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Psychia.ric comorbidities in epilepsy:popula.ion co-occurrence,genetic correla.ions a.d ca.sa. effects

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Genera. Psychia.ry 2024年第1期37卷 103-111页

作者： Viktor H a.lqvist Christina.Da.da.i Pa.l Ma.ley-Dowd Ha.riet Forbes Jessica.Ra.t Ca.chen Zhong Renee M Ga.dner Christina.Da.ma. Kristen Lya. cRa.G Newscha.fer Torbjorn Tomson Micha.l Lundberg Da.iel Berglind Neil M Da.ies Bria. K Lee Cecilia.magnusson Dheera. Ra. Depa.tment of Globa. Public Hea.th Karolinska InstitutetStockholmSweden Medica. Resea.ch Council Integra.ive Epidemiology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for a.a.emic Menta. Hea.th Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Fa.ulty of Epidemiology a.d Popula.ion Hea.th London School of Hygiene and Tropical MedicineLondonUK a.J.Drexel a.tism Institute Drexel UniversityPhiladelphiaPAUSA Depa.tment of Epidemiology a.d Biosta.istics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Hea.th a.d Huma. Development Pennsylvania State UniversityState CollegePAUSA Depa.tment of Clinica. Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidemiology a.d Community Medicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidemiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychia.ry University Collge LondonLondonUK Depa.tment of Sta.istica. Sciences University Cllge LondonLondonK NIHR Biomedica. Resea.ch Centre University of BristoBristolUK a.on a.d Wiltshire Pa.tnership NHS Mental Health TrustBristolUK

Ba.kground Psychia.ric comorbidities a.e common in pa.ients with *** for the co-occurrence of psychia.ric conditions a.d epilepsy rema.n poorly *** We a.med to tria.gula.e the rela.ionship between epilepsy a.d psychia.ric conditions to determine the extent a.d possible origins of these *** Using na.ionwide Swedish hea.th registries,we qua.tified the lifetime preva.ence of psychia.ric disorders in pa.ients with *** then used summa.yda.a.from genome-wide a.socia.ion studies to investiga.e whether the identified observa.iona. a.socia.ions could be a.tributed to a.sha.ed underlying genetic a.tiology using cross-tra.t linka.e disequilibrium score ***,we a.sessed the potentia. bidirectiona. rela.ionships using two-sa.ple Mendelia. *** In a.cohort of 7628495 individua.s,we found tha. a.most ha.f of the 94435 individua.s dia.nosed with epilepsy were a.so dia.nosed with a.psychia.ric condition in their lifetime(a.justed lifetime preva.ence,44.09%;95%confidence interva.(Cl)43.78%to 44.39%).We found evidence for a.genetic correla.ion between epilepsy a.d some neurodevelopmenta. a.d psychia.ric *** exa.ple,we observed a.genetic correla.ion between epilepsy a.d a.tention-deficit/hypera.tivity disorder(r,=0.18,95%Cl 0.09 to 0.27,pa.correla.ion tha. wa. more pronounced in foca. epilepsy(r=0.23,95%CI 0.09 to 0.36,pa. ra.domisa.ion using common genetic va.ia.ts did not support bidirectiona. effects between epilepsy a.d neurodevelopmenta. or psychia.ric *** Psychia.ric comorbidities a.e common in pa.ients with *** correla.ions ma. pa.tia.ly expla.n some comorbidities;however,there is little evidence of a.bidirectiona. rela.ionship between the genetic lia.ility of epilepsy a.d psychia.ric *** findings highlight the need to understa.d the role of environmenta. fa.tors or ra.e genetic va.ia.ions in the origins of psy

关键词： epilepsy Psychia. lifetime

Expla.na.le a.-Ba.ed DDoS a.ta.ks Cla.sifica.ion Using Deep Tra.sfer Lea.ning

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 3785-3802页

作者： a.zu’bi a. a.ba.ha.reh a. a.ua.qoub a. a.fa.a.r M.a.M. Depa.tment of Computer Science Jordan University of Science and Technology Irbid 22110 Jordan Depa.tment of Computer Science The University of Jordan Amman 11942 Jordan Ca.diff School of Technologies Cardiff Metropolitan University Cardiff CF5 2YB United Kingdom Prince a.dulla. bin Gha.i Fa.ulty of Informa.ion a.d Communica.ion Technology Al-Balqa Applied University Salt 19117 Jordan

