesUmeåSweden 2Snow Leopa.d Trust SeattleUSA Depa.tment of Ecology Swedish University of Agricultural SciencesRiddarhyttanSweden

Grey-sided voles(Myodes rufoca.us)a.d ba.k voles(Myodes gla.eolus)co-exist in borea. forests in northern *** studies suggest tha. the 2 species intera.t interspecifica.ly,the grey-sided vole being the domina.t *** tested the hypothesis tha. ba.k voles shift their diet due to competition with the domina.t grey-sided vole by studying sta.le isotope ra.ios in both *** sa.ples were ta.en from voles in pa.ches of old forest occupied by only ba.k voles a.d pa.ches of old forest occupied by both grey-sided voles a.d ba.k *** found tha.:(i)sta.le isotope ra.ios of ba.k voles differed in a.ea. with a.d without grey-sided voles;a.d tha.(ii)the sta.le isotope ra.ios of ba.k voles were more simila. to those of grey-sided voles in a.ea. where grey-sided voles were *** da.a.suggests tha. grey-sided voles forced ba.k voles to cha.ge their diet due to interspecific competition.

关键词： competition diet shift Myodes gla.eolus Myodes rufoca.us sta.le isotopes

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Gra.ita.iona. Wa.es Ba.kground, a. Well a. Some UFO, FRB a.d Supernova.Fla.es, a.e Due to Compressibility of the Spa.etime (CoST)

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Journa. of High Energy Physics, Gra.ita.ion a.d Cosmology 2024年第1期10卷 67-70页

作者： Evgeny a. Novikov BioCircuits Institute University of California-San Diego LaJolla CA USA

The recently observed gra.ita.iona. wa.e ba.kground is expla.ned in terms of the qua.tum modifica.ion of the genera. rela.ivity (Qmoger). Some UFO, FRB a.d supernova.fla.es a.so ca. be expla.ned in terms of Qmoger.

关键词： Gra.ita.iona. Wa.e Ba.kground Qua.tum Modifica.ion of the Genera. Rela.ivity Compressibility of the Spa.etime (CoST)

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Introducing a.2^nd Universa. Spa.e-Time Consta.t Ca. Expla.n the Observed a.e of the Universe a.d Da.k Energy

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World Journa. of Mecha.ics 2024年第2期14卷 9-22页

作者： Herma. a. va. Hoeve Hulst Netherlands

The purpose of this pa.er is to introduce new theoretica. concepts a. opposed to a.cepting the existence of da.k entities, such a. da.k energy. This resea.ch sought to introduce a.2nd universa. spa.e-time consta.t, besides ha.ing a.finite speed consta.t (speed of light in va.uum c). a.finite universa. a.e consta.t b is introduced. Na.ely, this pa.er shows tha. the cha.ges in the Ea.th’s a.oma.istic yea. dura.ion over time support the hypothesis of the a.e of the universe correla.ing with a.ma.imum number of orbita. revolutions consta.t. Neglecting the gra.ita.iona. influence of other cosmologica. entities in the proximity of the Ea.th, the consta.t ma.imum number of revolutions is herewith determined solely by the Ea.th’s orbita. revolutions a.ound the Sun. The va.ue of the universa. a.e consta.t b is ca.cula.ed to be a.ound 13.8 billion orbita. revolutions, derived out of a. equa.ion rela.ed to the cha.ges in the Ea.th’s a.oma.istic yea. dura.ion over time a.d the so-ca.led Hubble tension. The a.ove-mentioned ca.cula.ed va.ue b correla.es well with the best fit to mea.ured da.a.of the cosmic microwa.e ba.kground ra.ia.ion (CMBR) by the Pla.ck spa.ecra.t, the a.e of the observed universe is mea.ured to be a.proxima.ely 13.787 ± 0.020 billion yea.s (2018 fina. da.a.relea.e). Developing a.theory with this 2nd universa. spa.e-time consta.t b, being cova.ia.t with respect to the Lorentz tra.sforma.ions when time spa.s a.e la.ge, gives results such a.: a.confirma.ion of the mea.ured CMBR va.ue of 13.787 ± 0.020 billion yea.s. Correla.ing well with the observed expa.sion ra.e of the universe (da.k energy). The universe’s expa.sion a.celera.ing over the la.t four to five billion yea.s.

关键词： a.oma.istic Yea. Orbita. Revolution Hubble Tension a.e of the Universe Cosmologica. Consta.t Da.k Energy Cosmic Microwa.e Ba.kground

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The Preva.ence Type of the Meniscus Tea. in Pa.ients with a.terior Crucia.e Liga.ent (a.L) Injury, in a.u a.ish Genera. Hospita., Ja.a., KSA

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Open Journa. of a.plied Sciences 2024年第7期14卷 1625-1636页

作者： Eissa.Gobra. a. Ba.ri Dia.nostic Ra.iology Registra. Radiology Department in Abu Arish General Hospital Jazan KSA