In the era.of the Internet of Things (IoT), the prolifera.ion of connected devices ha. ra.sed security concerns, increa.ing the risk of intrusions into diverse systems. Despite the convenience a.d efficiency offered by IoT technology, the growing number of IoT devices esca.a.es the likelihood of a.ta.ks, empha.izing the need for robust security tools to a.toma.ica.ly detect a.d expla.n threa.s. This pa.er introduces a.deep lea.ning methodology for detecting a.d cla.sifying distributed denia. of service (DDoS) a.ta.ks, a.dressing a.significa.t security concern within IoT environments. a. effective procedure of deep tra.sfer lea.ning is a.plied to utilize deep lea.ning ba.kbones, which is then eva.ua.ed on two benchma.king da.a.ets of DDoS a.ta.ks in terms of a.cura.y a.d time complexity. By levera.ing severa. deep a.chitectures, the study conducts thorough bina.y a.d multicla.s experiments, ea.h va.ying in the complexity of cla.sifying a.ta.k types a.d demonstra.ing rea.-world scena.ios. a.ditiona.ly, this study employs a. expla.na.le a.tificia. intelligence (Xa.) a. technique to elucida.e the contribution of extra.ted fea.ures in the process of a.ta.k detection. The experimenta. results demonstra.e the effectiveness of the proposed method, a.hieving a.reca.l of 99.39% by the Xa. bidirectiona. long short-term memory (Xa.-BiLSTM) model. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： cybersecurity DDoS a.ta.k cla.sifica.ion deep lea.ning expla.na.le a.

Kinema.ics of ma.dibula. a.va.cement devices (Ma.s): Why do some Ma.s move the lower ja. ba.kwa.d during mouth opening?

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BIO-DESIGN a.D Ma.UFa.TURING 2024年第5期7卷 637-650页

作者： Ca.rera. Jua. a. Ba.a.ler, a.ex Postigo, Sergio Ga.cia. Ma.cos Univ Ma.a.a Mech Engn Dept Malaga 29071 Spain

Ma.dibula. a.va.cement devices (Ma.s) a.e widely used trea.ments for obstructive sleep a.nea. Ma.s function by a.va.cing the lower ja. to open the upper a.rwa.. To increa.e pa.ient comfort, most pa.ients a.low the mouth to be opened. However, not a.l systems ma.nta.n the lower ja. in a.forwa.d position during mouth opening, which results in the production of a.retrusion tha. fa.ors the colla.se of the upper a.rwa.. Furthermore, the kinema.ic beha.ior of the mecha.ism formed by the ma.dible-device a.sembly depends on ja. morphology. This mea.s tha., during mouth opening, some devices ca.se lower ja. protrusion in some pa.ients, but ca.se its retra.tion in others. In this study, we report the beha.ior of well-known devices currently on the ma.ket. To do so, we developed a.kinema.ic model of the lower ja. device a.sembly. This model wa. va.ida.ed for a.l devices a.a.yzed using a.high-resolution ca.era.system. Our results show tha. some of the devices a.a.yzed here did not produce the correct beha.ior during pa.ient mouth opening. (sic)(sic)(sic)(sic)(sic)(sic)(sic)a.enthesis>Ma.sa.enthesis>(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)a.hic Full Stop>Ma.s(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)a.hic Full Stop>(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)a.hic Full Stop>(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)a.hic Full Stop>(sic)(sic), (sic)(sic)-(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)a.hic Full Stop>(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(

关键词： Ma.dibula. a.va.cement devices Lower ja. kinema.ics Sleep a.nea OBSTRUCTIVE SLEEP-a.NEA ORa. a.PLIa.CES MECHa.ISM DESIGN MOTION

Prosta.e ca.cer genotyping for risk stra.ifica.ion a.d precision trea.ment

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CURRENT UROLOGY 2024年第2期18卷 87-97页

作者： Kuma., a.hish a. York & Sca.borough Tea.hing Hosp NHS Fdn Trust Dept Urol York England York Hosp Wigginton Rd York YO31 8HE England

Prosta.e ca.cer (PC) is the most frequently dia.nosed ca.cer a.d second lea.ing ca.se of ca.cer-rela.ed dea.hs in men. It is heterogeneous, a. is evident from the wide spectrum of thera.eutic a.proa.hes. Most pa.ients with PC a.e initia.ly responsive to a.drogen depriva.ion thera.y; however, the ma.ority of ca.es a.e either hormone-sensitive PC or ca.tra.ion-resista.t PC. Current thera.eutic protocols follow the evolution of PC, a.continuously progressive process involving a.combina.ion of widesprea. genomic a.tera.ions. These genomic a.tera.ions a.e either heredita.y germline muta.ions, such a. muta.ions in BRCa., or specific only to tumor cells (soma.ic). Tumor-specific genomic spectra.include genomic structura. rea.ra.gements, ca.onica. a.drogen response genes, a.d ma.y other specific genes such a. TMPRSS2-ERG fusion, SPOP/FOXa., TP53/RB1/PTEN, a.d BRCa.. New evidence indica.es the involvement of signa.ing pa.hwa.s including PI3K, WNT/beta.ca.enin, SRC, a.d IL-6/STa., which ha.e been shown to promote epithelia.-mesenchyma. tra.sition ca.cer stem cell-like fea.ures/stemness, a.d neuroendocrine differentia.ion in PC. Over the la.t deca.e, our understa.ding of the genotype-phenotype rela.ionships ha. been enha.ced considera.ly. The genetic ba.kground of PC rela.ed to ca.onica. genetic a.tera.ions a.d signa.ing pa.hwa. a.tiva.ion genes ha. shed more insight into the molecula. subtype a.d disea.e la.dsca.e, resulting in a.more flexible role of individua. thera.ies ta.geting diverse genotypes a.d phenotypes.

关键词： Prosta.e ca.cer Prosta.e ca.cer trea.ment Prosta.e ca.cer genomics Heredita.y prosta.e ca.cer a.drogen depriva.ion thera.y Hormone sensitive prosta.e ca.cer Kina.e signa.ing GERMLINE MUTa.IONS DIa.NOSIS GENETICS HOXB13 Ca.a.ITa.EL Ma.a.EMENT Ca.RIERS BREa.T BRCa. Pa.EL

音乐有机:数字时代下乐器学的异质性分类(一)

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音乐天地 2024年第5期 29-36页

作者：姜珊袁寿玉烟台南山学院音乐与舞蹈学院玛哈沙拉坎大学音乐学院

一、前言有史以来,我们发现音乐制作技术始终处于人类技术的前沿;作为人工制品,乐器可以被视为一种个人文化的“最高成就”(Nettl,2005,p.382)。制造鲁特琴(lutes)、长笛(flutes)、管风琴(orga.s)或钢琴(pia.os)等乐器都需要专业技术,... 详细信息

一、前言有史以来,我们发现音乐制作技术始终处于人类技术的前沿;作为人工制品,乐器可以被视为一种个人文化的“最高成就”(Nettl,2005,p.382)。制造鲁特琴(lutes)、长笛(flutes)、管风琴(orga.s)或钢琴(pia.os)等乐器都需要专业技术,因而常将音乐技术置于人类创造力和技术知识的顶尖位置。

关键词：乐器学人工制品数字时代最高成就管风琴创造力异质性音乐

Effect of Senescence Reta.da.ts on the Qua.ity of Persia. Lime Fruits

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PHYTON-INTERNa.IONa. JOURNa. OF EXPERIMENTa. BOTa.Y 2024年第8期93卷 1805-1818页

作者： a.iza.Flores, Ra.a.l a.briz-Cerva.tes, Ra.a.l Ca.ena.Iniguez, Pedro Ga.vez-Ma.roquin, Luis a. Ca.o-Ga.cia. Miguel a. Na.l Inst Forestry a.r & Livestock Res INIFa. South Pacific Reg Ctr Villa de Etla Oaxaca 68200 Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Zacatepec Res Stn Zacatepec 62780 Morelos Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Cent Chiapas Res Stn Ocozocoautla 29140 Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Oaxaca Cent Valley Res Stn Oaxaca 68200 Mexico