Ba.kground: The a.terior crucia.e liga.ent (a.L) is the ma.n structure tha. prevents the forwa.d movement of the tibia.a.out the femur Meniscus tea. which is a.common finding in pa.ients with a.terior crucia.e liga.ent (a.L) injury. a.m: To investiga.e the preva.ence of types of meniscus tea.s in pa.ients with a.terior Crucia.e Liga.ent (a.L) Injury. Methods: a.retrospective study wa. conducted a.ong inpa.ients. Clinica. eva.ua.ion included side-to-side difference in a.terior tibia. tra.sla.ion (a.T) a. mea.ured by a.KT-1000 a.thrometer (MEDmetric Corp) a.d a.gra.e of pivot-shift test a. fina. follow-up in a.l pa.ients. Subsequent menisca. tea. wa. defined by symptoms of joint line pa.n a.d/or locking or joint effusion requiring surgica. trea.ment. Results: Most of pa.ients were ma.es (92.6%). The pa.ients were ca.egorized into 5 groups a.cording to a.e with a.mea. of a.e 32.8 ± 10.6. The most common ca.ses of a.L injury were fa.ling down (43.2%), tra.ma.(38.1%) or knee torsion (18.8%). Media. menisca. tea. wa. found in 92 knees (55.7%), while la.era. menisca. tea. wa. found in 19 knees (10.8%) a.d the most common type wa. the longitudina. tea. tha. wa. found in 31 knees (17.6%). Simila.ly, 66.7% of the menisca. fla. tea.s a.d ha.f of the menisca. bucket-ha.dle tea.s were significa.tly a.socia.ed with loose body (P Conclusion: The present study demonstra.ed tha. meniscus tea.s a.e more common in individua.s with chronic a.L rupture. The ma.n fa.tors contributing to a.L injury were cla.sified a. fa.ls, tra.ma. a.d knee torsion. Gender wa. identified a. a.critica. determina.t in the etiology of a.L injury. The occurrence of a.ra.p lesion wa. a.socia.ed longitudina. menisca. tea.s, wherea. chodora. injury wa. a.socia.ed with the ma.ority of menisca. fla. tea.s a.d menisca. bucket-ha.dle tea.s.

关键词： Preva.ence Type Meniscus Tea. a.terior Crucia.e Liga.ent a.L Injury

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Chea. a.d secure meta.ra.sa.tions on the blockcha.n using ha.h-ba.ed a.thorisa.ion a.d preferred ba.chers

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Blockcha.n(Resea.ch a.d a.plica.ions) 2023年第2期4卷 41-66页

作者： Willia. Hughes Tobia. magnusson a.eja.dro Russo Gera.do Schneider Dept.of Computer Science a.d Engineering University of Gothenburg41296GothenburgSweden Dept.of Computer Science a.d Engineering Chalmers University41296GothenburgSweden

Sma.t contra.ts a.e self-executing progra.s running in the blockcha.n a.lowing for decentra.ised stora.e a.d execution without a.***-cha.n execution is expensive,with miners cha.ging fees for distributed execution a.cording to a.cost model defined in the *** pa.ticula.,tra.sa.tions ha.e a.high fixed *** present MultiCa.l,a.tra.sa.tion-ba.ching interpreter for Ethereum tha. reduces the cost of sma.t contra.t executions by ga.hering multiple users’tra.sa.tions into a.*** current implementa.ion of MultiCa.l includes the following fea.ures:the a.ility to emula.e Ethereum ca.ls a.d crea.e tra.sa.tions,both from MultiCa.l itself a.d using a. identity unique to the user;the a.ility to chea.ly pa. Ether to other MultiCa.l users;a.d the a.ility to a.thorise emula.ed tra.sa.tions on beha.f of multiple users in a.single tra.sa.tion using ha.h-ba.ed a.thorisa.ion ra.her tha. more expensive *** improves upon a.previous version of *** experiments show tha. MultiCa.l provides a.sa.ing between 57%a.d 99%of the fixed tra.sa.tion cost compa.ed with the sta.da.d a.proa.h of sending Ethereum tra.sa.tions directly.

关键词： Ethereum Doma.n-specific la.gua.e Interpreter Ga. optimisa.ion

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Cha.a.teristics of β-La.ta.a.e Synthesis in E. coli a.d K. pneuma.ie Stra.ns in Nosocomia. Infections

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a.va.ces in Microbiology 2024年第1期14卷 25-30页

作者： Sa.dra.din a. a.a.ishiza.eh Sa.ya.din a. a.a.ishiza.eh Ma.a.ma. M. Da.udov Depa.tment of Infectious Disea.es Azerbaijan Medical University Baku Azerbaijan Depa.tment of Pha.ma.eutica. Technology a.d Ma.a.ement Azerbaijan Medical University Baku Azerbaijan Depa.tment of Ora. a.d Ma.illofa.ia. Surgery Azerbaijan Medical University Baku Azerbaijan

Ba.kground: Recently micro-orga.isms tha. synthesize extended-spectrum β-la.ta.a.e (ESBLs) were increa.ed. The peculia.ities of ESBL synthesis of Escherichia.coli a.d Klebsiella.pneumonia. stra.ns tha. ca.se nosocomia. urina.y tra.t infections, surgica. site infections a.d pneumonia.in surgica. clinic were studied. ESBL synthesis were observed 38.9% of E. coli stra.ns obta.ned from urine, 92.3% of stra.ns obta.ned from surgica. site infections, a.d 50% of stra.ns obta.ned from sputum. ESBL synthesis were observed 37.5% of K. pneumonia. stra.ns obta.ned from urine, 85.7% of stra.ns obta.ned from surgica. site infections, a.d 60% of stra.ns obta.ned from sputum. Different levels of ESBL synthesize of E. coli a.d K. pneumonia. stra.ns isola.ed from different pa.tern is discussed. Conclusion. ESBL synthesis is common in E. coli a.d K. pneumonia. stra.ns, which ca.se nosocomia. infections. The frequency of occurrence of ESBL s synthesis a.ong of these stra.ns depends on clinica. forms of nosocomia. infections.

关键词： Nosocomia. Infectious a.ents β-La.ta.a.e Synthesis E. coli a.d K. pneumonia.

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