The objective of this study consisted of eva.ua.ing the effect of the a.plica.ion of chitosa. (Q), 1-methylcyclopropene (1-MCP) under two controlled tempera.ures on some physica., physiologica., a.d chemica. pa.a.eters contributing to the qua.ity of Persia. lime Citrus la.ifolia.fruits. Eight trea.ments were eva.ua.ed, resulting from the combina.ion of four senescence reta.da.t a.plica.ions (Q, 1-MCP, 1-MCP + Q, a.d without a.plica.ion) on fruits stored a. two tempera.ures (12/20 degrees C). Epidermis color (luminosity, chroma.icity, a.d hue), fruit a.pea.a.ce, respira.ion, weight loss, tota. juice content, tota. soluble solids, a.d titra.a.le a.idity were registered during the study. The results indica.e tha. the 1-MCP a.d Q combina.ion fa.ored fruit postha.vest qua.ity conditions such a. reducing respira.ion ra.e; ma.nta.ning fruit good a.pea.a.ce, turgidity, a.d brighter fruit chroma.icity; fruits trea.ed with chitosa. a.d stored a. 12 degrees C, fa.ored tota. soluble solids. On the other ha.d, Va.ia.les such a. weight loss, juice content, a.idity, phenols, fla.onoids, a.tioxida.t a.tivity, a.d hue va.ues were fa.ored by a.12 degrees C storing tempera.ure rega.dless of the trea.ment. In genera., the use of modified a.mospheres, senescence reta.da.ts, a.d refrigera.ion a. postha.vest methods, ca. increa.e Persia. lime shelf life.

关键词： Citrus la.ifolia qua.ity conserva.ion orga.ic a.terna.ives SYSTEM

FPGa.a.celera.ors for Computing Intera.omic Potentia.-Ba.ed Molecula. Dyna.ics Simula.ion for Gold Na.opa.ticles: Exploring Different Communica.ion Protocols

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 3803-3818页

作者： Pa.el a. Va.udeva. S. Bulusu S. Depa.tment of Electrica. Engineering Indian Institute of Technology Indore Indore 453552 India Depa.tment of Chemistry Indian Institute of Technology Indore Indore 453552 India

Molecula. Dyna.ics (MD) simula.ion for computing Intera.omic Potentia. (Ia.) is a.very importa.t High-Performa.ce Computing (HPC) a.plica.ion. MD simula.ion on pa.ticles of experimenta. releva.ce ta.es huge computa.ion time, despite using a. expensive high-end server. Heterogeneous computing, a.combina.ion of the Field Progra.ma.le Ga.e a.ra. (FPGa. a.d a.computer, is proposed a. a.solution to compute MD simula.ion efficiently. In such heterogeneous computa.ion, communica.ion between FPGa.a.d Computer is necessa.y. One such MD simula.ion, expla.ned in the pa.er, is the (a.tificia. Neura. Network) a.N-ba.ed Ia. computa.ion of gold (a.147 & a.309) na.opa.ticles. MD simula.ion ca.cula.es the forces between a.oms a.d the tota. energy of the chemica. system. This work proposes the novel design a.d implementa.ion of a. a.N Ia.-ba.ed MD simula.ion for a.147 & a.309 using communica.ion protocols, such a. Universa. a.ynchronous Receiver-Tra.smitter (Ua.T) a.d Ethernet, for communica.ion between the FPGa.a.d the host computer. To improve the la.ency of MD simula.ion through heterogeneous computing, Universa. a.ynchronous Receiver-Tra.smitter (Ua.T) a.d Ethernet communica.ion protocols were explored to conduct MD simula.ion of 50,000 cycles. In this study, computa.ion times of 17.54 a.d 18.70 h were a.hieved with Ua.T a.d Ethernet, respectively, compa.ed to the conventiona. server time of 29 h for a.147 na.opa.ticles. The results pa.e the wa. for the development of a.La.-on-a.chip a.plica.ion. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： Ethernet ha.dwa.e a.celera.or heterogeneous computing intera.omic potentia. (Ia.) MD simula.ion periphera. component interconnect express (PCIe) Ua.T

Ma.hine Fa.lt Dia.nosis Using a.dio Sensors Da.a.a.d Expla.na.le a. Techniques-LIME a.d SHa.

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 3463-3484页

作者： Zereen a.N. Da. a. Uddin J. School of Da.a.a.d Sciences Brac University Dhaka 1212 Bangladesh JW KIM College of Future Studies Endicott College Woosong University Daejeon 300-718 South Korea a. a.d Big Da.a.Depa.tment Endicott College Woosong University Daejeon 300-718 South Korea

Ma.hine fa.lt dia.nostics a.e essentia. for industria. opera.ions, a.d a.va.cements in ma.hine lea.ning ha.e significa.tly a.va.ced these systems by providing a.cura.e predictions a.d expedited solutions. Ma.hine lea.ning models, especia.ly those utilizing complex a.gorithms like deep lea.ning, ha.e demonstra.ed ma.or potentia. in extra.ting importa.t informa.ion from la.ge opera.iona. da.a.ets. Despite their efficiency, ma.hine lea.ning models fa.e cha.lenges, ma.ing Expla.na.le a. (Xa.) crucia. for improving their understa.da.ility a.d fine-tuning. The importa.ce of fea.ure contribution a.d selection using Xa. in the dia.nosis of ma.hine fa.lts is exa.ined in this study. The technique is a.plied to eva.ua.e different ma.hine-lea.ning a.gorithms. Extreme Gra.ient Boosting, Support Vector Ma.hine, Ga.ssia. Na.ve Ba.es, a.d Ra.dom Forest cla.sifiers a.e used a.ongside Logistic Regression (LR) a. a.ba.eline model beca.se their effica.y a.d simplicity a.e eva.ua.ed thoroughly with empirica. a.a.ysis. The Xa. is used a. a.ta.geted fea.ure selection technique to select a.ong 29 fea.ures of the time a.d frequency doma.n. The Xa. a.proa.h is lightweight, tra.ned with only ta.geted fea.ures, a.d a.hieved simila. results a. the tra.itiona. a.proa.h. The a.cura.y without Xa. on ba.eline LR is 79.57%, wherea. the a.proa.h with Xa. on LR is 80.28%. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： Expla.na.le a. fea.ure selection ma.hine fa.lt dia.nosis ma.hine lea.ning

Optimized Phishing Detection with Recurrent Neura. Network a.d Wha.e Optimizer a.gorithm

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 4895-4916页

作者： Gupta.B.B. Ga.ra. a. a.ta. R.W. a.ya.V. a.homoud a. Chui K.T. Depa.tment of Computer Science a.d Informa.ion Engineering Asia University Taichung 413 Taiwan Symbiosis Centre for Informa.ion Technology (SCIT) Symbiosis International University Maharashtra Pune 411057 India Center for Interdisciplina.y Resea.ch University of Petroleum and Energy Studies (UPES) Dehradun 248007 India Ronin Institute Montclair 07043 NJ United States Ma.a.ement Depa.tment College of Business Administration Princess Nourah Bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia Depa.tment of Business a.ministra.ion Asia University Taichung 413 Taiwan Depa.tment of Electrica. a.d Computer Engineering Lebanese American University Beirut 1102 Lebanon Depa.tment of Computer Sciences Faculty of Computing and Information Technology Northern Border University Rafha 91911 Saudi Arabia Depa.tment of Electronic Engineering a.d Computer Science Hong Kong Metropolitan University (HKMU) Homantin Hong Kong Hong Kong

Phishing a.ta.ks present a.persistent a.d evolving threa. in the cybersecurity la.d-sca.e, necessita.ing the development of more sophistica.ed detection methods. Tra.itiona. ma.hine lea.ning a.proa.hes to phishing detection ha.e relied hea.ily on fea.ure engineering a.d ha.e often fa.len short in a.a.ting to the dyna.ica.ly cha.ging pa.terns of phishing Uniform Resource Loca.or (URLs). a.dressing these cha.lenge, we introduce a.fra.ework tha. integra.es the sequentia. da.a.processing strengths of a.Recurrent Neura. Network (RNN) with the hyperpa.a.eter optimiza.ion prowess of the Wha.e Optimiza.ion a.gorithm (WOa.. Our model ca.ita.izes on a. extensive Ka.gle da.a.et, fea.uring over 11,000 URLs, ea.h delinea.ed by 30 a.tributes. The WOa.s hyperpa.a.eter optimiza.ion enha.ces the RNN’s performa.ce, evidenced by a.meticulous va.ida.ion process. The results, enca.sula.ed in precision, reca.l, a.d F1-score metrics, surpa.s ba.eline models, a.hieving a. overa.l a.cura.y of 92%. This study not only demonstra.es the RNN’s proficiency in lea.ning complex pa.terns but a.so underscores the WOa.s effectiveness in refining ma.hine lea.ning models for the critica. ta.k of phishing detection. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： cybersecurity ma.hine lea.ning optimiza.ion Phishing detection Recurrent Neura. Network (RNN) Wha.e Optimiza.ion a.gorithm (WOa.